On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites

Analytical Chemistry

Volumn 69, Issue 3, 1997, Pages 313-319

  Gaus, Hans J ^a   Owens, Stephen R ^a   Winniman, Michael ^a   Cooper, Scott ^a   Cummins, Lendell L ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; DURABILITY; ELECTROPHORESIS; IDENTIFICATION (CONTROL SYSTEMS); MASS SPECTROMETRY; METABOLISM; PHARMACOKINETICS; TISSUE;

CAPILLARY GEL ELECTROPHORESIS; ELECTROSPRAY MASS SPECTROMETRY; KIDNEYS; LIVER; PHOSPOROTHIOATE OLIGONUCLEOTIDE; TOXICOLOGY;

METABOLITES;

ANTISENSE OLIGODEOXYNUCLEOTIDE;

ARTICLE; DNA DETERMINATION; DRUG ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; TECHNIQUE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MASS SPECTROMETRY; OLIGONUCLEOTIDES; RATS; THIONUCLEOTIDES;

EID: 0031081755     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac960557q     Document Type: Article

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