The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies

Journal of Medicinal Chemistry

Volumn 51, Issue 5, 2008, Pages 1423-1431

  Joseph, Christine G ^a   Wilson, Krista R ^a   Wood, Michael S ^a   Sorenson, Nicholas B ^a   Phan, Dong V ^a   Xiang, Zhimin ^a   Witek, Rachel M ^a   Haskell Luevano, Carrie ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 (1 BENZYL 1H INDOL 3 YL METHYL) 9 METHYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 1 BENZYL 3 (1H INDOL 3 YL METHYL) 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 1,3 DIBENZYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 1,4 BENZODIAZEPIN 2,5 DIONE DERIVATIVE; 3 (4 AMINOBUTYL) 1 BENZYL 8 CHLORO 3,4 DIHYDRO 1H BENZOLE[E][1,4]DIAZEPIN 2,5 DIONE; 3 (4 AMINOBUTYL) 8 CHLORO 1 NAPHTHALEN 2 YL METHYL 3,4 DIHYDRO 1H BENZOLE[E][1,4]DIAZEPIN 2,5 DIONE; 3 BENZYL 1 BUTYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 3 BENZYL 1 PHENYL 2 YL METHYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 3 BENZYL 1 PROPYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 3 BENZYL 8 CHLORO 1 NAPHTHALEN 2 YL METHYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; 8 CHLORO 3 (1H INDOL 3 YL METHYL) 1 NAPHTHALEN 2 YL METHYL 3,4 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 2,5 DIONE; BENZODIAZEPINE DERIVATIVE; MELANOCORTIN RECEPTOR; N [3 (1 BENZYL 2,5 DIOXO 2,3,4,5 TETRAHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 YL)PROPYL]GUANIDINE; N [3 (1 BENZYL 8 CHLORO 2,5 DIOXO 2,3,4,5 TETRAHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 YL)PROPYL]GUANIDINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION;

BENZODIAZEPINES; BETA-GALACTOSIDASE; CELL LINE; GENES, REPORTER; HUMANS; LIGANDS; RECEPTORS, MELANOCORTIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41649108801     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701303z     Document Type: Article

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