Design, synthesis, and evaluation of a novel sequence-selective epoxide- containing DNA cross-linking agent based on the pyrrolo[2,1- c][1,4]benzodiazepine system

Journal of Medicinal Chemistry

Volumn 42, Issue 20, 1999, Pages 4028-4041

  Wilson, Stuart C ^a   Howard, Philip W ^a   Forrow, Stephen M ^b   Hartley, John A ^b   Adams, Lesley J ^a   Jenkins, Terence C ^c   Kelland, Lloyd R ^d   Thurston, David E ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 8 (2,3 EPOXYPROPOXY) 7 METHOXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ALKYLATING AGENT; ANTHRAMYCIN; ANTINEOPLASTIC AGENT; CISPLATIN; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; TOMAYMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CROSS RESISTANCE; DNA BINDING; DNA CROSS LINKING; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PREDICTION; STRUCTURE ANALYSIS;

EID: 0033533853     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981124d     Document Type: Article

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