Biosynthesis of sibiromycin, a potent antitumor antibiotic

Applied and Environmental Microbiology

Volumn 75, Issue 9, 2009, Pages 2869-2878

  Li, Wei ^a   Khullar, Ankush ^a   Chou, Shenchieh ^a   Sacramo, Ashley ^a   Gerratana, Barbara ^a,b  

^a University of Maryland   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR ANTIBIOTICS; ANTITUMOR PROPERTY; BENZODIAZEPINES; BIOSYNTHETIC PATHWAY; CARDIOTOXICITY; CLINICAL TRIAL; CLUSTER BOUNDARIES; COMPARATIVE GENOMICS; COMPLEMENTATION; DIHYDROPYRROLE; GENE CLUSTERS; GENE REPLACEMENT; GLYCOSYLATED; HYDROXYL GROUPS; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASE; OPEN READING FRAME;

AMINES; ANIMALS; ANTIBIOTICS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSTS; CLONING; DNA; ENZYMES; NUCLEIC ACIDS;

GENE ENCODING;

ANTHRAMYCIN; ANTHRANILIC ACID; ANTINEOPLASTIC ANTIBIOTIC; GENOMIC DNA; KYNURENINE; LINCOMYCIN; PEPTIDE SYNTHASE; PYRROLE DERIVATIVE; SIBIROMYCIN; TOMAYMYCIN; AMINOGLYCOSIDE; BACTERIAL DNA;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; DNA; ECOTOXICOLOGY; FUNGUS; GENE EXPRESSION; GENOMICS; MICROBIAL ACTIVITY; TUMOR;

ARTICLE; BACTERIUM; COMPARATIVE GENOMIC HYBRIDIZATION; DRUG SYNTHESIS; GENE CLUSTER; GENE INACTIVATION; GENE SEQUENCE; GENETIC PROCEDURES; HYDROXYLATION; MOLECULAR CLONING; NONHUMAN; NONRIBOSOMAL PEPTIDE SYNTHESIS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; STREPTOMYCES; STREPTOSPORANGIUM SIBIRICUM; ACTINOBACTERIA; BACTERIAL GENE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; GENE DELETION; GENE ORDER; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY;

ACTINOBACTERIA (CLASS); ANIMALIA;

ACTINOBACTERIA; AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, BACTERIAL; GENE DELETION; GENE ORDER; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; SEQUENCE ANALYSIS, DNA;

EID: 65549123941     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02326-08     Document Type: Article

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