Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 6, 2008, Pages 911-921

  Gourdeau, Henriette ^a   McAlpine, James B ^a   Ranger, Maxime ^a   Simard, Bryan ^b   Berger, Francois ^b   Beaudry, Francis ^c   Falardeau, Pierre ^a  

^a Thallion Pharmaceuticals Inc   (Canada)

^b INSERM   (France)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cancer; Dibenzodiazepine; Glioma; Peripheral benzodiazepine receptor (PBR); Xenografts

Indexed keywords

4,6,8 TRIHYDROXY 10 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYL) 5,10 DIHYDRODIBENZO[B,E][1,4]DIAZEPIN 11 ONE; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; ECO 4601; LIGAND; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BRAIN TUMOR; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; FEMALE; GLIOMA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RAT; STANDARD; TECHNOLOGY; TREATMENT OUTCOME; TREATMENT RESPONSE; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BENZODIAZEPINES; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA MODULATORS; GLIOMA; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED ICR; MICE, NUDE; NEOPLASM TRANSPLANTATION; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; TRANSPLANTATION, HETEROLOGOUS;

EID: 41049092908     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0544-2     Document Type: Article

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