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Volumn 26, Issue 1, 2012, Pages 146-161

Mechanism of HIV antiretroviral drugs progress toward drug resistance

Author keywords

Antiretroviral; Drug resistance; HIV

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; DARUNAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; FOSAMPRENAVIR; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; INDINAVIR; INTEGRASE INHIBITOR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RALTEGRAVIR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; TIPRANAVIR; TNTELENCE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 84855654765     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2011.01009.x     Document Type: Review
Times cited : (29)

References (168)
  • 1
    • 0019774135 scopus 로고
    • An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction
    • Masur H., Michelis M.A., Greene J.B. et al. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N. Engl. J. Med. (1981) 305 1431-1438.
    • (1981) N. Engl. J. Med. , vol.305 , pp. 1431-1438
    • Masur, H.1    Michelis, M.A.2    Greene, J.B.3
  • 2
    • 0022622384 scopus 로고
    • AIDS in haemophiliacs, parenteral drug abusers, and homosexuals
    • Fuchs D., Wachter H., Wille R. AIDS in haemophiliacs, parenteral drug abusers, and homosexuals. Lancet (1986) 1 324.
    • (1986) Lancet , vol.1 , pp. 324
    • Fuchs, D.1    Wachter, H.2    Wille, R.3
  • 3
    • 84937092210 scopus 로고
    • Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug-addicted mothers
    • Rubinstein A., Sicklick M., Gupta A. et al. Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug-addicted mothers. JAMA (1983) 249 2350-2356.
    • (1983) JAMA , vol.249 , pp. 2350-2356
    • Rubinstein, A.1    Sicklick, M.2    Gupta, A.3
  • 4
    • 0025773543 scopus 로고
    • HIV epidemiology: past, present, and future
    • Blattner W.A. HIV epidemiology: past, present, and future. FASEB J. (1991) 5 2340-2348.
    • (1991) FASEB J. , vol.5 , pp. 2340-2348
    • Blattner, W.A.1
  • 5
    • 0023637962 scopus 로고
    • Transmission of the human immunodeficiency virus
    • Friedland G.H., Klein R.S. Transmission of the human immunodeficiency virus. N. Engl. J. Med. (1987) 317 1125-1135.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 1125-1135
    • Friedland, G.H.1    Klein, R.S.2
  • 7
    • 0020596551 scopus 로고
    • Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
    • Barre-Sinoussi F., Chermann J.C., Rey F. et al. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science (1983) 220 868-871.
    • (1983) Science , vol.220 , pp. 868-871
    • Barre-Sinoussi, F.1    Chermann, J.C.2    Rey, F.3
  • 8
    • 0021261510 scopus 로고
    • Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
    • Gallo R.C., Salahuddin S.Z., Popovic M. et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science (1984) 224 500-503.
    • (1984) Science , vol.224 , pp. 500-503
    • Gallo, R.C.1    Salahuddin, S.Z.2    Popovic, M.3
  • 10
    • 58149133507 scopus 로고    scopus 로고
    • Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
    • Sarafianos S.G., Marchand B., Das K. et al. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J. Mol. Biol. (2009) 385 693-713.
    • (2009) J. Mol. Biol. , vol.385 , pp. 693-713
    • Sarafianos, S.G.1    Marchand, B.2    Das, K.3
  • 11
    • 0037338420 scopus 로고    scopus 로고
    • The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is modulated by residue 294 of the small subunit
    • Sevilya Z., Loya S., Adir N., Hizi A. The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is modulated by residue 294 of the small subunit. Nucleic Acids Res. (2003) 31 1481-1487.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 1481-1487
    • Sevilya, Z.1    Loya, S.2    Adir, N.3    Hizi, A.4
  • 12
    • 0037436406 scopus 로고    scopus 로고
    • Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: the effects on the ribonuclease H activity
    • Sevilya Z., Loya S., Duvshani A., Adir N., Hizi A. Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: the effects on the ribonuclease H activity. J. Mol. Biol. (2003) 327 19-30.
    • (2003) J. Mol. Biol. , vol.327 , pp. 19-30
    • Sevilya, Z.1    Loya, S.2    Duvshani, A.3    Adir, N.4    Hizi, A.5
  • 13
    • 23244448649 scopus 로고    scopus 로고
    • Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer
    • Wapling J., Moore K.L., Sonza S., Mak J., Tachedjian G. Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer. J. Virol. (2005) 79 10247-10257.
    • (2005) J. Virol. , vol.79 , pp. 10247-10257
    • Wapling, J.1    Moore, K.L.2    Sonza, S.3    Mak, J.4    Tachedjian, G.5
  • 14
    • 24644493205 scopus 로고    scopus 로고
    • Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain
    • Abram M.E., Parniak M.A. Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain. J. Virol. (2005) 79 11952-11961.
    • (2005) J. Virol. , vol.79 , pp. 11952-11961
    • Abram, M.E.1    Parniak, M.A.2
  • 15
    • 2942597505 scopus 로고    scopus 로고
    • Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates
    • Rezende L.F., Prasad V.R. Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates. Int. J. Biochem. Cell Biol. (2004) 36 1716-1734.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1716-1734
    • Rezende, L.F.1    Prasad, V.R.2
  • 16
    • 84855643427 scopus 로고    scopus 로고
    • HIV reverse transcriptase: structural interpretation of drug resistant genetic variants from India
    • Kandathil A.J., Joseph A.P., Kannangai R. et al. HIV reverse transcriptase: structural interpretation of drug resistant genetic variants from India. Bioinformation (2009) 4 36-45.
    • (2009) Bioinformation , vol.4 , pp. 36-45
    • Kandathil, A.J.1    Joseph, A.P.2    Kannangai, R.3
  • 17
    • 0034111063 scopus 로고    scopus 로고
    • Trapping of a catalytic HIV reverse transcriptase*template: primer complex through a disulfide bond
    • Huang H., Harrison S.C., Verdine G.L. Trapping of a catalytic HIV reverse transcriptase*template: primer complex through a disulfide bond. Chem. Biol. (2000) 7 355-364.
    • (2000) Chem. Biol. , vol.7 , pp. 355-364
    • Huang, H.1    Harrison, S.C.2    Verdine, G.L.3
  • 18
    • 61449222979 scopus 로고    scopus 로고
    • 5′-aminocarbonyl phosphonates as new zidovudine depot forms: antiviral properties, intracellular transformations, and pharmacokinetic parameters
    • Khandazhinskaya A.L., Yanvarev D.V., Jasko M.V. et al. 5′-aminocarbonyl phosphonates as new zidovudine depot forms: antiviral properties, intracellular transformations, and pharmacokinetic parameters. Drug Metab. Dispos. (2009) 37 494-501.
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 494-501
    • Khandazhinskaya, A.L.1    Yanvarev, D.V.2    Jasko, M.V.3
  • 19
    • 0024349612 scopus 로고
    • In vivo activity against HIV and favorable toxicity profile of 2′,3′-dideoxyinosine
    • Yarchoan R., Mitsuya H., Thomas R.V. et al. In vivo activity against HIV and favorable toxicity profile of 2′, 3′-dideoxyinosine. Science (1989) 245 412-415.
    • (1989) Science , vol.245 , pp. 412-415
    • Yarchoan, R.1    Mitsuya, H.2    Thomas, R.V.3
  • 20
    • 33847325683 scopus 로고    scopus 로고
    • Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI) - 2′,3′-dideoxycytidine (ddC): relevance to HIV-dementia
    • Opii W.O., Sultana R., Abdul H.M., Ansari M.A., Nath A., Butterfield D.A. Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI) - 2′, 3′-dideoxycytidine (ddC): relevance to HIV-dementia. Exp. Neurol. (2007) 204 29-38.
    • (2007) Exp. Neurol. , vol.204 , pp. 29-38
    • Opii, W.O.1    Sultana, R.2    Abdul, H.M.3    Ansari, M.A.4    Nath, A.5    Butterfield, D.A.6
  • 21
    • 29244465548 scopus 로고    scopus 로고
    • Synthesis and anti-HIV activity of beta-D-3′-azido-2′,3′-unsaturated nucleosides and beta-D-3′-azido-3′-deoxyribofuranosylnucleosides
    • Gadthula S., Chu C.K., Schinazi R.F. Synthesis and anti-HIV activity of beta-D-3′-azido-2′, 3′-unsaturated nucleosides and beta-D-3′-azido-3′-deoxyribofuranosylnucleosides. Nucleosides Nucleotides Nucleic Acids (2005) 24 1707-1727.
    • (2005) Nucleosides Nucleotides Nucleic Acids , vol.24 , pp. 1707-1727
    • Gadthula, S.1    Chu, C.K.2    Schinazi, R.F.3
  • 22
    • 0042934026 scopus 로고    scopus 로고
    • Effect of transport inhibitors and additional anti-HIV drugs on the movement of lamivudine (3TC) across the guinea pig brain barriers
    • Gibbs J.E., Rashid T., Thomas S.A. Effect of transport inhibitors and additional anti-HIV drugs on the movement of lamivudine (3TC) across the guinea pig brain barriers. J. Pharmacol. Exp. Ther. (2003) 306 1035-1041.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 1035-1041
    • Gibbs, J.E.1    Rashid, T.2    Thomas, S.A.3
  • 23
  • 24
    • 43049105858 scopus 로고    scopus 로고
    • Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase
    • Menendez-Arias L. Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase. Virus Res. (2008) 134 124-146.
    • (2008) Virus Res. , vol.134 , pp. 124-146
    • Menendez-Arias, L.1
  • 25
    • 0027415886 scopus 로고
    • Clinical correlates and molecular basis of HIV drug resistance
    • Wainberg M.A., Gu Z., Gao Q. et al. Clinical correlates and molecular basis of HIV drug resistance. J. Acquir. Immune Defic. Syndr. (1993) 6(Suppl 1) S36-S46.
    • (1993) J. Acquir. Immune Defic. Syndr. , vol.6 , Issue.SUPPL. 1
    • Wainberg, M.A.1    Gu, Z.2    Gao, Q.3
  • 26
    • 0027278781 scopus 로고
    • Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents
    • Richman D.D. Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents. Antimicrob. Agents Chemother. (1993) 37 1207-1213.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1207-1213
    • Richman, D.D.1
  • 27
    • 0025270231 scopus 로고
    • AZT (zidovudine) may act postintegrationally to inhibit generation of HIV-1 progeny virus in chronically infected cells
    • Rooke R., Tremblay M., Wainberg M.A. AZT (zidovudine) may act postintegrationally to inhibit generation of HIV-1 progeny virus in chronically infected cells. Virology (1990) 176 205-215.
    • (1990) Virology , vol.176 , pp. 205-215
    • Rooke, R.1    Tremblay, M.2    Wainberg, M.A.3
  • 29
    • 0033133780 scopus 로고    scopus 로고
    • Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site
    • Sarafianos S.G., Das K., Ding J., Boyer P.L., Hughes S.H., Arnold E. Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site. Chem. Biol. (1999) 6 R137-R146.
    • (1999) Chem. Biol. , vol.6
    • Sarafianos, S.G.1    Das, K.2    Ding, J.3    Boyer, P.L.4    Hughes, S.H.5    Arnold, E.6
  • 30
    • 0033165851 scopus 로고    scopus 로고
    • A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
    • Meyer P.R., Matsuura S.E., Mian A.M., So A.G., Scott W.A. A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol. Cell (1999) 4 35-43.
    • (1999) Mol. Cell , vol.4 , pp. 35-43
    • Meyer, P.R.1    Matsuura, S.E.2    Mian, A.M.3    So, A.G.4    Scott, W.A.5
  • 31
    • 0034737638 scopus 로고    scopus 로고
    • Mechanism by which phosphonoformic acid resistance mutations restore 3′-azido-3′-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase
    • Arion D., Sluis-Cremer N., Parniak M.A. Mechanism by which phosphonoformic acid resistance mutations restore 3′-azido-3′-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase. J. Biol. Chem. (2000) 275 9251-9255.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9251-9255
    • Arion, D.1    Sluis-Cremer, N.2    Parniak, M.A.3
  • 32
    • 19244372885 scopus 로고    scopus 로고
    • Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine
    • Garcia-Lerma J.G., MacInnes H., Bennett D., Weinstock H., Heneine W. Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine. J. Virol. (2004) 78 7545-7552.
    • (2004) J. Virol. , vol.78 , pp. 7545-7552
    • Garcia-Lerma, J.G.1    MacInnes, H.2    Bennett, D.3    Weinstock, H.4    Heneine, W.5
  • 33
    • 0033014502 scopus 로고    scopus 로고
    • HIV resistance to zidovudine: the role of pyrophosphorolysis
    • Arion D., Parniak M.A. HIV resistance to zidovudine: the role of pyrophosphorolysis. Drug Resist. Updat. (1999) 2 91-95.
    • (1999) Drug Resist. Updat. , vol.2 , pp. 91-95
    • Arion, D.1    Parniak, M.A.2
  • 34
    • 0027318776 scopus 로고
    • Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA
    • Jacobo-Molina A., Ding J., Nanni R.G. et al. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc. Natl Acad. Sci. USA (1993) 90 6320-6324.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6320-6324
    • Jacobo-Molina, A.1    Ding, J.2    Nanni, R.G.3
  • 35
    • 0035158709 scopus 로고    scopus 로고
    • Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus
    • de Ronde A., van Dooren M., van Der Hoek L. et al. Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus. J. Virol. (2001) 75 595-602.
    • (2001) J. Virol. , vol.75 , pp. 595-602
    • de Ronde, A.1    van Dooren, M.2    van Der Hoek, L.3
  • 36
    • 0035923671 scopus 로고    scopus 로고
    • Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons
    • Garcia-Lerma J.G., Nidtha S., Blumoff K., Weinstock H., Heneine W. Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons. Proc. Natl Acad. Sci. USA (2001) 98 13907-13912.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 13907-13912
    • Garcia-Lerma, J.G.1    Nidtha, S.2    Blumoff, K.3    Weinstock, H.4    Heneine, W.5
  • 37
    • 0025980022 scopus 로고
    • BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine
    • Richman D., Rosenthal A.S., Skoog M. et al. BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine. Antimicrob. Agents Chemother. (1991) 35 305-308.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 305-308
    • Richman, D.1    Rosenthal, A.S.2    Skoog, M.3
  • 38
    • 0027178052 scopus 로고
    • U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
    • Dueweke T.J., Poppe S.M., Romero D.L. et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agents Chemother. (1993) 37 1127-1131.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1127-1131
    • Dueweke, T.J.1    Poppe, S.M.2    Romero, D.L.3
  • 39
    • 68849132703 scopus 로고    scopus 로고
    • Solution structural dynamics of HIV-1 reverse transcriptase heterodimer
    • Seckler J.M., Howard K.J., Barkley M.D., Wintrode P.L. Solution structural dynamics of HIV-1 reverse transcriptase heterodimer. Biochemistry (2009) 48 7646-7655.
    • (2009) Biochemistry , vol.48 , pp. 7646-7655
    • Seckler, J.M.1    Howard, K.J.2    Barkley, M.D.3    Wintrode, P.L.4
  • 40
    • 2942524068 scopus 로고    scopus 로고
    • Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1
    • Balzarini J. Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1. Curr. Top. Med. Chem. (2004) 4 921-944.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 921-944
    • Balzarini, J.1
  • 41
    • 0034124381 scopus 로고    scopus 로고
    • Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir
    • Van Laethem K., Witvrouw M., Balzarini J. et al. Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir. AIDS (2000) 14 469-471.
    • (2000) AIDS , vol.14 , pp. 469-471
    • Van Laethem, K.1    Witvrouw, M.2    Balzarini, J.3
  • 42
    • 70350066155 scopus 로고    scopus 로고
    • Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase
    • Cullen M.D., Ho W.C., Bauman J.D. et al. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. J. Med. Chem. (2009) 52 6467-6473.
    • (2009) J. Med. Chem. , vol.52 , pp. 6467-6473
    • Cullen, M.D.1    Ho, W.C.2    Bauman, J.D.3
  • 43
    • 2942565660 scopus 로고    scopus 로고
    • Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors
    • Domaoal R.A., Demeter L.M. Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors. Int. J. Biochem. Cell Biol. (2004) 36 1735-1751.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1735-1751
    • Domaoal, R.A.1    Demeter, L.M.2
  • 44
    • 0035281213 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance
    • Deeks S.G. International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance. J. Acquir. Immune Defic. Syndr. (2001) 26(Suppl 1) S25-S33.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.26 , Issue.SUPPL. 1
    • Deeks, S.G.1
  • 45
    • 35748933494 scopus 로고    scopus 로고
    • Update of the drug resistance mutations in HIV-1: 2007
    • Johnson V.A., Brun-Vezinet F., Clotet B. et al. Update of the drug resistance mutations in HIV-1: 2007. Top. HIV Med. (2007) 15 119-125.
    • (2007) Top. HIV Med. , vol.15 , pp. 119-125
    • Johnson, V.A.1    Brun-Vezinet, F.2    Clotet, B.3
  • 46
    • 33746838109 scopus 로고    scopus 로고
    • Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138
    • Ren J., Nichols C.E., Stamp A. et al. Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138. FEBS J. (2006) 273 3850-3860.
    • (2006) FEBS J. , vol.273 , pp. 3850-3860
    • Ren, J.1    Nichols, C.E.2    Stamp, A.3
  • 47
    • 0034002944 scopus 로고    scopus 로고
    • Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260)
    • Demeter L.M., Shafer R.W., Meehan P.M. et al. Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260). Antimicrob. Agents Chemother. (2000) 44 794-797.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 794-797
    • Demeter, L.M.1    Shafer, R.W.2    Meehan, P.M.3
  • 48
    • 0034019566 scopus 로고    scopus 로고
    • A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1
    • Petropoulos C.J., Parkin N.T., Limoli K.L. et al. A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob. Agents Chemother. (2000) 44 920-928.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 920-928
    • Petropoulos, C.J.1    Parkin, N.T.2    Limoli, K.L.3
  • 49
    • 0842289678 scopus 로고    scopus 로고
    • Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
    • Ren J., Nichols C.E., Chamberlain P.P., Weaver K.L., Short S.A., Stammers D.K. Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors. J. Mol. Biol. (2004) 336 569-578.
    • (2004) J. Mol. Biol. , vol.336 , pp. 569-578
    • Ren, J.1    Nichols, C.E.2    Chamberlain, P.P.3    Weaver, K.L.4    Short, S.A.5    Stammers, D.K.6
  • 50
    • 33751529192 scopus 로고    scopus 로고
    • Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097
    • Das K., Sarafianos S.G., Clark A.D. Jr, Boyer P.L., Hughes S.H., Arnold E. Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. J. Mol. Biol. (2007) 365 77-89.
    • (2007) J. Mol. Biol. , vol.365 , pp. 77-89
    • Das, K.1    Sarafianos, S.G.2    Clark Jr., A.D.3    Boyer, P.L.4    Hughes, S.H.5    Arnold, E.6
  • 51
    • 34248998744 scopus 로고    scopus 로고
    • Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases
    • Ren J., Nichols C.E., Chamberlain P.P. et al. Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. J. Med. Chem. (2007) 50 2301-2309.
    • (2007) J. Med. Chem. , vol.50 , pp. 2301-2309
    • Ren, J.1    Nichols, C.E.2    Chamberlain, P.P.3
  • 52
    • 50849105061 scopus 로고    scopus 로고
    • Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
    • Bauman J.D., Das K., Ho W.C. et al. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res. (2008) 36 5083-5092.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5083-5092
    • Bauman, J.D.1    Das, K.2    Ho, W.C.3
  • 53
    • 0035037383 scopus 로고    scopus 로고
    • Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy
    • Bacheler L., Jeffrey S., Hanna G. et al. Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy. J. Virol. (2001) 75 4999-5008.
    • (2001) J. Virol. , vol.75 , pp. 4999-5008
    • Bacheler, L.1    Jeffrey, S.2    Hanna, G.3
  • 54
    • 0035816374 scopus 로고    scopus 로고
    • Development of drug resistance in patients receiving combinations of zidovudine, didanosine and nevirapine
    • Conway B., Wainberg M.A., Hall D. et al. Development of drug resistance in patients receiving combinations of zidovudine, didanosine and nevirapine. AIDS (2001) 15 1269-1274.
    • (2001) AIDS , vol.15 , pp. 1269-1274
    • Conway, B.1    Wainberg, M.A.2    Hall, D.3
  • 55
    • 0034081772 scopus 로고    scopus 로고
    • Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine
    • Hanna G.J., Johnson V.A., Kuritzkes D.R. et al. Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine. J. Infect. Dis. (2000) 181 904-911.
    • (2000) J. Infect. Dis. , vol.181 , pp. 904-911
    • Hanna, G.J.1    Johnson, V.A.2    Kuritzkes, D.R.3
  • 56
    • 0035368238 scopus 로고    scopus 로고
    • The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
    • Hsiou Y., Ding J., Das K. et al. The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J. Mol. Biol. (2001) 309 437-445.
    • (2001) J. Mol. Biol. , vol.309 , pp. 437-445
    • Hsiou, Y.1    Ding, J.2    Das, K.3
  • 58
    • 0036222716 scopus 로고    scopus 로고
    • Genotypic testing for human immunodeficiency virus type 1 drug resistance
    • Shafer R.W. Genotypic testing for human immunodeficiency virus type 1 drug resistance. Clin. Microbiol. Rev. (2002) 15 247-277.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 247-277
    • Shafer, R.W.1
  • 59
    • 4143099182 scopus 로고    scopus 로고
    • Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure
    • Ceccherini-Silberstein F., Erba F., Gago F. et al. Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure. AIDS (2004) 18 F11-F19.
    • (2004) AIDS , vol.18
    • Ceccherini-Silberstein, F.1    Erba, F.2    Gago, F.3
  • 60
    • 0000131149 scopus 로고    scopus 로고
    • Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies
    • Erickson J.W., Gulnik S.V., Markowitz M. Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies. AIDS (1999) 13(Suppl A) S189-S204.
    • (1999) AIDS , vol.13 , Issue.SUPPL.
    • Erickson, J.W.1    Gulnik, S.V.2    Markowitz, M.3
  • 61
    • 0035060195 scopus 로고    scopus 로고
    • Discovery and clinical development of HIV-1 protease inhibitors
    • Huff J.R., Kahn J. Discovery and clinical development of HIV-1 protease inhibitors. Adv. Protein Chem. (2001) 56 213-251.
    • (2001) Adv. Protein Chem. , vol.56 , pp. 213-251
    • Huff, J.R.1    Kahn, J.2
  • 62
    • 35348992176 scopus 로고    scopus 로고
    • Protease inhibitor resistance in HIV-infected patients: molecular and clinical perspectives
    • Martinez-Cajas J.L., Wainberg M.A. Protease inhibitor resistance in HIV-infected patients: molecular and clinical perspectives. Antiviral Res. (2007) 76 203-221.
    • (2007) Antiviral Res. , vol.76 , pp. 203-221
    • Martinez-Cajas, J.L.1    Wainberg, M.A.2
  • 64
    • 1842454635 scopus 로고    scopus 로고
    • HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs
    • Perryman A.L., Lin J.H., McCammon J.A. HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs. Protein Sci. (2004) 13 1108-1123.
    • (2004) Protein Sci. , vol.13 , pp. 1108-1123
    • Perryman, A.L.1    Lin, J.H.2    McCammon, J.A.3
  • 65
    • 0035887670 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 reverse-transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population
    • Gonzales M.J., Machekano R.N., Shafer R.W. Human immunodeficiency virus type 1 reverse-transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J. Infect. Dis. (2001) 184 998-1006.
    • (2001) J. Infect. Dis. , vol.184 , pp. 998-1006
    • Gonzales, M.J.1    Machekano, R.N.2    Shafer, R.W.3
  • 66
    • 31344466766 scopus 로고    scopus 로고
    • HIV-1 genotypes related to failure of nelfinavir as the first protease inhibitor treatment
    • Tupinambas U., Aleixo A., Greco D. HIV-1 genotypes related to failure of nelfinavir as the first protease inhibitor treatment. Braz. J. Infect. Dis. (2005) 9 324-329.
    • (2005) Braz. J. Infect. Dis. , vol.9 , pp. 324-329
    • Tupinambas, U.1    Aleixo, A.2    Greco, D.3
  • 67
    • 0035835499 scopus 로고    scopus 로고
    • Phenotypic cross-resistance to nelfinavir: the role of prior antiretroviral therapy and the number of mutations in the protease gene
    • Dronda F., Casado J.L., Moreno S. et al. Phenotypic cross-resistance to nelfinavir: the role of prior antiretroviral therapy and the number of mutations in the protease gene. AIDS Res. Hum. Retroviruses (2001) 17 211-215.
    • (2001) AIDS Res. Hum. Retroviruses , vol.17 , pp. 211-215
    • Dronda, F.1    Casado, J.L.2    Moreno, S.3
  • 68
    • 0034011272 scopus 로고    scopus 로고
    • Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity
    • Falloon J., Piscitelli S., Vogel S. et al. Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. Clin. Infect. Dis. (2000) 30 313-318.
    • (2000) Clin. Infect. Dis. , vol.30 , pp. 313-318
    • Falloon, J.1    Piscitelli, S.2    Vogel, S.3
  • 69
    • 0033921617 scopus 로고    scopus 로고
    • Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples
    • Hertogs K., Bloor S., Kemp S.D. et al. Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples. AIDS (2000) 14 1203-1210.
    • (2000) AIDS , vol.14 , pp. 1203-1210
    • Hertogs, K.1    Bloor, S.2    Kemp, S.D.3
  • 70
    • 0033827606 scopus 로고    scopus 로고
    • Baseline human immunodeficiency virus type 1 phenotype, genotype, and RNA response after switching from long-term hard-capsule saquinavir to indinavir or soft-gel-capsule saquinavir in AIDS clinical trials group protocol 333
    • Para M.F., Glidden D.V., Coombs R.W. et al. Baseline human immunodeficiency virus type 1 phenotype, genotype, and RNA response after switching from long-term hard-capsule saquinavir to indinavir or soft-gel-capsule saquinavir in AIDS clinical trials group protocol 333. J. Infect. Dis. (2000) 182 733-743.
    • (2000) J. Infect. Dis. , vol.182 , pp. 733-743
    • Para, M.F.1    Glidden, D.V.2    Coombs, R.W.3
  • 71
    • 0035163687 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir
    • Cote H.C., Brumme Z.L., Harrigan P.R. Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir. J. Virol. (2001) 75 589-594.
    • (2001) J. Virol. , vol.75 , pp. 589-594
    • Cote, H.C.1    Brumme, Z.L.2    Harrigan, P.R.3
  • 72
    • 0034915565 scopus 로고    scopus 로고
    • Impact of HIV type 1 protease, reverse transcriptase, cleavage site, and p6 mutations on the virological response to quadruple therapy with saquinavir, ritonavir, and two nucleoside analogs
    • Kaufmann G.R., Suzuki K., Cunningham P. et al. Impact of HIV type 1 protease, reverse transcriptase, cleavage site, and p6 mutations on the virological response to quadruple therapy with saquinavir, ritonavir, and two nucleoside analogs. AIDS Res. Hum. Retroviruses (2001) 17 487-497.
    • (2001) AIDS Res. Hum. Retroviruses , vol.17 , pp. 487-497
    • Kaufmann, G.R.1    Suzuki, K.2    Cunningham, P.3
  • 73
    • 69249221543 scopus 로고    scopus 로고
    • Positive selection pressure introduces secondary mutations at Gag cleavage sites in human immunodeficiency virus type 1 harboring major protease resistance mutations
    • Banke S., Lillemark M.R., Gerstoft J., Obel N., Jorgensen L.B. Positive selection pressure introduces secondary mutations at Gag cleavage sites in human immunodeficiency virus type 1 harboring major protease resistance mutations. J. Virol. (2009) 83 8916-8924.
    • (2009) J. Virol. , vol.83 , pp. 8916-8924
    • Banke, S.1    Lillemark, M.R.2    Gerstoft, J.3    Obel, N.4    Jorgensen, L.B.5
  • 74
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra J.H., Schleif W.A., Blahy O.M. et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature (1995) 374 569-571.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 75
    • 0033863985 scopus 로고    scopus 로고
    • Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug
    • Mammano F., Trouplin V., Zennou V., Clavel F. Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug. J. Virol. (2000) 74 8524-8531.
    • (2000) J. Virol. , vol.74 , pp. 8524-8531
    • Mammano, F.1    Trouplin, V.2    Zennou, V.3    Clavel, F.4
  • 76
    • 0036203533 scopus 로고    scopus 로고
    • Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy
    • Kantor R., Fessel W.J., Zolopa A.R. et al. Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. Antimicrob. Agents Chemother. (2002) 46 1086-1092.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1086-1092
    • Kantor, R.1    Fessel, W.J.2    Zolopa, A.R.3
  • 77
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado J., Savara A.V., Sutton L., D'Aquila R.T. Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J. Virol. (1999) 73 3744-3752.
    • (1999) J. Virol. , vol.73 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.V.2    Sutton, L.3    D'Aquila, R.T.4
  • 78
    • 0031950370 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy
    • Eastman P.S., Mittler J., Kelso R. et al. Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy. J. Virol. (1998) 72 5154-5164.
    • (1998) J. Virol. , vol.72 , pp. 5154-5164
    • Eastman, P.S.1    Mittler, J.2    Kelso, R.3
  • 79
    • 1342290276 scopus 로고    scopus 로고
    • Effect of polymorphisms on the replicative capacity of protease inhibitor-resistant HIV-1 variants under drug pressure
    • Sune C., Brennan L., Stover D.R., Klimkait T. Effect of polymorphisms on the replicative capacity of protease inhibitor-resistant HIV-1 variants under drug pressure. Clin. Microbiol. Infect. (2004) 10 119-126.
    • (2004) Clin. Microbiol. Infect. , vol.10 , pp. 119-126
    • Sune, C.1    Brennan, L.2    Stover, D.R.3    Klimkait, T.4
  • 80
    • 10344263394 scopus 로고    scopus 로고
    • Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor
    • Condra J.H., Holder D.J., Schleif W.A. et al. Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J. Virol. (1996) 70 8270-8276.
    • (1996) J. Virol. , vol.70 , pp. 8270-8276
    • Condra, J.H.1    Holder, D.J.2    Schleif, W.A.3
  • 81
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • Kempf D.J., Isaacson J.D., King M.S. et al. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J. Virol. (2001) 75 7462-7469.
    • (2001) J. Virol. , vol.75 , pp. 7462-7469
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 82
    • 0033820923 scopus 로고    scopus 로고
    • Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide. HIV Variant Working Group
    • Pieniazek D., Rayfield M., Hu D.J. et al. Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide. HIV Variant Working Group. AIDS (2000) 14 1489-1495.
    • (2000) AIDS , vol.14 , pp. 1489-1495
    • Pieniazek, D.1    Rayfield, M.2    Hu, D.J.3
  • 83
    • 0035173377 scopus 로고    scopus 로고
    • Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database: an expanded data model integrating natural language text and sequence analysis programs
    • Kantor R., Machekano R., Gonzales M.J., Dupnik K., Schapiro J.M., Shafer R.W. Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database: an expanded data model integrating natural language text and sequence analysis programs. Nucleic Acids Res. (2001) 29 296-299.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 296-299
    • Kantor, R.1    Machekano, R.2    Gonzales, M.J.3    Dupnik, K.4    Schapiro, J.M.5    Shafer, R.W.6
  • 84
    • 0035968306 scopus 로고    scopus 로고
    • HIV integrase, a brief overview from chemistry to therapeutics
    • Craigie R. HIV integrase, a brief overview from chemistry to therapeutics. J. Biol. Chem. (2001) 276 23213-23216.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23213-23216
    • Craigie, R.1
  • 85
    • 0037315284 scopus 로고    scopus 로고
    • Dipyrimidine-based inhibitors of HIV-1 integrase
    • Neamati N. Dipyrimidine-based inhibitors of HIV-1 integrase. Expert Opin. Investig. Drugs (2003) 12 289-292.
    • (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 289-292
    • Neamati, N.1
  • 86
    • 0035147120 scopus 로고    scopus 로고
    • Structure-based HIV-1 integrase inhibitor design: a future perspective
    • Neamati N. Structure-based HIV-1 integrase inhibitor design: a future perspective. Expert Opin. Investig. Drugs (2001) 10 281-296.
    • (2001) Expert Opin. Investig. Drugs , vol.10 , pp. 281-296
    • Neamati, N.1
  • 87
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    • Hazuda D.J., Felock P., Witmer M. et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science (2000) 287 646-650.
    • (2000) Science , vol.287 , pp. 646-650
    • Hazuda, D.J.1    Felock, P.2    Witmer, M.3
  • 89
    • 12944270496 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
    • Espeseth A.S., Felock P., Wolfe A. et al. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc. Natl Acad. Sci. USA (2000) 97 11244-11249.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11244-11249
    • Espeseth, A.S.1    Felock, P.2    Wolfe, A.3
  • 90
    • 0037076324 scopus 로고    scopus 로고
    • Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes
    • Grobler J.A., Stillmock K., Hu B. et al. Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes. Proc. Natl Acad. Sci. USA (2002) 99 6661-6666.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 6661-6666
    • Grobler, J.A.1    Stillmock, K.2    Hu, B.3
  • 91
    • 3242769788 scopus 로고    scopus 로고
    • Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
    • Hazuda D.J., Young S.D., Guare J.P. et al. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science (2004) 305 528-532.
    • (2004) Science , vol.305 , pp. 528-532
    • Hazuda, D.J.1    Young, S.D.2    Guare, J.P.3
  • 92
    • 42449119376 scopus 로고    scopus 로고
    • Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection
    • Yi Y., Loftin L., Wang L., Ratcliffe S.J., Isaacman-Beck J., Collman R.G. Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection. J. Acquir. Immune Defic. Syndr. (2008) 47 285-292.
    • (2008) J. Acquir. Immune Defic. Syndr. , vol.47 , pp. 285-292
    • Yi, Y.1    Loftin, L.2    Wang, L.3    Ratcliffe, S.J.4    Isaacman-Beck, J.5    Collman, R.G.6
  • 93
    • 63149093637 scopus 로고    scopus 로고
    • HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide
    • Ray N., Blackburn L.A., Doms R.W. HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide. J. Virol. (2009) 83 2989-2995.
    • (2009) J. Virol. , vol.83 , pp. 2989-2995
    • Ray, N.1    Blackburn, L.A.2    Doms, R.W.3
  • 95
    • 0038187684 scopus 로고    scopus 로고
    • Novel therapies based on mechanisms of HIV-1 cell entry
    • Kilby J.M., Eron J.J. Novel therapies based on mechanisms of HIV-1 cell entry. N. Engl. J. Med. (2003) 348 2228-2238.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2228-2238
    • Kilby, J.M.1    Eron, J.J.2
  • 97
    • 0037323819 scopus 로고    scopus 로고
    • Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART
    • Moyle G. Stopping HIV fusion with enfuvirtide: the first step to extracellular HAART. J. Antimicrob. Chemother. (2003) 51 213-217.
    • (2003) J. Antimicrob. Chemother. , vol.51 , pp. 213-217
    • Moyle, G.1
  • 98
    • 0037059049 scopus 로고    scopus 로고
    • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    • Reeves J.D., Gallo S.A., Ahmad N. et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc. Natl Acad. Sci. USA (2002) 99 16249-16254.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 16249-16254
    • Reeves, J.D.1    Gallo, S.A.2    Ahmad, N.3
  • 99
    • 0037119027 scopus 로고    scopus 로고
    • Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients
    • Xu L., Hue S., Taylor S. et al. Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients. AIDS (2002) 16 1684-1686.
    • (2002) AIDS , vol.16 , pp. 1684-1686
    • Xu, L.1    Hue, S.2    Taylor, S.3
  • 100
    • 0036066762 scopus 로고    scopus 로고
    • The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in HIV-infected adults
    • Kilby J.M., Lalezari J.P., Eron J.J. et al. The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in HIV-infected adults. AIDS Res. Hum. Retroviruses (2002) 18 685-693.
    • (2002) AIDS Res. Hum. Retroviruses , vol.18 , pp. 685-693
    • Kilby, J.M.1    Lalezari, J.P.2    Eron, J.J.3
  • 101
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari J.P., Henry K., O'Hearn M. et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N. Engl. J. Med. (2003) 348 2175-2185.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2175-2185
    • Lalezari, J.P.1    Henry, K.2    O'Hearn, M.3
  • 102
    • 0037471311 scopus 로고    scopus 로고
    • A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy
    • Lalezari J.P., Eron J.J., Carlson M. et al. A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy. AIDS (2003) 17 691-698.
    • (2003) AIDS , vol.17 , pp. 691-698
    • Lalezari, J.P.1    Eron, J.J.2    Carlson, M.3
  • 103
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A., Clotet B., Cooper D. et al. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N. Engl. J. Med. (2003) 348 2186-2195.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3
  • 104
    • 1542319002 scopus 로고    scopus 로고
    • Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis
    • Witvrouw M., Pannecouque C., Switzer W.M., Folks T.M., De Clercq E., Heneine W. Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis. Antivir. Ther. (2004) 9 57-65.
    • (2004) Antivir. Ther. , vol.9 , pp. 57-65
    • Witvrouw, M.1    Pannecouque, C.2    Switzer, W.M.3    Folks, T.M.4    De Clercq, E.5    Heneine, W.6
  • 105
    • 30744447460 scopus 로고    scopus 로고
    • Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
    • Fatkenheuer G., Pozniak A.L., Johnson M.A. et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat. Med. (2005) 11 1170-1172.
    • (2005) Nat. Med. , vol.11 , pp. 1170-1172
    • Fatkenheuer, G.1    Pozniak, A.L.2    Johnson, M.A.3
  • 106
    • 34347379935 scopus 로고    scopus 로고
    • Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211
    • Gulick R.M., Su Z., Flexner C. et al. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211. J. Infect. Dis. (2007) 196 304-312.
    • (2007) J. Infect. Dis. , vol.196 , pp. 304-312
    • Gulick, R.M.1    Su, Z.2    Flexner, C.3
  • 107
    • 0036846898 scopus 로고    scopus 로고
    • New anti-HIV agents and targets
    • De Clercq E. New anti-HIV agents and targets. Med. Res. Rev. (2002) 22 531-565.
    • (2002) Med. Res. Rev. , vol.22 , pp. 531-565
    • De Clercq, E.1
  • 108
    • 33846932573 scopus 로고    scopus 로고
    • HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211
    • Wilkin T.J., Su Z., Kuritzkes D.R. et al. HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211. Clin. Infect. Dis. (2007) 44 591-595.
    • (2007) Clin. Infect. Dis. , vol.44 , pp. 591-595
    • Wilkin, T.J.1    Su, Z.2    Kuritzkes, D.R.3
  • 109
    • 3042780489 scopus 로고    scopus 로고
    • Co-receptor antagonists as HIV-1 entry inhibitors
    • Shaheen F., Collman R.G. Co-receptor antagonists as HIV-1 entry inhibitors. Curr. Opin. Infect. Dis. (2004) 17 7-16.
    • (2004) Curr. Opin. Infect. Dis. , vol.17 , pp. 7-16
    • Shaheen, F.1    Collman, R.G.2
  • 110
    • 13044256383 scopus 로고    scopus 로고
    • A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
    • Baba M., Nishimura O., Kanzaki N. et al. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc. Natl Acad. Sci. USA (1999) 96 5698-5703.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5698-5703
    • Baba, M.1    Nishimura, O.2    Kanzaki, N.3
  • 111
    • 22544456536 scopus 로고    scopus 로고
    • Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals
    • Brumme Z.L., Goodrich J., Mayer H.B. et al. Molecular and clinical epidemiology of CXCR4-using HIV-1 in a large population of antiretroviral-naive individuals. J. Infect. Dis. (2005) 192 466-474.
    • (2005) J. Infect. Dis. , vol.192 , pp. 466-474
    • Brumme, Z.L.1    Goodrich, J.2    Mayer, H.B.3
  • 112
    • 33746160257 scopus 로고    scopus 로고
    • HIV-1 coreceptor use in triple-class treatment-experienced patients: baseline prevalence, correlates, and relationship to enfuvirtide response
    • Melby T., Despirito M., Demasi R., Heilek-Snyder G., Greenberg M.L., Graham N. HIV-1 coreceptor use in triple-class treatment-experienced patients: baseline prevalence, correlates, and relationship to enfuvirtide response. J. Infect. Dis. (2006) 194 238-246.
    • (2006) J. Infect. Dis. , vol.194 , pp. 238-246
    • Melby, T.1    Despirito, M.2    Demasi, R.3    Heilek-Snyder, G.4    Greenberg, M.L.5    Graham, N.6
  • 113
    • 14844333093 scopus 로고    scopus 로고
    • Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection
    • Moyle G.J., Wildfire A., Mandalia S. et al. Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J. Infect. Dis. (2005) 191 866-872.
    • (2005) J. Infect. Dis. , vol.191 , pp. 866-872
    • Moyle, G.J.1    Wildfire, A.2    Mandalia, S.3
  • 114
    • 56449131382 scopus 로고    scopus 로고
    • Baseline resistance of primary human immunodeficiency virus type 1 strains to the CXCR4 inhibitor AMD3100
    • Harrison J.E., Lynch J.B., Sierra L.J. et al. Baseline resistance of primary human immunodeficiency virus type 1 strains to the CXCR4 inhibitor AMD3100. J. Virol. (2008) 82 11695-11704.
    • (2008) J. Virol. , vol.82 , pp. 11695-11704
    • Harrison, J.E.1    Lynch, J.B.2    Sierra, L.J.3
  • 115
    • 0032954383 scopus 로고    scopus 로고
    • T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure
    • Arakaki R., Tamamura H., Premanathan M. et al. T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure. J. Virol. (1999) 73 1719-1723.
    • (1999) J. Virol. , vol.73 , pp. 1719-1723
    • Arakaki, R.1    Tamamura, H.2    Premanathan, M.3
  • 116
    • 0033914412 scopus 로고    scopus 로고
    • Prevalence of mutations associated with reduced antiretroviral drug susceptibility among human immunodeficiency virus type 1 seroconverters in the United States, 1993-1998
    • Weinstock H., Respess R., Heneine W. et al. Prevalence of mutations associated with reduced antiretroviral drug susceptibility among human immunodeficiency virus type 1 seroconverters in the United States, 1993-1998. J. Infect. Dis. (2000) 182 330-333.
    • (2000) J. Infect. Dis. , vol.182 , pp. 330-333
    • Weinstock, H.1    Respess, R.2    Heneine, W.3
  • 117
    • 0034008567 scopus 로고    scopus 로고
    • Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in Spain. The ERASE-2 Study Group
    • Puig T., Perez-Olmeda M., Rubio A. et al. Prevalence of genotypic resistance to nucleoside analogues and protease inhibitors in Spain. The ERASE-2 Study Group. AIDS (2000) 14 727-732.
    • (2000) AIDS , vol.14 , pp. 727-732
    • Puig, T.1    Perez-Olmeda, M.2    Rubio, A.3
  • 118
    • 0034639490 scopus 로고    scopus 로고
    • Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens
    • Havlir D.V., Hellmann N.S., Petropoulos C.J. et al. Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens. JAMA (2000) 283 229-234.
    • (2000) JAMA , vol.283 , pp. 229-234
    • Havlir, D.V.1    Hellmann, N.S.2    Petropoulos, C.J.3
  • 119
    • 19944431012 scopus 로고    scopus 로고
    • Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy
    • Harrigan P.R., Hogg R.S., Dong W.W. et al. Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. J. Infect. Dis. (2005) 191 339-347.
    • (2005) J. Infect. Dis. , vol.191 , pp. 339-347
    • Harrigan, P.R.1    Hogg, R.S.2    Dong, W.W.3
  • 120
    • 0037013040 scopus 로고    scopus 로고
    • Drug resistance at low viraemia in HIV-1-infected patients with antiretroviral combination therapy
    • Aleman S., Soderbarg K., Visco-Comandini U., Sitbon G., Sonnerborg A. Drug resistance at low viraemia in HIV-1-infected patients with antiretroviral combination therapy. AIDS (2002) 16 1039-1044.
    • (2002) AIDS , vol.16 , pp. 1039-1044
    • Aleman, S.1    Soderbarg, K.2    Visco-Comandini, U.3    Sitbon, G.4    Sonnerborg, A.5
  • 121
    • 0036234480 scopus 로고    scopus 로고
    • Human immunodeficiency viruses and drug therapy: resistance and implications for antiretroviral therapy
    • Idemyor V. Human immunodeficiency viruses and drug therapy: resistance and implications for antiretroviral therapy. Pharmacotherapy (2002) 22 659-662.
    • (2002) Pharmacotherapy , vol.22 , pp. 659-662
    • Idemyor, V.1
  • 122
    • 0035280397 scopus 로고    scopus 로고
    • Frequency of genotypic and phenotypic drug-resistant HIV-1 among therapy-naive patients of the German Seroconverter Study
    • Duwe S., Brunn M., Altmann D. et al. Frequency of genotypic and phenotypic drug-resistant HIV-1 among therapy-naive patients of the German Seroconverter Study. J. Acquir. Immune Defic. Syndr. (2001) 26 266-273.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.26 , pp. 266-273
    • Duwe, S.1    Brunn, M.2    Altmann, D.3
  • 123
    • 0033673684 scopus 로고    scopus 로고
    • Resistance to antiretroviral drugs in patients with primary HIV-1 infection. Investigators of the Quebec Primary Infection Study
    • Brenner B., Wainberg M.A., Salomon H. et al. Resistance to antiretroviral drugs in patients with primary HIV-1 infection. Investigators of the Quebec Primary Infection Study. Int. J. Antimicrob. Agents (2000) 16 429-434.
    • (2000) Int. J. Antimicrob. Agents , vol.16 , pp. 429-434
    • Brenner, B.1    Wainberg, M.A.2    Salomon, H.3
  • 124
    • 0037043652 scopus 로고    scopus 로고
    • Antiretroviral-drug resistance among patients recently infected with HIV
    • Little S.J., Holte S., Routy J.P. et al. Antiretroviral-drug resistance among patients recently infected with HIV. N. Engl. J. Med. (2002) 347 385-394.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 385-394
    • Little, S.J.1    Holte, S.2    Routy, J.P.3
  • 125
    • 0037055016 scopus 로고    scopus 로고
    • Time trends in primary HIV-1 drug resistance among recently infected persons
    • Grant R.M., Hecht F.M., Warmerdam M. et al. Time trends in primary HIV-1 drug resistance among recently infected persons. JAMA (2002) 288 181-188.
    • (2002) JAMA , vol.288 , pp. 181-188
    • Grant, R.M.1    Hecht, F.M.2    Warmerdam, M.3
  • 126
    • 4143113433 scopus 로고    scopus 로고
    • Persistence of primary drug resistance among recently HIV-1 infected adults
    • Barbour J.D., Hecht F.M., Wrin T. et al. Persistence of primary drug resistance among recently HIV-1 infected adults. AIDS (2004) 18 1683-1689.
    • (2004) AIDS , vol.18 , pp. 1683-1689
    • Barbour, J.D.1    Hecht, F.M.2    Wrin, T.3
  • 127
    • 16544376890 scopus 로고    scopus 로고
    • Primary drug-resistance in HIV-positive patients on initiation of first-line antiretroviral therapy in Germany
    • Oette M., Kaiser R., Daumer M. et al. Primary drug-resistance in HIV-positive patients on initiation of first-line antiretroviral therapy in Germany. Eur. J. Med. Res. (2004) 9 273-278.
    • (2004) Eur. J. Med. Res. , vol.9 , pp. 273-278
    • Oette, M.1    Kaiser, R.2    Daumer, M.3
  • 128
    • 0036062842 scopus 로고    scopus 로고
    • Prevalence of mutations related to HIV-1 antiretroviral resistance in Brazilian patients failing HAART
    • Tanuri A., Caridea E., Dantas M.C. et al. Prevalence of mutations related to HIV-1 antiretroviral resistance in Brazilian patients failing HAART. J. Clin. Virol. (2002) 25 39-46.
    • (2002) J. Clin. Virol. , vol.25 , pp. 39-46
    • Tanuri, A.1    Caridea, E.2    Dantas, M.C.3
  • 129
    • 0034074743 scopus 로고    scopus 로고
    • Prevalence of genotypic and phenotypic resistance to anti-retroviral drugs in a cohort of therapy-naive HIV-1 infected US military personnel
    • Wegner S.A., Brodine S.K., Mascola J.R. et al. Prevalence of genotypic and phenotypic resistance to anti-retroviral drugs in a cohort of therapy-naive HIV-1 infected US military personnel. AIDS (2000) 14 1009-1015.
    • (2000) AIDS , vol.14 , pp. 1009-1015
    • Wegner, S.A.1    Brodine, S.K.2    Mascola, J.R.3
  • 130
    • 0002035867 scopus 로고    scopus 로고
    • Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study
    • Salomon H., Wainberg M.A., Brenner B. et al. Prevalence of HIV-1 resistant to antiretroviral drugs in 81 individuals newly infected by sexual contact or injecting drug use. Investigators of the Quebec Primary Infection Study. AIDS (2000) 14 F17-F23.
    • (2000) AIDS , vol.14
    • Salomon, H.1    Wainberg, M.A.2    Brenner, B.3
  • 131
    • 0038182982 scopus 로고    scopus 로고
    • Identification of a transmission chain of HIV type 1 containing drug resistance-associated mutations
    • Taylor S., Cane P., Hue S. et al. Identification of a transmission chain of HIV type 1 containing drug resistance-associated mutations. AIDS Res. Hum. Retroviruses (2003) 19 353-361.
    • (2003) AIDS Res. Hum. Retroviruses , vol.19 , pp. 353-361
    • Taylor, S.1    Cane, P.2    Hue, S.3
  • 132
    • 0037320994 scopus 로고    scopus 로고
    • Rates of transmission of antiretroviral drug resistant strains of HIV-1
    • Ammaranond P., Cunningham P., Oelrichs R. et al. Rates of transmission of antiretroviral drug resistant strains of HIV-1. J. Clin. Virol. (2003) 26 153-161.
    • (2003) J. Clin. Virol. , vol.26 , pp. 153-161
    • Ammaranond, P.1    Cunningham, P.2    Oelrichs, R.3
  • 133
    • 0347479194 scopus 로고    scopus 로고
    • Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus
    • Gandhi R.T., Wurcel A., Rosenberg E.S. et al. Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus. Clin. Infect. Dis. (2003) 37 1693-1698.
    • (2003) Clin. Infect. Dis. , vol.37 , pp. 1693-1698
    • Gandhi, R.T.1    Wurcel, A.2    Rosenberg, E.S.3
  • 134
    • 0032562985 scopus 로고    scopus 로고
    • Public health implications of antiretroviral therapy and HIV drug resistance
    • Wainberg M.A., Friedland G. Public health implications of antiretroviral therapy and HIV drug resistance. JAMA (1998) 279 1977-1983.
    • (1998) JAMA , vol.279 , pp. 1977-1983
    • Wainberg, M.A.1    Friedland, G.2
  • 135
    • 0033022106 scopus 로고    scopus 로고
    • Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development
    • Palmer S., Shafer R.W., Merigan T.C. Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development. AIDS (1999) 13 661-667.
    • (1999) AIDS , vol.13 , pp. 661-667
    • Palmer, S.1    Shafer, R.W.2    Merigan, T.C.3
  • 136
    • 0035281108 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance
    • Loveday C. International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance. J. Acquir. Immune Defic. Syndr. (2001) 26(Suppl 1) S10-S24.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.26 , Issue.SUPPL. 1
    • Loveday, C.1
  • 137
    • 0035280944 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Resistance to protease inhibitors
    • Miller V. International perspectives on antiretroviral resistance. Resistance to protease inhibitors. J. Acquir. Immune Defic. Syndr. (2001) 26(Suppl 1) S34-S50.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.26 , Issue.SUPPL. 1
    • Miller, V.1
  • 138
    • 17344390474 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society - USA Panel
    • Hirsch M.S., Conway B., D'Aquila R.T. et al. Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society - USA Panel. JAMA (1998) 279 1984-1991.
    • (1998) JAMA , vol.279 , pp. 1984-1991
    • Hirsch, M.S.1    Conway, B.2    D'Aquila, R.T.3
  • 140
    • 0034785773 scopus 로고    scopus 로고
    • Predicting the unpredictable: transmission of drug-resistant HIV
    • Blower S.M., Aschenbach A.N., Gershengorn H.B., Kahn J.O. Predicting the unpredictable: transmission of drug-resistant HIV. Nat. Med. (2001) 7 1016-1020.
    • (2001) Nat. Med. , vol.7 , pp. 1016-1020
    • Blower, S.M.1    Aschenbach, A.N.2    Gershengorn, H.B.3    Kahn, J.O.4
  • 141
    • 0036569234 scopus 로고    scopus 로고
    • A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection
    • Opravil M., Hirschel B., Lazzarin A. et al. A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection. J. Infect. Dis. (2002) 185 1251-1260.
    • (2002) J. Infect. Dis. , vol.185 , pp. 1251-1260
    • Opravil, M.1    Hirschel, B.2    Lazzarin, A.3
  • 142
    • 0038234808 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel
    • Hirsch M.S., Brun-Vezinet F., Clotet B. et al. Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel. Clin. Infect. Dis. (2003) 37 113-128.
    • (2003) Clin. Infect. Dis. , vol.37 , pp. 113-128
    • Hirsch, M.S.1    Brun-Vezinet, F.2    Clotet, B.3
  • 143
    • 0035876041 scopus 로고    scopus 로고
    • Non-adherence to highly active antiretroviral therapy predicts progression to AIDS
    • Bangsberg D.R., Perry S., Charlebois E.D. et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS (2001) 15 1181-1183.
    • (2001) AIDS , vol.15 , pp. 1181-1183
    • Bangsberg, D.R.1    Perry, S.2    Charlebois, E.D.3
  • 144
    • 0037444053 scopus 로고    scopus 로고
    • Determining the relative efficacy of highly active antiretroviral therapy
    • Louie M., Hogan C., Di Mascio M. et al. Determining the relative efficacy of highly active antiretroviral therapy. J. Infect. Dis. (2003) 187 896-900.
    • (2003) J. Infect. Dis. , vol.187 , pp. 896-900
    • Louie, M.1    Hogan, C.2    Di Mascio, M.3
  • 145
    • 0036972260 scopus 로고    scopus 로고
    • Analysis of virological efficacy in trials of antiretroviral regimens: drawbacks of not including viral load measurements after premature discontinuation of therapy
    • Kirk O., Pedersen C., Law M. et al. Analysis of virological efficacy in trials of antiretroviral regimens: drawbacks of not including viral load measurements after premature discontinuation of therapy. Antivir. Ther. (2002) 7 271-281.
    • (2002) Antivir. Ther. , vol.7 , pp. 271-281
    • Kirk, O.1    Pedersen, C.2    Law, M.3
  • 146
    • 0036678490 scopus 로고    scopus 로고
    • Adherence, resistance, and timing: current issues in the use of new therapies
    • 56-57, 68
    • Volberding P. Adherence, resistance, and timing: current issues in the use of new therapies. AIDS Read. (2002) 12 349-350, 56-57, 68.
    • (2002) AIDS Read. , vol.12 , pp. 349-350
    • Volberding, P.1
  • 147
    • 0037013038 scopus 로고    scopus 로고
    • Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1year of follow-up
    • Hogg R.S., Heath K., Bangsberg D. et al. Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1year of follow-up. AIDS (2002) 16 1051-1058.
    • (2002) AIDS , vol.16 , pp. 1051-1058
    • Hogg, R.S.1    Heath, K.2    Bangsberg, D.3
  • 148
    • 0037200171 scopus 로고    scopus 로고
    • Predictors of treatment failure during highly active antiretroviral therapy (racing trial)
    • Masuhr A., Mueller M., Simon V. et al. Predictors of treatment failure during highly active antiretroviral therapy (racing trial). Eur. J. Med. Res. (2002) 7 341-346.
    • (2002) Eur. J. Med. Res. , vol.7 , pp. 341-346
    • Masuhr, A.1    Mueller, M.2    Simon, V.3
  • 149
    • 0036639184 scopus 로고    scopus 로고
    • Virologic rebound on HAART in the context of low treatment adherence is associated with a low prevalence of antiretroviral drug resistance
    • Walsh J.C., Pozniak A.L., Nelson M.R., Mandalia S., Gazzard B.G. Virologic rebound on HAART in the context of low treatment adherence is associated with a low prevalence of antiretroviral drug resistance. J. Acquir. Immune Defic. Syndr. (2002) 30 278-287.
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.30 , pp. 278-287
    • Walsh, J.C.1    Pozniak, A.L.2    Nelson, M.R.3    Mandalia, S.4    Gazzard, B.G.5
  • 151
    • 0034927546 scopus 로고    scopus 로고
    • Analysis of HIV type 1 protease and reverse transcriptase sequences from Venezuela for drug resistance-associated mutations and subtype classification: a UNAIDS study
    • Delgado E., Leon-Ponte M., Villahermosa M.L. et al. Analysis of HIV type 1 protease and reverse transcriptase sequences from Venezuela for drug resistance-associated mutations and subtype classification: a UNAIDS study. AIDS Res. Hum. Retroviruses (2001) 17 753-758.
    • (2001) AIDS Res. Hum. Retroviruses , vol.17 , pp. 753-758
    • Delgado, E.1    Leon-Ponte, M.2    Villahermosa, M.L.3
  • 152
    • 0035964694 scopus 로고    scopus 로고
    • Changes in the rate of genotypic resistance to antiretroviral drugs in Spain
    • Gallego O., Ruiz L., Vallejo A. et al. Changes in the rate of genotypic resistance to antiretroviral drugs in Spain. AIDS (2001) 15 1894-1896.
    • (2001) AIDS , vol.15 , pp. 1894-1896
    • Gallego, O.1    Ruiz, L.2    Vallejo, A.3
  • 153
    • 0035941385 scopus 로고    scopus 로고
    • Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains
    • Goudsmit J., Weverling G.J., van der Hoek L. et al. Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains. AIDS (2001) 15 2293-2301.
    • (2001) AIDS , vol.15 , pp. 2293-2301
    • Goudsmit, J.1    Weverling, G.J.2    van der Hoek, L.3
  • 154
    • 7844241226 scopus 로고    scopus 로고
    • Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries
    • Schmit J.C., Van Laethem K., Ruiz L. et al. Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries. AIDS (1998) 12 2007-2015.
    • (1998) AIDS , vol.12 , pp. 2007-2015
    • Schmit, J.C.1    Van Laethem, K.2    Ruiz, L.3
  • 155
    • 3142660152 scopus 로고    scopus 로고
    • The prevalence of antiretroviral drug resistance in the United States
    • Richman D.D., Morton S.C., Wrin T. et al. The prevalence of antiretroviral drug resistance in the United States. AIDS (2004) 18 1393-1401.
    • (2004) AIDS , vol.18 , pp. 1393-1401
    • Richman, D.D.1    Morton, S.C.2    Wrin, T.3
  • 157
    • 0030953711 scopus 로고    scopus 로고
    • Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group
    • Imrie A., Beveridge A., Genn W., Vizzard J., Cooper D.A. Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group. J. Infect. Dis. (1997) 175 1502-1506.
    • (1997) J. Infect. Dis. , vol.175 , pp. 1502-1506
    • Imrie, A.1    Beveridge, A.2    Genn, W.3    Vizzard, J.4    Cooper, D.A.5
  • 158
    • 0034006789 scopus 로고    scopus 로고
    • Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team
    • Kuritzkes D.R., Sevin A., Young B. et al. Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team. J. Infect. Dis. (2000) 181 491-497.
    • (2000) J. Infect. Dis. , vol.181 , pp. 491-497
    • Kuritzkes, D.R.1    Sevin, A.2    Young, B.3
  • 159
    • 0033762620 scopus 로고    scopus 로고
    • Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen
    • Izopet J., Massip P., Souyris C. et al. Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen. AIDS (2000) 14 2247-2255.
    • (2000) AIDS , vol.14 , pp. 2247-2255
    • Izopet, J.1    Massip, P.2    Souyris, C.3
  • 160
    • 0343183245 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA Panel
    • Hirsch M.S., Brun-Vezinet F., D'Aquila R.T. et al. Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA Panel. JAMA (2000) 283 2417-2426.
    • (2000) JAMA , vol.283 , pp. 2417-2426
    • Hirsch, M.S.1    Brun-Vezinet, F.2    D'Aquila, R.T.3
  • 161
    • 46349112103 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel
    • Hirsch M., G nthard H., Schapiro J. et al. Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Clin. Infect. Dis. (2008) 47 266-285.
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 266-285
    • Hirsch, M.1    G nthard, H.2    Schapiro, J.3
  • 162
    • 0033612928 scopus 로고    scopus 로고
    • Transmission of antiretroviral-drug-resistant HIV-1 variants
    • Yerly S., Kaiser L., Race E., Bru J.P., Clavel F., Perrin L. Transmission of antiretroviral-drug-resistant HIV-1 variants. Lancet (1999) 354 729-733.
    • (1999) Lancet , vol.354 , pp. 729-733
    • Yerly, S.1    Kaiser, L.2    Race, E.3    Bru, J.P.4    Clavel, F.5    Perrin, L.6
  • 163
    • 0033615280 scopus 로고    scopus 로고
    • Reduced antiretroviral drug susceptibility among patients with primary HIV infection
    • Little S.J., Daar E.S., D'Aquila R.T. et al. Reduced antiretroviral drug susceptibility among patients with primary HIV infection. JAMA (1999) 282 1142-1149.
    • (1999) JAMA , vol.282 , pp. 1142-1149
    • Little, S.J.1    Daar, E.S.2    D'Aquila, R.T.3
  • 164
    • 12144290307 scopus 로고    scopus 로고
    • Surveillance of HIV antiretroviral drug resistance in treated individuals in England: 1998-2000
    • Scott P., Arnold E., Evans B. et al. Surveillance of HIV antiretroviral drug resistance in treated individuals in England: 1998-2000. J. Antimicrob. Chemother. (2004) 53 469-473.
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 469-473
    • Scott, P.1    Arnold, E.2    Evans, B.3
  • 165
    • 0038298328 scopus 로고    scopus 로고
    • Stability of adherence to highly active antiretroviral therapy over time among clients enrolled in the treatment adherence demonstration project
    • Tesoriero J., French T., Weiss L., Waters M., Finkelstein R., Agins B. Stability of adherence to highly active antiretroviral therapy over time among clients enrolled in the treatment adherence demonstration project. J. Acquir. Immune Defic. Syndr. (2003) 33 484-493.
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.33 , pp. 484-493
    • Tesoriero, J.1    French, T.2    Weiss, L.3    Waters, M.4    Finkelstein, R.5    Agins, B.6
  • 166
    • 0036188036 scopus 로고    scopus 로고
    • Impact of highly active antiretroviral treatment on HIV seroincidence among men who have sex with men: San Francisco
    • Katz M.H., Schwarcz S.K., Kellogg T.A. et al. Impact of highly active antiretroviral treatment on HIV seroincidence among men who have sex with men: San Francisco. Am. J. Public Health (2002) 92 388-394.
    • (2002) Am. J. Public Health , vol.92 , pp. 388-394
    • Katz, M.H.1    Schwarcz, S.K.2    Kellogg, T.A.3
  • 167
    • 0242383496 scopus 로고    scopus 로고
    • Worldwide transmission of drug-resistant HIV
    • Wensing A.M., Boucher C.A. Worldwide transmission of drug-resistant HIV. AIDS Rev. (2003) 5 140-155.
    • (2003) AIDS Rev. , vol.5 , pp. 140-155
    • Wensing, A.M.1    Boucher, C.A.2
  • 168
    • 19944429038 scopus 로고    scopus 로고
    • Drug-resistant HIV infection among drug-naive patients in Israel
    • Grossman Z., Lorber M., Maayan S. et al. Drug-resistant HIV infection among drug-naive patients in Israel. Clin. Infect. Dis. (2005) 40 294-302.
    • (2005) Clin. Infect. Dis. , vol.40 , pp. 294-302
    • Grossman, Z.1    Lorber, M.2    Maayan, S.3


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