Evidence for quantum mechanical tunneling in the coupled cobalt-carbon bond homolysis-substrate radical generation reaction catalyzed by methylmalonyl-CoA mutase [16]

Journal of the American Chemical Society

Volumn 122, Issue 22, 2000, Pages 5417-5418

  Chowdhury, Shantanu ^a   Banerjee, Ruma ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; COBALT; ISOMERASE; ISOTOPE; MUTASE;

CATALYSIS; CATALYST; CHEMICAL REACTION; DATA ANALYSIS; ENZYME ACTIVITY; LETTER; STEADY STATE;

EID: 0034616853     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja994302g     Document Type: Letter

References (26)

1. Abbreviations used: AdoCbl: 5′deoxyadenosylcobalamin, Co-carbon: cobalt-carbon, CoA: coenzyme A.
2. 12; John Wiley and Sons: New York, 1999; pp 707-730.
3. Halpern, J. Science 1985, 227, 869-875.
4. Padmakumar, R.; Padmakumar, R.; Banerjee, R. Biochemistry 1997, 36, 3713-3718.
5. (a) Kwart, H. Acc. Chem. Res. 1982, 15, 401-408.
6. (b) Kohen, A.; Klinman, J. P.; Chem. Biol. 1999, 6, R191-198.
7. (c) Kohen, A.; Klinman, J. P. Acc. Chem. Res. 1998, 31, 397-404.
8. 6d and was >99.5 atom % enriched in deuterium.
9. (b) Padmakumar, R.; Banerjee, R. J. Biol. Chem. 1995, 270, 9295-9300.
10. (c) McKie, N.; Keep, N. H.; Patchett, M. L.; Leadlay, P. F. Biochem. J. 1990, 269, 293-298.
11. (d) Padmakumar, R.; Padmakumar, R.; Banerjee, R. Methods Enzymol. 1997, 279, 220-224.
12. Kim, Y.; Kreevoy, M. M. J. Am. Chem. Soc. 1992, 114, 7116-7123.
13. -2 is small, then equilibration between the isotopomers would be less important.
14. Bevington, P. R.; Robinson, D. K. In Data reduction and error analysis for the physical sciences; WCB/McGraw-Hill: New York, 1992.
15. Hay, B. P.; Finke, R. G. J. Am. Chem. Soc. 1986, 108, 4820-4829.
16. Marsh, E. N. G.; Ballou, D. P. Biochemistry 1998, 37, 11864-11872.
17. Licht, S. S.; Booker, S.; Stubbe, J. Biochemistry 1999, 38, 1221-1233.
18. Essenberg, M. K.; Frey, P. A.; Abeles, R. H. J. Am. Chem. Soc. 1971, 93, 1242.
19. Weisblat, D. A.; Babior, B. M. J. Biol. Chem. 1971, 246, 6064-6061.
20. Cleland, W. W. CRC Crit. Rev. Biochem. 1982, 13, 385-428.
21. For example: (a) Cha, Y.; Murray, C. J.; Klinman, J. P. Science 1989, 243, 1325-1330. (b) Grant, K. L.; Klinman, J. P. Biochemistry 1989, 28, 6597-6605. (c) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-2611. (d) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-11 (e) Kohen, A.; Cannio, R.; Bartolucci, S.; Klinman, J. P. Nature 1999, 399, 496-9.
22. For example: (a) Cha, Y.; Murray, C. J.; Klinman, J. P. Science 1989, 243, 1325-1330. (b) Grant, K. L.; Klinman, J. P. Biochemistry 1989, 28, 6597-6605. (c) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-2611. (d) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-11 (e) Kohen, A.; Cannio, R.; Bartolucci, S.; Klinman, J. P. Nature 1999, 399, 496-9.
23. For example: (a) Cha, Y.; Murray, C. J.; Klinman, J. P. Science 1989, 243, 1325-1330. (b) Grant, K. L.; Klinman, J. P. Biochemistry 1989, 28, 6597-6605. (c) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-2611. (d) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-11 (e) Kohen, A.; Cannio, R.; Bartolucci, S.; Klinman, J. P. Nature 1999, 399, 496-9.
24. For example: (a) Cha, Y.; Murray, C. J.; Klinman, J. P. Science 1989, 243, 1325-1330. (b) Grant, K. L.; Klinman, J. P. Biochemistry 1989, 28, 6597-6605. (c) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-2611. (d) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-11 (e) Kohen, A.; Cannio, R.; Bartolucci, S.; Klinman, J. P. Nature 1999, 399, 496-9.
25. For example: (a) Cha, Y.; Murray, C. J.; Klinman, J. P. Science 1989, 243, 1325-1330. (b) Grant, K. L.; Klinman, J. P. Biochemistry 1989, 28, 6597-6605. (c) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-2611. (d) Kohen, A.; Jonsson, T.; Klinman, J. P. Biochemistry 1997, 36, 2603-11 (e) Kohen, A.; Cannio, R.; Bartolucci, S.; Klinman, J. P. Nature 1999, 399, 496-9.
26. Licht, S. S.; Lawrence, C. C.; Stubbe, J. Biochemistry 1999, 38, 1234-1242.