Linker Length Modulates DNA Cross-Linking Reactivity and Cytotoxic Potency of C8/C8′ Ether-Linked C2-exo-Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Dimers

Journal of Medicinal Chemistry

Volumn 47, Issue 5, 2004, Pages 1161-1174

  Gregson, Stephen J ^a   Howard, Philip W ^a   Gullick, Darren R ^a   Hamaguchi, Anzu ^b   Corcoran, Kathryn E ^a   Brooks, Natalie A ^b   Hartley, John A ^b   Jenkins, Terence C ^c   Patel, Sejal ^d   Guille, Matthew J ^d   Thurston, David E ^a,e  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

^d UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^e UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [(PENTANE 1,5 DIYL)DIOXY]BIS(7 METHOXY 2 METHYLIDINE 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE); 1,1' [(PROPANE 1,3 DIYL)DIOXY]BIS(7 METHOXY 2 METHYLIDENE 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE); 1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTHRAMYCIN; DIMER; DNA; DRG 16; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; SJG 136; TOMAYMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN K 562; CONCENTRATION RESPONSE; DIMERIZATION; DNA CROSS LINKING; DRUG DNA INTERACTION; DRUG POTENCY; HUMAN; HUMAN CELL; MITSUNOBU REACTION; MOLECULAR MODEL;

ANTINEOPLASTIC AGENTS; AUTORADIOGRAPHY; BENZODIAZEPINES; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; DEOXYRIBONUCLEASE BAMHI; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, AGAR GEL; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID DENATURATION; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10744225213     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030897l     Document Type: Article

References (29)

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