Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 737-748

  Gregson, S J ^a   Howard, P W ^a   Hartley, J A ^b   Brooks, N A ^b   Adams, L J ^c   Jenkins, T C ^c   Kelland, L R ^d   Thurston, D E ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [(PROPANE 1,3 DIYL)DIOXY]BIS 7 METHOXY 2 METHYLIDENE 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; DIAZEPINE DERIVATIVE; DNA; MELPHALAN; PYRROLOBENZODIAZEPINE; SJG 136; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; BINDING AFFINITY; BINDING SITE; COVALENT BOND; CYTOTOXICITY; DNA CROSS LINKING; DRUG DNA BINDING; PROTEIN DENATURATION; SYNTHESIS; THERMAL INJURY;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINONES; CISPLATIN; CROSS-LINKING REAGENTS; DNA; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, AGAR GEL; HEATING; HUMANS; MODELS, MOLECULAR; PROTEIN DENATURATION; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035282633     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001064n     Document Type: Article

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