Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 4, 2010, Pages 571-579

  Deng, Pan ^a   Chen, Xiaoyan ^a   Zhang, Guodong ^b   Zhong, Dafang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b PFIZER INC   (United States)

Author keywords

Ion pair reversed phase; Liquid chromatography tandem mass spectrometry; Metabolite; Pharmacokinetics; Phosphorothioate oligonucleotide

Indexed keywords

BUFFER; DICHLOROMETHANE; DRUG METABOLITE; HEXAFLUORO 2 PROPANOL; METHANOL; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; PHENOL; TRIETHYLAMINE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROSPRAY; FLOW RATE; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS; ANIMAL; BLOOD; COMPARATIVE STUDY; LIQUID CHROMATOGRAPHY; PROCEDURES;

ANIMALS; CHROMATOGRAPHY, LIQUID; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RATS; TANDEM MASS SPECTROMETRY;

EID: 77950368765     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.01.040     Document Type: Article

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