Synthesis and antitumor activity of novel enediyne-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1172-1180

  Hu, Wan Ping ^a   Liang, Jium Jia ^a   Kao, Chai Lin ^a   Chen, You Chiang ^a   Chen, Chung Yu ^a   Tsai, Feng Yuan ^b   Wu, Ming Jung ^c   Chang, Long Sen ^c   Chen, Yeh Long ^a   Wang, Jeh Jeng ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; DC 81; Enediyne; Pyrrolo 2,1 c 1,4 benzodiazepine

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [4 (2 PHENYLETHYNYLPHENYL)BUT 3 YNYL)OXYL] 1,2,3,11A TETRAHYDROBENZO[E]PYRROLO[1,2 A][1,4]DIAZEPIN 5 ONE; ACTIN; BENZODIAZEPINE DERIVATIVE; CASPASE 3; ENEDIYNE; LIPOCORTIN 5; PROTEIN P53; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; QUANTUM YIELD;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZODIAZEPINES; CASPASE 3; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENEDIYNES; HUMANS; INDOLES; ORGANOPHOSPHORUS COMPOUNDS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58949091407     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.036     Document Type: Article

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