Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in Rat-2 cells

IUBMB Life

Volumn 50, Issue 2, 2000, Pages 119-124

  Kim, Joo Hee ^a   Kim, Jung Hee ^a   Song, Woo Keun ^a   Kim, Jae Hong ^a   Chun, Jang Soo ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

EGF receptor; Erk 1 2; Protein kinase C; Sphingosine 1 phosphate

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR RECEPTOR; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; SPHINGOSINE 1 PHOSPHATE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; HELA CELLS; HISTORY, MEDIEVAL; HUMANS; INDOLES; LYSOPHOSPHOLIPIDS; MALEIMIDES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PERTUSSIS TOXIN; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SPHINGOSINE; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TYRPHOSTINS; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA;

EID: 0033661659     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540050212132     Document Type: Article

References (29)

1. Sphingosine 1-phosphate: A ligand for the EDG-1 family of G-protein-coupled receptors
2. Sphingolipids as differential regulators of cellular signalling processes
3. Sphingosine-1-phosphate in cell growth and cell death
4. Sphingosine-1-phosphate: Extracellular mediator or intracellular second messenger?
5. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5
6. Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells
7. Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase
8. Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism
9. 2+ system in HL60 leukemia cells
10. Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes
11. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
12. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
13. Signal characteristics of G protein-transactivated EGF receptor
14. Signalling pathway leading to an activation of mitogen-activated protein kinase by stimulating M3 muscarinic receptor
15. Protein kinase C regulates chondrogenesis of mesenchymes via mitogen-activated protein kinase signaling
16. Opposing role of mitogen-activated protein kinase subtypes, erk-1/2 and p38, in the regulation of chondrogenesis of mesenchymes
17. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP
18. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
19. Inhibition by cAMP of Ras-dependent activation of Raf
20. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate
21. Epidermal growth factor receptors: Critical mediators of multiple receptor pathways
22. Tyrosine kinase inhibition: An approach to drug development
23. Multiple positive and negative regulators of signaling by the EGF-receptor
24. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity
25. 2+](i) elevation can substitute for receptor activation
26. Angiotensin II stimulates ERK via two pathways in epithelial cells: Protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway
27. Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion
28. Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway