Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity

Journal of Medicinal Chemistry

Volumn 45, Issue 21, 2002, Pages 4679-4688

  Kamal, Ahmed ^a   Ramesh, G ^a   Laxman, N ^a   Ramulu, P ^a   Srinivas, O ^a   Neelima, K ^b   Kondapi, Anand K ^b   Sreenu, V B ^c   Nagarajaram, H A ^c  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

^c CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; DOUBLE STRANDED DNA; IMINE; LACTAM; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; RESTRICTION ENDONUCLEASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DENATURATION; DNA CROSS LINKING; DRUG DESIGN; DRUG DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; DEOXYRIBONUCLEASE BAMHI; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID DENATURATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037057577     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020124h     Document Type: Article

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