-
1
-
-
0032506055
-
Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
-
Arion, D., Kaushik, N., McCormick, S., Borkow, G., and Parniak, M.A. (1998). Phenotypic mechanism of HIV-1 resistance to 3′-azido-3′-deoxythymidine (AZT): Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 37, 15908-15917.
-
(1998)
Biochemistry
, vol.37
, pp. 15908-15917
-
-
Arion, D.1
Kaushik, N.2
McCormick, S.3
Borkow, G.4
Parniak, M.A.5
-
2
-
-
0017234748
-
On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase
-
Battula, N., and Loeb, L.A. (1976). On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase. J. Biol. Chem. 251, 982-986.
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 982-986
-
-
Battula, N.1
Loeb, L.A.2
-
3
-
-
0020443521
-
Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography
-
Bochner, B.R., and Ames, B.N. (1982). Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography. J. Biol. Chem. 257, 9759-9769.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 9759-9769
-
-
Bochner, B.R.1
Ames, B.N.2
-
4
-
-
0032486287
-
Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3′-azido-3′-deoxythymidine 5′-monophosphate-terminated primer
-
Canard, B., Sarfati, S.R., and Richardson, C.C. (1998). Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3′-azido-3′-deoxythymidine 5′-monophosphate-terminated primer. J. Biol. Chem. 273, 14596-14604.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14596-14604
-
-
Canard, B.1
Sarfati, S.R.2
Richardson, C.C.3
-
5
-
-
0028221001
-
Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate
-
Carroll, S.S., Geib, J., Olsen, D.B., Stahlhut, M., Shafer, J.A., and Kuo, L.C. (1994). Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate. Biochemistry 33, 2113-2120.
-
(1994)
Biochemistry
, vol.33
, pp. 2113-2120
-
-
Carroll, S.S.1
Geib, J.2
Olsen, D.B.3
Stahlhut, M.4
Shafer, J.A.5
Kuo, L.C.6
-
6
-
-
0023189465
-
Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs
-
Cheng, Y.-C., Dutschman, G.E., Bastow, K.F., Sarngadharan, M.G., and Ting, R.Y.C. (1987). Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs. J. Biol. Chem. 262, 2187-2189.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 2187-2189
-
-
Cheng, Y.-C.1
Dutschman, G.E.2
Bastow, K.F.3
Sarngadharan, M.G.4
Ting, R.Y.C.5
-
7
-
-
0002716966
-
Immunological and pharmacological approaches to the control of retroviral infections
-
J.M. Coffin, S.H. Hughes, and H.E. Varmus, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press)
-
Emini, E.A., and Fan, H.Y. (1997). Immunological and pharmacological approaches to the control of retroviral infections. In Retroviruses, J.M. Coffin, S.H. Hughes, and H.E. Varmus, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press), pp. 637-706.
-
(1997)
Retroviruses
, pp. 637-706
-
-
Emini, E.A.1
Fan, H.Y.2
-
8
-
-
0022996630
-
Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase
-
Furman, P.A., Fyfe, J.A., St. Clair, M.H., Weinhold, K., Rideout, J.L., Freeman, G.A., Nusinoff-Lehrman, S., Bolognesi, D.P., Broder, S., Mitsuya, H., and Barry, D.W. (1986). Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA 83, 8333-8337.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 8333-8337
-
-
Furman, P.A.1
Fyfe, J.A.2
Clair, S.M.H.3
Weinhold, K.4
Rideout, J.L.5
Freeman, G.A.6
Nusinoff-Lehrman, S.7
Bolognesi, D.P.8
Broder, S.9
Mitsuya, H.10
Barry, D.W.11
-
9
-
-
0015718863
-
Analysis of nucleotide pools in animal cells
-
Hauschka, P.V. (1973). Analysis of nucleotide pools in animal cells. Methods Cell Biol. 7, 361-462.
-
(1973)
Methods Cell Biol.
, vol.7
, pp. 361-462
-
-
Hauschka, P.V.1
-
10
-
-
0027365750
-
Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase
-
Hsieh, J.-C., Zinnen, S., and Modrich, P. (1993). Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. J. Biol. Chem. 268, 24607-24613.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 24607-24613
-
-
Hsieh, J.-C.1
Zinnen, S.2
Modrich, P.3
-
11
-
-
0025339708
-
Selective action of 3′-azido-3′-deoxythymidine 5′-triphosphate on viral reverse transcriptases and human DNA polymerases
-
Huang, P., Farquhar, D., and Plunkett, W. (1990). Selective action of 3′-azido-3′-deoxythymidine 5′-triphosphate on viral reverse transcriptases and human DNA polymerases. J. Biol. Chem. 265, 11914-11918.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 11914-11918
-
-
Huang, P.1
Farquhar, D.2
Plunkett, W.3
-
12
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang, H., Chopra, R., Verdine, G.L., and Harrison, S.C. (1998). Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance. Science 282, 1669-1675.
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
13
-
-
0030703245
-
Pre-steady-state kinetic characterization of wild type and 3′-azido-3′-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: Implication of RNA directed DNA polymerization in the mechanism of AZT resistance
-
Kerr, S.G., and Anderson, K.S. (1997). Pre-steady-state kinetic characterization of wild type and 3′-azido-3′-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: Implication of RNA directed DNA polymerization in the mechanism of AZT resistance. Biochemistry 36, 14064-14070.
-
(1997)
Biochemistry
, vol.36
, pp. 14064-14070
-
-
Kerr, S.G.1
Anderson, K.S.2
-
14
-
-
0343811737
-
Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC
-
Krebs, R., Immendörfer, U., Thrall, S.H., Wöhrl, B.M., and Goody, R.S. (1997). Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC. Biochemistry 36, 10292-10300.
-
(1997)
Biochemistry
, vol.36
, pp. 10292-10300
-
-
Krebs, R.1
Immendörfer, U.2
Thrall, S.H.3
Wöhrl, B.M.4
Goody, R.S.5
-
15
-
-
0026755210
-
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3′-azido-3′-deoxythymidine
-
Lacey, S.F., Reardon, J.E., Furfine, E.S., Kunkel, T.A., Bebenek, K., Eckert, K.A., Kemp, S.D., and Larder, B.A. (1992). Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3′-azido-3′-deoxythymidine. J. Biol. Chem. 267, 15789-15794.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 15789-15794
-
-
Lacey, S.F.1
Reardon, J.E.2
Furfine, E.S.3
Kunkel, T.A.4
Bebenek, K.5
Eckert, K.A.6
Kemp, S.D.7
Larder, B.A.8
-
16
-
-
0024508058
-
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
-
Larder, B.A., Darby, G., and Richman, D.D. (1989). HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 243, 1731-1734.
-
(1989)
Science
, vol.243
, pp. 1731-1734
-
-
Larder, B.A.1
Darby, G.2
Richman, D.D.3
-
17
-
-
0025138304
-
Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay
-
Larder, B.A., Chesebro, B., and Richman, D.D. (1990). Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay. Antimicrob. Agents Chemother. 34, 436-441.
-
(1990)
Antimicrob. Agents Chemother.
, vol.34
, pp. 436-441
-
-
Larder, B.A.1
Chesebro, B.2
Richman, D.D.3
-
18
-
-
0032506228
-
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism
-
Meyer, P.R., Matsuura, S.E., So, A.G., and Scott, W.A. (1998). Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism. Proc. Natl. Acad. Sci. USA 95, 13471-13476.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13471-13476
-
-
Meyer, P.R.1
Matsuura, S.E.2
So, A.G.3
Scott, W.A.4
-
19
-
-
0025186450
-
Molecular targets for AIDS therapy
-
Mitsuya, H., Yarchoan, R., and Broder, S. (1990). Molecular targets for AIDS therapy. Science 249, 1533-1544.
-
(1990)
Science
, vol.249
, pp. 1533-1544
-
-
Mitsuya, H.1
Yarchoan, R.2
Broder, S.3
-
20
-
-
0026646614
-
Permissible amino acid substitutions within the putative nucleoside-binding site of herpes simplex virus type 1 established by random sequence mutagenesis
-
Munir, K.M., French, D.C., Dube, D.K., and Loeb, L.A. (1992). Permissible amino acid substitutions within the putative nucleoside-binding site of herpes simplex virus type 1 established by random sequence mutagenesis. J. Biol. Chem. 267, 6584-6589.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 6584-6589
-
-
Munir, K.M.1
French, D.C.2
Dube, D.K.3
Loeb, L.A.4
-
21
-
-
0027414018
-
Human immunodeficiency virus reverse transcriptase. A kinetic analysis of RNA-dependent and DNA-dependent DNA polymerization
-
Reardon, J.E. (1993). Human immunodeficiency virus reverse transcriptase. A kinetic analysis of RNA-dependent and DNA-dependent DNA polymerization. J. Biol. Chem. 268, 8743-8751.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 8743-8751
-
-
Reardon, J.E.1
-
22
-
-
11544277817
-
3′-Azido-3′-deoxythymidine drug-resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
-
Ren, J., Esnouf, R.M., Hopkins, A.L., Jones, E.Y., Kirby, I., Keeling, J., Ross, C.K., Larder, B.A., Stuart, D.I., and Stammers, D.K. (1998). 3′-Azido-3′-deoxythymidine drug-resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes. Proc. Natl. Acad. Sci. USA 95, 9518-9523.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9518-9523
-
-
Ren, J.1
Esnouf, R.M.2
Hopkins, A.L.3
Jones, E.Y.4
Kirby, I.5
Keeling, J.6
Ross, C.K.7
Larder, B.A.8
Stuart, D.I.9
Stammers, D.K.10
-
23
-
-
0024273119
-
The accuracy of reverse transcriptase from HIV-1
-
Roberts, J.D., Bebenek, K., and Kunkel, T.A. (1988). The accuracy of reverse transcriptase from HIV-1. Science 242, 1171-1173.
-
(1988)
Science
, vol.242
, pp. 1171-1173
-
-
Roberts, J.D.1
Bebenek, K.2
Kunkel, T.A.3
-
24
-
-
0025325983
-
The "megaprimer" method of site-directed mutagenesis
-
Sarkar, G., and Sommer, S.S. (1990). The "megaprimer" method of site-directed mutagenesis. BioTechniques 8, 404-407.
-
(1990)
BioTechniques
, vol.8
, pp. 404-407
-
-
Sarkar, G.1
Sommer, S.S.2
-
25
-
-
0343765844
-
4N counterparts as substrates of firefly luciferase, dinucleoside tetraphosphatase and phosphodiesterases
-
4N counterparts as substrates of firefly luciferase, dinucleoside tetraphosphatase and phosphodiesterases. Biochim. Biophys. Acta 1334, 191-199.
-
(1997)
Biochim. Biophys. Acta
, vol.1334
, pp. 191-199
-
-
Sillero, M.A.G.1
Madrid, O.2
Zaera, E.3
Sillero, A.4
-
26
-
-
0023475103
-
3′-azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
-
St. Clair, M.H., Richards, C.A., Spector, T., Weinhold, K.J., Miller, W.H., Langlois, A.J., and Furman, P.A. (1987). 3′-azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob. Agents Chemother. 31, 1972-1977.
-
(1987)
Antimicrob. Agents Chemother.
, vol.31
, pp. 1972-1977
-
-
Clair, S.M.H.1
Richards, C.A.2
Spector, T.3
Weinhold, K.J.4
Miller, W.H.5
Langlois, A.J.6
Furman, P.A.7
-
27
-
-
0025865730
-
Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase
-
Tan, C.-K., Zhang, J., Li, Z.-Y., Tarpley, W.G., Downey, K.M., and So, A.G. (1991). Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase. Biochemistry 30, 2651-2655.
-
(1991)
Biochemistry
, vol.30
, pp. 2651-2655
-
-
Tan, C.-K.1
Zhang, J.2
Li, Z.-Y.3
Tarpley, W.G.4
Downey, K.M.5
So, A.G.6
-
28
-
-
0030987309
-
Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase
-
Tong, W., Lu, C.-D., Sharma, S.K., Matsuura, S., So, A.G., and Scott, W.A. (1997). Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase. Biochemistry 36, 5749-5757.
-
(1997)
Biochemistry
, vol.36
, pp. 5749-5757
-
-
Tong, W.1
Lu, C.-D.2
Sharma, S.K.3
Matsuura, S.4
So, A.G.5
Scott, W.A.6
-
29
-
-
0031046557
-
Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′-3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay
-
Ueno, T., and Mitsuya, H. (1997). Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2′-3′-dideoxynucleotide analogs using the single-nucleotide incorporation assay. Biochemistry 36, 1092-1099.
-
(1997)
Biochemistry
, vol.36
, pp. 1092-1099
-
-
Ueno, T.1
Mitsuya, H.2
|