Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells

Cancer Letters

Volumn 186, Issue 1, 2002, Pages 83-91

  Lee, Yong Soo ^a   Jin, Da Qing ^b   Kwon, Eun Jin ^b   Park, Seung Hee ^b   Lee, Eung Seok ^b   Jeong, Tae Cheon ^b   Nam, Doo Hyun ^b   Huh, Keun ^b   Kim, Jung Ae ^b  

^a Duksung Women's University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

Apoptosis; Asiatic acid; HepG2 cell; Intracellular Ca2+; p53; Triterpene

Indexed keywords

3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; ADENOSINE TRIPHOSPHATASE INHIBITOR; ASIATIC ACID; CALCIMYCIN; CALCIUM CHELATING AGENT; CALCIUM ION; CALCIUM IONOPHORE; DANTROLENE; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; PROTEIN P53; THAPSIGARGIN; TRITERPENE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL LINE; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIVER CELL CARCINOMA; NULL CELL; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER NEOPLASMS; TRITERPENES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036883604     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00260-4     Document Type: Article

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