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Volumn 92, Issue 6, 2010, Pages 716-723

S1P metabolism in cancer and other pathological conditions

Author keywords

Apoptosis; Cancer; Lymphocyte trafficking cancer; Lysophospholipid; S1P lyase; S1P phosphatase; Sphingolipid; Sphingosine 1 phosphate; Sphingosine kinase; Sphingosine phosphate lyase; Tumorigenesis

Indexed keywords

2 AMINO 2 (3 OCTYLPHENYLCARBAMOYL)ETHYL PHOSPHATE; BML 248; DIMETHYLSPHINGOSINE; ENZYME INHIBITOR; FINGOLIMOD; G PROTEIN COUPLED RECEPTOR; LT 1002; LT 1009; MONOCLONAL ANTIBODY; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; SPHINGOSINE 1 PHOSPHATE PHOSPHATASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 77953289068     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.02.014     Document Type: Review
Times cited : (56)

References (117)
  • 1
    • 21844457949 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
    • Rosen H., Goetzl E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 2005, 5:560-570.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 560-570
    • Rosen, H.1    Goetzl, E.J.2
  • 5
    • 0026049696 scopus 로고
    • Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
    • Zhang H., Desai N.N., Olivera A., Seki T., Brooker G., Spiegel S. Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol. 1991, 114:155-167.
    • (1991) J. Cell Biol. , vol.114 , pp. 155-167
    • Zhang, H.1    Desai, N.N.2    Olivera, A.3    Seki, T.4    Brooker, G.5    Spiegel, S.6
  • 6
    • 0037201970 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: dual messenger functions
    • Payne S.G., Milstien S., Spiegel S. Sphingosine-1-phosphate: dual messenger functions. FEBS Lett. 2002, 531:54-57.
    • (2002) FEBS Lett. , vol.531 , pp. 54-57
    • Payne, S.G.1    Milstien, S.2    Spiegel, S.3
  • 7
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: an enigmatic signalling lipid
    • Spiegel S., Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 2003, 4:397-407.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 8
    • 65949092331 scopus 로고    scopus 로고
    • When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy
    • Ader I., Malavaud B., Cuvillier O. When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. Cancer Res. 2009, 69:3723-3726.
    • (2009) Cancer Res. , vol.69 , pp. 3723-3726
    • Ader, I.1    Malavaud, B.2    Cuvillier, O.3
  • 10
    • 3242696730 scopus 로고    scopus 로고
    • Physiological and pathological actions of sphingosine 1-phosphate
    • Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin. Cell Dev. Biol. 2004, 15:513-520.
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 513-520
    • Hla, T.1
  • 11
    • 33645278951 scopus 로고    scopus 로고
    • Sphingosine kinase: biochemical and cellular regulation and role in disease
    • Taha T.A., Hannun Y.A., Obeid L.M. Sphingosine kinase: biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol. 2006, 39:113-131.
    • (2006) J. Biochem. Mol. Biol. , vol.39 , pp. 113-131
    • Taha, T.A.1    Hannun, Y.A.2    Obeid, L.M.3
  • 12
    • 1842455323 scopus 로고    scopus 로고
    • Point-counterpoint of sphingosine 1-phosphate metabolism
    • Saba J.D., Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ. Res. 2004, 94:724-734.
    • (2004) Circ. Res. , vol.94 , pp. 724-734
    • Saba, J.D.1    Hla, T.2
  • 17
    • 23844498431 scopus 로고    scopus 로고
    • Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
    • Van Brocklyn J.R., Jackson C.A., Pearl D.K., Kotur M.S., Snyder P.J., Prior T.W. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J. Neuropathol. Exp. Neurol. 2005, 64:695-705.
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 695-705
    • Van Brocklyn, J.R.1    Jackson, C.A.2    Pearl, D.K.3    Kotur, M.S.4    Snyder, P.J.5    Prior, T.W.6
  • 20
    • 27844517355 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
    • Chalfant C.E., Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell Sci. 2005, 118:4605-4612.
    • (2005) J. Cell Sci. , vol.118 , pp. 4605-4612
    • Chalfant, C.E.1    Spiegel, S.2
  • 21
    • 0037203319 scopus 로고    scopus 로고
    • Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility
    • Tilly J.L., Kolesnick R.N. Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility. Biochim. Biophys. Acta 2002, 1585:135-138.
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 135-138
    • Tilly, J.L.1    Kolesnick, R.N.2
  • 22
    • 0035793032 scopus 로고    scopus 로고
    • The role and clinical applications of bioactive lysolipids in ovarian cancer
    • Xu Y., Xiao Y.J., Baudhuin L.M., Schwartz B.M. The role and clinical applications of bioactive lysolipids in ovarian cancer. J. Soc. Gynecol. Investig. 2001, 8:1-13.
    • (2001) J. Soc. Gynecol. Investig. , vol.8 , pp. 1-13
    • Xu, Y.1    Xiao, Y.J.2    Baudhuin, L.M.3    Schwartz, B.M.4
  • 23
    • 33947314618 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again
    • Oskouian B., Saba J. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. Cell Cycle 2007, 6:522-527.
    • (2007) Cell Cycle , vol.6 , pp. 522-527
    • Oskouian, B.1    Saba, J.2
  • 25
    • 33646422463 scopus 로고    scopus 로고
    • Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis
    • Lawlor E.R., Soucek L., Brown-Swigart L., Shchors K., Bialucha C.U., Evan G.I. Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. Cancer Res. 2006, 66:4591-4601.
    • (2006) Cancer Res. , vol.66 , pp. 4591-4601
    • Lawlor, E.R.1    Soucek, L.2    Brown-Swigart, L.3    Shchors, K.4    Bialucha, C.U.5    Evan, G.I.6
  • 26
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy S., Ross K.N., Lander E.S., Golub T.R. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 2003, 33:49-54.
    • (2003) Nat. Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 31
    • 0344875587 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors
    • Olivera A., Rosenfeldt H.M., Bektas M., Wang F., Ishii I., Chun J., Milstien S., Spiegel S. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J. Biol. Chem. 2003, 278:46452-46460.
    • (2003) J. Biol. Chem. , vol.278 , pp. 46452-46460
    • Olivera, A.1    Rosenfeldt, H.M.2    Bektas, M.3    Wang, F.4    Ishii, I.5    Chun, J.6    Milstien, S.7    Spiegel, S.8
  • 32
    • 0037178555 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta
    • Van Brocklyn J., Letterle C., Snyder P., Prior T. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. Cancer Lett. 2002, 181:195-204.
    • (2002) Cancer Lett. , vol.181 , pp. 195-204
    • Van Brocklyn, J.1    Letterle, C.2    Snyder, P.3    Prior, T.4
  • 33
    • 42749092078 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis
    • Li Q.F., Wu C.T., Guo Q., Wang H., Wang L.S. Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. Biochem. Biophys. Res. Commun. 2008, 371:159-162.
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 159-162
    • Li, Q.F.1    Wu, C.T.2    Guo, Q.3    Wang, H.4    Wang, L.S.5
  • 35
    • 54249151827 scopus 로고    scopus 로고
    • Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2
    • Li M.H., Sanchez T., Pappalardo A., Lynch K.R., Hla T., Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol. Cancer Res. 2008, 6:1649-1656.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1649-1656
    • Li, M.H.1    Sanchez, T.2    Pappalardo, A.3    Lynch, K.R.4    Hla, T.5    Ferrer, F.6
  • 37
    • 0025351642 scopus 로고
    • Intracellular calcium release mediated by sphingosine derivatives generated in cells
    • Ghosh T.K., Bian J., Gill D.L. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 1990, 248:1653-1656.
    • (1990) Science , vol.248 , pp. 1653-1656
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 38
    • 0026457994 scopus 로고
    • Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation
    • Desai N.N., Zhang H., Olivera A., Mattie M.E., Spiegel S. Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation. J. Biol. Chem. 1992, 267:23122-23128.
    • (1992) J. Biol. Chem. , vol.267 , pp. 23122-23128
    • Desai, N.N.1    Zhang, H.2    Olivera, A.3    Mattie, M.E.4    Spiegel, S.5
  • 39
    • 0030968768 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts
    • Pt 2
    • Wang F., Nobes C.D., Hall A., Spiegel S. Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Biochem. J. 1997, 324(Pt 2):481-488.
    • (1997) Biochem. J. , vol.324 , pp. 481-488
    • Wang, F.1    Nobes, C.D.2    Hall, A.3    Spiegel, S.4
  • 40
    • 0035525748 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
    • Cuvillier O., Levade T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood 2001, 98:2828-2836.
    • (2001) Blood , vol.98 , pp. 2828-2836
    • Cuvillier, O.1    Levade, T.2
  • 41
    • 30544434809 scopus 로고    scopus 로고
    • Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner
    • Betito S., Cuvillier O. Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. Biochem. Biophys. Res. Commun. 2006, 340:1273-1277.
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 1273-1277
    • Betito, S.1    Cuvillier, O.2
  • 42
    • 68849112045 scopus 로고    scopus 로고
    • S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells
    • Chang C.L., Ho M.C., Lee P.H., Hsu C.Y., Huang W.P., Lee H. S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. Am. J. Physiol. Cell. Physiol. 2009, 297:C451-C458.
    • (2009) Am. J. Physiol. Cell. Physiol. , vol.297
    • Chang, C.L.1    Ho, M.C.2    Lee, P.H.3    Hsu, C.Y.4    Huang, W.P.5    Lee, H.6
  • 45
    • 33644886904 scopus 로고    scopus 로고
    • High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation
    • Akao Y., Banno Y., Nakagawa Y., Hasegawa N., Kim T.J., Murate T., Igarashi Y., Nozawa Y. High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. Biochem. Biophys. Res. Commun. 2006, 342:1284-1290.
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 1284-1290
    • Akao, Y.1    Banno, Y.2    Nakagawa, Y.3    Hasegawa, N.4    Kim, T.J.5    Murate, T.6    Igarashi, Y.7    Nozawa, Y.8
  • 47
    • 0036436697 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
    • Nava V.E., Hobson J.P., Murthy S., Milstien S., Spiegel S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell Res. 2002, 281:115-127.
    • (2002) Exp. Cell Res. , vol.281 , pp. 115-127
    • Nava, V.E.1    Hobson, J.P.2    Murthy, S.3    Milstien, S.4    Spiegel, S.5
  • 48
    • 33645801577 scopus 로고    scopus 로고
    • Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis
    • Taha T.A., Kitatani K., El-Alwani M., Bielawski J., Hannun Y.A., Obeid L.M. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006, 20:482-484.
    • (2006) FASEB J. , vol.20 , pp. 482-484
    • Taha, T.A.1    Kitatani, K.2    El-Alwani, M.3    Bielawski, J.4    Hannun, Y.A.5    Obeid, L.M.6
  • 49
    • 46949104885 scopus 로고    scopus 로고
    • " Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets
    • Takabe K., Paugh S.W., Milstien S., Spiegel S. " Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol. Rev. 2008, 60:181-195.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 181-195
    • Takabe, K.1    Paugh, S.W.2    Milstien, S.3    Spiegel, S.4
  • 50
    • 25844457390 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
    • Sarkar S., Maceyka M., Hait N.C., Paugh S.W., Sankala H., Milstien S., Spiegel S. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett. 2005, 579:5313-5317.
    • (2005) FEBS Lett. , vol.579 , pp. 5313-5317
    • Sarkar, S.1    Maceyka, M.2    Hait, N.C.3    Paugh, S.W.4    Sankala, H.5    Milstien, S.6    Spiegel, S.7
  • 52
    • 0141445962 scopus 로고    scopus 로고
    • Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
    • Johnson K.R., Johnson K.Y., Becker K.P., Bielawski J., Mao C., Obeid L.M. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J. Biol. Chem. 2003, 278:34541-34547.
    • (2003) J. Biol. Chem. , vol.278 , pp. 34541-34547
    • Johnson, K.R.1    Johnson, K.Y.2    Becker, K.P.3    Bielawski, J.4    Mao, C.5    Obeid, L.M.6
  • 53
    • 33644974376 scopus 로고    scopus 로고
    • Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
    • Bonhoure E., Pchejetski D., Aouali N., Morjani H., Levade T., Kohama T., Cuvillier O. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 2006, 20:95-102.
    • (2006) Leukemia , vol.20 , pp. 95-102
    • Bonhoure, E.1    Pchejetski, D.2    Aouali, N.3    Morjani, H.4    Levade, T.5    Kohama, T.6    Cuvillier, O.7
  • 54
    • 0032056362 scopus 로고    scopus 로고
    • 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase
    • Kleuser B., Cuvillier O., Spiegel S. 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. Cancer Res. 1998, 58:1817-1824.
    • (1998) Cancer Res. , vol.58 , pp. 1817-1824
    • Kleuser, B.1    Cuvillier, O.2    Spiegel, S.3
  • 55
    • 0035127922 scopus 로고    scopus 로고
    • Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase
    • Misasi R., Sorice M., Di Marzio L., Campana W.M., Molinari S., Cifone M.G., Pavan A., Pontieri G.M., O'Brien J.S. Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. FASEB J. 2001, 15:467-474.
    • (2001) FASEB J. , vol.15 , pp. 467-474
    • Misasi, R.1    Sorice, M.2    Di Marzio, L.3    Campana, W.M.4    Molinari, S.5    Cifone, M.G.6    Pavan, A.7    Pontieri, G.M.8    O'Brien, J.S.9
  • 56
    • 0035089286 scopus 로고    scopus 로고
    • Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
    • Edsall L.C., Cuvillier O., Twitty S., Spiegel S., Milstien S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J. Neurochem. 2001, 76:1573-1584.
    • (2001) J. Neurochem. , vol.76 , pp. 1573-1584
    • Edsall, L.C.1    Cuvillier, O.2    Twitty, S.3    Spiegel, S.4    Milstien, S.5
  • 57
    • 12444323123 scopus 로고    scopus 로고
    • Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression
    • Bektas M., Jolly P.S., Muller C., Eberle J., Spiegel S., Geilen C.C. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. Oncogene 2005, 24:178-187.
    • (2005) Oncogene , vol.24 , pp. 178-187
    • Bektas, M.1    Jolly, P.S.2    Muller, C.3    Eberle, J.4    Spiegel, S.5    Geilen, C.C.6
  • 58
    • 0036841720 scopus 로고    scopus 로고
    • Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
    • Shu X., Wu W., Mosteller R.D., Broek D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 2002, 22:7758-7768.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7758-7768
    • Shu, X.1    Wu, W.2    Mosteller, R.D.3    Broek, D.4
  • 59
    • 70249125866 scopus 로고    scopus 로고
    • Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
    • Weigert A., Schiffmann S., Sekar D., Ley S., Menrad H., Werno C., Grosch S., Geisslinger G., Brune B. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. Int. J. Cancer 2009, 125:2114-2121.
    • (2009) Int. J. Cancer , vol.125 , pp. 2114-2121
    • Weigert, A.1    Schiffmann, S.2    Sekar, D.3    Ley, S.4    Menrad, H.5    Werno, C.6    Grosch, S.7    Geisslinger, G.8    Brune, B.9
  • 60
    • 0033828148 scopus 로고    scopus 로고
    • Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium
    • Pt 9
    • Li G., Alexander H., Schneider N., Alexander S. Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium. Microbiol. 2000, 146(Pt 9):2219-2227.
    • (2000) Microbiol. , vol.146 , pp. 2219-2227
    • Li, G.1    Alexander, H.2    Schneider, N.3    Alexander, S.4
  • 61
    • 2942666365 scopus 로고    scopus 로고
    • Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs
    • Min J., Stegner A.L., Alexander H., Alexander S. Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. Eukaryot .Cell 2004, 3:795-805.
    • (2004) Eukaryot .Cell , vol.3 , pp. 795-805
    • Min, J.1    Stegner, A.L.2    Alexander, H.3    Alexander, S.4
  • 62
    • 18544390682 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner
    • Min J., Van Veldhoven P.P., Zhang L., Hanigan M.H., Alexander H., Alexander S. Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol. Cancer Res. 2005, 3:287-296.
    • (2005) Mol. Cancer Res. , vol.3 , pp. 287-296
    • Min, J.1    Van Veldhoven, P.P.2    Zhang, L.3    Hanigan, M.H.4    Alexander, H.5    Alexander, S.6
  • 63
    • 58749094798 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61
    • Young N., Pearl D.K., Van Brocklyn J.R. Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. Mol. Cancer Res. 2009, 7:23-32.
    • (2009) Mol. Cancer Res. , vol.7 , pp. 23-32
    • Young, N.1    Pearl, D.K.2    Van Brocklyn, J.R.3
  • 64
    • 0041378169 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells
    • Van Brocklyn J.R., Young N., Roof R. Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. Cancer Lett. 2003, 199:53-60.
    • (2003) Cancer Lett. , vol.199 , pp. 53-60
    • Van Brocklyn, J.R.1    Young, N.2    Roof, R.3
  • 65
    • 18144420388 scopus 로고    scopus 로고
    • 2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration
    • 2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res. 2005, 65:3788-3795.
    • (2005) Cancer Res. , vol.65 , pp. 3788-3795
    • Lepley, D.1    Paik, J.H.2    Hla, T.3    Ferrer, F.4
  • 66
    • 53349127597 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness
    • Bryan L., Paugh B.S., Kapitonov D., Wilczynska K.M., Alvarez S.M., Singh S.K., Milstien S., Spiegel S., Kordula T. Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. Mol. Cancer Res. 2008, 6:1469-1477.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1469-1477
    • Bryan, L.1    Paugh, B.S.2    Kapitonov, D.3    Wilczynska, K.M.4    Alvarez, S.M.5    Singh, S.K.6    Milstien, S.7    Spiegel, S.8    Kordula, T.9
  • 68
    • 0141679087 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells
    • Yamaguchi H., Kitayama J., Takuwa N., Arikawa K., Inoki I., Takehara K., Nagawa H., Takuwa Y. Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. Biochem. J. 2003, 374:715-722.
    • (2003) Biochem. J. , vol.374 , pp. 715-722
    • Yamaguchi, H.1    Kitayama, J.2    Takuwa, N.3    Arikawa, K.4    Inoki, I.5    Takehara, K.6    Nagawa, H.7    Takuwa, Y.8
  • 69
    • 66449125409 scopus 로고    scopus 로고
    • Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2
    • Bergelin N., Blom T., Heikkila J., Lof C., Alam C., Balthasar S., Slotte J.P., Hinkkanen A., Tornquist K. Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. Endocrinology 2009, 150:2055-2063.
    • (2009) Endocrinology , vol.150 , pp. 2055-2063
    • Bergelin, N.1    Blom, T.2    Heikkila, J.3    Lof, C.4    Alam, C.5    Balthasar, S.6    Slotte, J.P.7    Hinkkanen, A.8    Tornquist, K.9
  • 70
    • 29744452168 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation
    • Yamashita H., Kitayama J., Shida D., Yamaguchi H., Mori K., Osada M., Aoki S., Yatomi Y., Takuwa Y., Nagawa H. Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. J. Surg. Res. 2006, 130:80-87.
    • (2006) J. Surg. Res. , vol.130 , pp. 80-87
    • Yamashita, H.1    Kitayama, J.2    Shida, D.3    Yamaguchi, H.4    Mori, K.5    Osada, M.6    Aoki, S.7    Yatomi, Y.8    Takuwa, Y.9    Nagawa, H.10
  • 73
    • 67649924581 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells
    • Guo X.Z., Zhang W.W., Wang L.S., Lu Z.Z., Wang H., Xu J.H., Tian H. Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells. Zhonghua Nei Ke Za Zhi 2006, 45:752-754.
    • (2006) Zhonghua Nei Ke Za Zhi , vol.45 , pp. 752-754
    • Guo, X.Z.1    Zhang, W.W.2    Wang, L.S.3    Lu, Z.Z.4    Wang, H.5    Xu, J.H.6    Tian, H.7
  • 75
    • 34249656324 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 activation by ERK-mediated phosphorylation
    • Hait N.C., Bellamy A., Milstien S., Kordula T., Spiegel S. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J. Biol. Chem. 2007, 282:12058-12065.
    • (2007) J. Biol. Chem. , vol.282 , pp. 12058-12065
    • Hait, N.C.1    Bellamy, A.2    Milstien, S.3    Kordula, T.4    Spiegel, S.5
  • 77
    • 9644252866 scopus 로고    scopus 로고
    • Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
    • Chae S.S., Paik J.H., Furneaux H., Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J. Clin. Invest. 2004, 114:1082-1089.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1082-1089
    • Chae, S.S.1    Paik, J.H.2    Furneaux, H.3    Hla, T.4
  • 80
    • 0033607517 scopus 로고    scopus 로고
    • Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells
    • Xia P., Wang L., Gamble J.R., Vadas M.A. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J. Biol. Chem. 1999, 274:34499-34505.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34499-34505
    • Xia, P.1    Wang, L.2    Gamble, J.R.3    Vadas, M.A.4
  • 81
    • 0035831465 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells
    • Kim I., Moon S.O., Kim S.H., Kim H.J., Koh Y.S., Koh G.Y. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J. Biol. Chem. 2001, 276:7614-7620.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7614-7620
    • Kim, I.1    Moon, S.O.2    Kim, S.H.3    Kim, H.J.4    Koh, Y.S.5    Koh, G.Y.6
  • 82
    • 0141591547 scopus 로고    scopus 로고
    • 1 receptors in endothelial cells: implications for cross-talk between sphingolipid and growth factor receptors
    • 1 receptors in endothelial cells: implications for cross-talk between sphingolipid and growth factor receptors. Proc. Natl. Acad. Sci. U S A 2003, 100:10664-10669.
    • (2003) Proc. Natl. Acad. Sci. U S A , vol.100 , pp. 10664-10669
    • Igarashi, J.1    Erwin, P.A.2    Dantas, A.P.3    Chen, H.4    Michel, T.5
  • 84
    • 0034462185 scopus 로고    scopus 로고
    • Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
    • Okamoto H., Takuwa N., Yokomizo T., Sugimoto N., Sakurada S., Shigematsu H., Takuwa Y. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol. Cell Biol. 2000, 20:9247-9261.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 9247-9261
    • Okamoto, H.1    Takuwa, N.2    Yokomizo, T.3    Sugimoto, N.4    Sakurada, S.5    Shigematsu, H.6    Takuwa, Y.7
  • 85
    • 0037162037 scopus 로고    scopus 로고
    • Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors
    • Kluk M.J., Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta 2002, 1582:72-80.
    • (2002) Biochim. Biophys. Acta , vol.1582 , pp. 72-80
    • Kluk, M.J.1    Hla, T.2
  • 87
    • 1842474897 scopus 로고    scopus 로고
    • Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation
    • Langlois S., Gingras D., Beliveau R. Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. Blood 2004, 103:3020-3028.
    • (2004) Blood , vol.103 , pp. 3020-3028
    • Langlois, S.1    Gingras, D.2    Beliveau, R.3
  • 88
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel P., Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis. Rev. 2007, 26:225-239.
    • (2007) Cancer Metastasis. Rev. , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 89
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat. Med. 2003, 9:669-676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 90
    • 54249088951 scopus 로고    scopus 로고
    • Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells
    • Ader I., Brizuela L., Bouquerel P., Malavaud B., Cuvillier O. Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells. Cancer Res. 2008, 68:8635-8642.
    • (2008) Cancer Res. , vol.68 , pp. 8635-8642
    • Ader, I.1    Brizuela, L.2    Bouquerel, P.3    Malavaud, B.4    Cuvillier, O.5
  • 91
    • 41249103991 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2
    • Anelli V., Gault C.R., Cheng A.B., Obeid L.M. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J. Biol. Chem. 2008, 283:3365-3375.
    • (2008) J. Biol. Chem. , vol.283 , pp. 3365-3375
    • Anelli, V.1    Gault, C.R.2    Cheng, A.B.3    Obeid, L.M.4
  • 92
    • 34848892421 scopus 로고    scopus 로고
    • Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina
    • Skoura A., Sanchez T., Claffey K., Mandala S.M., Proia R.L., Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J. Clin. Invest. 2007, 117:2506-2516.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2506-2516
    • Skoura, A.1    Sanchez, T.2    Claffey, K.3    Mandala, S.M.4    Proia, R.L.5    Hla, T.6
  • 93
    • 62549143484 scopus 로고    scopus 로고
    • Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells
    • Schnitzer S.E., Weigert A., Zhou J., Brune B. Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol. Cancer Res. 2009, 7:393-401.
    • (2009) Mol. Cancer Res. , vol.7 , pp. 393-401
    • Schnitzer, S.E.1    Weigert, A.2    Zhou, J.3    Brune, B.4
  • 94
    • 0038286415 scopus 로고    scopus 로고
    • Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
    • Azuma H., Takahara S., Horie S., Muto S., Otsuki Y., Katsuoka Y. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J. Urol. 2003, 169:2372-2377.
    • (2003) J. Urol. , vol.169 , pp. 2372-2377
    • Azuma, H.1    Takahara, S.2    Horie, S.3    Muto, S.4    Otsuki, Y.5    Katsuoka, Y.6
  • 103
    • 0025756765 scopus 로고
    • Cell membrane signaling as target in cancer therapy: inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice
    • Endo K., Igarashi Y., Nisar M., Zhou Q.H., Hakomori S. Cell membrane signaling as target in cancer therapy: inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res. 1991, 51:1613-1618.
    • (1991) Cancer Res. , vol.51 , pp. 1613-1618
    • Endo, K.1    Igarashi, Y.2    Nisar, M.3    Zhou, Q.H.4    Hakomori, S.5
  • 104
    • 0026319890 scopus 로고
    • Cell membrane signaling as target in cancer therapy. II: inhibitory effect of N, N, N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation
    • Okoshi H., Hakomori S., Nisar M., Zhou Q.H., Kimura S., Tashiro K., Igarashi Y. Cell membrane signaling as target in cancer therapy. II: inhibitory effect of N, N, N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. Cancer Res. 1991, 51:6019-6024.
    • (1991) Cancer Res. , vol.51 , pp. 6019-6024
    • Okoshi, H.1    Hakomori, S.2    Nisar, M.3    Zhou, Q.H.4    Kimura, S.5    Tashiro, K.6    Igarashi, Y.7
  • 108
    • 26644434393 scopus 로고    scopus 로고
    • The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity
    • Bandhuvula P., Tam Y.Y., Oskouian B., Saba J.D. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J. Biol. Chem. 2005, 280:33697-33700.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33697-33700
    • Bandhuvula, P.1    Tam, Y.Y.2    Oskouian, B.3    Saba, J.D.4
  • 109
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab S.R., Pereira J.P., Matloubian M., Xu Y., Huang Y., Cyster J.G. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005, 309:1735-1739.
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3    Xu, Y.4    Huang, Y.5    Cyster, J.G.6
  • 110
    • 58149474166 scopus 로고    scopus 로고
    • Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
    • Vogel P., Donoviel M.S., Read R., Hansen G.M., Hazlewood J., Anderson S.J., Sun W., Swaffield J., Oravecz T. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One 2009, 4:e4112.
    • (2009) PLoS One , vol.4
    • Vogel, P.1    Donoviel, M.S.2    Read, R.3    Hansen, G.M.4    Hazlewood, J.5    Anderson, S.J.6    Sun, W.7    Swaffield, J.8    Oravecz, T.9
  • 111
    • 33947577504 scopus 로고    scopus 로고
    • Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
    • Katsel P., Li C., Haroutunian V. Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?. Neurochem. Res. 2007, 32:845-856.
    • (2007) Neurochem. Res. , vol.32 , pp. 845-856
    • Katsel, P.1    Li, C.2    Haroutunian, V.3
  • 115
    • 51349156152 scopus 로고    scopus 로고
    • Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing
    • Liu Z.J., Velazquez O.C. Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid. Redox. Signal 2008, 10:1869-1882.
    • (2008) Antioxid. Redox. Signal , vol.10 , pp. 1869-1882
    • Liu, Z.J.1    Velazquez, O.C.2


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