Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 6, 2009, Pages 1284-1295

  Chen, Long ^a   Liu, Lei ^a   Yin, Jun ^a   Luo, Yan ^a   Huang, Shile ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

c Jun N terminal kinase; Extracellular signal regulated kinase 1 2; Hydrogen peroxide; Protein phosphatase 2A; Protein phosphatase 5

Indexed keywords

HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 5; REACTIVE OXYGEN METABOLITE; SERINE; STRESS ACTIVATED PROTEIN KINASE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; FEMALE; HUMANS; HYDROGEN PEROXIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NUCLEAR PROTEINS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHOPROTEIN PHOSPHATASES; PREGNANCY; PROTEIN PHOSPHATASE 2; RATS; REACTIVE OXYGEN SPECIES;

MURINAE;

EID: 60349084974     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.10.029     Document Type: Article

References (44)

1. Adler EM, Gough NR, Blundon JA. Differentiation of PC12 cells. Sci STKE 2006:tr9.
2. Alexi T., Borlongan C.V., Faull R.L., Williams C.E., Clark R.G., Gluckman P.D., et al. Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases. Prog Neurobiol 60 (2000) 409-470
3. Baxter L.C., Sparks D.L., Johnson S.C., Lenoski B., Lopez J.E., Connor D.J., et al. Relationship of cognitive measures and gray and white matter in Alzheimer's disease. J Alzheimers Dis 9 (2006) 253-260
4. Behl C. Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches. Prog Neurobiol 57 (1999) 301-323
5. Behl C., Davis J.B., Lesley R., and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77 (1994) 817-827
6. Chen L., Liu L., Luo Y., and Huang S. MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem 105 (2008) 251-261
7. Chen L., Liu L., and Huang S. Cadmium activates MAPK pathway via induction of reactive oxygen species and inhibition of protein phosphatase 2A and 5. Free Radic Biol Med 45 (2008) 1035-1044
8. 2 injury. J Neurochem 82 (2002) 19-29
9. Davila D., and Torres-Aleman I. Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor i signaling. Mol Biol Cell 19 (2008) 2014-2025
10. Doherty G.H., Oldreive C., and Harvey J. Neuroprotective actions of leptin on central and peripheral neurons in vitro. Neuroscience 154 (2008) 1297-1307
11. 2 injury. Brain Res 1163 (2007) 10-20
12. Fatokun A.A., Stone T.W., and Smith R.A. Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: mechanisms and protection by adenosine receptor ligands. Brain Res 1132 (2007) 193-202
13. Figueiredo-Pereira M.E., Yakushin S., and Cohen G. Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells. J Biol Chem 273 (1998) 12703-12709
14. Franklin C.C., and Kraft A.S. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem 272 (1997) 16917-16923
15. 2+ currents: involvement of ROS and NF-kappaB. J Neurochem 81 (2002) 1043-1051
16. Huang S., Shu L., Dilling M.B., Easton J., Harwood F.C., Ichijo H., et al. Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell 11 (2003) 1491-1501
17. Huang S., Shu L., Easton J., Harwood F.C., Germain G.S., Ichijo H., et al. Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. J Biol Chem 279 (2004) 36490-36496
18. Janssens V., and Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353 (2001) 417-439
19. Jellinger K.A. Cell death mechanisms in Parkinson's disease. J Neural Transm 107 (2000) 1-29
20. Jumblatt J.E., and Tischler A.S. Regulation of muscarinic ligand binding sites by nerve growth factor in PC12 phaeochromocytoma cells. Nature 297 (1982) 152-154
21. Kamata H., and Hirata H. Redox regulation of cellular signalling. Cell Signal 11 (1999) 1-14
22. Kim S., Moon C., Eun S., Ryu P., and Jo S. Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. Biochem Biophys Res Commun 328 (2005) 326-334
23. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81 (2001) 807-869
24. Li Z., Arnaud L., Rockwell P., and Figueiredo-Pereira M.E. A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells. J Neurochem 90 (2004) 19-28
25. Monaghan T.K., Mackenzie C.J., Plevin R., and Lutz E.M. PACAP-38 induces neuronal differentiation of human SH-SY5Y neuroblastoma cells via cAMP-mediated activation of ERK and p38 MAP kinases. J Neurochem 104 (2008) 74-88
26. Morita K., Saitoh M., Tobiume K., Matsuura H., Enomoto S., Nishitoh H., et al. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J 20 (2001) 6028-6036
27. Ouyang M., and Shen X. Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Neurochem 97 (2006) 234-244
28. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22 (2001) 153-183
29. Pahlman S., Mamaeva S., Meyerson G., Mattsson M.E., Bjelfman C., Ortoft E., et al. Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function. Acta Physiol Scand Suppl 592 (1990) 25-37
30. Rockwell P., Martinez J., Papa L., and Gomes E. Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium. Cell Signal 16 (2004) 343-353
31. Roos W.P., and Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med 12 (2006) 440-450
32. Rudrabhatla P., Zheng Y.L., Amin N.D., Kesavapany S., Albers W., and Pant H.C. Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J Biol Chem 283 (2008) 26737-26747
33. 2-induced cell death. Eur J Pharmacol 483 (2004) 163-173
34. Sanvicens N., Gomez-Vicente V., Messeguer A., and Cotter T.G. The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways. J Neurochem 98 (2006) 735-747
35. Stadtman E. Protein oxidation and aging. Science 257 (1992) 1220-1224
36. Stohs S.J., and Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18 (1995) 321-336
37. Valencia A., and Moran J. Reactive oxygen species induce different cell death mechanisms in cultured neurons. Free Radic Biol Med 36 (2004) 1112-1125
38. Van Kanegan M.J., Adams D.G., Wadzinski B.E., and Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 280 (2005) 36029-36036
39. Wang Z., Yang H., Tachado S.D., Capo-Aponte J.E., Bildin V.N., Koziel H., et al. Phosphatase-mediated crosstalk control of ERK and p38 MAPK signaling in corneal epithelial cells. Invest Ophthalmol Vis Sci 47 (2006) 5267-5275
40. Whitfield J., Neame S.J., Paquet L., Bernard O., and Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29 (2001) 629-643
41. Wu D.C., Re D.B., Nagai M., Ischiropoulos H., and Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc Natl Acad Sci USA 103 (2006) 12132-12137
42. Yeo J.E., Kim J.H., and Kang S.K. Selenium attenuates ROS-mediated apoptotic cell death of injured spinal cord through prevention of mitochondria dysfunction; in vitro and in vivo study. Cell Physiol Biochem 21 (2008) 225-238
43. Yu Y., Du J.R., Wang C.Y., and Qian Z.M. Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells. Exp Brain Res 184 (2008) 307-312
44. Zhang Y., Dawson V.L., and Dawson T.M. Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis 7 (2000) 240-250