Novel pathway of ceramide production in mitochondria: Thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25352-25362

  Novgorodov, Sergei A ^b   Wu, Bill X ^b   Gudz, Tatyana I ^a,b   Bielawski, Jacek ^b   Ovchinnikova, Tatiana V ^c   Hannun, Yusuf A ^b   Obeid, Lina M ^a,b  

^a RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA; APOPTOTIC PATHWAYS; CERAMIDES; IN-VIVO; LIVER MITOCHONDRIA; MATRIX; MITOCHONDRIAL MATRIX; OUTER MEMBRANE; OUTER MITOCHONDRIAL MEMBRANES; SPHINGOLIPIDS; SPHINGOSINE; THIOESTERASES;

AMIDES; CELL DEATH; CELL MEMBRANES; HYDROLYSIS; LAKES; MAMMALS;

MITOCHONDRIA;

CERAMIDE; NEUTRAL CERAMIDASE; PALMITIC ACID; PALMITOYL COENZYME A; PEPTIDE; SPHINGOSINE; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG; ZERVAMICIN IIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; EXTRACELLULAR MATRIX; HYDROLYSIS; LIPOGENESIS; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; RAT; REGULATORY MECHANISM; WILD TYPE;

ANIMALS; CERAMIDES; HYDROLYSIS; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; NEUTRAL CERAMIDASE; PALMITOYL COENZYME A; PALMITOYL-COA HYDROLASE; PEPTAIBOLS; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOSINE;

MUS;

EID: 79960117964     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.214866     Document Type: Article

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