A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 6, 2004, Pages 1547-1549

  Chen, Zhizhi ^a   Gregson, Stephen J ^a   Howard, Philip W ^a   Thurston, David E ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cytotoxic; DNA binding; PBDs; SAR

Indexed keywords

ANTHRAMYCIN; BENZODIAZEPINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HECK REACTION; HUMAN; HUMAN CELL; NONHUMAN;

BENZODIAZEPINES; CELL LINE, TUMOR; HUMANS; PYRROLES;

EID: 1542284728     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.094     Document Type: Article

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