Chromatographic methods for the determination of therapeutic oligonucleotides

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 883-884, Issue , 2012, Pages 76-94

  McGinnis, A Cary ^a   Chen, Buyun ^a   Bartlett, Michael G ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

DNA; Ion exchange; Ion pair; LC MS; Oligonucleotides; RNA

Indexed keywords

ANTISENSE; APTAMERS; BIO-MARKER DISCOVERY; BIOANALYTICAL METHODS; BIOLOGICAL MATRIXES; CHROMATOGRAPHIC METHODS; DRUG APPROVALS; ION PAIR; LC-MS; MASS SPECTROMETRIC DETECTION; MATRIX ASSISTED LASER DESORPTION/IONIZATION; METABOLITE ANALYSIS; MICRORNA (MIRNA); NON-CODING RNAS; SAMPLE PREPARATION; SMALL INTERFERING RNA (SIRNA); THERAPEUTIC POTENTIALS; ULTRA-VIOLET;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DESORPTION; DNA; ION EXCHANGE; MOLECULAR BIOLOGY; RNA; ULTRAVIOLET LASERS;

OLIGONUCLEOTIDES;

COMPLEMENTARY DNA; DNA; HEXAFLUORO 2 PROPANOL; IMMUNOLOGICAL ADJUVANT; OLIGONUCLEOTIDE; RNA; SMALL INTERFERING RNA; UNTRANSLATED RNA;

CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; REVIEW; RNA SEQUENCE; ULTRAVIOLET RADIATION;

APTAMERS, NUCLEOTIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; DNA, ANTISENSE; HUMANS; OLIGONUCLEOTIDES; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84856491505     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.007     Document Type: Review

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