Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3895-3906

  Kamal, Ahmed ^a   Kumar, P Praveen ^a   Seshadri, B N ^a   Srinivas, O ^a   Kumar, M Shiva ^a   Sen, Subrata ^b   Kurian, Nisha ^b   Juvekar, Aarti S ^b   Zingde, Surekha M ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b TATA MEMORIAL HOSPITAL   (India)

Author keywords

Cytotoxicity; Diethylphosphonate; DNA binding affinity; Pyrrolobenzodiazepine

Indexed keywords

7 METHOXY 8 [5 [4 [2 (DIETHOXYPHOSPHORYL)ETHYL]PIPERAZIN 1 YL]PENTYL]OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; RECEPTOR AFFINITY;

AMINATION; ANIMALS; BENZODIAZEPINES; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; DIMERIZATION; DNA; HUMANS; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; PHOSPHONIC ACIDS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 41749105579     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.040     Document Type: Article

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