Ca 2+ and sphingolipids as modulators for apoptosis and cancer;El Ca 2+ y los esfingolípidos como moduladores de la apoptosis y el cáncer

Investigacion Clinica

Volumn 53, Issue 1, 2012, Pages 84-110

  Pimentel, Adriana A ^a,b   Benaim, Gustavo ^a,c  

^a Fundacion Instituto de Estudios Avanzados IDEA   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c FACULTAD DE CIENCIAS   (Venezuela)

Author keywords

Apoptosis; Ca 2+; Cancer; SERCA inhibitors; Sphingolipids

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CASPASE; CERAMIDE 1 PHOSPHATE; PLASMA MEMBRANE CALCIUM PUMP; PROTEIN BCL 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; THAPSIGARGIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CALCIUM CHANNEL; CERAMIDE; SPHINGOSINE; TUMOR PROTEIN;

APOPTOSIS; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; NEOPLASM; PROTEIN AGGREGATION; PROTEIN UNFOLDING; REVIEW; TUMOR CELL; CALCIUM SIGNALING; DRUG EFFECT; HUMAN; ION TRANSPORT; MITOCHONDRION; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM CHANNELS; CALCIUM SIGNALING; CERAMIDES; ENDOPLASMIC RETICULUM STRESS; HUMANS; ION TRANSPORT; MITOCHONDRIA; NEOPLASM PROTEINS; NEOPLASMS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; SPHINGOSINE;

EID: 84859075820     PISSN: 05355133     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (149)

1. Carafoli E. Calcium Signaling: A tale for all seasons. Proc Natl Acad Sci USA 2002; 99: 1115-1122.
2. Fedrizzi L, Lim D, Carafoli E. Calcium and signal transduction. Biochem Mol Biol Educ 2008; 36:175-80.
3. 2+-ATPasa de la membrana plasmática de tripanosomatideos. Acta Cient Venezol 1993; 44: 57-66.
4. Carafoli E. Intracellular calcium homeostasis. Annu Rev Biochem 1987; 56: 395-433.
5. Grabarek Z. Structural basis for diversity of the EF-hand calcium-binding proteins. J Mol Biol 2006; 359: 509-25.
6. Benaim G, Cervino V, Villalobo A. Comparative phosphorylation of calmudulin from trypanosomatids and bovine brain by calmudulin-binding protein kinase. Comp Biochem Physiol Part C 1998; 120: 57-65.
7. Benaim G, Villalobo A. Phosphorylation of calmodulin: Functional implications. Eur J Biochem 2002; 269: 3619-3631.
8. 2+-ATPasa de la membrane plasmática como enzima clave en la homeostasis intracelular del calcio. Estimula-ción por etanol y otros efectores. Acta Cient Venezol 2004; 55: 304-314.
9. Biswas DK, Reddy PV, Pickard M, Makkad B, Pettit N, Pardee AB. Calmudulin is essential for estrogen receptor interaction with its motif and activation of responsive promoter. J Biol Chem 1998; 273: 33817-33824.
10. Gallo D, Jacquot Y, Laurent G, Leclercq G. Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells. Mol Cell Endocrinol. 2008; 291: 20-6.
11. Rodríguez-Mora OC, Liar MM, McCubrey JA, Franklin RA. Calcium/Calmudulin-independent kinase I and Calcium/ Calmudulin-dependent kinase in the control of the cell cycle progresión in MCF-7 human breast cancer cells. Cancer Res 2005; 65: 5408-5416.
12. 2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis". J Biol Chem 1984; 259: 8471-8477.
13. Lee WJ, Roberts-Thomson SJ, Holman NA, May FJ, Lehrbach GM, Montheith GH. Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cells lines. Cell Signaling 2002; 14: 1015-1022.
14. Lee WJ, Robinson JA, Holman NA, Mc-Call MN, Roberts-Thomson SJ, Monyeith GR. Antisense-mediated inhibition of the plasma membrane calcium ATPase suppresses proliferation of MCF-7 cells. J Biol Chem 2005a; 280: 27076-27084.
15. Lee WJ, Roberts-Thomson SJ, Montheith GH. Plasma membrane calcium ATPasa 2 and 4 in human breast cancer cells lines. Biochem Biophys Res Commun 2005b; 337: 779-783.
16. Nestler EJ. Electrical exitability of neurons. En Nestler E J, Hyman S E, Malenca R C. Molecular neuropharmacology. Parte 1, Cápitulo 3. USA: Editorial McGraw-Hill; 2001. p: 33-57.
17. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003; 4: 517-529.
18. Takemura H, Hughes AR, Thastrup O, Putney JW Jr. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulate calcium fluxes at the plasma membrane. J Biol Chem 1989; 264:12266-12271.
19. 2+-ATPase. Proc Natl Acad Sci USA 1990; 87: 2466-2470.
20. 2+ entry channels. J Biol Chem 2001; 276: 18888-18896.
21. 2+ entry in mouse mammary epithelial cell. Cell Biochem Funct 2001; 19: 213-219.
22. Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedegaard M. Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 cancer cells. Cancer Res 2000; 60: 5395-5400.
23. Clapham DE. TRP channels as cellular sensors. Nature 2003; 426: 517-524.
24. 2+ signaling. Cell Calcium 2006; 40: 261-275.
25. Chang L, Barritt GJ. TRPM8 in prostate cancer cells: a potential diagnostic andprognostic marker with a secretory function? Endocr Relat Cancer 2006; 13: 27-38.
26. Rottingen J-A, Iversen J-G. Ruled by waves? Intracellular and intercellular calcium signalling. Acta Physiol Scand 2000; 169: 203-219.
27. Hasselbach W, Makinose M. The calcium pump of the "relaxing granules" of muscle and its dependence on ATP-splitting. Biochem Z 1961; 333: 518-528.
28. MacLennan DH. Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum. J Biol Chem 1970; 245: 4508-4518.
29. Brini M, Carafoli E. Calcium signaling: a historical account recent developments and future perspectives. Cell Mol Life Sci 2000; 57: 354-370.
30. Szasz I, Sarkadi B, Schubert A, Gardos G. Effects of lanthanum on calcium-dependent phenomena in human red cells. Biochim Biophys Acta 1978; 512: 331-340.
31. 2+ transport ATPase. J. Membrane Biol 1994; 141: 1-6.
32. 2+concentration and induces apoptosis in human breast cancer cells (MCF-7). Cancer Chemother Pharmacol 2011; [Epub ahead of print]. DOI10.1007/ s00280-011-1677-x.
33. 2+transport in isolated mitochondrial vesicles from Leishmania braziliensis promastigotes. Mol Biochem Parasitol 1990; 39: 61-68.
34. Futerman A, Hannun Y. The complex life of simple sphingolipids. EMBO Rep 2004; 5: 777-782.
35. Merril AH Jr, Schmelz E-M, Dillehay DL, Spiegel S, Shayman JA, Schroeder JJ, Riley RT, Voss KA, Wang E. Sphingolipids-The enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol Appl Pharmacol 1997; 142: 208-225.
36. 2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel. Arch Biochem Biophys 2005; 436: 333-345.
37. Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem 2011; 286: 25352-25362.
38. Mathias P, Peña LA, Nolesnick RN. Signal transduction of stress via ceramida. Biochem J 1998; 355: 465-480.
39. 2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation of a store-operated calcium channel. Biochem Biophys Res Commun 2005; 336: 54-60.
40. Chen Y, Liu Y, Sullards MC, Merrill AH Jr. An introduction to sphingolipid metabolism and analysis by new technologies. Neuromolecular Med 2010; 12:306-319.
41. Hannun YA, Obeid LM. Many ceramides. J Biol Chem. 2011; 286:27855-27862.
42. Clarke CJ, Wu BX, Hannun YA. The neutral sphingomyelinase family: identifying biochemical connections. Adv Enzyme Regul 2011; 51:51-58.
43. Gomez-Muñoz A. Ceramide-1-phosphate: a novel regulator of cell activation. FEBS Lett 2004; 562: 5-10.
44. Pyne S, Pyne NJ. Sphingosine-1-phosphate signalling in mammalian cells. Biochem J 2000; 349: 385-402.
45. Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie 2010; 92:716-723.
46. Fyrst H, Saba JD. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim Biophys Acta 2008; 1781:448-458.
47. Maceyka M, Payne SG, Milstein S, Spiegel S. Sphingosine kinase, Sphingosine-1- phosphate, and apoptosis. Biochim Biophys Acta 2002; 1585: 193-201.
48. Mathias S, Dressler KA, Kolesnick RN. Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor. Proc. Natl Acad Sci USA 1991; 88: 10009-10013.
49. Liu J, Mathias S, Yang Z, Kolesnick RN. Renaturation and tumor necrosis factor-cr stimulation of a 97-kDa ceramide-activated protein kinase. J Biol Chem 1994; 269: 3047-3052.
50. Muller G, Ayoub M, Storz P, Rennecke J, Fabbro D, Pfizenmaier K. PKCξ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid, EMBO J 1995; 4: 1961-1969.
51. Wolff RA, Dobrowsky RT, Bielawska A, Obeid LV, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction, J Biol Chem 1994; 269: 19605-19609.
52. Wiegmann K, Schütze S, Machleidt TH, Witte D, Krönke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signalling. Cell 1994; 78: 1005-1015.
53. Chen M, Quintan J, Fuk Z, Thompson C, Kufe DW, Weichselbaum RR. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, Tumor Necrosis Factor α, and ceramide. Cancer Res 1995; 55: 991-999.
54. Schwandner R, Wiegmann K, Bernardo K, Kreder D, Krönke M. TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase. J Biol Chem 1998; 273: 5916-5922.
55. Ravid T, Tsaba A, Gee P, Rasooly R, Medina E, Goldkorn T. Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol 2003; 284: L1082-L1092.
56. Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem 2011; 286: 15929-15942.
57. Karasavvas N, Erukulla RK, Bittman R, Lockshin R, Zakeri Z. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine: The ceramide amide group is not required for apoptosis. Eur J Biochem 1996; 236: 729-737.
58. Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 1989; 243: 500-507.
59. Gómez-Muñoz A. Modulation of cell signaling by ceramides. Biochim Biophys Acta 1998; 1391: 92-109.
60. 2+-ATPasa from human erythrocytes. Biochem J 2002; 362: 247-251.
61. Strub GM, Maceyka M, Hait NC, Milstien S, Spiegel S. Extra cellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol. 2010; 688:141-155.
62. Spiegel S, Milstein S. Exogenous and intracellularly generate sphingosine 1-phospate can regulate cellular processes by divergent pathways. Biochem Soc Transaction 2003; 31: 1216-1219.
63. 2+ mobilization, ras-mitogen-activated protein kinase activation and adenylate cyclase inhibition. J Biol Chem 1998; 273: 27104-27110.
64. Kon J, Sato K, Watanabe T, Tomura H, Kuwabara A, Kimura T, Tamama K, Ishizuka T, Murata N, Kanda T Kobayashi I, Ohta H, Ui M, Okajima F. Comparison of intrinsic activities of putative sphingosine- 1-phosphate receptors sub-types to regulate several signaling pathways in their cDNA-transfected Chinese Hamster ovary cells. J Biol Chem 1999; 274: 23940-23947.
65. Olivera A, Spiegel S. Sphingosine-1-Phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 1993; 365: 557-560.
66. Cuvillier O, Rosenthal DS, Smulson ME, Spiegel S. Sphingosine-1-Phosphate inhibits activation of caspases that cleave Poly(ADP-ribose) Polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. J Biol Chem 1998; 273: 2910-2916.
67. Kim J, Song W, Chun J. Sphingosine-1-Phosphate activates ERK-1/-2 by transactivating epidermal growth factor in rat-2 cells. IUBMB Life 2000; 50: 119-124.
68. Pettus B, Bielawska A, Spiegel S, Roddy P, Hannun Y, Chalfant C. Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2. J Biol Chem 2004; 279: 11320-11326.
69. 2+ from inositol trisphosphateand phosphatidic acid-sensitive intracellular stores through a mechanism independent of inositol trisphosphate. J Biol Chem 1996; 271: 11148-55.
70. Grimm Ch, Kraft R, Schultz G, Harteneck Ch. Activation of the Melastatin-Related Cation Channel TRPM3 by D-erythro-Sphingosine. Mol Pharmacol 2005; 67: 798-805.
71. Relling DP, Hintz KK, Ren J. Acute exposure of ceramide enhances cardiac contractile function in isolated ventricular myocytes. Br J Pharmacol 2003; 140: 1163-1168.
72. Lepple-Wienhues A, Belka C, Laun T, Jekle A, Walter B, Wieland U, Welz M, Heil L, Kun J, Busch G, Weller M, Bamberg M, Gulbins E, Lang F. Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc Natl Acad Sci USA 1999; 96: 13795-13800.
73. Mathes C, Fleig A, Penner R. Calcium release- activated calcium current (ICRAC) is a direct target for sphingosine. J Biol Chem 1998; 273: 25020-25030.
74. Nakamura Y, Nakashima S, Ojio K, Banno Y, Miyata H, Nozawa Y. Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells. J Immunol 1996; 156: 256-262.
75. Gisjbers S, Mannaerts G, Himpems B, Van Veldhoven P. N-acetyl-sphingenine- 1-phosphate is a potent calcium mobilizing agent. FEBS Lett 1999; 453: 269-272.
76. Hogback S, Leppimaki P, Rudnas B, Bjorklund S, Slotte J, Tronquist K. Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. Biochem J 2003; 370: 111-119.
77. Gomez-Muñoz A, Frago L, Alvarez L, Valera-Nieto I. Stimulation of DNA synthesis by natural ceramide 1-phosphate. Biochem J 1997; 325: 435-440.
78. Rile G, Yatomi Y, Takafuta T, Ozaki Y. Ceramide 1-phosphate formation in neutrophils. Acta Hematol 2003; 265: 14917-14921.
79. van Brocklyn JR, Lee MJ, Menzeleev R, Olivera A, Edsall L, Cuvillier O, Thomas DM, Coopman PJ, Thangada S, Liu CH, Hla T, Spiegel S. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol 1998; 142: 229-240.
80. 2+ signaling by G-protein-coupled receptors. EMBO J 1998; 17: 2830-2837.
81. Alfonso A, De la Rosa LA, Vieytes MR, Botana LM. Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. Biochem Pharmacol 2003; 65: 465-478.
82. Durieux M, Carlisle S, Salafranca M, Lynch K. Responses to sphingosine-1-phosphate in X. Laevis oocytes: similarities with lysophosphatidic acid signalling. Am J Physiol 1993; 264: c1360-c1364.
83. Sukocheva O, Wahg L, Albanese N, Pitson ST, Vadas M, Xia P. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol Endocrinol 2003; 17: 2002-2012.
84. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-776.
85. Rasheva VI, Domingos PM. Cellular responses to endoplasmic reticulum stress and apoptosis. Apoptosis 2009; 14: 996-1007.
86. Gaut JR, Hendershot LM. The modification and assembly of proteins in the endoplasmic reticulum. Curr Opin Cell Biol 1993; 5: 589-595.
87. Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006; 7: 880-885.
88. Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 2005; 74: 739-789.
89. Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett 1996; 395: 143-147.
90. McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 2001; 21: 1249-1259.
91. Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-666.
92. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103: 239-252.
93. Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA 2003; 100: 2432-2437.
94. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 2000; 403: 98-103.
95. Chen CL, Lin CF, Chang WT, Huang WC, Teng CF, Lin YS. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood 2008; 111: 4365-74.
96. Kitamura K, Miyamura A, Takata K, Inden M, Tsuchiya D, Nakamura K. Taniguchi T. Possible involvement of both endoplasmic reticulumand mitochondriadependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Pharmacol Sci 2003; 92: 228-236.
97. Chen LH, Chen JCh, Watts R, Thorne RF, Kiejda KA, Dong Zhang X, Hersey P. Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein. Cancer Res 2008; 68: 834-842.
98. Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S. 1,1-Bis (3'-indolyl)-1-(p-substituted phenyl) methanes colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis 2008; 29: 1139-1147.
99. McCormick Th, McColl KS, Distelhorst CW. Mouse Lymphoma Cells Destined to Undergo Apoptosis in Response to Thapsigargin Treatment Fail to Generate a Calcium-mediated grp78/grp94 Stress Response. J Biol Chem 1997; 272: 6087-6092.
100. Hu P, Han Z, Couvillon AD, Exton JH. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 2004; 279: 49420-49429.
101. Martinez JA, Zhang Z, Svetlov SI, Hayes RL, Wang KK, Larner SF. Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis 2010; 15: 1480-1493.
102. Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 2002; 277: 34287-34294.
103. Tonks NK, Cohen P. Calcineurin is a calcium ion-dependent, calmodulin-stimulated protein. Biochim Biophys Acta 1983; 747: 191-193.
104. 2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999; 284: 339-343.
105. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003; 304: 437-444.
106. Denmeade SR, Isaac JT. The SERCA Pump as a Therapeutic Target: making a "smart bomb" for prostate cancer. Cancer Biol & Ther 2005; 4:14-22.
107. Wu Y, Fabritius M, Ip C. Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer. Cancer Biol Ther 2009; 8: 146-152.
108. Christensen SB, Skytte DM, Denmeade SR, Dionne C, Møller JV, Nissen P, Isaacs JT. A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells. Anticancer Agents Med Chem 2009; 9: 276-294.
109. 2+) ATPases. Biochim Biophys Acta 2011; 1813:1118-11127.
110. Demaurex N, Distelhorst C. Apoptosisthe calcium connection. Science 2003; 300: 65-67.
111. 2+: a control point of apoptosis. Science 2003; 300: 135-139.
112. Nakamura K, Bossy-Wetzel E, Burns K, Fadel MP, Lozyk M, Goping IS, Opas M, Bleackley RC, Green DR, Michalak M. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J Cell Biol 2000; 150: 731-740.
113. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J 2001; 20: 2690-2701.
114. Arnaudeau S, Frieden M, Nakamura K, Castelbou C, Michalak M, Demaurex M. Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem 2002; 277: 46696-46705.
115. 2+) influx in Bcl-2-overexpressing cells. J Cell Biol 2000; 148: 857-862.
116. 2+ stores. J Biol Chem 2002; 277: 9219-9225.
117. Chen R, Valencia I, Zhong F, McColl K, Roderick Ll, Bootman M, Berridge M, Conway S, Holmes A, Mignery G, Velez P, Distelhorst C. Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol 2004; 166: 193-203.
118. Oakes Sc, Scorrano L, Opferman J, Bassik M, Nishino M, Pozzan T, Korsmeyer St. Proapoptotic Bax and Bak regulate the type 1 inositol trisphosphatee receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci USA 2004; 102: 105-110.
119. Ferrari D, Pinton P, Campanella M, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R. Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem Biophys Res Commun 2010; 391: 575-581.
120. Boland MP, Foster SJ, O'Neill LAJ. Daunorubicin Activates NFB and Induces B-dependent Gene Expression in HL-60 Promyelocytic and Jurkat T Lymphoma Cells. J Biol Chem 1997; 272: 12952-12960.
121. Goldkorn T, Balabam N, Shannon M, Chea V, Matsukuma K, Gilchirst D, Wang D, Chan C. H2O2 acts in cellular membranes to generate ceramida signaling and initiate apoptosis in tracheobronchial epithelial cells. J Cell Sci 2003; 111: 3209-3220.
122. Liu B, Andrieu-Abadie N, Levade Th, Zhang P, Obeid LM, Hannun Y. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death. J Biol Chem 1998; 273:11313-11320.
123. Liu YY, Han TY, Giuliano AE, Ichikawa S, Hirabayashi Y, Cabot MC. Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis. Exp Cell Res 1999; 252: 464-70.
124. Lozano J, Berra E, Municio M, Dias-Meco M, Domínguez I, Sanz L, Moscat J. Protein kinase C ξ isoform is critical for B dependent promoter activation by sphingomielinase. J Biol Chem 1994; 269: 19200-19202.
125. Sawai H, Okazaqui T, Takeda Y, Tashima M, Sawada H, Okuma M, Kishi S, Umehara H, Domae N. Ceramida induced traslocation of protein kinase C- δ y ξ to the cytosol. J Biol Chem 1997; 272: 2452-2458.
126. Bourbon NA, Sandirasegarane L, Kester M. Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. J Biol Chem 2002; 277: 3286-3292.
127. Ruvolo P, Deng X, Ito T, Carr B, May W. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J Biol Chem 1999; 274: 20296-20300.
128. Zhang X-F, Li B-X, Dong Ch-Y, Ren R. Apoptosis of human colon carcinoma HT-29 cells induced by ceramida. World J Gastroenterol 2006; 12: 3581-3584.
129. Struckhoff AP, Bittman R, Burow ME, Clejan S, Elliott S, Hammond T, Tang Y, Beckman BS. Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. J Pharmacol Exp Ther.2004; 309: 523-532.
130. Pirianov G, Danielsson C, Carlberg C, James SY, Colston KW. Potentiation by vitamin D analogs of TNFa and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2. Cell Death Differ 1999; 6: 890-901.
131. Jarvis WD, Fornari FA jr, Auer KI, Freemerman AJ, Szabo E, Birrer MJ, Johnson ChR, Barbour SE, Dent P, Grant S. Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. Mol Pharmacol 1997; 52: 935-947.
132. Nica AF, Tsao CC, Watt JC, Jiffar T, Kurinna S, Jurasz P, Konopleva M, Andreeff M, Radomski MW, Ruvolo PP. Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle 2008; 7: 3362-3370.
133. Cuvillier O, Edsall L, Spiegel S. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J Biol Chem 2000; 275: 15691-15700.
134. Nava V, Hobson J, Murthy S, Milstein S, Spiegel S. Sphingosine kinase tipe 1 promotes estrogen-dependent tumorogenesis of breast cancer MCF-7 cells. Exp Cell Res 2002; 281: 115-127.
135. Le Stunff H, Mikami A, Giussani P, Hobson J, Jolly P, Miltien S, Spiegel S. Role of sphingosine-1-Phosphate 1 in epidermal growth factor-induced chemotaxis. J Biol Chem 2004; 279: 34290-34297.
136. Sarkar S, Maceyka M, Hait N, Paugh St, Sankala H, Milstein Sh, Spiegel S. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett 2005; 579: 5313-5317.
137. Teitelbaum I, Strasheim A, Berl T. Epidermal growth factor-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting tubule cells. Regulation by g protein, calcium, and protein kinase C. J Clin Invest 1990; 85: 1044-1050.
138. Wu J, Spiegel S, Sturgill T. Sphingosine-1-Phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein dependent mechanism. J Biol Chem 1995; 270: 11484-11488.
139. Rakhit S, Conway A, Tate R, Bower T, Pyne N, Pyne S. Sphingosine-1-phosphate stimulation of the p24/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of endothelial differentiation gen-1. Biochem J 1999; 338: 643-649.
140. Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S, Spiegel S. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 1999; 147: 545-558.
141. Shu X, Wu W, Mosteller R, Broek D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol Cell Biol 2002; 22: 7758-7768.
142. French KJ, Upson JJ, Keller SN, Zhuang Y, Yun JK, Smith ChD. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther 2006; 318: 596-603.
143. Cuvillier O, Ader I, Bouquerel P, Brizuela L, Malavaud B, Mazerolles C, Rischmann P. Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting. Curr Mol Pharmacol 2010; 3: 53-65.
144. Ling B, Chen L, Alcorn J, Ma B, Yang J. Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer. Invest New Drugs 2011; 29: 396-399.
145. Dickson MA, Carvajal RD, Merrill AH Jr, Gonen M, Cane LM, Schwartz GK. A phase I Clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin Cancer Res. 2011; 17:2484-2492.
146. Gomez-Muñoz A, Kong J, Salh B, Steinbrecher U. Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J Lipid Res 2004; 45: 99-105.
147. Gomez-Muñoz A, Kong J, Parhar K, Wang SW, Gangoiti P, González M, Eivemark S, Salh B, Duronio V, Steinbrecher U. Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase pathway. FEBS Lett 2005; 579: 3744-3750.
148. Gangoiti P, Granado MH, Wang SW, Kong JY, Steinbrecher UP, Gómez-Muñoz A. Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways. Cell Signal. 2008; 20:726-736.
149. Carpio L, Stephan E, Kamer A, Dziak R. Prostaglanding Leukot. Fatty Acids 1999; 61: 267-273.