Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice

Carcinogenesis

Volumn 20, Issue 1, 1999, Pages 59-63

  Shiota, Goshi ^a   Harada, Ken Ichi ^a   Ishida, Masato ^a   Tomie, Yasushi ^a   Okubo, Michiko ^a   Katayama, Shunsuke ^a   Ito, Hisao ^a   Kawasaki, Hironaka ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; DIETHYLNITROSAMINE; GLYCYRRHIZIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER CELL CARCINOMA; LIVER FUNCTION TEST; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOMA; ANIMALS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCYRRHIZIC ACID; HEPATITIS, CHRONIC; HEPATITIS, VIRAL, HUMAN; LIVER; LIVER FUNCTION TESTS; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; ORGAN SIZE;

EID: 0032897024     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.1.59     Document Type: Article

References (29)

1. Parkin, D.M., Stjernsward, J. and Muir, C.S. (1984) Estimates of the worldwide frequency of twelve major cancers. Bull. WHO, 62, 163-182.
2. Hubert, B. (1994) Does hepatitis C virus cause hepatocellular carcinoma? Hepatology, 19, 251-255.
3. Tsukuma, H., Tomohiko, H., Tanaka, S. et al. (1994) Risk factors for heatocellular carcinoma among patients with chronic liver diseases. N. Engl. J. Med., 328, 1797-1801.
4. Kiyosawa, K., Sodeyama, T., Tanaka, E. et al. (1991) Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus. Hepatology, 12, 671-675.
5. Takano, S., Yokosuka, O., Imazeki, F., Tagawa, M. and Omata, M. (1995) Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. Hepatology, 21, 650-655.
6. Omata, M. and Takano, S. (1994) Occurrence of hepatocellular carcinoma in chronic viral hepatitis. Cancer Chemother. Pharmacol., 33, S153-S154.
7. Ohtsuki, K., Oh-ishi, M. and Nagata, N. (1992) The stimulatory and inhibitory effects of glycyrrhizin and a glycyrrhetinic acid derivative on phosphorylation of lipocortin 1 by A-kinase in vitro. Biochem. Int., 28, 1045-1053.
8. Finney, R.S.H. and Somers, G.F. (1959) The anti-inflammatory activity of glycyrrhetic acid and derivatives. J. Pharmacol., 10, 613-620.
9. Doll, R., Hill, I.D., Hutton, C. and Underwood, D.L. (1962) Triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet, 2, 793-796.
10. Pompei, R., Flore, O., Marccialis, M.A., Pani, A. and Loddo, B. (1979) Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature, 281, 689-690.
11. Dargan, D.J. and Subaka-Sharpe, J.H. (1986) The antiviral activity against herpes simplex virus of the triterpenoid compounds carenoxolone sodium and cycloxolone sodium. J. Antimicrob. Chem., 18, 185-200.
12. Hirabayashi, K., Iwata, S., Matsumoto, H. et al. (1991) Antiviral activity of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1) in vitro. Chem. Pharm. Bull., 39, 112-115.
13. Abe, N., Ebina, T. and Ishida, N. (1982) Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiol. Immunol., 26, 535-539.
14. Fujisawa, K., Watanabe, Y. and Kimura, K. (1990) Therapeutic approach to chronic active hepatitis with glycyrrhizin. Asian Med. J., 23, 745-756.
15. Suzuki, H., Ohta, Y., Takino, T., Fujisawa, K. and Hirayama, C. (1983) Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis-double blind trail. Asian Med. J., 26, 423-438.
16. Takino, T. (1984) The effects of hepatotherapeutic drugs on chronic liver diseases evaluated by double blind trials in Japan. J. Kyoto Pref. Univ. Med., 93, 689-703.
17. Liu, R.H., Baldwin, B., Tennant, B.C. and Hotchkiss, J.H. (1991) Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection. Cancer Res., 51, 3925-3929.
18. Liu, R.H., Jacob, J.R., Tennant, B.C. and Hotchkiss, J.H. (1992) Nitrate and nitrosamine synthesis by hepatocytes isolated from normal woodchucks (Marmota monax) and woodchucks chronically infected with woodchuck hepatitis virus. Cancer Res., 52, 4139-4143.
19. Matsuzaki, T., Murase, N., Yamaguchi, A., Shinozuka, H., Furuya, T., Burrell, N., Iwatsuki, S. and Starzl, T.E. (1992) Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats. Transplant. Proc., 24, 748-751.
20. Ward, J.M. (1980) Morphology of hepatocellular neoplasmas in B6C3F1 mice. Cancer Lett., 9, 319-325.
21. Di Bisceglie, A.M., Goodman, Z.D., Ishak, K.G., Hoffnagle, J.H., Melpolder, J.J. and Alter, H.J. (1991) Long-term clinical and histological follow-up of chronic posttransfusion hepatitis. Hepatology, 14, 969-974.
22. Kiyosawa, K., Sodeyama, T., Tanaka, E. et al. (1990) Interrelationship of blood transfusion, non-A, non-B, hepatitis and hepatocellular carcinoma. Analysis by detection of antibody to hepatitis C virus. Hepatology, 12, 671-675.
23. Shiota, G., Okano, J., Kawasaki, H., Kawamoto, T. and Nakamura, T. (1995) Serum hepatocyte growth factor levels in liver diseases: clinical implications. Hepatology, 21, 106-112.
24. Hagiwara, H., Hayashi, N., Mita, E., Ueda, K., Takehara T., Kasahara, A., Fusamoto, H. and Kamada, T. (1993) Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy. Gastroenterology, 104, 877-883.
25. Hoofnagle, J.M., Mullen, K.D., Jones, D.B. et al. (1986) Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. N. Engl. J. Med., 315, 1575-1578.
26. Bisceglie, A.D., Martin, P., Kassianidies, C. et al. (1989) Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double-blind, placebo-controlled trial. N. Engl. J. Med., 321, 1506-1510.
27. Kasahara, A., Hayashi, N., Mochizuki, K. et al. (1998) Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Hepatology, 27, 1394-1402.
28. Nishiguchi, S., Kuroki, T., Nakatani, S. et al. (1995) Randomized trial of effects of interferon-α on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet, 346, 1051-1055.
29. Arase, Y., Ikeda, K., Murashima, N. et al. (1997) The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer, 79, 1494-1500.