Dual functions for connexins: Cx43 regulates growth independently of gap junction formation

Experimental Cell Research

Volumn 271, Issue 2, 2001, Pages 238-248

  Moorby, Catriona ^a   Patel, Minal ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Connexins; Cx43; Gap junction; Growth

Indexed keywords

CONNEXIN 43; CONNEXIN 43 S255A; CONNEXIN 43 S279A; CONNEXIN 43 S282A; GAP JUNCTION PROTEIN; HEPTANOL; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DENSITY; CELL TRANSFER; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOPLASM; FIBROBLAST; GAP JUNCTION; GROWTH INHIBITION; GROWTH REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; REGULATORY MECHANISM;

VERTEBRATA;

EID: 0035842338     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5357     Document Type: Article

References (46)

1. Permeability of membrane junctions
2. The cell-cell channel in the control of cell growth
3. Growth inhibition of transformed cells correlates with their junctional communication with normal cells
4. Growth factors modulate junctional cell-to-cell communication
5. Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-beta and peptide hormones in normal human keratinocytes
6. Dissociation of PDGF receptor tyrosine kinase activity from PDGF-mediated inhibition of gap junctional communication
7. HGF/SF inhibits junctional communication
8. Acute loss of cell-cell communication caused by G protein-coupled receptors: A critical role for c-Src
9. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth
10. Transfection of C6 glioma cells with connexin 43 cDNA: Analysis of expression, intercellular coupling and cell proliferation
11. Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases
12. Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential
13. Epidermal growth factor disrupts gapjunctional communication and induces phosphorylation of connexin43 on serine
14. Restoration of cell-to-cell communication in thyroid cell lines by transfection with and stable expression of the connexin-32 gene. Impact on cell proliferation and tissue-specific gene expression
15. Transfection of C6 glioma cells with connexin32: The effects of expression of a nonendogenous gap junction protein
16. Negative growth control of HeLa cells by connexin genes: Connexin species specificity
17. Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43)
18. Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner
19. Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo
20. Isolation of monoclonal antibodies specific for the human c-myc proto-oncogene product
21. An Hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein
22. Expression of a Cx43 deletion mutant in 3T3 A31 fibroblasts prevents PDGF-induced inhibition of cell communication and suppresses cell growth
23. Rapid and efficient site-specific mutagenesis without phenotypic selection
24. Heptanol-induced decrease in cardiac gap junctional conductance is mediated by a decrease in the fluidity of membranous cholesterol-rich domains
25. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells
26. Physiological role of gap-junctional hemichannels. Extracellular calciumdependent isosmotic volume regulation
27. Cell adhesion more than just glue
28. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein
29. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes
30. Interaction of c-Src with gap junction protein connexin-43: Role in the regulation of cell-cell communication
31. c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes
32. Immunolocalization and expression of functional and non-functional cell-to-cell channels from wild-type and mutant rat heart connexin43 cDNA
33. Functional analysis of human cardiac gap junction channel mutants
34. Connexins, connexons and intercellular communication
35. The dual role of cytoskeletal anchor proteins in cell adhesion and signal transduction
36. The role of beta-catenin in cell adhesion, signal transduction, and cancer
37. Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes
38. Cardiac malformation in neonatal mice lacking connexin 43
39. Unique and shared functions of different connexins in mice
40. Tyrosine phosphorylation of connexin 43 by v-src is mediated by SH2 and SH3 domain interactions
41. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and deficient cell lines
42. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques
43. Selected glimpses into the activation and function of Src kinase
44. MAGUK proteins: Structure and role in the tight junction
45. The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells