The marine sponge toxin agelasine B increases the intracellular Ca 2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)

Cancer Chemotherapy and Pharmacology

Volumn 69, Issue 1, 2012, Pages 71-83

  Pimentel, Adriana A ^a,b   Felibertt, Pimali ^c   Sojo, Felipe ^d   Colman, Laura ^a,e   Mayora, Adriana ^a,d   Silva, May Li ^a   Rojas, Hector ^e   Dipolo, Reinaldo ^a,e   Suarez, Alírica I ^b   Compagnone, Reinaldo S ^d   Arvelo, Francisco ^a,d   Galindo Castro, Ivan ^a   De Sanctis, Juan B ^f   Chirino, Perla ^f   Benaim, Gustavo ^a,d  

^a Fundacion Instituto de Estudios Avanzados IDEA   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c UNIVERSIDAD DE CARABOBO   (Venezuela)

^d FACULTAD DE CIENCIAS   (Venezuela)

^e INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^f UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Agelasine B; Calcium; Natural products; SERCA; Thapsigargin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); AGELASIN B; ANTINEOPLASTIC AGENT; CALCIUM ION; CASPASE 7; CASPASE 8; MARINE TOXIN; PROTEIN BCL 2; RHODAMINE 123; STAUROSPORINE; THAPSIGARGIN; UNCLASSIFIED DRUG;

AGELAS; AGELAS CLATHRODES; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG PURIFICATION; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

AGELAS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CALCIUM; CELL LINE, TUMOR; CELLS, CULTURED; FEMALE; FIBROBLASTS; HUMANS; IN SITU NICK-END LABELING; INHIBITORY CONCENTRATION 50; MALE; MICROSCOPY, CONFOCAL; NAPHTHALENES; PROSTATIC NEOPLASMS; PURINES;

EID: 84856704070     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1677-x     Document Type: Article

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