Integrase inhibitors and cellular immunity suppress retrovir replication in rhesus macaques

Science

Volumn 305, Issue 5683, 2004, Pages 528-532

  Hazuda, Daria J ^a   Young, Steven D ^a   Guare, James P ^a   Anthony, Neville J ^a   Gomez, Robert P ^a   Wai, John S ^a   Vacca, Joseph P ^a   Handt, Larry ^a   Motzel, Sherri L ^a   Klein, Hilton J ^a   Dornadula, Geethanjali ^a   Danovich, Robert M ^a   Witmer, Marc V ^a   Wilson, Keith A A ^a   Tussey, Lynda ^a   Schleif, William A ^a   Gabryelski, Lori S ^a   Jin, Lixia ^a   Miller, Michael D ^a   Casimiro, Danilo R ^a   Emini, Emilio A ^a   Shiver, John W ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; CELLS; CHEMOTHERAPY; DIAGNOSIS; DISEASES; GROWTH KINETICS; HEALTH CARE; VIRUSES;

CELLULAR IMMUNITY; INFECTION; RETROVIRAL INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS (SHIV);

ENZYME INHIBITION;

CD4 ANTIGEN; INTEGRASE INHIBITOR; L 870812; UNCLASSIFIED DRUG;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELLULAR IMMUNITY; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFICACY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; LYMPHOCYTE DEPLETION; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; RETROVIRUS INFECTION; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIREMIA; VIRUS LOAD; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DRUG RESISTANCE, VIRAL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; IMMUNITY, CELLULAR; INTEGRASE INHIBITORS; INTEGRASES; LEUKOCYTES, MONONUCLEAR; MACACA MULATTA; MUTATION; NAPHTHYRIDINES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL LOAD; VIREMIA; VIRUS REPLICATION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; MACACA MULATTA; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 3242769788     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098632     Document Type: Article

References (20)

1. S. J. Little et al., N. Engl. J. Med. 347, 385 (2002).
2. F. J. Palella Jr. et al., N. Engl. J. Med. 338, 853 (1998).
3. G. M. Lucas, R. E. Chaisson, R. D. Moore, Ann. Intern. Med. 131, 81 (1999).
4. S. Yerly et al., Lancet 354, 729 (1999).
5. M. R. Furtado et al., N. Engl. J. Med. 340, 1614 (1999).
6. M. Hogberg, I. Morrison, Exp. Opin. Ther. Patents 10, 1189 (2000).
7. H. Jonckheere, J. Anne, E. De Clercq, Med. Res. Rev. 20, 129 (2000).
8. F. Lebon, M. Ledecq, Curr. Med. Chem. 7, 455 (2000).
9. D. Esposito, R. Craigie, Adv. Virus Res. 52, 319 (1999).
10. E. Asante-Appiah, A. M. Skalka, Adv. Virus Res. 52, 351 (1999).
11. D. J. Hazuda et al., Science 287, 646 (2000).
12. N. J. Anthony et al., in PCT Patent Appl. WO 0230931-A2 (2002).
13. K. A. Reimann et al., J. Virol. 70, 6922 (1996).
14. D. J. Hazuda et al., unpublished results.
15. V. Fikkert et al., J. Virol. 77, 11459 (2003).
16. R. E. Chaisson, J. C. Keruly, R. D. Moore, J. Am. Med. Assoc. 284, 3128 (2000).
17. M. Egger et al., Lancet 360, 119 (2002).
18. Materials and methods are available as supporting material on Science Online.
19. C. A. Heid, J. Stevens, K. J. Livak, P. M. Williams, Genome Res. 6, 986 (1996).
20. We appreciate the technical support of P. Felock, K. Stillmock, A. Carella, G. Moyer, R. Newton, P. Sczerba, P. Reebeck, M. Washington, and K. Wright.