Backleak, tight junctions, and cell-cell adhesion in postischemic injury to the renal allograft

Journal of Clinical Investigation

Volumn 101, Issue 10, 1998, Pages 2054-2064

  Kwon, Osun ^a   Nelson, W James ^a   Sibley, Richard ^a   Huie, Philip ^a   Scandling, John D ^a   Dafoe, Donald ^a   Alfrey, Edward ^a   Myers, Bryan D ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adherens complex; Cell substratum adhesion; Fractional dextran clearances; Tubule cell pathobiology; Zonula occludens

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CYTOPLASM PROTEIN; CYTOPLASM PROTEIN ZO 1; DEXTRAN 40; INTEGRIN; INULIN; LAMININ; SODIUM; TAMM HORSFALL GLYCOPROTEIN; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; CELL ADHESION; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; HUMAN; IMMUNOHISTOCHEMISTRY; INULIN CLEARANCE; KIDNEY ALLOGRAFT; KIDNEY ISCHEMIA; KIDNEY TUBULE ABSORPTION; NATRIURESIS; PLASMA OSMOLALITY; PRIORITY JOURNAL; REPERFUSION INJURY; TIGHT JUNCTION; URINE FLOW RATE;

EID: 0032524021     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI772     Document Type: Article

References (39)

1. Arendhorst, W.J., W.F. Finn, and C.W. Gottschalk. 1976. Micropuncture study of acute renal failure following temporary renal ischemia in the rat. Kidney Int. 10(Suppl. 6):S100-S105.
2. Tanner, G.A., and S. Sophasan. 1976. Kidney pressures after temporary renal artery occlusion in the rat. Am. J. Physiol. 230:1173-1181.
3. Burke, T.J., R.E. Cronin, K.L., Duchin, L.N. Peterson, and R.W. Schrier. 1980. Ischemia and tubule obstruction during acute renal failure in dogs: mannitol in protection. Am. J. Physiol. 238:F305-F314.
4. Alejandro, V., J.D. Scandling, R.K. Sibley, D. Dafoe, E. Alfrey, W.M. Deen, and B.D. Myers. 1945. Mechanisms of filtration failure during post-ischemic injury of the human kidney. A study of the reperfused renal allograft. J. Clin. Invest. 95:820-831.
5. Myers, B.D., C. Miller, J. Mehigan, C. Olcott, H. Golbetz, C.R. Robertson, G. Derby, R. Spencer, and S. Friedman. 1984. Nature of the renal injury following total renal ischemia in man. J. Clin. Invest. 73:329-341.
6. Myers, B.D. 1996. Pathogenetic processes in human acute renal failure. Semin. Dialysis. 9:444-453.
7. Hanley, M.J., and K. Davidson. 1981. Prior mannitol and furosemide infusion in a model of ischemic acute renal failure. Am. J. Physiol. 241:F556-F564.
8. Eisenbach, G.M., and M. Steinhausen. 1973. Micropuncture studies after temporary ischemia of rat kidneys. Pfluger's Arch. 343:11-25.
9. Yagil, Y., B.D. Myers, and R.L. Jamison. 1988. Course and pathogenesis of postischemic acute renal failure in the rat. Am. J. Physiol. 24:F257-F264.
10. Molitoris, B.A., S.A. Falk, and R.H. Dahl. 1989. Ischemia-induced loss of epithelial polarity. Role of the tight junction. J. Clin. Invest. 84:1334-1339.
11. Molitoris, B.A. 1991. Ischemia-induced loss of epithelial polarity: potential role of the actin cytoskeleton. Am. J. Physiol. 260:F769-F778.
12. Goligorsky, M.S., W. Lieberthal, L. Racusen, and E.E. Simon. 1993. Integrin receptors in renal tubular epithelium: new insights into pathophysiology of acute renal failure. Am. J. Physiol. 264:F1-F8.
13. Noiri, E., V. Romanov, T. Forest, J. Gailit, G.F. DiBona, F. Miller, P. Som, Z.H. Oster, and M.S. Goligorsky. 1995. Pathophysiology of renal tubular obstruction: therapeutic role of synthetic RGD peptides in acute renal failure. Kidney Int. 48:1375-1385.
14. Lieberthal, W., J.B. Mckenney, C.R. Kiefer, L.M. Synder, V.M. Kroshian, and M.D. Sjaastad. 1997. β1 integrin-mediated adhesion between renal tubular cells after anoxic injury. J. Am. Soc. Nephrol. 8:175-183.
15. Mandel, L.J., R. Bacallao, and G. Zampighi. 1993. Uncoupling of the molecular "fence" and paracellular "gate" functions in epithelial tight junctions. Nature. 361:552-555.
16. Moran, S.M., and B.D. Myers. 1985. Pathophysiology of protracted acute renal failure in man. J. Clin. Invest. 76:1440-1448.
17. Myers, B.D., R. Chui, M. Hilberman, and A.S. Michaels. 1979. Transtubular leakage of glomerular filtrate in human acute renal failure. Am. J. Physiol. 237:F319-F325.
18. Granath, K.A., and B.E. Kvist. 1967. Molecular weight distribution analysis by gel chromatography on Sephadex. J. Chromatography. 28:69-81.
19. Scott, T.A., and E.H. Melvin. 1953. Determination of dextran with anthrone. Anal. Chem. 25:1656-1661.
20. Chang, R.L.S., I.F. Ueki, J.L. Troy, W.M. Deen, C.R. Robertson, and B.M. Brenner. 1975. Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in the rats using neutral dextran. Biophys. J. 15:887-906.
21. Chang, R.L.S., C.R. Robertson, W.M. Deen, and B.M. Brenner. 1975. Permselectivity of the glomerular capillary wall to macromolecules. I. Theoretical considerations. Biophys. J. 15:861-886.
22. Sonnenberg, A., H. Daams, M.A. Van der Valk, J. Hilkens, and J. Hilgers. 1986. Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin. J. Histochem. Cytochem. 34:1037-1046.
23. Brenner, B.M., M.P. Bohrer, C. Baylis, and W.M. Deen. 1977. Determinants of glomerular permselectivity: insights derived from observations in vivo. Kidney Int. 12:229-237.
24. Deen, W.M., C.R. Bridges, B.M. Brenner, and B.D. Myers. 1985. A heteroporous model of size-selectivity: application to normal and nephrotic humans. Am. J. Physiol. 249:F374-F389.
25. Myers, B.D., B. Carrie, R.R. Yee, M. Hilberman, and A.S. Michaels. 1980. Pathophysiology of hemodynamically-mediated acute renal failure in man. Kidney Int. 18:495-504.
26. Daniels, B.S., E.B. Hauser, W.M. Deen, and T.H. Hostetter. 1992. Glomerular basement membrane: in vitro studies of water and protein permeability. Am. J. Physiol. 262:F919-F926.
27. Olsen, T.S., H.S. Olsen, and H.E. Hansen. 1985. Tubular ultrastructure in acute renal failure in man: epithelial necrosis and regeneration. Virchows Arch. (Pathol. Anat.). 406:75-89.
28. Jones, D.B. 1982. Ultrastructure of human acute renal failure. Lab. Invest. 46:254-264.
29. Solez, K., L. Morel-Maroger, and J.D. Sraer. 1979. The morphology of "acute tubular necrosis" in man: analysis of 57 renal biopsies and a comparison with glycerol model. Medicine (Baltimore). 58:362-376.
30. Solez, K. 1983. Pathogenesis of acute renal failure. Int. Rev. Exp. Pathol. 24:277-328.
31. Trump, B.F., I.K. Berezesky, and R.A. Cowley. 1982. The cellular and subcellular characteristics of acute and chronic injury with emphasis on the role of calcium. In Pathophysiology of Shock, Anoxia, and Ischemia. R.A. Cowley and B.E. Trump, editors. Williams & Wilkins, Baltimore. 6-46.
32. Solez, K., L.C. Racusen, N. Marcussen, I. Slatnik, I. Keown, J-F. Burdick, and S. Olsen. 1993. Morphology of ischemic acute renal failure, normal function, and cyclosporine toxicity in cyclosporine-treated renal allograft recipients. Kidney Int. 43:1058-1067.
33. Furuse, M., M. Itoh, T. Hirase, A. Nagafuchi, S. Yonemura, S. Tsukita, and S. Tsukita. 1994. Direct association between occludin and ZO-1 and its possible involvement in the localization of occludin at tight junctions. J. Cell Biol. 127:1617-1626.
34. Ozawa, M., H. Baribault, and R. Kemler. 1989. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO (Eur. Mol. Biol. Organ.) J. 8:1711-1719.
35. Nagafuchi, A., and M. Takeichi. 1988. Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO (Eur. Mol. Biol. Organ.) J. 7:3679-3684.
36. Piepenhagen, P.A., and W.J. Nelson. 1995. Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron. Am. J. Physiol. 269:C1433-C1449.
37. Gumbiner, B. 1996. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell. 84:345-357.
38. Bacallao, R., A. Garfinkel, S. Monke, G. Zampighi, and L.J. Mandel. 1994. ATP depletion: a novel method to study junctional properties in epithelial tissues. I. Rearrangement of the actin cytoskeleton. J. Cell Sci. 107:3301-3313.
39. Furuse, M., T. Hirase, M. Itoh, A. Nagatuchi, S. Yonemura, and S. Tsukita. 1993. Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 103:1777-1788.