Molecular mechanisms of antisense drugs: RNase H

Antisense and Nucleic Acid Drug Development

Volumn 8, Issue 2, 1998, Pages 133-134

  Crooke, Stanley T ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; RIBONUCLEASE H;

CONFERENCE PAPER; PRIORITY JOURNAL; RNA DEGRADATION; RNA STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 0031922256     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1998.8.133     Document Type: Conference Paper

References (9)

1. CROOKE, S.T. (1998). Basic principles of antiscnse therapeutics. In: Handbook of Experimental Pharmacology, vol. 1, S.T. Crooke, ed. (Springer Verlag, Berlin), pp. 1-50.
2. CROOKE, S.T., LEMONIDIS, K.M., NEILSON, L., GRIFFEY, R., LESNIK, E.A., and MONIA, B.P. (1995). Kinetic characteristics of E. coli RNase H1: Cleavage of various antisense oligonucleotides-RNA duplexes. Biolchem. J. 312, 599-608.
3. CROUCH, R.J., and DIRKSEN, M.L. (1982). Ribonucleases H. In: Nucleases. S.M. Linn and R.J. Roberts, eds. (Cold Spring Harbor Laboratory Press, Plainview, NY), pp. 211-241.
4. EDER, P.S., WALDER, R.T., and WALDER, J.A. (1993). Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA. Biochimie 75, 123-126.
5. FRANK, P., ALBERT, S., CAZENAVE, C., and TOULMÉ, J.J. (1994). Purification and characterization of human ribonuclease HII. Nucleic Acids Res. 22, 5247-5254.
6. LIMA, W.F., and CROOKE, S.T. (1997a). Binding affinity and specificity of Escherichia coli RNase H1: Impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids. Biochemistry 36, 390-398.
7. LIMA, W.F., and CROOKE, S.T. (1997b). Cleavage of single-strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1. J. Biol. Chem. 272, 27513-27516.
8. LIMA, W.F., MOHAN, V., and CROOKE, S.T. (1997). The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity. J. Biol. Chem. 272, 18191-18199.
9. WU, H., LIMA, W.F., and CROOKE, S.T. (1998). Molecular cloning and expression of cDNA for human RNase H. Antisense Nucleic Acid Drug Dev. 8, 53-61.