An efficient, PIFA mediated approach to benzo-, naphtho-, and heterocycle-fused pyrrolo[2,1-c][1,4]diazepines. An advantageous access to the antitumor antibiotic DC-81

Journal of Organic Chemistry

Volumn 70, Issue 6, 2005, Pages 2256-2264

  Correa, Arkaitz ^a   Tellitu, Imanol ^a   Domínguez, Esther ^a   Moreno, Isabel ^a   SanMartin, Raul ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; ESTERS; MOLECULAR DYNAMICS; REACTION KINETICS; SYNTHESIS (CHEMICAL); TUMORS;

1-PYROLINE METHYL ESTER; ANTITUMOR ANTIBIOTICS; AROYLATION; CYCLIZATION;

KETONES;

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 1,2,3,12,13,13A HEXAHYDRO 5H NAPHTHO[2,1 F]PYRROLO[2,1 C][1,4]DIAZEPIN 5,13 DIONE; 1,2,3,9,10,10A HEXAHYDRO 5H PYRROLO[2,1 F]THIENO[3,2 F][1,4]DIAZEPIN 5,10 DIONE; 12 METHOXY 1,2,3,12,13,13A HEXAHYDRO 5H NAPHTHO[2,1 F]PYRROLO[2,1 C][1,4]DIAZEPIN 5,13 DIONE; 6 METHYL 1,2,3,9,10,10A HEXAHYDRO 5H DIPYRROLO[2,3 F:2,1 C][1,4]DIAZEPIN 5,10 DIONE; 7 METHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5,11 DIONE; 7,10 DIMETHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5,11 DIONE; 7,8 DIMETHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5,11 DIONE; 7,8,10 TRIMETHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5,11 DIONE; 8 BENZYLOXY 7 METHOXY 1,2,3 TRIHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 DIONE; 8 BENZYLOXY 7 METHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 DIONE; 8 BENZYLOXY 7 METHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5,11 DIONE; 8 BENZYLOXY 7,10 DIMETHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5,11 DIONE; 9 METHOXY 1,2,3,9,10,10A HEXAHYDRO 5H PYRROLO[2,1 F]THIENO[3,2 F][1,4]DIAZEPIN 5,10 DIONE; 9 METHOXY 6 METHYL 1,2,3,9,10,10A HEXAHYDRO 5H PYRROLO[2,1 F]THIENO[3,2 F:2,1 C][1,4]DIAZEPIN 5,10 DIONE; DIAZEPINE DERIVATIVE; ESTER DERIVATIVE; NITROGEN DERIVATIVE; PROLINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; CYCLIZATION; DRUG SYNTHESIS;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CYCLIZATION; DRUG DESIGN; IMINES; MOLECULAR CONFORMATION; ORGANOPHOSPHORUS COMPOUNDS; PYRAZOLES; PYRROLES; SULFUR COMPOUNDS;

EID: 15444370706     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo047872u     Document Type: Article

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