Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity

Molecular Brain Research

Volumn 87, Issue 2, 2001, Pages 257-262

  Culmsee, Carsten ^a,b,c   Bondada, Subbarao ^b,d   Mattson, Mark P ^a,b,e  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d UNIVERSITY OF KENTUCKY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid beta peptide; DNA repair; Epileptic seizure; Glutamate; Topoisomerase inhibitor

Indexed keywords

AMYLOID BETA PROTEIN; CAMPTOTHECIN; DNA DEPENDENT PROTEIN KINASE; DNA TOPOISOMERASE INHIBITOR; DOUBLE STRANDED DNA; ETOPOSIDE; GLUTAMIC ACID; KAINIC ACID;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; HIPPOCAMPUS; HYPERSENSITIVITY; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SCID MOUSE; SEIZURE; STROKE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CAMPTOTHECIN; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EPILEPSY; ETOPOSIDE; GLUTAMIC ACID; HIPPOCAMPUS; MICE; MICE, SCID; NEURONS; NEUROTOXINS; NUCLEIC ACID SYNTHESIS INHIBITORS; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES;

EID: 0035809792     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00008-0     Document Type: Article

References (47)

1. DNA strand breaks in Alzheimer's disease
2. The nuclear serin/threonine protein kinase DNA-PK
3. The DNA activated protein kinase-DNA-PK
4. The DNA-dependent protein kinase participates in the activation of NF-kB following DNA damage
5. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
6. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
7. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
8. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
9. Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells
10. Caspases and calpain substrates: Roles in synaptic plasticity and cell death
11. Excitotoxic cell death
12. Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain
13. Pifithrin-a and its derivatives protect neurons from apoptotic insults in vitro and reduce brain damage in mouse models of excitotoxicity and ischemia
14. Pathobiology of ischaemic stroke: An integrated review
15. The DNA damage response in DNA-dependent protein deficient scid mouse cells: Replication protein A hyperphosphorylation and p53 induction
16. Mitochondria in apoptosis
17. Ku 70 deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
18. Increases in DNA lesions and the DNA damage indicator Gadd54 following transient cerebral ischemia
19. Identification of the catalytic subunit of DNA dependent protein kinase as the product of the mouse scid gene
20. DNA-dependent protein kinase is not required for the p53-dependent response to DNA-damage
21. WAF1/cip1 and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase
22. DNA-dependent kinase (p350) as a candidate gene for the murine scid defect
23. Evidence that 4-hydroxy nonenal mediates oxidative stress-induced neuronal apoptosis
24. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
25. The DNA-dependent protein kinase, DNA-PK: 10 years and no end in sight
26. Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double strand breaks
27. Ischemic cell death in brain neurons
28. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
29. Apoptosis and expression of DNA repair proteins in schaemic brain injury in man
30. Recent advances on caspases in development and neurodegeneration
31. Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in culture hippocampal neurons
32. 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
33. Apoptosis and neurodegenerative disorders
34. Apoptotic and antiapoptotic mechanisms in stroke
35. Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits
36. Poly (ADP-ribose) polymerase, nitric oxide and cell death
37. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase
38. Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion
39. Interleukin-1β-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing
40. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis
41. Caspase-dependent and independent death of camptothecin-treated embryonic cortical neurons
42. Targeted disruption of catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
43. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
44. Bax involvement in p53-mediated neuronal cell death
45. Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumor agents
46. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
47. Stimulation of beta2-adrenoceptors inhibits apoptosis in rat brain after transient forebrain ischemia