Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6868-6875

  Kamal, Ahmed ^a   Ramu, R ^a   Tekumalla, Venkatesh ^a   Khanna, G B Ramesh ^a   Barkume, Madan S ^b   Juvekar, Aarti S ^b   Zingde, Surekha M ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b TATA MEMORIAL HOSPITAL   (India)

Author keywords

Anthraquinones; Anticancer activity; DNA binding; Pyrrolobenzodiazepines

Indexed keywords

1,4 BIS[3 (7 METHOXY 8 OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE)PROPYLOXY]ANTHRACENE 9,10 DIONE; 1,4 BIS[4 (7 METHOXY 8 OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE)BUTYLOXY]ANTHRACENE 9,10 DIONE; 1,4 BIS[5 (7 METHOXY 8 OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE)PENTYLOXY]ANTHRACENE 9,10 DIONE; 7 METHOXY 8 [N (9,10 DIHYDRO 9,10 DIOXO 1 ANTHRACENYL)BUTANE 4 CARBOXAMIDE]OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [N (9,10 DIHYDRO 9,10 DIOXO 1 ANTHRACENYL)PROPANE 3 CARBOXAMIDE]OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTHRAQUINONE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; DNA; DOXORUBICIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; BINDING SITES; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PYRROLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548838271     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.026     Document Type: Article

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