Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis

Journal of Chromatography B: Biomedical Applications

Volumn 692, Issue 1, 1997, Pages 43-51

  Chen, Shu Hui ^a,b   Qian, Mingxin ^a   Brennan, James M ^a,c   Gallo, James M ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c DUPONT COMPANY   (United States)

Author keywords

Oligodeoxynucleotides; Phosphorsthioates

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ACCURACY; ANIMAL MODEL; ANIMAL TISSUE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG TISSUE LEVEL; DRUG URINE LEVEL; GEL ELECTROPHORESIS; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; LUNG; LUNG CARCINOMA; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; SPLEEN; TECHNIQUE; TISSUE HOMOGENATE;

ANIMALS; CARCINOMA, SMALL CELL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; ELECTROPHORESIS, CAPILLARY; LUNG NEOPLASMS; MICE; MICE, NUDE; OLIGONUCLEOTIDES, ANTISENSE; REPRODUCIBILITY OF RESULTS; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); THIONUCLEOTIDES; TISSUE DISTRIBUTION;

EID: 0030963933     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00499-9     Document Type: Article

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