-
1
-
-
0032525275
-
Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: Critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases
-
Amacker, M., and U. Hubscher. 1998. Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases. J. Mol. Biol. 278:757-765.
-
(1998)
J. Mol. Biol.
, vol.278
, pp. 757-765
-
-
Amacker, M.1
Hubscher, U.2
-
2
-
-
0026669087
-
Conformational changes of HIV reverse transcriptase subunits on formation of the heterodimer: Correlation with kcat and Km
-
Anderson, S. F., and J. E. Coleman. 1992. Conformational changes of HIV reverse transcriptase subunits on formation of the heterodimer: correlation with kcat and Km. Biochemistry 31:8221-8228.
-
(1992)
Biochemistry
, vol.31
, pp. 8221-8228
-
-
Anderson, S.F.1
Coleman, J.E.2
-
3
-
-
0028842828
-
Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation
-
Babe, L. M., J. Rose, and C. S. Craik. 1995. Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation. Proc. Natl. Acad. Sci. USA 92:10069-10073.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 10069-10073
-
-
Babe, L.M.1
Rose, J.2
Craik, C.S.3
-
4
-
-
0034771945
-
Interaction of human immunodeficiency virus type 1 Vif with Gag and Gag-Pol precursors: Co-encapsidation and interference with viral protease-mediated Gag processing
-
Bardy, M., B. Gay, S. Pebernard, N. Chazal, M. Courcoul, R. Vigne, E. Decroly, and P. Boulanger. 2001. Interaction of human immunodeficiency virus type 1 Vif with Gag and Gag-Pol precursors: co-encapsidation and interference with viral protease-mediated Gag processing. J. Gen. Virol. 82:2719-2733.
-
(2001)
J. Gen. Virol.
, vol.82
, pp. 2719-2733
-
-
Bardy, M.1
Gay, B.2
Pebernard, S.3
Chazal, N.4
Courcoul, M.5
Vigne, R.6
Decroly, E.7
Boulanger, P.8
-
5
-
-
0025044785
-
Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast
-
Bathurst, I. C., L. K. Moen, M. A. Lujan, H. L. Gibson, P. H. Feucht, S. Pichuantes, C. S. Craik, D. V. Santi, and P. J. Barr. 1990. Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast. Biochem. Biophys. Res. Commun. 171:589-595.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.171
, pp. 589-595
-
-
Bathurst, I.C.1
Moen, L.K.2
Lujan, M.A.3
Gibson, H.L.4
Feucht, P.H.5
Pichuantes, S.6
Craik, C.S.7
Santi, D.V.8
Barr, P.J.9
-
7
-
-
0031000566
-
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone
-
Borkow, G., R. S. Fletcher, J. Barnard, D. Arion, D. Motakis, G. I. Dmitrienko, and M. A. Parniak. 1997. Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)- 2-hydroxy-1-naphthaldehyde hydrazone. Biochemistry 36:3179-3185.
-
(1997)
Biochemistry
, vol.36
, pp. 3179-3185
-
-
Borkow, G.1
Fletcher, R.S.2
Barnard, J.3
Arion, D.4
Motakis, D.5
Dmitrienko, G.I.6
Parniak, M.A.7
-
8
-
-
0029815034
-
Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease
-
Bukovsky, A., and H. Gottlinger. 1996. Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease. J. Virol. 70:6820-6825.
-
(1996)
J. Virol.
, vol.70
, pp. 6820-6825
-
-
Bukovsky, A.1
Gottlinger, H.2
-
9
-
-
0026721466
-
Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease
-
Chattopadhyay, D., D. B. Evans, M. R. Deibel, Jr., A. F. Vosters, F. M. Eckenrode, H. M. Einspahr, J. O. Hui, A. G. Tomasselli, H. A. Zurcher-Neely, and R. L. Heinrikson. 1992. Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease. J. Biol. Chem. 267:14227-14232.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 14227-14232
-
-
Chattopadhyay, D.1
Evans, D.B.2
Deibel Jr., M.R.3
Vosters, A.F.4
Eckenrode, F.M.5
Einspahr, H.M.6
Hui, J.O.7
Tomasselli, A.G.8
Zurcher-Neely, H.A.9
Heinrikson, R.L.10
-
10
-
-
0033175319
-
Isolation and characterization of Rous sarcoma virus recombinant reverse transcriptase dimers
-
Chernov, A. P., A. V. Koryagin, and V. A. Ivanov. 1999. Isolation and characterization of Rous sarcoma virus recombinant reverse transcriptase dimers. Biochemistry (Moscow) 64:933-937.
-
(1999)
Biochemistry (Moscow)
, vol.64
, pp. 933-937
-
-
Chernov, A.P.1
Koryagin, A.V.2
Ivanov, V.A.3
-
11
-
-
0032553427
-
Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins
-
Cherry, E., C. Liang, L. Rong, Y. Quan, P. Inouye, X. Li, N. Morin, M. Kotler, and M. A. Wainberg. 1998. Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins. J. Mol. Biol. 284:43-56.
-
(1998)
J. Mol. Biol.
, vol.284
, pp. 43-56
-
-
Cherry, E.1
Liang, C.2
Rong, L.3
Quan, Y.4
Inouye, P.5
Li, X.6
Morin, N.7
Kotler, M.8
Wainberg, M.A.9
-
12
-
-
0032543542
-
Effect of HIV constructs containing protease-reverse transcriptase fusion proteins on viral replication
-
Cherry, E., N. Morin, and M. A. Wainberg. 1998. Effect of HIV constructs containing protease-reverse transcriptase fusion proteins on viral replication. AIDS 12:967-975.
-
(1998)
AIDS
, vol.12
, pp. 967-975
-
-
Cherry, E.1
Morin, N.2
Wainberg, M.A.3
-
13
-
-
0030027067
-
Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method
-
Chou, K. C., A. G. Tomasselli, I. M. Reardon, and R. L. Heinrikson. 1996. Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method. Proteins 24:51-72.
-
(1996)
Proteins
, vol.24
, pp. 51-72
-
-
Chou, K.C.1
Tomasselli, A.G.2
Reardon, I.M.3
Heinrikson, R.L.4
-
14
-
-
0025908083
-
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
-
Davies, J. F., Z. Hostomska, Z. Hostomsky, S. R. Jordan, and D. A. Matthews. 1991. Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science 252:88-95.
-
(1991)
Science
, vol.252
, pp. 88-95
-
-
Davies, J.F.1
Hostomska, Z.2
Hostomsky, Z.3
Jordan, S.R.4
Matthews, D.A.5
-
15
-
-
0002929101
-
A model for evolutionary change in proteins
-
M. O. Dayhoff (ed.). The National Biomedical Research Foundation, Washington, D.C.
-
Dayhoff, M. O., R. V. Eck, and C. M. Park. 1972. A model for evolutionary change in proteins, p. 89-99. In M. O. Dayhoff (ed.), Atlas of protein sequence and structure, vol. 5. The National Biomedical Research Foundation, Washington, D.C.
-
(1972)
Atlas of Protein Sequence and Structure
, vol.5
, pp. 89-99
-
-
Dayhoff, M.O.1
Eck, R.V.2
Park, C.M.3
-
16
-
-
0027179694
-
Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex
-
Engelman, A., F. D. Bushman, and R. Craigie. 1993. Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J. 12:3269-3275.
-
(1993)
EMBO J.
, vol.12
, pp. 3269-3275
-
-
Engelman, A.1
Bushman, F.D.2
Craigie, R.3
-
17
-
-
0026649557
-
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
-
Engelman, A., and R. Craigie. 1992. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J. Virol. 66:6361-6369.
-
(1992)
J. Virol.
, vol.66
, pp. 6361-6369
-
-
Engelman, A.1
Craigie, R.2
-
18
-
-
0029067367
-
The differential processing of homodimers of reverse transcriptases from human immunodeficiency viruses type 1 and 2 is a consequence of the distinct specificities of the viral proteases
-
Fan, N., K. B. Rank, J. W. Leone, R. L. Heinrikson, C. A. Bannow, C. W. Smith, D. B. Evans, S. M. Poppe, W. G. Tarpley, and D. J. Rothrock. 1995. The differential processing of homodimers of reverse transcriptases from human immunodeficiency viruses type 1 and 2 is a consequence of the distinct specificities of the viral proteases. J. Biol. Chem. 270:13573-13579.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 13573-13579
-
-
Fan, N.1
Rank, K.B.2
Leone, J.W.3
Heinrikson, R.L.4
Bannow, C.A.5
Smith, C.W.6
Evans, D.B.7
Poppe, S.M.8
Tarpley, W.G.9
Rothrock, D.J.10
-
19
-
-
0021821677
-
A molecular clone of HTLV-III with biological activity
-
Fisher, A. G., E. Collalti, L. Ratner, R. C. Gallo, and F. Wong-Staal. 1985. A molecular clone of HTLV-III with biological activity. Nature 316:262-265.
-
(1985)
Nature
, vol.316
, pp. 262-265
-
-
Fisher, A.G.1
Collalti, E.2
Ratner, L.3
Gallo, R.C.4
Wong-Staal, F.5
-
20
-
-
0030087537
-
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase
-
Fletcher, R. S., G. Holleschak, E. Nagy, D. Arion, G. Borkow, Z. Gu, M. A. Wainberg, and M. A. Parniak. 1996. Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Protein Expr. Purif. 7:27-32.
-
(1996)
Protein Expr. Purif.
, vol.7
, pp. 27-32
-
-
Fletcher, R.S.1
Holleschak, G.2
Nagy, E.3
Arion, D.4
Borkow, G.5
Gu, Z.6
Wainberg, M.A.7
Parniak, M.A.8
-
21
-
-
0015544077
-
A single subunit from avian myeloblastosis virus with both RNA-directed DNA polymerase and ribonuclease H activity
-
Grandgenett, D. P., G. F. Gerard, and M. Green. 1973. A single subunit from avian myeloblastosis virus with both RNA-directed DNA polymerase and ribonuclease H activity. Proc. Natl. Acad. Sci. USA 70:230-234.
-
(1973)
Proc. Natl. Acad. Sci. USA
, vol.70
, pp. 230-234
-
-
Grandgenett, D.P.1
Gerard, G.F.2
Green, M.3
-
22
-
-
0025278597
-
Identification of a human immunodeficiency virus-1 protease cleavage site within the 66,000 Dalton subunit of reverse transcriptase
-
Graves, M. C., M. C. Meidel, Y. C. Pan, M. Manneberg, H. W. Lahm, and F. Gruninger-Leitch 1990. Identification of a human immunodeficiency virus-1 protease cleavage site within the 66,000 Dalton subunit of reverse transcriptase. Biochem. Biophys. Res. Commun. 168:30-36.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.168
, pp. 30-36
-
-
Graves, M.C.1
Meidel, M.C.2
Pan, Y.C.3
Manneberg, M.4
Lahm, H.W.5
Gruninger-Leitch, F.6
-
23
-
-
0026721254
-
Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites
-
Griffiths, J. T., L. H. Phylip, J. Konvalinka, P. Strop, A. Gustchina, A. Wlodawer, R. J. Davenport, R. Briggs, B. M. Dunn, and J. Kay. 1992. Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites. Biochemistry 31:5193-5200.
-
(1992)
Biochemistry
, vol.31
, pp. 5193-5200
-
-
Griffiths, J.T.1
Phylip, L.H.2
Konvalinka, J.3
Strop, P.4
Gustchina, A.5
Wlodawer, A.6
Davenport, R.J.7
Briggs, R.8
Dunn, B.M.9
Kay, J.10
-
24
-
-
0023673620
-
Identification and characterization of HIV-specific RNase H by monoclonal antibody
-
Hansen, J., T. Schulze, W. Mellert, and K. Moelling. 1988. Identification and characterization of HIV-specific RNase H by monoclonal antibody. EMBO J. 7:239-243.
-
(1988)
EMBO J.
, vol.7
, pp. 239-243
-
-
Hansen, J.1
Schulze, T.2
Mellert, W.3
Moelling, K.4
-
25
-
-
0024830949
-
Proteolytic processing of polyproteins in the replication of RNA viruses
-
Hellen, C. U., H. G. Krausslich, and E. Wimmer. 1989. Proteolytic processing of polyproteins in the replication of RNA viruses. Biochemistry 28:9881-9890.
-
(1989)
Biochemistry
, vol.28
, pp. 9881-9890
-
-
Hellen, C.U.1
Krausslich, H.G.2
Wimmer, E.3
-
26
-
-
0017331644
-
RNA-dependent DNA polymerase of avian sarcoma virus B77. I. Isolation and partial characterization of the alpha, beta2, and alphabeta forms of the enzyme
-
Hizi, A., and W. K. Joklik. 1977. RNA-dependent DNA polymerase of avian sarcoma virus B77. I. Isolation and partial characterization of the alpha, beta2, and alphabeta forms of the enzyme. J. Biol. Chem. 252:2281-2289.
-
(1977)
J. Biol. Chem.
, vol.252
, pp. 2281-2289
-
-
Hizi, A.1
Joklik, W.K.2
-
27
-
-
0026315440
-
Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase
-
Hostomska, Z., D. A. Matthews, J. F. Davies, B. R. Nodes, and Z. Hostomsky. 1991. Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase. J. Biol. Chem. 266:14697-14702.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14697-14702
-
-
Hostomska, Z.1
Matthews, D.A.2
Davies, J.F.3
Nodes, B.R.4
Hostomsky, Z.5
-
28
-
-
0028144429
-
Strand displacement activity of the human immunodeficiency virus type 1 reverse transcriptase heterodimer and its individual subunits
-
Hottiger, M., V. N. Podust, R. L. Thimmig, C. McHenry, and U. Hubscher. 1994. Strand displacement activity of the human immunodeficiency virus type 1 reverse transcriptase heterodimer and its individual subunits. J. Biol. Chem. 269:986-991.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 986-991
-
-
Hottiger, M.1
Podust, V.N.2
Thimmig, R.L.3
McHenry, C.4
Hubscher, U.5
-
29
-
-
0022484140
-
Murine leukemia virus pol gene products: Analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Eschenchia coli
-
Hu, S. C., D. L. Court, M. Zweig, and J. G. Levin. 1986. Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Eschenchia coli. J. Virol. 60:267-274.
-
(1986)
J. Virol.
, vol.60
, pp. 267-274
-
-
Hu, S.C.1
Court, D.L.2
Zweig, M.3
Levin, J.G.4
-
30
-
-
0029980485
-
A soluble active mutant of HIV-1 integrase: Involvement of both the core and carboxyl-terminal domains in multimerization
-
Jenkins, T. M., A. Engelman, R. Ghirlando, and R. Craigie. 1996. A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization. J. Biol. Chem. 271:7712-7718.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7712-7718
-
-
Jenkins, T.M.1
Engelman, A.2
Ghirlando, R.3
Craigie, R.4
-
31
-
-
0026665238
-
Retroviral integrase functions as a multimer and can turn over catalytically
-
Jones, K. S., J. Coleman, G. W. Merkel, T. M. Laue, and A. M. Skalka. 1992. Retroviral integrase functions as a multimer and can turn over catalytically. J. Biol. Chem. 267:16037-16040.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 16037-16040
-
-
Jones, K.S.1
Coleman, J.2
Merkel, G.W.3
Laue, T.M.4
Skalka, A.M.5
-
32
-
-
0034990535
-
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase
-
Julias, J. G., A. L. Ferris, P. L. Boyer, and S. H. Hughes. 2001. Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase. J. Virol. 75:6537-6546.
-
(2001)
J. Virol.
, vol.75
, pp. 6537-6546
-
-
Julias, J.G.1
Ferris, A.L.2
Boyer, P.L.3
Hughes, S.H.4
-
33
-
-
0025922096
-
Mutating P2 and P1 residues at cleavage junctions in the HIV-1 pol polyprotein. Effects on hydrolysis by HIV-1 proteinase
-
Jupp, R. A., L. H. Phylip, J. S. Mills, S. F. Le Grice, and J. Kay. 1991. Mutating P2 and P1 residues at cleavage junctions in the HIV-1 pol polyprotein. Effects on hydrolysis by HIV-1 proteinase. FEBS Lett. 283:180-184.
-
(1991)
FEBS Lett.
, vol.283
, pp. 180-184
-
-
Jupp, R.A.1
Phylip, L.H.2
Mills, J.S.3
Le Grice, S.F.4
Kay, J.5
-
34
-
-
0027932364
-
The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency
-
Kaplan, A. H., M. Manchester, and R. Swanstrom. 1994. The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency. J. Virol. 68:6782-6786.
-
(1994)
J. Virol.
, vol.68
, pp. 6782-6786
-
-
Kaplan, A.H.1
Manchester, M.2
Swanstrom, R.3
-
35
-
-
0026562720
-
Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene
-
Kimpton, J., and M. Emerman. 1992. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene. J. Virol. 66:2232-2239.
-
(1992)
J. Virol.
, vol.66
, pp. 2232-2239
-
-
Kimpton, J.1
Emerman, M.2
-
36
-
-
0028793647
-
Molecular biological characterization of the human foamy virus reverse transcriptase and ribonuclease H domains
-
Kogel, D., M. Aboud, and R. M. Flugel. 1995. Molecular biological characterization of the human foamy virus reverse transcriptase and ribonuclease H domains. Virology 213:97-108.
-
(1995)
Virology
, vol.213
, pp. 97-108
-
-
Kogel, D.1
Aboud, M.2
Flugel, R.M.3
-
37
-
-
0026693137
-
Crystal structure at 3.5 a resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt, L. A., J. Wang, J. M. Friedman, P. A. Rice, and T. A. Steitz. 1992. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-1790.
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
38
-
-
0026757343
-
Human immunodeficiency virus type 1 gag-protease fusion proteins are enzymatically active
-
Kotler, M., G. Arad, and S. H. Hughes. 1992. Human immunodeficiency virus type 1 gag-protease fusion proteins are enzymatically active. J. Virol. 66:6781-6783.
-
(1992)
J. Virol.
, vol.66
, pp. 6781-6783
-
-
Kotler, M.1
Arad, G.2
Hughes, S.H.3
-
39
-
-
0024063076
-
Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation
-
Le Grice, S. F., J. Mills, and J. Mous. 1988. Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation. EMBO J. 7:2547-2553.
-
(1988)
EMBO J.
, vol.7
, pp. 2547-2553
-
-
Le Grice, S.F.1
Mills, J.2
Mous, J.3
-
40
-
-
0026070438
-
Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase
-
Le Grice, S. F., T. Naas, B. Wohlgensinger, and O. Schatz. 1991. Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase. EMBO J. 10:3905-3911.
-
(1991)
EMBO J.
, vol.10
, pp. 3905-3911
-
-
Le Grice, S.F.1
Naas, T.2
Wohlgensinger, B.3
Schatz, O.4
-
41
-
-
0023807396
-
Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli
-
Leuthardt, A., and S. F. Le Grice. 1988. Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli. Gene 68:35-42.
-
(1988)
Gene
, vol.68
, pp. 35-42
-
-
Leuthardt, A.1
Le Grice, S.F.2
-
42
-
-
0027461280
-
Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase
-
Li, X., E. Amandoron, M. A. Wainberg, and M. A. Parniak. 1993. Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase. J. Med. Virol. 39:251-259.
-
(1993)
J. Med. Virol.
, vol.39
, pp. 251-259
-
-
Li, X.1
Amandoron, E.2
Wainberg, M.A.3
Parniak, M.A.4
-
43
-
-
0029417217
-
In vivo processing of Pi160gag-pol from human immunodeficiency virus type 1 (HIV) in acutely infected, cultured human T-lymphocytes
-
Lindhofer, H., K. von der Helm, and H. Nitschko. 1995. In vivo processing of Pi160gag-pol from human immunodeficiency virus type 1 (HIV) in acutely infected, cultured human T-lymphocytes. Virology 214:624-627.
-
(1995)
Virology
, vol.214
, pp. 624-627
-
-
Lindhofer, H.1
Von Der Helm, K.2
Nitschko, H.3
-
44
-
-
0024590979
-
Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases
-
Loeb, D. D., C. A. Hutchison III, M. H. Edgell, W. G. Farmerie, and R. Swanstrom. 1989. Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases. J. Virol. 63:111-121.
-
(1989)
J. Virol.
, vol.63
, pp. 111-121
-
-
Loeb, D.D.1
Hutchison III, C.A.2
Edgell, M.H.3
Farmerie, W.G.4
Swanstrom, R.5
-
45
-
-
0027936212
-
Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein
-
Louis, J. M., N. T. Nashed, K. D. Parris, A. R. Kimmel, and D. M. Jerina. 1994. Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein. Proc. Natl. Acad. Sci. USA 91:7970-7974.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7970-7974
-
-
Louis, J.M.1
Nashed, N.T.2
Parris, K.D.3
Kimmel, A.R.4
Jerina, D.M.5
-
46
-
-
0024231976
-
HIV-1 reverse transcriptase: Crystallization and analysis of domain structure by limited proteolysis
-
Lowe, D. M., A. Aitken, C. Bradley, G. K. Darby, B. A. Larder, K. L. Powell, D. J. Purifoy, M. Tisdale, and D. K. Stammers. 1988. HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis. Biochemistry 27:8884-8889.
-
(1988)
Biochemistry
, vol.27
, pp. 8884-8889
-
-
Lowe, D.M.1
Aitken, A.2
Bradley, C.3
Darby, G.K.4
Larder, B.A.5
Powell, K.L.6
Purifoy, D.J.7
Tisdale, M.8
Stammers, D.K.9
-
47
-
-
0030880581
-
HIV protease substrate conformation: Modulation by cyclophilin a
-
McCornack, M. A., L. T. Kakalis, C. Caserta, R. E. Handschumacher, and I. M. Armitage. 1997. HIV protease substrate conformation: modulation by cyclophilin A. FEBS Lett. 414:84-88.
-
(1997)
FEBS Lett.
, vol.414
, pp. 84-88
-
-
McCornack, M.A.1
Kakalis, L.T.2
Caserta, C.3
Handschumacher, R.E.4
Armitage, I.M.5
-
48
-
-
0032540238
-
An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukemia virus RT exists as a monomer. 3
-
Misra, H. S., P. K. Pandey, and V. N. Pandey. 1998. An enzymatically active chimeric HIV-1 reverse transcriptase (RT) with the RNase-H domain of murine leukemia virus RT exists as a monomer. 3. Biol. Chem. 273:9785-9789.
-
(1998)
Biol. Chem.
, vol.273
, pp. 9785-9789
-
-
Misra, H.S.1
Pandey, P.K.2
Pandey, V.N.3
-
49
-
-
0025093302
-
Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptase
-
Mizrahi, V., M. T. Usdin, A. Harington, and L. R. Dudding. 1990. Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptase. Nucleic Acids Res. 18:5359-5363.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 5359-5363
-
-
Mizrahi, V.1
Usdin, M.T.2
Harington, A.3
Dudding, L.R.4
-
50
-
-
0033576276
-
The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase
-
Morris, M. C., C. Berducou, J. Mery, F. Heitz, and G. Divita. 1999. The thumb domain of the P51-subunit is essential for activation of HIV reverse transcriptase. Biochemistry 38:15097-15103.
-
(1999)
Biochemistry
, vol.38
, pp. 15097-15103
-
-
Morris, M.C.1
Berducou, C.2
Mery, J.3
Heitz, F.4
Divita, G.5
-
51
-
-
0036095739
-
A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors
-
Motakis, D., and M. A. Parniak. 2002. A tight-binding mode of inhibition is essential for anti-human immunodeficiency virus type 1 virucidal activity of nonnucleoside reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 46:1851-1856.
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 1851-1856
-
-
Motakis, D.1
Parniak, M.A.2
-
52
-
-
0016823421
-
Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay
-
Panet, A., D. Baltimore, and T. Hanafusa. 1975. Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay. J. Virol. 16:146-152.
-
(1975)
J. Virol.
, vol.16
, pp. 146-152
-
-
Panet, A.1
Baltimore, D.2
Hanafusa, T.3
-
53
-
-
0018145096
-
A competition immunoassay for characterizing the reverse transcriptase of mammalian RNA tumor viruses
-
Panet, A., and Z. Kra-Oz. 1978. A competition immunoassay for characterizing the reverse transcriptase of mammalian RNA tumor viruses. Virology 89:95-101.
-
(1978)
Virology
, vol.89
, pp. 95-101
-
-
Panet, A.1
Kra-Oz, Z.2
-
54
-
-
0025286146
-
Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase
-
Partin, K., H. G. Krausslich, L. Ehrlich, E. Wimmer, and C. Carter. 1990. Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase. J. Virol. 64:3938-3947.
-
(1990)
J. Virol.
, vol.64
, pp. 3938-3947
-
-
Partin, K.1
Krausslich, H.G.2
Ehrlich, L.3
Wimmer, E.4
Carter, C.5
-
55
-
-
0023646642
-
Sequence specificity of retroviral proteases
-
Pearl, L. H., and W. R. Taylor. 1987. Sequence specificity of retroviral proteases. Nature 328:482.
-
(1987)
Nature
, vol.328
, pp. 482
-
-
Pearl, L.H.1
Taylor, W.R.2
-
56
-
-
3543142335
-
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism
-
Pettit, S. C., L. E. Everitt, S. Choudhury, B. M. Dunn, and A. H. Kaplan. 2004. Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism. J. Virol. 78:8477-8485.
-
(2004)
J. Virol.
, vol.78
, pp. 8477-8485
-
-
Pettit, S.C.1
Everitt, L.E.2
Choudhury, S.3
Dunn, B.M.4
Kaplan, A.H.5
-
57
-
-
0037213627
-
The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage
-
Pettit, S. C., S. Gulnik, L. Everitt, and A. H. Kaplan. 2003. The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage. J. Virol. 77:366-374.
-
(2003)
J. Virol.
, vol.77
, pp. 366-374
-
-
Pettit, S.C.1
Gulnik, S.2
Everitt, L.3
Kaplan, A.H.4
-
58
-
-
0026316549
-
Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid
-
Pettit, S. C., J. Simsic, D. D. Loeb, L. Everitt, C. A. Hutchison III, and R. Swanstrom. 1991. Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid. J. Biol. Chem. 266:14539-14547.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14539-14547
-
-
Pettit, S.C.1
Simsic, J.2
Loeb, D.D.3
Everitt, L.4
Hutchison III, C.A.5
Swanstrom, R.6
-
59
-
-
0031816127
-
Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease
-
Pfrepper, K.-I., H.-R. Rackwitz, M. Schnölzer, H. Heid, M. Löchelt, and R. M. Flügel. 1998. Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease. J. Virol. 72:7648-7652.
-
(1998)
J. Virol.
, vol.72
, pp. 7648-7652
-
-
Pfrepper, K.-I.1
Rackwitz, H.-R.2
Schnölzer, M.3
Heid, H.4
Löchelt, M.5
Flügel, R.M.6
-
60
-
-
0034283345
-
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
-
Prabu-Jeyabalan, M., E. Nalivaika, and C. A. Schiffer. 2000. How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease. J. Mol. Biol. 301:1207-1220.
-
(2000)
J. Mol. Biol.
, vol.301
, pp. 1207-1220
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
61
-
-
0036121219
-
Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
-
Prabu-Jeyabalan, M., E. Nalivaika, and C. A. Schiffer. 2002. Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. Structure (Cambridge) 10:369-381.
-
(2002)
Structure (Cambridge)
, vol.10
, pp. 369-381
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
62
-
-
0029978462
-
Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation
-
Quillent, C., A. M. Borman, S. Paulous, C. Dauguet, and F. Clavel. 1996. Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation. Virology 219:29-36.
-
(1996)
Virology
, vol.219
, pp. 29-36
-
-
Quillent, C.1
Borman, A.M.2
Paulous, S.3
Dauguet, C.4
Clavel, F.5
-
63
-
-
33745158157
-
A simple method of estimating fifty per cent endpoints
-
Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 27:493-497.
-
(1938)
Am. J. Hyg.
, vol.27
, pp. 493-497
-
-
Reed, L.J.1
Muench, H.2
-
64
-
-
0025297454
-
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention
-
Restle, T., B. Muller, and R. S. Goody. 1990. Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention. J. Biol. Chem. 265:8986-8988.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 8986-8988
-
-
Restle, T.1
Muller, B.2
Goody, R.S.3
-
65
-
-
0029939026
-
Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites
-
Ridky, T. W., C. E. Cameron, J. Cameron, J. Leis, T. Copeland, A. Wlodawer, I. T. Weber, and R. W. Harrison. 1996. Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites. J. Biol. Chem. 271:4709-4717.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4709-4717
-
-
Ridky, T.W.1
Cameron, C.E.2
Cameron, J.3
Leis, J.4
Copeland, T.5
Wlodawer, A.6
Weber, I.T.7
Harrison, R.W.8
-
66
-
-
0028220377
-
Human immunodeficiency virus type 1 (HIV-1) recombinant reverse transcriptase. Asymmetry in p66 subunits of the p66/p66 homodimer
-
Sharma, S. K., N. Fan, and D. B. Evans. 1994. Human immunodeficiency virus type 1 (HIV-1) recombinant reverse transcriptase. Asymmetry in p66 subunits of the p66/p66 homodimer. FEBS Lett. 343:125-130.
-
(1994)
FEBS Lett.
, vol.343
, pp. 125-130
-
-
Sharma, S.K.1
Fan, N.2
Evans, D.B.3
-
67
-
-
2942620594
-
Proteolytic processing of an HIV-1 pol polyprotein precursor: Insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation
-
Sluis-Cremer, N., D. Arion, M. E. Abram, and M. A. Parniak. 2004. Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. Int. J. Biochem. Cell Biol. 36:1836-1847.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 1836-1847
-
-
Sluis-Cremer, N.1
Arion, D.2
Abram, M.E.3
Parniak, M.A.4
-
68
-
-
6744266646
-
Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors
-
Speck, R. R., C. Flexner, C. J. Tian, and X. F. Yu. 2000. Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors. Antimicrob. Agents Chemother. 44:1397-1403.
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 1397-1403
-
-
Speck, R.R.1
Flexner, C.2
Tian, C.J.3
Yu, X.F.4
-
69
-
-
0015962730
-
Structural studies of avian myeloblastosis virus: Comparison of polypeptides in virion and core component by dodecyl sulfate-polyacrylamide gel electrophoresis
-
Stromberg, K., N. E. Hurley, N. L. Davis, R. R. Rueckert, and E. Fleissner. 1974. Structural studies of avian myeloblastosis virus: comparison of polypeptides in virion and core component by dodecyl sulfate-polyacrylamide gel electrophoresis. J. Virol. 13:513-528.
-
(1974)
J. Virol.
, vol.13
, pp. 513-528
-
-
Stromberg, K.1
Hurley, N.E.2
Davis, N.L.3
Rueckert, R.R.4
Fleissner, E.5
-
70
-
-
0023788116
-
Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: Role of the C terminus in antibody reactivity and enzyme function
-
Tisdale, M., P. Ertl, B. A. Larder, D. J. Purifoy, G. Darby, and K. L. Powell. 1988. Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C terminus in antibody reactivity and enzyme function. J. Virol. 62:3662-3667.
-
(1988)
J. Virol.
, vol.62
, pp. 3662-3667
-
-
Tisdale, M.1
Ertl, P.2
Larder, B.A.3
Purifoy, D.J.4
Darby, G.5
Powell, K.L.6
-
71
-
-
0027524696
-
Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease
-
Tomasselli, A. G., J. L. Sarcich, L. J. Barrett, I. M. Reardon, W. J. Howe, D. B. Evans, S. K. Sharma, and R. L. Heinrikson. 1993. Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease. Protein Sci. 2:2167-2176.
-
(1993)
Protein Sci.
, vol.2
, pp. 2167-2176
-
-
Tomasselli, A.G.1
Sarcich, J.L.2
Barrett, L.J.3
Reardon, I.M.4
Howe, W.J.5
Evans, D.B.6
Sharma, S.K.7
Heinrikson, R.L.8
-
72
-
-
1842407760
-
Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity
-
Tozser, J., P. Bagossi, I. T. Weber, J. M. Louis, T. D. Copeland, and S. Oroszlan. 1997. Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity. J. Biol. Chem. 272:16807-16814.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16807-16814
-
-
Tozser, J.1
Bagossi, P.2
Weber, I.T.3
Louis, J.M.4
Copeland, T.D.5
Oroszlan, S.6
-
73
-
-
0037530288
-
Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis
-
Tozser, J., S. Shulenin, J. Kadas, P. Boross, P. Bagossi, T. D. Copeland, B. C. Nair, M. G. Sarngadharan, and S. Oroszlan. 2003. Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis. Virology 310:16-23.
-
(2003)
Virology
, vol.310
, pp. 16-23
-
-
Tozser, J.1
Shulenin, S.2
Kadas, J.3
Boross, P.4
Bagossi, P.5
Copeland, T.D.6
Nair, B.C.7
Sarngadharan, M.G.8
Oroszlan, S.9
-
74
-
-
0020056250
-
Reverse transcriptase associated with avian sarcoma-leukosis viruses. I. Comparison of intra-virion content of multiple enzyme forms
-
Ueno, A., A. Ishihama, and K. Toyoshima. 1982. Reverse transcriptase associated with avian sarcoma-leukosis viruses. I. Comparison of intra-virion content of multiple enzyme forms. J. Biochem. (Tokyo) 91:311-322.
-
(1982)
J. Biochem. (Tokyo)
, vol.91
, pp. 311-322
-
-
Ueno, A.1
Ishihama, A.2
Toyoshima, K.3
-
75
-
-
0030419901
-
Proteolytic processing and particle maturation
-
Vogt, V. M. 1996. Proteolytic processing and particle maturation. Curr. Top. Microbiol. Immunol. 214:95-131.
-
(1996)
Curr. Top. Microbiol. Immunol.
, vol.214
, pp. 95-131
-
-
Vogt, V.M.1
-
76
-
-
0028360742
-
Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer
-
Wang, J., S. J. Smerdon, J. Jager, L. A. Kohlstaedt, P. A. Rice, J. M. Friedman, and T. A. Steitz. 1994. Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc. Natl. Acad. Sci. USA 91:7242-7246.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7242-7246
-
-
Wang, J.1
Smerdon, S.J.2
Jager, J.3
Kohlstaedt, L.A.4
Rice, P.A.5
Friedman, J.M.6
Steitz, T.A.7
-
77
-
-
0033867168
-
Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active
-
Werner, S., and B. M. Wohrl. 2000. Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active. Eur. J. Biochem. 267:4740-4744.
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 4740-4744
-
-
Werner, S.1
Wohrl, B.M.2
-
78
-
-
0029013602
-
Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing
-
Zybarth, G., and C. Carter. 1995. Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing. J. Virol. 69:3878-3884.
-
(1995)
J. Virol.
, vol.69
, pp. 3878-3884
-
-
Zybarth, G.1
Carter, C.2
-
79
-
-
0027957918
-
Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain
-
Zybarth, G., H. G. Krausslich, K. Partin, and C. Carter. 1994. Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain. J. Virol. 68:240-250.
-
(1994)
J. Virol.
, vol.68
, pp. 240-250
-
-
Zybarth, G.1
Krausslich, H.G.2
Partin, K.3
Carter, C.4
|