The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links

Journal of the American Chemical Society

Volumn 131, Issue 38, 2009, Pages 13756-13766

  Rahman, Khondaker M ^a   Thompson, Andrew S ^b   James, Colin H ^a   Narayanaswamy, Mathangi ^a,c   Thurston, David E ^a,c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b University of Bath   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL TRIAL; HPLC/MS; IN-CELL; IN-VITRO; INTERACTIVE AGENTS; INTERSTRAND CROSS-LINKS; MECHANISM OF ACTION; MODELING STUDIES; PHASE II; PYRROLOBENZODIAZEPINE; RANK ORDER; SEQUENCE-DEPENDENT; THERMAL DENATURATIONS;

BINDING ENERGY; BINDING SITES; DNA; DNA SEQUENCES; GENES; IMPACT RESISTANCE; INTERACTIVE DEVICES; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PYROLYSIS;

PLUTONIUM;

BENZODIAZEPINE DERIVATIVE; DIMER; DNA; GUANINE DERIVATIVE; SJG 136; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BINDING SITE; DENATURATION; DNA ADDUCT; DNA CROSS LINKING; FEASIBILITY STUDY; IN VITRO STUDY; IN VIVO STUDY; MODEL; OBSERVATIONAL STUDY; PHARMACODYNAMICS;

BASE SEQUENCE; BENZODIAZEPINONES; CROSS-LINKING REAGENTS; DIMERIZATION; DNA ADDUCTS; NUCLEIC ACID CONFORMATION; PYRROLES;

EID: 70349743960     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja902986x     Document Type: Article

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