A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

Pharmacology and Therapeutics

Volumn 134, Issue 1, 2012, Pages 82-106

  Astashkina, Anna ^a   Mann, Brenda ^b   Grainger, David W ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

3 D and 2 D culture; Cellular models; HTS screens; Reasons for failure; Role of microenvironment; Toxicity

Indexed keywords

SCLEROPROTEIN;

BIOREACTOR; CELL CULTURE; CELL INTERACTION; CELL TYPE; DRUG APPROVAL; DRUG COST; DRUG PROTEIN BINDING; DRUG RECALL; DRUG SAFETY; DRUG TOXICITY; EXPLANT; EXTRACELLULAR MATRIX; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNE SYSTEM; IN VITRO STUDY; MICROENVIRONMENT; MOLECULAR INTERACTION; NONHUMAN; ORGAN CULTURE; PHENOTYPE; PLURIPOTENT STEM CELL; PRIMARY CELL CULTURE; PRIORITY JOURNAL; REVIEW; TISSUE OXYGENATION;

ANIMALS; CELL CULTURE TECHNIQUES; DRUG DISCOVERY; DRUG TOXICITY; HUMANS;

EID: 84857361302     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.01.001     Document Type: Review

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