Vitamin A and β-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine

Food and Chemical Toxicology

Volumn 45, Issue 4, 2007, Pages 563-567

  Sampaio, Alda R D ^a   Chagas, Carlos E A ^a   Ong, Thomas P ^a   Moreno, Fernando S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Carotene; 1,2 Dimethylhydrazine; 5 Azacytidine; Chemoprevention; Hepatocarcinogenesis; Vitamin A

Indexed keywords

1,2 DIMETHYLHYDRAZINE; AZACITIDINE; BETA CAROTENE; CORN OIL; N (2 FLUORENYL)ACETAMIDE; RETINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CONTROL; CANCER INHIBITION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EARLY DIAGNOSIS; LIVER CARCINOGENESIS; LIVER CELL; LIVER RESECTION; MALE; NONHUMAN; RAT;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTICARCINOGENIC AGENTS; AZACITIDINE; BETA CAROTENE; DNA REPAIR; GAMMA-GLUTAMYLTRANSFERASE; LIVER NEOPLASMS, EXPERIMENTAL; MALE; RATS; RATS, WISTAR; VITAMIN A;

ANIMALIA; RATTUS NORVEGICUS; ZEA MAYS;

EID: 33846874352     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.10.001     Document Type: Article

References (31)

1. Bender C.M., Zingg J.M., and Jones P.A. DNA methylation as a target for drug design. Pharm. Res. 15 (1998) 175-187
2. Carr B.I., Reilly J.G., Smith S.S., Winberg C., and Riggs A. The tumorgenicity of 5-azacytidine in male Fisher rats. Carcinogenesis 5 (1984) 1583-1590
3. Choi M.S., Shim Y.H., Hwa J.Y., Lee S.K., Ro J.K., Kim J.S., and Yu E. Expression of DNA methyltransferases in multistep hepatocarcinogenesis. Hum. Pathol. 34 (2003) 11-17
4. Denda A., Rao P.M., Rajalakshmi S., and Sarma D.S. 5-Azacytidine potentiates initiation induced by carcinogens in rat liver. Carcinogenesis 6 (1985) 145-146
5. Doerksen T., Benoit G., and Trasler J.M. Deoxyribonucleic acid hypomethylation of male germ cells by mitotic and meiotic exposure to 5-azacytidine is associated with altered testicular histology. Endocrinology 141 (2000) 3235-3244
6. Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol. 4 (2003) 351-358
7. Fenaux P. Inhibitors of DNA methylation: beyond myelodysplastic syndromes. Nat. Clin. Pract. Oncol. 2 (2005) S36-S44
8. Fonseca E.M.A.V., Chagas C.E.A., Mazzantini R.P., Heidor R., Ong T.P., and Moreno F.S. All-trans and 9-cis retinoic acids, retinol and beta-carotene chemoprevention activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage. Carcinogenesis 26 (2005) 1940-1946
9. Garcea R., Daino L., Pascale R., Simile M.M., Puddu M., Ruggiu M.E., Seddaiu M.A., Satta G., Sequenza M.J., and Feo F. Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio. Carcinogenesis 10 (1989) 1183-1192
10. Ishikawa T., Zhang S.S.-M., Qin X., Takahashi Y., Oda H., Nakatsuru Y., and Ide F. DNA repair and cancer: lessons from mutant mouse models. Cancer Sci. 95 (2004) 112-117
11. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001), National Academics, Washington, DC pp. 82-161
12. Johanning G.L., Heimburger D.C., and Piyathilake C.J. DNA methylation and diet in cancer. J. Nutr. 132 (2002) 3814S-3818S
13. Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3 (2002) 415-428
14. Karpf A.R., and Jones D.A. Reactivating the expression of methylation silenced genes in human cancer. Oncogene 21 (2002) 5496-5503
15. Lee S., Lee H.J., Kim J.H., Lee H.S., Jang J.J., and Kang G.H. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am. J. Pathol. 163 (2003) 1371-1378
16. Matsuzaki K., Deng G., Tanaka H., Kakar S., Miura S., and Kim Y.S. The relationship between global methylation level, loss of heterozygosity and microsatellite instability in sporadic colorectal cancer. Clin. Cancer Res. 11 (2005) 8564-8569
17. Moreno F.S., Rizzi M.B., Dagli M.L., and Penteado M.V. Inhibitory effects of beta-carotene on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model. Carcinogenesis 12 (1991) 1817-1822
18. Moreno F.S., Wu T.S., Penteado M.V., Rizzi M.B., Jordão Jr. A.A., Almeida-Muradian L.B., and Dagli M.L. A comparison of beta-carotene and vitamin A effects on hepatocarcinogenesis model. Int. J. Vitam. Nutr. Res. 65 (1995) 87-94
19. Moreno F.S., S-Wu T., Naves M.M., Silveira E.R., Oloris S.C., Costa M.A., Dagli M.L., and Ong T.P. Inhibitory effects of beta-carotene and vitamin A during progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation. Nutr. Cancer. 44 (2002) 80-88
20. O' Neill M.E., Carroll Y., Corridan B., Olmedilla B., Granado F., Blanco I., Van den Berg H., Hininger I., Rousell A.-M., Chopra M., Southon S., and Thurnham D.I. A European carotenoid database to assess carotenoid intakes and its use in five-country comparative study. Br. J. Nutr. 85 (2001) 499-507
21. O'Toole S.M., Pegg A.E., and Swenberg J.A. Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine. Cancer Res. 53 (1993) 3895-3898
22. Prasanna P., Shack S., Wilson V.L., and Samid D. Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2-deoxycytidine-induced carcinogenesis. Clin. Cancer Res. 1 (1995) 865-871
23. Rizzi M.B., Dagli M.L., Jordão Jr. A.A., Penteado M.V., and Moreno F.S. Beta-carotene inhibits persistent and stimulates remodeling γ-GT-positive preneoplastic lesions during early promotion of hepatocarcinogenesis. Int. J. Vitam. Nutr. Res. 67 (1997) 415-422
24. Rutenburg A.M., Kim H., Fischbein J.W., Hanker J.S., Wasserkrug H.L., and Seligman A.M. Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity. J. Histochem. Cytochem. 17 (1969) 517-526
25. Silveira E.R., Naves M.M., Vannucchi H., Jordão Jr. A.A., Dagli M.L., and Moreno F.S. Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats. Nutr. Cancer. 39 (2001) 244-251
26. Silverman L.R., and Mufti G.J. Methylation inhibitor therapy in the treatment of myelodysplastic syndrome. Nat. Clin. Pract. Oncol. 2 (2005) S12-S23
27. Squire R.A., and Levitt M.H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res. 35 (1975) 3214-3223
28. Webster R.P., Gawde M.D., and Bhattacharya R.K. Effect of vitamin A status on carcinogen-induced DNA damage and repair enzymes in rat. In vivo 10 (1996) 113-118
29. Wolterbeek A.P., Roggeband R., van Moorsel C.J., Baan R.A., Koeman J.H., Feron V.J., and Rutten A.A. Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture. Cancer Lett. 91 (1995) 2005-2014
30. Yamada Y., Jackson-Grusby L., Linhart L., Meissner A., Eden A., Lin H., and Jaenisch R. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc. Natl. Acad. Sci. USA 102 (2005) 13580-13585
31. Yang B., Guo M., Herman J.G., and Clark D.P. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am. J. Pathol. 163 (2003) 1101-1107