Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 20, 2004, Pages 5427-5436

  Kamal, Ahmed ^a   Ramesh, G ^a   Srinivas, O ^a   Ramulu, P ^a   Laxman, N ^a   Rehana, Tasneem ^a   Deepak, M ^b   Achary, M S ^b   Nagarajaram, H A ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

Author keywords

Cytotoxicity; DNA binding affinity; Pyrrolobenzodiazepines

Indexed keywords

7 METHOXY 8 [3 (7 METHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ON 8 YLOXY)PROPOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; 7 METHOXY 8 [5 (7 METHOXY 1,2,3,10,11,11A HEXAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ON 8 YLOXY)PENTYLOXY] 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG DESIGN; DRUG DNA INTERACTION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; REACTION ANALYSIS;

AMINES; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BENZODIAZEPINES; CELL LINE, TUMOR; DIMERIZATION; DNA; DRUG DESIGN; HUMANS; IMINES; INTERCALATING AGENTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PYRROLES;

EID: 4544328629     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.045     Document Type: Article

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