Quantification of raf antisense oligonucleotide (rafAON) in biological matrices by LC-MS/MS to support pharmacokinetics of a liposome-entrapped rafAON formulation

Biomedical Chromatography

Volumn 19, Issue 4, 2005, Pages 272-278

  Johnson, Jenifer L ^a   Guo, Wei ^a   Zang, June ^a   Khan, Sumsullah ^a   Bardin, Sofia ^a   Ahmad, Ateeq ^a   Duggan, Jeffrey X ^a   Ahmad, Imran ^a  

^a NeoPharm Inc   (United States)

Author keywords

Antisense oligonucleotide; Electrospray tandem MS; Plasma; Serine threonine protein kinase; Tissue homogenates

Indexed keywords

AMINO ACIDS; MAMMALS; MASS SPECTROMETRY; NEGATIVE IONS; OLIGONUCLEOTIDES; PHARMACOKINETICS; PHASE SEPARATION; PROTEINS;

ANTISENSE OLIGONUCLEOTIDES; ELECTROSPRAY TANDEM MS; ELECTROSPRAYS; INTERNAL STANDARDS; LC-MS-MS; MICE PLASMA; PEAKS AREAS; SERINE-THREONINE PROTEIN KINASE; TANDEM MS; TISSUE HOMOGENATES;

TISSUE;

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; LIPOSOME; RAF PROTEIN;

ACCURACY; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; ELECTROSPRAY MASS SPECTROMETRY; HEART; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; LUNG; MONKEY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; SPLEEN; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; TISSUE HOMOGENATE;

ANIMALIA;

EID: 21044433207     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.450     Document Type: Article

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