Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2

Archives of Biochemistry and Biophysics

Volumn 464, Issue 2, 2007, Pages 155-168

  Lafite, Pierre ^a   Dijols, Sylvie ^a   Zeldin, Darryl C ^b   Dansette, Patrick M ^a   Mansuy, Daniel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Arachidonic acid epoxidation; Benzo 1,3 dioxole; Drug metabolism; Ebastine; Hemeproteins; Hydroxylation; Monooxygenases; Terfenadine; Vascular P450s

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; ALLYL COMPOUND; CARBENE; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2J2; CYTOCHROME P450 2J2 INHIBITOR; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; EBASTINE; IMIDAZOLE; IRON; PROPANE; TERFENADINE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; OXYGENASES;

EID: 34547655500     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.03.028     Document Type: Article

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