Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular Carcinoma

Planta Medica

Volumn 75, Issue 15, 2009, Pages 1580-1585

  Zhou, Xue Ying ^a,b   Fu, Feng Hua ^b   Li, Zhen ^b   Dong, Qiu Ju ^b   He, Jie ^b   Wang, Chang Hai ^a,b  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b YANTAI UNIVERSITY   (China)

Author keywords

Antitumor activity; Caspase independent apoptosis; Cell cycle arrest; Escin; Hepatocellular carcinoma; Inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME C; ESCIN; PROTEIN BAX; PROTEIN BCL 2; SAPONIN; TRITERPENE;

AESCULUS WILSONII; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MIXTURE; FEMALE; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MEDICINAL PLANT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PULSED FIELD GEL ELECTROPHORESIS; TUMOR GROWTH; WESTERN BLOTTING;

AESCULUS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCIN; FEMALE; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED STRAINS; PHYTOTHERAPY; PLANT EXTRACTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

AESCULUS; MUS;

EID: 73949100760     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185838     Document Type: Article

References (31)

1. Llovet J M., Beaugrand M. Hepatocellular carcinoma: present status and future prospects. J Hepatol 2003 38 S136-S149
2. German Drug Codex Alimentarius Commission. German drugs code. Aescin, A. 1997 2030
3. Matsuda H, Li Y, Murakami T, Ninomiya K, Yamahara J, Yoshikawa M. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull 1997 20 1092-1095 (Pubitemid 27497995)
4. Marhuenda E, Alarcon de la Lastra C, Martin M J. Antisecretory and gastroprotective effects of escine in rats. Gen Pharmacol 1994 25 1213-1219
5. Fu F H., Hou Y Z., Jiang W L., Wang R H., Liu K. Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions. World J Surg 2005 29 1614-1620
6. Sun F, Fu F H., He J, Dong Q J., Li Z, Gou H T. Dose-and time-effect relationship on anti-inflammation of Aescine-Arginine and its effect on nitric oxide synthesis. Chin Pharmacol Bull 2008 24 672-675
7. Konoshima T, Lee K H. Cytotoxic sapogenols from Aesculus hippocastanum. J Nat Prod 1986 49 650-656
8. Guo W, Xu B, Yang X W., Liu Q, Cui J R. Preliminary studies of effect sodium aescinate against cancer in vitro and in vivo. Chin Pharmacol Bull 2003 19 351-352
9. Yang X W., Zhao J, Cui J R., Guo W. Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylla I. ASNUP 2004 36 31-35
10. waf1/cip1 in colon cancer cells. Mol Cancer Ther 2006 5 1459-1466
11. Zou M, Han Y, Ji X. Escin inhibits growth of HTC8 cells and enhances the cells' sensitivity to 5-FU. Chin J Dig 2001 21 248-249
12. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990 82 1107-1112
13. Kawabe Y, Ochi A. Programmed cell death and extrathymic reduction of Vb81 CD41 T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature (London) 1991 349 245-248
14. Brown D G., Sun X M., Cohen G M. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 1993 268 3037-3039
15. Feng G P., Kaplowitz N. Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002 282 G825-G834
16. Abrams J M., White K, Fessler L I., Steller H. Programmed cell death during Drosophila embryogenesis. Development 1993 117 29-43
17. Hsieh T C., Wu P, Park S, Wu J M. Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity (PSP). BMC Complement Altern Med 2006 6 30-44
18. Watanabe H, Kanbe K, Shinozaki T, Hoshino H, Chigira M. Apoptosis of a fibrosarcoma induced by protein-free culture involves DNA cleavage to large fragments but not internucleosomal fragmentation. Int J Cancer 1995 62 191-198
19. Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase 3 to trigger DNA fragmentation during apoptosis. Cell 1997 89 175-184 (Pubitemid 27199890)
20. Enari M, Sakahira H, Yokoyoma H, Okawa K, Iwamtsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998 391 43-50
21. Liu X S., Li P, Widlack P, Zou H, Luo X, Garrard W T., Wang X D. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci USA 1998 95 8461-8466
22. Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin S A., Zamzami N, Kroemer G. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 2000 476 118-123
23. Lipton S A., Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 2002 111 147-150
24. Wang X C., Yang C L., Cai J J., Shi Y G., Xue D. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science 2002 298 1587-1592
25. Cohen G M. Caspases: the executioners of apoptosis. Biochem J 1997 326 (Pt1) 1-16
26. Woo M, Hakem R, Soengas M S., Ducan G S., Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman S A., Senaldi G, Howard T, Lowe S W., Mak T W. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 1998 12 806-819
27. Bröker L E., Kruyt F A., Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res 2005 11 3155-3162
28. Kunz K, Lorkowski G, Petersen G, Samcova E, Schaffler K, Wauschkuhn C H. Bioavailability of escin after administration of two oral formulations containing aesculus extract. Arzneimittelforschung 1998 48 822-825
29. Loew D, Schrodter A, Schwankl W, Marz R W. Measurement of the bioavailability of aescin-containing extracts. Methods Find Exp Clin Pharmacol 2000 22 537-542
30. Schrader E, Schwankl W, Sieder C, Christoffel V. Comparison of the bioavailability of beta-aescin after single oral administration of two different drug formulations containing an extract of horse-chestnut seeds. Pharmazie 1995 50 623-627
31. Hu X M., Zeng F D. Pharmacokinetics of sodium-aescinate induced by ischemia-reperfusion in cerebral damage rats. Chin J Clin Pharmacol Ther 2005 10 828-831