-
1
-
-
68049085675
-
A 21st century revisionist's view at A turning point in enzymology
-
Nagel, Z. D. & Klinman, J. P. A 21st century revisionist's view at a turning point in enzymology. Nature Chem. Biol. 5, 543-550 (2009).
-
(2009)
Nature Chem. Biol.
, vol.5
, pp. 543-550
-
-
Nagel, Z.D.1
Klinman, J.P.2
-
2
-
-
77955138384
-
Heavy atom motions and tunneling in hydrogen transfer reactions: The importance of the pre-tunneling state
-
Limbach, H-H., Schowen, K. B. & Schowen, R. L. Heavy atom motions and tunneling in hydrogen transfer reactions: the importance of the pre-tunneling state. J. Phys. Org. Chem. 23, 586-605 (2010).
-
(2010)
J. Phys. Org. Chem.
, vol.23
, pp. 586-605
-
-
Limbach, H.-H.1
Schowen, K.B.2
Schowen, R.L.3
-
3
-
-
65549106864
-
Probing coupled motions in enzymatic hydrogen tunnelling reactions
-
Allemann, R. K., Evans, R. M. & Loveridge, E. J. Probing coupled motions in enzymatic hydrogen tunnelling reactions. Biochem. Soc. Trans. 37, 349-353 (2009).
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 349-353
-
-
Allemann, R.K.1
Evans, R.M.2
Loveridge, E.J.3
-
4
-
-
33645801770
-
Atomic description of an enzyme reaction dominated by proton tunneling
-
Masgrau, L. et al. Atomic description of an enzyme reaction dominated by proton tunneling. Science 312, 237-241 (2006).
-
(2006)
Science
, vol.312
, pp. 237-241
-
-
Masgrau, L.1
-
5
-
-
33748614305
-
Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis
-
Antoniou, D., Basner, J., Núñez, S. & Schwartz, S. D. Computational and theoretical methods to explore the relation between enzyme dynamics and catalysis. Chem. Rev. 106, 3170-3187 (2006).
-
(2006)
Chem. Rev.
, vol.106
, pp. 3170-3187
-
-
Antoniou, D.1
Basner, J.2
Núñez, S.3
Schwartz, S.D.4
-
6
-
-
33646935697
-
Dynamical contributions to enzyme catalysis: Critical tests of a popular hypothesis
-
Olsson, M. H. M., Parson, W. W. & Warshel, A. Dynamical contributions to enzyme catalysis: critical tests of a popular hypothesis. Chem. Rev. 106, 1737-1756 (2006).
-
(2006)
Chem. Rev.
, vol.106
, pp. 1737-1756
-
-
Olsson, M.H.M.1
Parson, W.W.2
Warshel, A.3
-
7
-
-
79958826524
-
Protein dynamics and enzyme catalysis: Insights from simulations
-
McGeagh, J. D., Ranaghan, K. E. & Mulholland, A. J. Protein dynamics and enzyme catalysis: insights from simulations. Biochim. Biophys. Acta 1814, 1077-1092 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1814
, pp. 1077-1092
-
-
McGeagh, J.D.1
Ranaghan, K.E.2
Mulholland, A.J.3
-
8
-
-
0033305793
-
Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis
-
Kuznetsov, A. & Ulstrup, J. Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis. Can. J. Chem. 77, 1085-1096 (1999).
-
(1999)
Can. J. Chem.
, vol.77
, pp. 1085-1096
-
-
Kuznetsov, A.1
Ulstrup, J.2
-
10
-
-
72249089538
-
Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed h-tunneling reaction
-
Pudney, C. R. et al. Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. J. Am. Chem. Soc. 131, 17072-17073 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 17072-17073
-
-
Pudney, C.R.1
-
11
-
-
68049093016
-
Enzymatic transition states and dynamic motion in barrier crossing
-
Schwartz, S. D. & Schramm, V. L. Enzymatic transition states and dynamic motion in barrier crossing. Nature Chem. Biol. 5, 551-558 (2009).
-
(2009)
Nature Chem. Biol.
, vol.5
, pp. 551-558
-
-
Schwartz, S.D.1
Schramm, V.L.2
-
12
-
-
78650152378
-
Slow conformational motions that favor sub-picosecond motions important for catalysis
-
Pineda, J. R. E. T., Antoniou, D. & Schwartz, S. D. Slow conformational motions that favor sub-picosecond motions important for catalysis. J. Phys. Chem. B 114, 15985-15990 (2010).
-
(2010)
J. Phys. Chem. B
, vol.114
, pp. 15985-15990
-
-
Pineda, J.R.E.T.1
Antoniou, D.2
Schwartz, S.D.3
-
13
-
-
37249032102
-
Dynamic personalities of proteins
-
Henzler-Wildman, K. & Kern, D. Dynamic personalities of proteins. Nature 450, 964-972 (2007).
-
(2007)
Nature
, vol.450
, pp. 964-972
-
-
Henzler-Wildman, K.1
Kern, D.2
-
14
-
-
0042905762
-
A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions: The beta-neopentylcobalamin system combined with prior adocobalamin data
-
Doll, K. M. & Finke, R. G. A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions: the beta-neopentylcobalamin system combined with prior adocobalamin data. Inorg. Chem. 42, 4849-4856 (2003).
-
(2003)
Inorg. Chem.
, vol.42
, pp. 4849-4856
-
-
Doll, K.M.1
Finke, R.G.2
-
15
-
-
0043236031
-
The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling
-
Doll, K. M., Bender, B. R. & Finke, R. G. The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling. J. Am. Chem. Soc. 125, 10877-10884 (2003).
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 10877-10884
-
-
Doll, K.M.1
Bender, B.R.2
Finke, R.G.3
-
16
-
-
77955127388
-
An analysis of all the relevant facts and arguments indicates that enzyme catalysis does not involve large contributions from nuclear tunneling
-
Kamerlin, S. C. L. & Warshel, A. An analysis of all the relevant facts and arguments indicates that enzyme catalysis does not involve large contributions from nuclear tunneling. J. Phys. Org. Chem. 23, 677-684 (2010).
-
(2010)
J. Phys. Org. Chem.
, vol.23
, pp. 677-684
-
-
Kamerlin, S.C.L.1
Warshel, A.2
-
17
-
-
70350453758
-
Enzyme millisecond conformational dynamics do not catalyze the chemical step
-
Pisliakov, A. V., Cao, J., Kamerlin, S. C. L. & Warshel, A. Enzyme millisecond conformational dynamics do not catalyze the chemical step. Proc. Natl Acad. Sci. USA 106, 17359-17364 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 17359-17364
-
-
Pisliakov, A.V.1
Cao, J.2
Kamerlin, S.C.L.3
Warshel, A.4
-
18
-
-
33748589503
-
Isotope effects and quantum tunneling in enzyme-catalyzed hydrogen transfer. Part I. The experimental basis
-
Romesberg, F. E. & Schowen, R. L. Isotope effects and quantum tunneling in enzyme-catalyzed hydrogen transfer. Part I. The experimental basis. Adv. Phys. Org. Chem. 39, 27-77 (2004).
-
(2004)
Adv. Phys. Org. Chem.
, vol.39
, pp. 27-77
-
-
Romesberg, F.E.1
Schowen, R.L.2
-
19
-
-
34547456661
-
Origin of the temperature dependence of isotope effects in enzymatic reactions: The case of dihydrofolate reductase
-
Liu, H. & Warshel, A. Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase. J. Phys. Chem. B 111, 7852-7861 (2007).
-
(2007)
J. Phys. Chem. B
, vol.111
, pp. 7852-7861
-
-
Liu, H.1
Warshel, A.2
-
20
-
-
33845282135
-
Theoretical transition structures for hydride transfer to methyleneiminium ion from methylamine and dihydropyridine. on the nonlinearity of hydride transfers
-
Wu, Y. D. & Houk, K. Theoretical transition structures for hydride transfer to methyleneiminium ion from methylamine and dihydropyridine. On the nonlinearity of hydride transfers. J. Am. Chem. Soc. 109, 2226-2227 (1987).
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 2226-2227
-
-
Wu, Y.D.1
Houk, K.2
-
21
-
-
79955972786
-
Effect of ph on hydride transfer by escherichia coli dihydrofolate reductase
-
Loveridge, E. J. & Allemann, R. K. Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase. ChemBioChem 12, 1258-1262 (2011).
-
(2011)
ChemBioChem
, vol.12
, pp. 1258-1262
-
-
Loveridge, E.J.1
Allemann, R.K.2
-
22
-
-
1842830209
-
Tunneling and coupled motion in the escherichia coli dihydrofolate reductase catalysis
-
Sikorski, R. S. et al. Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis. J. Am. Chem. Soc. 126, 4778-4779 (2004).
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 4778-4779
-
-
Sikorski, R.S.1
-
23
-
-
0033519723
-
Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase
-
Kohen, A., Cannio, R., Bartolucci, S. & Klinman, J. P. Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase. Nature 399, 496-499 (1999).
-
(1999)
Nature
, vol.399
, pp. 496-499
-
-
Kohen, A.1
Cannio, R.2
Bartolucci, S.3
Klinman, J.P.4
-
24
-
-
0034616853
-
Evidence for quantum mechanical tunneling in the coupled cobalt-carbon bond homolysis-substrate radical generation reaction catalyzed by methylmalonyl-coa mutase
-
Chowdhury, S. & Banerjee, R. Evidence for quantum mechanical tunneling in the coupled cobalt-carbon bond homolysis-substrate radical generation reaction catalyzed by methylmalonyl-CoA mutase. J. Am. Chem. Soc. 122, 5417-5418 (2000).
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 5417-5418
-
-
Chowdhury, S.1
Banerjee, R.2
-
25
-
-
29344449107
-
Oxygen-and temperature-dependent kinetic isotope effects in choline oxidase: Correlating reversible hydride transfer with environmentally enhanced tunneling
-
Fan, F. & Gadda, G. Oxygen-and temperature-dependent kinetic isotope effects in choline oxidase: correlating reversible hydride transfer with environmentally enhanced tunneling. J. Am. Chem. Soc. 127, 17954-17961 (2005).
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 17954-17961
-
-
Fan, F.1
Gadda, G.2
-
26
-
-
57349195545
-
Hydrogen tunneling in glucose oxidation by the archaeon thermoplasma acidophilum
-
Anandarajah, K. & Schowen, K. Hydrogen tunneling in glucose oxidation by the archaeon Thermoplasma acidophilum. Z. Phys. Chem. 222, 1333-1347 (2008).
-
(2008)
Z. Phys. Chem.
, vol.222
, pp. 1333-1347
-
-
Anandarajah, K.1
Schowen, K.2
-
27
-
-
68149157996
-
Structural and mechanistic aspects of flavoproteins: Probes of hydrogen tunnelling
-
Hay, S., Pudney, C. R. & Scrutton, N. S. Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling. FEBS J. 276, 3930-3941 (2009).
-
(2009)
FEBS J.
, vol.276
, pp. 3930-3941
-
-
Hay, S.1
Pudney, C.R.2
Scrutton, N.S.3
-
28
-
-
63649139679
-
Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase
-
Heyes, D. J., Sakuma, M., de Visser, S. P. & Scrutton, N. S. Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase. J. Biol. Chem. 284, 3762-3767 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3762-3767
-
-
Heyes, D.J.1
Sakuma, M.2
De Visser, S.P.3
Scrutton, N.S.4
-
29
-
-
0031015737
-
Loop and subdomain movements in the mechanism of escherichia coli dihydrofolate reductase: Crystallographic evidence
-
Sawaya, M. R. & Kraut, J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry 36, 586-603 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 586-603
-
-
Sawaya, M.R.1
Kraut, J.2
-
30
-
-
79953823548
-
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis
-
Bhabha, G. et al. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science 332, 234-238 (2011).
-
(2011)
Science
, vol.332
, pp. 234-238
-
-
Bhabha, G.1
-
31
-
-
80052149070
-
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
-
Adamczyk, A. J., Cao, J., Kamerlin, S. C. L. & Warshel, A. Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions. Proc. Natl Acad. Sci. USA 108, 14115-14120 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14115-14120
-
-
Adamczyk, A.J.1
Cao, J.2
Kamerlin, S.C.L.3
Warshel, A.4
-
32
-
-
1842531419
-
Pivotal role of gly 121 in dihydrofolate reductase from escherichia coli: The altered structure of a mutant enzyme may form the basis of its diminished catalytic performance
-
Swanwick, R. S., Shrimpton, P. J. & Allemann, R. K. Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance. Biochemistry 43, 4119-4127 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 4119-4127
-
-
Swanwick, R.S.1
Shrimpton, P.J.2
Allemann, R.K.3
-
33
-
-
0023668190
-
Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from escherichia coli
-
Fierke, C. A., Johnson, K. A. & Benkovic, S. J. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry 26, 4085-4092 (1987).
-
(1987)
Biochemistry
, vol.26
, pp. 4085-4092
-
-
Fierke, C.A.1
Johnson, K.A.2
Benkovic, S.J.3
-
34
-
-
0041761262
-
Hydride transfer during catalysis by dihydrofolate reductase from thermotoga maritima
-
Maglia, G., Javed, M. H. & Allemann, R. K. Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima. Biochem. J. 374, 529-535 (2003).
-
(2003)
Biochem. J.
, vol.374
, pp. 529-535
-
-
Maglia, G.1
Javed, M.H.2
Allemann, R.K.3
-
35
-
-
83755168786
-
The role of large-scale motions in catalysis by dihydrofolate reductase
-
Loveridge, E. J. et al. The role of large-scale motions in catalysis by dihydrofolate reductase. J. Am. Chem. Soc. 133, 20561-20570 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 20561-20570
-
-
Loveridge, E.J.1
-
36
-
-
67849095470
-
III functionally important conformations of the met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations
-
Arora, K. & Brooks, C. L. III Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations. J. Am. Chem. Soc. 131, 5642-5647 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 5642-5647
-
-
Arora, K.1
Brooks, C.L.2
-
37
-
-
0035928796
-
Backbone dynamics in dihydrofolate reductase complexes: Role of loop flexibility in the catalytic mechanism
-
Osborne, M. J., Schnell, J., Benkovic, S. J., Dyson, H. J. & Wright, P. E. Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism. Biochemistry 40, 9846-9859 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 9846-9859
-
-
Osborne, M.J.1
Schnell, J.2
Benkovic, S.J.3
Dyson, H.J.4
Wright, P.E.5
-
38
-
-
77953879146
-
The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from thermotoga maritima is influenced by intersubunit interactions
-
Loveridge, E. J. & Allemann, R. K. The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from Thermotoga maritima is influenced by intersubunit interactions. Biochemistry 49, 5390-5396 (2010).
-
(2010)
Biochemistry
, vol.49
, pp. 5390-5396
-
-
Loveridge, E.J.1
Allemann, R.K.2
-
39
-
-
76149110500
-
Solvent effects on catalysis by escherichia coli dihydrofolate reductase
-
Loveridge, E. J., Tey, L-H. & Allemann, R. K. Solvent effects on catalysis by Escherichia coli dihydrofolate reductase. J. Am. Chem. Soc. 132, 1137-1143 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 1137-1143
-
-
Loveridge, E.J.1
Tey, L.-H.2
Allemann, R.K.3
-
40
-
-
56749083652
-
Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from thermotoga maritima
-
Loveridge, E. J., Evans, R. M. & Allemann, R. K. Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima. Chem. Eur. J. 14, 10782-10788 (2008).
-
(2008)
Chem. Eur. J.
, vol.14
, pp. 10782-10788
-
-
Loveridge, E.J.1
Evans, R.M.2
Allemann, R.K.3
-
41
-
-
34249104188
-
The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies
-
Liu, H. & Warshel, A. The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies. Biochemistry 46, 6011-6025 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 6011-6025
-
-
Liu, H.1
Warshel, A.2
-
42
-
-
32944457660
-
Coupling of protein motions and hydrogen transfer during catalysis by escherichia coli dihydrofolate reductase
-
Swanwick, R. S., Maglia, G., Tey, L-H. & Allemann, R. K. Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase. Biochem. J. 394, 259-265 (2006).
-
(2006)
Biochem. J.
, vol.394
, pp. 259-265
-
-
Swanwick, R.S.1
Maglia, G.2
Tey, L.-H.3
Allemann, R.K.4
-
43
-
-
36949079198
-
Crystalline dihydropteroylglutamic acid
-
Blakley, R. Crystalline dihydropteroylglutamic acid. Nature 188, 231-232 (1960).
-
(1960)
Nature
, vol.188
, pp. 231-232
-
-
Blakley, R.1
-
44
-
-
0020466628
-
Kinetic mechanism of the reaction catalyzed by dihydrofolate reductase from escherichia coli
-
Stone, S. R. & Morrison, J. F. Kinetic mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli. Biochemistry 21, 3757-3765 (1982).
-
(1982)
Biochemistry
, vol.21
, pp. 3757-3765
-
-
Stone, S.R.1
Morrison, J.F.2
-
45
-
-
34250213275
-
Temperature dependence of acidity constants, a tool to affect separation selectivity in capillary electrophoresis
-
Reijenga, J. C., Gagliardi, L. G. & Kenndler, E. Temperature dependence of acidity constants, a tool to affect separation selectivity in capillary electrophoresis. J. Chromatogr. A 1155, 142-145 (2007).
-
(2007)
J. Chromatogr. A
, vol.1155
, pp. 142-145
-
-
Reijenga, J.C.1
Gagliardi, L.G.2
Kenndler, E.3
|