Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a wistar rat hepatocarcinogenesis model

Nutrition and Cancer

Volumn 50, Issue 1, 2004, Pages 101-109

  Scolastici, Clarissa ^a   Ong, Thomas Prates ^b   Moreno, Fernando Salvador ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CORN OIL; CYCLINE; GLUTATHIONE TRANSFERASE; ISOPRENOID; OLIVE OIL; SQUALENE; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER PREVENTION; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CHOLESTEROL BLOOD LEVEL; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DOSE RESPONSE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER WEIGHT; MALE; NONHUMAN; RAT; STATISTICAL ANALYSIS;

ANIMALIA; RATTUS NORVEGICUS; ZEA MAYS;

EID: 9744231424     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/s15327914nc5001_13     Document Type: Article

References (65)

1. Newmark HL: Squalene, olive oil, and cancer risk. Ann N Y Acad Sci 889, 193-203, 1999.
2. Reddy BS: Dietary fat and colon cancer. Lipids 27, 807-813, 1992.
3. Rao CV, Newmark HL, and Reddy BS: Chemopreventive effect of squalene on colon cancer. Carcinogenesis 19, 287-290, 1998.
4. Sporn MB and Suh N: Chemoprevention of cancer. Carcinogenesis 21, 525-530, 2000.
5. Elson CE and Yu SG: The Chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables. J Nutr 124, 607-614, 1994.
6. Crowell PL: Prevention and therapy of cancer by dietary monoterpenes. J Nutr 129, 775S-778S, 1999.
7. Van Duren BL and Goldschimidt BM: Co-carcinogenic and tumor-promotion agents in tobacco Carcinogenesis. J Natl Cancer Inst 56, 1237-1342, 1976.
8. Murakoshi M, Nishino H, Tokuda H, Owashima A, Okuzimi J, et al.: Inhibition by squalene of the tumor-promoting activity of 12-O- tetradecanoyphorbol-13-acetate in mouse-skin Carcinogenesis. Int J Cancer 56, 950-952, 1992.
9. Desai KN, Wei H, and Lamartiniere CA: The preventive and therapeutic potential of the squalene-containing compound, roidex, on tumor promotion and regression. Cancer Lett 101,93-96, 1996.
10. Smith TJ, Yang G, Seril, DN, Liao J, and Kim S: Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene. Carcinogenesis 19, 703-706, 1998.
11. Brown MS and Goldstein JL: Regulation of the mevalonate pathway. Nature 343, 425-130, 1990.
12. Quesney-Huneeus V, Galick HA, Siperstein MD, Erickson SK, Spencer TA, et al.: The dual role of mevalonate in the cell cycle. J Biol Chem 258, 378-385, 1983.
13. Elson CE, Peffley DM, and Hentosh PMH: Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. Proc Soc Exp Biol Med 221, 294-311, 1999.
14. Siperstein MD: Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth. J Lipid Res 25, 1462-1468, 1984.
15. Barret JR: Plants provide prevention. Environ Health Perspect 110, 180, 2002.
16. Bishayee A, Sarkar A, and Chatterjee M: Further evidence for chemopreventive potential of β-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by β-carotene than by retinoic acid. Nutr Cancer 37, 89-98, 2002.
17. Moreno FS, Wu TS, Naves MMV, Silveira ER, Oloris SC, et al.: Inhibitory effects of β-carotene and vitamin A during the progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation. Nutr Cancer 44, 80-88, 2002.
18. Solt D and Farber E: New principle for the analysis of chemical carcinogenesis. Nature 263, 701-703, 1976.
19. Semple-Roberts E, Hayes MA, Armstrong D, Becker RA, Racz WJ, et al.: Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int J Cancer 40, 643-645, 1987.
20. Farber E and Sarma DS: Biology of disease. Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest 56, 4-22, 1987.
21. Moreno FS, Wu T-S, Penteado MVC, Rizzi MBSL, Jordão Jr AA, et al.: A comparison of β-carotene and vitamin A effects on a hepatocarcinogenesis model. Int J Vit Nutr Res 65, 1-8, 1995.
22. Oliveira VN, Mazzantini RP, Ong TP, Jordão JAA, Vannuchi H, et al.: Absence of inhibitory effects of phenylacetate on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model of carcinogenesis. Int J Med Biol Environ 29, 179-184, 2001.
23. Farber E: The sequential analysis of liver cancer induction. Biochim Biophys Acta 605, 149-166, 1980.
24. Enzmann H, Bomhard E, Iatropoulos M, Ahr HJ, Schluelter G, et al.: Short- and intermediate-term carcinogenicity testing: a review. Part 1: the prototypes mouse skin tumour assay and rat liver focus assay. Food Chem Toxicol 36, 979-995, 1998.
25. Higgins GM and Anderson RM: Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12, 186-202, 1931.
26. Bannasch P and Zerban H: Tumor of the liver. In: Pathology of tumors in laboratory animals, Turusov VS and Mohr U (eds). Lyon, France: Int Agency Res Cancer, 1990, pp. 199-240.
27. Squire RA and Levitt MH: Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 35, 3214-3223, 1975.
28. Hsu SM, Raine L, and Fanger N: Use of avidin-biotin-peroxidase Complex (ABC) and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29, 577-580, 1981.
29. Goldsworthy TL, Fransson-Steen R, and Maronpot RR: Importance of and approaches to quantification of hepatocyte apoptosis. Toxicol Pathol 24, 24-35, 1996.
30. Tice RR, Andrews PW, and Singh NP: The single cell gel assay: a sensitive technique for evaluation intercellular differences in DNA damage and repair. Basic Life Sci 53, 291-301, 1990.
31. Olive PL, Banath JP, and Durand RE: Heterogeneity in ration-induced DNA damage and repair in tumor and normal cells using the "comet assay." Radiat Res 122, 86-94, 1990.
32. Vaghef H and Hellman B: Detection of styrene and styrene oxide-induced DNA damage in various organs of mice using the comet assay. Pharmacol Toxicol 83, 69-74, 1998.
33. Barbisan LF, Scolastici C, Miyamoto M, Salvadori DM, Ribeiro LR, et al.: Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine. Genet Mol Res 2, 295-308, 2003.
34. Rushmore TH, Harris L, Nagai M, Sharma RN, Hayes MA, et al.: Purification and characterization of P-52 (glutathione S-transferase-P or 7-7) from normal liver and putative preneoplastic liver nodules. Cancer Res 48, 2805-2812, 1988.
35. Tatematsu M, Mera Y, Ito N, Satoh K, and Sato K: Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of gamma-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis 11, 1621-1626, 1985.
36. Wargovich MJ, Jimenez A, McKee K, Steele VE, Velasco M, et al.: Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 21, 1149-1155, 2000.
37. Ong TP, Espíndola R, Heidor R, Dagli M, Moura A, et al.: The chemopreventive activities of farnesol and geraniol in rats submitted to the resistant hepatocyte model of hepatocarcinogenesis involve inhibition of cell proliferation. Eur J Cancer 38, 587, 2002.
38. Kong J and Ringer DP: Quantitative analysis of changes in cell proliferation and apoptosis during preneoplastic and neoplastic stages of hepatocarcinogenesis in rat. Cancer Lett 105, 241-248, 1996.
39. Grasl-Kraupp B, Ruttkay-Nedecky B, Mullauer L, Tarper H, Wolfgang H, et al.: Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression. Hepatology 25, 906-912, 1997.
40. Shiota G, Maeta Y, Mukoyama T, Yanagidani A, Udagawa A, et al.: Effects of sho-saiko-to on hepatocarcinogenesis and 8-hidroxy-2′-deoxyguanosine formation. Hepatology 35, 1125-1133, 2002.
41. Sarkar A, Bishayee A, and Chatterjee M: Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis. Cancer Biochem Biophys 15, 111-125, 1995.
42. Bartoli GM, Giannattasio B, Palozza P, and Cittadini A: Superoxide dismutase depletion and lipid peroxidation in rat liver microsomal membranes: correlation with liver carcinogenesis. Biochim Biophys Acta 966, 214-221, 1988.
43. Boitier E, Merad-Boudia M, Guguen-Guillouzo C, Defer N, Ceballos-Picot I, et al.: Impairment of the mitochondrial respiratory chain activity in diethylnitrosamine-induced rat hepatomas: possible involvement of oxygen free radicals. Cancer Res 55, 3028-3035, 1995.
44. Shen HM and Ong CN: Mutations of the p53 tumor suppressor gene and Ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat Res 366, 23-14, 1996.
45. Uemura T, Saikato K, Takagi A, Hasegawa R, and Kurokawa Y: Oxidative DNA damage and cell proliferation in the livers of B6C3F1 mice exposed to pentachlorophenol in their diet. Fundam Appl Toxicol 30, 285-289, 1996.
46. Owen WR, Giacosa A, Hull WE, Haubner R, Wurtele G, et al.: Olive oil consumption and health: the possible role of antioxidants. Lancet Oncol 1, 107-112, 2000.
47. Yamamoto Y: Role of active oxygen species and antioxidants in photoaging. J Dermatol Sci 27, 1-4, 2001.
48. O'Sullivan L, Woods JA, and O'Brien NM: Squalene but not n-3 fatty acids protect against hydrogen peroxide-induced sister chromatid exchange in Chinese hamster V79 cells. Nutr Res 22, 847-857, 2002.
49. Feitelson MA, Sun B, Satiroglu TNL, Liu J, Pan J, et al.: Genetic mechanism of hepatocarcinogenesis. Oncogene 21, 2593-2604, 2002.
50. Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, et al.: Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - a comprehensive study of loss of heterozygozity and microsatellite instability at 39 loci and DNA hypermethylation on eight CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32, 970-979, 2000.
51. Fenech M: The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res 475, 57-67, 2001.
52. Owen RW, Mier W, Giacosa A, Hull WE, Spigelhalder B, et al.: Phenolic compounds and squalene in olive oils: the concentration and anti-oxidant potential of total phenols, simple phenols, secoiridoids, lignans and squalene. Food Chem Toxicol 38, 647-659, 2000.
53. Toledo LP, Ong TP, Pinho AL, Jordáo A Jr, Vanucchi H, et al.: Inhibitory effects of lutein and lycopene on placental glutathione S-transferase-positive preneoplastic lesions and DNA strand breakage induced in Wistar rats by the resistant hepatocyte model of hepatocarcinogenesis. Nutr Cancer 47, 62-69, 2003.
54. Moreno J: Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages raw 264.7. Free Rad Biol Med 35, 1073-1081, 2003.
55. Dominguez-Malagon H and Gaytan-Graham S: Hepatocellular carcinoma: an update. Ultrastruc Pathol 25, 497-516, 2001.
56. Porsch-Hallstrom I, Blanck A, Eriksson LC, and Gustafsson JA: Expression of the c-myc, c-fos, and c-Ha-ras protooncogenes during sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model. Carcinogenesis 10, 1793-1800, 1989.
57. Buchmann A, Bauer-Hofmann R, Mahr J, Drinkwater NR, Luz A, et al.: Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. Proc Natl Acad Sci USA 88, 911-915, 1991.
58. Tokusashi Y, Fukuda I, and Ogawa K: Absence of p53 mutations and various frequencies of Ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens. Mol Carcinog 10, 45-51, 1994.
59. Zhang Z, Yeung WK, Huang Y, and Chen ZY: Effect of squalene and shark liver oil on serum cholesterol level in hamsters. Int J Food Sci Nutr 53, 411-118, 2002.
60. Nakamura Y, Tonogai Y, Tsumura Y, Shibata T, and Uchiyama M: Effect of dietary squalene on the fecal steroid excretions and lipid levels of serum and liver in the rat. Nutr Res 17, 243-257, 1997.
61. Strandberg TE, Tilvis RS, and Miettinen TA: Metabolism variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. J Lipid Res 31, 1637-1643, 1990.
62. Chan P, Tomlinson B, Lee CB, and Lee YS. Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. J Clin Pharmacol 36, 422-427, 1996.
63. Gregg RG, Davidson M, and Wilce PA: Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats. Int J Blochem 18, 389-393, 1986.
64. Abel S, Smuts CM, De Villiers C, and Gelderblom WCA: Changes in essential fatty acid patterns associated with normal liver regeneration and the progression of hepatocyte nodules in rat hepatocarcinogenesis. Carcinogenesis 22, 795-804, 2001.
65. Smith TJ: Squalene: potential chemopreventive agent. Expert Opin Investig Drug 9, 1841-1848, 2000.