Acute exposure of ceramide enhances cardiac contractile function in isolated ventricular myocytes

British Journal of Pharmacology

Volumn 140, Issue 7, 2003, Pages 1163-1168

  Relling, David P ^a   Hintz, Kadon K ^a   Ren, Jun ^a,b  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b UNIVERSITY OF WYOMING   (United States)

Author keywords

Cardiac myocyte; Cell signaling; Ceramide; Shortening and relengthening

Indexed keywords

CALCIUM; CERAMIDE DERIVATIVE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FLUORESCENCE MICROSCOPY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE EXCITABILITY; MALE; MUSCLE LENGTH; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION TIME;

ANIMALS; CALCIUM; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; FURA-2; HEART VENTRICLES; KINETICS; MALE; MICROSCOPY, CONFOCAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1642422330     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705510     Document Type: Article

References (30)

1. 2+-ATPase from human erythrocytes. Biochem. J., 362, 247-251.
2. COLLIGAN, P.B., RELLING, D.P. & REN, J. (2002). Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. Cell Mol. Biol., 48, OL251-OL257 (online).
3. CONDRESCU, M. & REEVES, J.P. (2001). Inhibition of sodium-calcium exchange by ceramide and sphingosine. J. Biol. Chem., 276, 4046-4054.
4. DELPY, E., HATEM, S.N., ANDRIEU, N., DE VAUMAS, C., HENAFF, M., RUCKER-MARTIN, C., JAFFREQOU, J.-P., LAURENT, G., LEVADE, T. & MERCADIER, J.-J. (1999). Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes. Cardiovasc. Res., 43, 398-407.
5. DOBROWSKY, R.T. & HANNUN, Y.A. (1992). Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem., 267, 5048-5051.
6. FRIEDRICHS, G.S., SWILLO, R.E., JOW, B., BRIDAL, T., NUMANN, R., WARNER, L.M., KILLAR, L.M. & SIDEK, K. (2002). Sphingosine modulates myocyte electrophysiology, induces negative inotropy, and decreases survival after myocardial ischemia. J. Cardiovasc. Pharmacol., 39, 18-28.
7. HERBERT, J.M., AUGEREAU, J.M., GLEYE, J. & MAFFRAND, J.P. (1990). Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun., 172, 993-999.
8. HERNANDEZ, O.M., DISCHER, D.J., BISHOPRIC, N.H. & WEBSTER, K.A. (2000). Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ. Res., 86, 198-204.
9. HUWILER, A., DORSCH, S., BRINER, V.A., VAN DEN BOSCH, H. & PFEILSCHIFTER, J. (1999a). Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells. Biochem. Biophys. Res. Commun., 258, 60-65.
10. HUWILER, A., PFEILSCHlFTER, J. & VAN DEN BOSCH, H. (1999b). Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J. Biol. Chem., 274, 7190-7195.
11. IBITAYO, A.I., TSUNODA, Y., NOZU, F., OWYANG, C. & BITAR, K.N. (1998). Src kinase and Pl 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle. Am. J. Physiol., 275, G705-G711.
12. LEVADE, T., AUGE, N., VELDMAN, R.J., CUVILLIER, O., NEGRE-SALVAYRE, A. & SALVAYRE, R. (2001). Sphingolipid mediators in cardiovascular cell biology and pathology. Circ. Res., 89, 957-968.
13. LI, H., JUNK, P., HUWILER, A., BURKHARDT, C., WALLERATH, T., PFEILSCHIFTER, J. & FORSTERMANN, U. (2002). Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase. Circulation, 106, 2250-2256.
14. LIU, G., KLEINE, L. & HEBERT, R.L. (1999). Advances in the signal transduction of ceramide and related sphingolipids. Crit. Rev. Clin. Lab. Sci., 36, 511-573.
15. MATHIAS, S., DRESSLER, K.A. & KOLESNICK, R.N. (1991). Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. Proc. Natl. Acad. Sci. U.S.A., 88, 10009-10013.
16. MATHIAS, S., PENA, L.A. & KOLESNICK, R.N. (1998). Signal transduction of stress via ceramide. Biochem. J., 335, 465-480.
17. 2- channel conductance. Circ. Res., 75, 981-989.
18. 2-ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. Biochem. Biophys. Res. Commun., 268, 636-641.
19. NICKOLA, M.W., WOLD, L.E., COLLIGAN, P.B., WANG, G.-J., SAMSON, W.K. & REN, J. (2000). Leptin attenuates cardiac contraction in rat ventricular myocytes: role of NO. Hypertension, 36, 501-505.
20. ORAL, H., DORN II, G.W. & MANN, D.L. (1997). Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-α in the adult mammalian cardiac myocyte. J. Biol. Chem., 272, 4836-4842.
21. POWIS, G., BONJOUKLIAN, R., BERGGREN, M.M., GALLEGOS, A., ABRAHAM, R., ASHENDEL, C., ZALKOW, L., MATTER, W.F., DODGE, J., GRINDEY, G. & VLAHOS, C.J. (1994). Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res., 54, 2419-2423.
22. REN, J. (2000). Attenuated cardiac contractile responsiveness to insulin-like growth factor I in ventricular myocytes from biobreeding spontaneous diabetic rats. Cardiovasc. Res., 46, 162-171.
23. REN, J., DOMINGUEZ, L., SOWERS, J.R. & DAVIDOFF, A. (1996). Troglitazone attenuates high glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes. Diabetes, 45, 1822-1825.
24. 2+ current in adult rat ventricular myocytes. Am. J. Physiol., 272, H2591-H2598.
25. 2+ release in cardiomyocytes. Nat. Cell Biol., 3, 867-873.
26. WYMANN, M.P., BULGARELLI-LEVA, G., ZVELEBIL, M.J., PIROLA, L., VANHAESEBROECK, B., WATERFIELD, M.D. & PANAYOTOU, G. (1996). Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol., 16, 1722-1733.
27. YOKOYAMA, T., VACA, L., ROSSEN, R.D., DURANTE, W., HAZARIKA, P. & MANN, D.L. (1993). Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart. J. Clin. Investig., 92, 2303-2312.
28. i in canine cerebral vascular muscle. Am. J. Physiol., 278, H1421-H1428.
29. ZHOU, Y.-T., GRAYBURN, P., KARIM, A., SHIMABUKURO, M., HIGA, M., BAETENS, D., ORCI, L. & UNGER, R.H. (2000). Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. U.S.A., 97, 1784-1789.
30. ZU HERINGDORF, D.M., VAN KOPPEN, C.J. & JAKOBS, K.H. (1997). Molecular diversity of sphingolipid signalling. FEBS Lett., 410, 34-38.