EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a G(i/o) to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition

Journal of Biological Chemistry

Volumn 273, Issue 42, 1998, Pages 27104-27110

  Okamotot, Hiroyuki ^a   Takuwa, Noriko ^a   Gonda, Koichi ^a   Okazaki, Hiroshi ^a   Chang, Kuyngho ^a   Yatomi, Yutaka ^b   Shigematsu, Hiroshi ^a   Takuwa, Yoh ^a,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c Foundation for Advancement of International Science   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CELL SURFACE RECEPTOR; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; RAS PROTEIN; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSYLPHOSPHORYLCHOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY;

ADENYLATE CYCLASE; ADENYLATE CYCLASE TOXIN; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; FORSKOLIN; GENISTEIN; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; IMMEDIATE-EARLY PROTEINS; LYSOPHOSPHOLIPIDS; PERTUSSIS TOXIN; PHOSPHOLIPASE C; RAS PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; VIRULENCE FACTORS, BORDETELLA;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0032538463     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.42.27104     Document Type: Article

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