An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2073-2077

  Tiberghien, Arnaud C ^a   Evans, David A ^a   Kiakos, Konstantinos ^b   Martin, Christopher R H ^a   Hartley, John A ^a,b   Thurston, David E ^a,c   Howard, Philip W ^a,c  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Anticancer agent; Cross linking; DNA binding; Interstrand; PBD; PBD dimer; Pyrrolobenzodiazepine; Sequence selective

Indexed keywords

DNA; MELPHALAN; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DNA DETERMINATION; DNA SYNTHESIS; DRUG PENETRATION; DRUG POTENCY; GENE TARGETING; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION;

BASE SEQUENCE; BENZODIAZEPINES; CROSS-LINKING REAGENTS; DIMERIZATION; DNA; DNA FOOTPRINTING; HUMANS; K562 CELLS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PYRROLES; SEQUENCE HOMOLOGY, NUCLEIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749083920     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.096     Document Type: Article

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