Sublethal doses of β-amyloid peptide abrogate DNA-dependent protein kinase activity

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2618-2631

  Cardinale, Alessio ^a   Racaniello, Mauro ^a,b   Saladini, Serena ^a   De Chiara, Giovanna ^b   Mollinari, Cristiana ^b,c   De Stefano, Maria Chiara ^b   Pocchiari, Maurizio ^b   Garaci, Enrico ^d   Merlo, Daniela ^a,b  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PEPTIDES; ANTIOXIDANT TREATMENT; CATALYTIC SUBUNITS; COMPLEX ACTIVITY; CYTOTOXIC EFFECTS; DNA DAMAGES; DNA REPAIR; DNA-DEPENDENT PROTEIN KINASE; DOUBLE STRAND BREAKS; DOWN-REGULATION; KINASE ACTIVITY; MULTICELLULAR EUKARYOTES; NEURODEGENERATIVE DISORDERS; NEURONAL LOSS; NEUROTOXICITY; NONHOMOLOGOUS END JOINING; NONLETHAL; OXIDATIVE INJURY; PC12 CELLS; PROTEIN LEVEL; REACTIVE OXYGEN SPECIES; SUBLETHAL DOSE;

CELLS; CYTOTOXICITY; ENZYMES; GLYCOPROTEINS; JOINING; NEURODEGENERATIVE DISEASES; OLIGOMERS; OXIDATIVE STRESS; REPAIR;

DNA;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; DNA DEPENDENT PROTEIN KINASE; OLIGOMER;

ARTICLE; CELL NUCLEUS; CELL STRAIN; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; HUMANS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PC12 CELLS; PROTEIN MULTIMERIZATION; RATS;

EUKARYOTA;

EID: 84856076402     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.276550     Document Type: Article

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