-
1
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
1. Esnouf, R., Ren, J., Ross, R., Jones, Y., Stammers, D. & Stuart, D. (1995). Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nat. Struct. Biol. 2, 303-308.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, R.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
2
-
-
0028842293
-
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
-
2. Rodgers, D.W., et al., & Harrison, S.C. (1995). The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc. Natl Acad. Sci. USA 92, 1222-1226.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 1222-1226
-
-
Rodgers, D.W.1
Harrison, S.C.2
-
3
-
-
0030586090
-
Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution: Implications of conformational changes for polymerization and inhibition mechanisms
-
3. Hsiou, Y., Ding, J., Das, K., Clark, A.D., Jr., Hughes, S.H. & Arnold, E. (1996). Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure 4, 853-860.
-
(1996)
Structure
, vol.4
, pp. 853-860
-
-
Hsiou, Y.1
Ding, J.2
Das, K.3
Clark A.D., Jr.4
Hughes, S.H.5
Arnold, E.6
-
4
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA
-
4. Jacobo-Molina, A., et al., & Arnold, E. (1993). Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA. Proc. Natl Acad. Sci. USA 90, 6320-6324.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Arnold, E.2
-
5
-
-
0002674039
-
A review of HIV-1 RT structural studies and implications for drug design
-
(P. Veerapandian, ed), Marcel Dekker, Inc., New York
-
5. Ding, J., et al., & Arnold, E. (1997). A review of HIV-1 RT structural studies and implications for drug design. In Structure Based Drug Design. (P. Veerapandian, ed), pp. 41 -82, Marcel Dekker, Inc., New York.
-
(1997)
Structure Based Drug Design
, pp. 41-82
-
-
Ding, J.1
Arnold, E.2
-
6
-
-
0030930760
-
Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: Evidence for induced fit mechanism
-
6. Sawaya, M.R., Prasad, R., Wilson, S., Kraut, J. & Pelletier, H. (1997). Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for induced fit mechanism. Biochemistry 36, 11205-11215.
-
(1997)
Biochemistry
, vol.36
, pp. 11205-11215
-
-
Sawaya, M.R.1
Prasad, R.2
Wilson, S.3
Kraut, J.4
Pelletier, H.5
-
7
-
-
0028049441
-
Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP
-
7. Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H. & Kraut, J. (1994). Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science 264, 1891-1903.
-
(1994)
Science
, vol.264
, pp. 1891-1903
-
-
Pelletier, H.1
Sawaya, M.R.2
Kumar, A.3
Wilson, S.H.4
Kraut, J.5
-
8
-
-
0032518398
-
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
-
8. Doublie, S., Tabor, S., Long, A.M., Richardson, C.C. & Ellenberger, T. (1998). Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution. Nature 391, 251-258.
-
(1998)
Nature
, vol.391
, pp. 251-258
-
-
Doublie, S.1
Tabor, S.2
Long, A.M.3
Richardson, C.C.4
Ellenberger, T.5
-
9
-
-
0032535528
-
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase: Structural basis for nucleotide incorporation
-
9. Li, Y., Korolev, S. & Waksman, G. (1998). Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase: structural basis for nucleotide incorporation. EMBO J. 17, 7514-7525.
-
(1998)
EMBO J.
, vol.17
, pp. 7514-7525
-
-
Li, Y.1
Korolev, S.2
Waksman, G.3
-
10
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
10. Huang, H., Chopra, R., Verdine, G.L. & Harrison, S.C. (1998). Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282, 1669-1675.
-
(1998)
Science
, vol.282
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
11
-
-
0031039885
-
A minor groove binding track in reverse transcriptase
-
11. Bebenek, K., et al., & Kunkel, T.A. (1997). A minor groove binding track in reverse transcriptase. Nat. Struct. Biol. 4, 194-197.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 194-197
-
-
Bebenek, K.1
Kunkel, T.A.2
-
12
-
-
0032509101
-
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with double-stranded DNA and an antibody Fab fragment at 2.8 Å resolution
-
12. Ding, J., et al., & Arnold, E. (1998). Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with double-stranded DNA and an antibody Fab fragment at 2.8 Å resolution. J. Mol. Biol. 284, 1095-1111.
-
(1998)
J. Mol. Biol.
, vol.284
, pp. 1095-1111
-
-
Ding, J.1
Arnold, E.2
-
13
-
-
0030592095
-
Structure of Taq polymerase with DNA at the polymerase active site
-
13. Eom, S.H., Wang, J. & Steitz, T.A. (1996). Structure of Taq polymerase with DNA at the polymerase active site. Nature 382, 278-281.
-
(1996)
Nature
, vol.382
, pp. 278-281
-
-
Eom, S.H.1
Wang, J.2
Steitz, T.A.3
-
14
-
-
0029817866
-
Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity and fidelity
-
14. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H. & Kraut, J. (1996). Crystal structures of human DNA polymerase β complexed with DNA: implications for catalytic mechanism, processivity and fidelity. Biochemistry 35, 12742-12761.
-
(1996)
Biochemistry
, vol.35
, pp. 12742-12761
-
-
Pelletier, H.1
Sawaya, M.R.2
Wolfle, W.3
Wilson, S.H.4
Kraut, J.5
-
15
-
-
0030786006
-
Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer
-
15. Ding, J., Hughes, S.H. & Arnold, E. (1997). Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer. Biopolymers 44, 125-138.
-
(1997)
Biopolymers
, vol.44
, pp. 125-138
-
-
Ding, J.1
Hughes, S.H.2
Arnold, E.3
-
16
-
-
0032518524
-
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
-
16. Kiefer, J.R., Mao, C., Braman, J.C. & Beese, L.S. (1998). Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature 391, 304-307.
-
(1998)
Nature
, vol.391
, pp. 304-307
-
-
Kiefer, J.R.1
Mao, C.2
Braman, J.C.3
Beese, L.S.4
-
17
-
-
0028341306
-
The sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not
-
17. Boyer, P.L., et al., & Hughes, S.H. (1994). The sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Proc. Natl Acad. Sci. USA 91, 4882-4886.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 4882-4886
-
-
Boyer, P.L.1
Hughes, S.H.2
-
18
-
-
0027231782
-
Structure of DNA polymerase I Klenow fragment bound to duplex DNA
-
18. Beese, L.S., Derbyshire, V. & Steitz, T.A. (1993). Structure of DNA polymerase I Klenow fragment bound to duplex DNA. Science 260, 352-355.
-
(1993)
Science
, vol.260
, pp. 352-355
-
-
Beese, L.S.1
Derbyshire, V.2
Steitz, T.A.3
-
19
-
-
0029112612
-
Site-directed mutagenesis of Arg72 of HIV-1 reverse transcriptase
-
19. Sarafianos, S.G., Pandey, V.N., Kaushik, N. & Modak, M.J. (1995). Site-directed mutagenesis of Arg72 of HIV-1 reverse transcriptase. J. Biol. Chem. 270, 19279-19735.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19279-19735
-
-
Sarafianos, S.G.1
Pandey, V.N.2
Kaushik, N.3
Modak, M.J.4
-
20
-
-
0032509209
-
Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase
-
20. Harris, D., Kaushik, N., Pandey, P.K., Yadav, P.N.S. & Pandey, V.N. (1998). Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase. J. Biol. Chem. 273, 33624-33634.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33624-33634
-
-
Harris, D.1
Kaushik, N.2
Pandey, P.K.3
Yadav, P.N.S.4
Pandey, V.N.5
-
21
-
-
0029894752
-
Significance of O helix residues of E, coli pol I in DNA synthesis: Dynamics of dNTP binding pocket
-
21. Kaushik, N., Pandey, V.N. & Modak, M.J. (1996). Significance of O helix residues of E, coli pol I in DNA synthesis: Dynamics of dNTP binding pocket. Biochemistry 35, 7256-7266.
-
(1996)
Biochemistry
, vol.35
, pp. 7256-7266
-
-
Kaushik, N.1
Pandey, V.N.2
Modak, M.J.3
-
22
-
-
0026019625
-
Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: A two-metal-ion mechanism
-
22. Beese, L.S. & Steitz, T.A. (1991 ). Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two-metal-ion mechanism. EMBO J. 10, 25-33.
-
(1991)
EMBO J.
, vol.10
, pp. 25-33
-
-
Beese, L.S.1
Steitz, T.A.2
-
23
-
-
0020473266
-
Does the Mg (II) ion interact with the alpha phosphate of adenosine triphosphate? an investigation by oxygen-17 nuclear magnetic resonance
-
23. Huang, S.L. & Tsai, M.D. (1982). Does the Mg (II) ion interact with the alpha phosphate of adenosine triphosphate? An investigation by oxygen-17 nuclear magnetic resonance. Biochemistry 21, 951 -959.
-
(1982)
Biochemistry
, vol.21
, pp. 951-959
-
-
Huang, S.L.1
Tsai, M.D.2
-
24
-
-
0026612278
-
31P NMR of Mg-ATP in dilute solutions, complexation and exchange
-
31P NMR of Mg-ATP in dilute solutions, complexation and exchange. Int. J. Biochem. 24, 1533-1559.
-
(1992)
Int. J. Biochem.
, vol.24
, pp. 1533-1559
-
-
Glonek, T.1
-
25
-
-
0028206048
-
Function and structure relationships in DNA polymerases
-
25. Joyce, C.M. & Steitz, T.A. (1994). Function and structure relationships in DNA polymerases. Ann. Rev. Biochem. 63, 777-822.
-
(1994)
Ann. Rev. Biochem.
, vol.63
, pp. 777-822
-
-
Joyce, C.M.1
Steitz, T.A.2
-
26
-
-
0029052967
-
Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase
-
26. Patel, P.H., et al., & Arnold, E. (1995). Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase. Biochemistry 34, 5351-5363.
-
(1995)
Biochemistry
, vol.34
, pp. 5351-5363
-
-
Patel, P.H.1
Arnold, E.2
-
27
-
-
0023251351
-
Site-specific mutagenesis of AIDS virus reverse transcriptase
-
27. Larder, B.A., Purifoy, D.J.M., Powell, K.L. & Darby, G. (1987). Site-specific mutagenesis of AIDS virus reverse transcriptase. Nature 327, 716-717.
-
(1987)
Nature
, vol.327
, pp. 716-717
-
-
Larder, B.A.1
Purifoy, D.J.M.2
Powell, K.L.3
Darby, G.4
-
28
-
-
0026496655
-
Mutational analysis of the fingers domain of human immunodeficiency virus type-1 reverse transcriptase
-
28. Boyer, P.L., Ferris, A.L. & Hughes, S.H. (1992). Mutational analysis of the fingers domain of human immunodeficiency virus type-1 reverse transcriptase. J. Virol. 66, 7533-7537.
-
(1992)
J. Virol.
, vol.66
, pp. 7533-7537
-
-
Boyer, P.L.1
Ferris, A.L.2
Hughes, S.H.3
-
29
-
-
0029786278
-
Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase
-
29. Kaushik, N., Rege, N., Yadav, P.N., Sarafianos, S.G. & Modak, M.J. (1996). Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase. Biochemistry 35, 11536-11546.
-
(1996)
Biochemistry
, vol.35
, pp. 11536-11546
-
-
Kaushik, N.1
Rege, N.2
Yadav, P.N.3
Sarafianos, S.G.4
Modak, M.J.5
-
30
-
-
0029023051
-
A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy-and dideoxyribonucleotides
-
30. Tabor, S. & Richardson, C.C. (1995). A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy-and dideoxyribonucleotides. Proc. Natl Acad. Sci. USA 92, 6339-6343.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 6339-6343
-
-
Tabor, S.1
Richardson, C.C.2
-
31
-
-
2642689663
-
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα-GTPγS
-
31. Tesmer, J.G., Sunahara, R.K., Gilman, A.G. & Sprang, S.R. (1997). Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα-GTPySγ. Science 278, 1907-1916.
-
(1997)
Science
, vol.278
, pp. 1907-1916
-
-
Tesmer, J.G.1
Sunahara, R.K.2
Gilman, A.G.3
Sprang, S.R.4
-
32
-
-
0032412405
-
The structure, catalytic mechanism and regulation of adenylyl cyclase
-
32. Tesmer, J.G., & Sprang, S.R. (1998). The structure, catalytic mechanism and regulation of adenylyl cyclase. Curr. Opin. Struct. Biol. 8, 713-719.
-
(1998)
Curr. Opin. Struct. Biol.
, vol.8
, pp. 713-719
-
-
Tesmer, J.G.1
Sprang, S.R.2
-
33
-
-
0028940084
-
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
-
33. Shirasaka, T., et al., & Mitsuya, H. (1995). Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc. Natl. Acad. Sci. USA 92, 2398-2402.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 2398-2402
-
-
Shirasaka, T.1
Mitsuya, H.2
-
34
-
-
0030048748
-
Multidrug-resistant HIV1 strains resulting from combination antiretroviral therapies
-
34. Iversen, A.K.N., et al., & Merigan, T.C. (1996). Multidrug-resistant HIV1 strains resulting from combination antiretroviral therapies. J. Virol. 70, 1086-1090.
-
(1996)
J. Virol.
, vol.70
, pp. 1086-1090
-
-
Iversen, A.K.N.1
Merigan, T.C.2
-
35
-
-
0029038744
-
Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase
-
35. Sarafianos, S.G., Pandey, V.N., Kaushik, N. & Modak, M.J. (1995). Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase. Biochemistry 34, 7207-7216.
-
(1995)
Biochemistry
, vol.34
, pp. 7207-7216
-
-
Sarafianos, S.G.1
Pandey, V.N.2
Kaushik, N.3
Modak, M.J.4
-
36
-
-
0025950055
-
Resistance to ddl and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
-
36. St. Clair, M.H., et al. & Larder, B.A. (1991). Resistance to ddl and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 253, 1557-1559.
-
(1991)
Science
, vol.253
, pp. 1557-1559
-
-
St. Clair, M.H.1
Larder, B.A.2
-
37
-
-
0028057581
-
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine
-
37. Gu, Z., et al., & Wainberg, M.A. (1994). Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxycytidine and 2′,3′-dideoxy-3′-thiacytidine. Antimicrob. Agents Chemother. 38, 275-281.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 275-281
-
-
Gu, Z.1
Wainberg, M.A.2
-
38
-
-
0028031833
-
Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the HIV-1 reverse transcriptase
-
38. Zhang, D., et al., & D' Aquila, R.T. (1994). Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the HIV-1 reverse transcriptase. Antimicrob. Agents Chemother. 38, 282-287.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 282-287
-
-
Zhang, D.1
D'Aquila, R.T.2
-
39
-
-
0029154895
-
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine
-
39. Gu, Z., et al., & Wainberg, M.A. (1995). K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine. Antimicrob. Agents. Chemother. 39, 1888-1891.
-
(1995)
Antimicrob. Agents. Chemother.
, vol.39
, pp. 1888-1891
-
-
Gu, Z.1
Wainberg, M.A.2
-
40
-
-
0032533207
-
A 6-basepair insert in the reverse transcriptase of HIV-1 confers resistance to multiple nucleoside inhibitors
-
40. Winters, M.A., et al., & Merigan, T.C. (1998). A 6-basepair insert in the reverse transcriptase of HIV-1 confers resistance to multiple nucleoside inhibitors. J. Clin. Invest. 102, 1769-1775.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1769-1775
-
-
Winters, M.A.1
Merigan, T.C.2
-
41
-
-
0032952450
-
Closing in on HIV drug resistance
-
41. Larder, B.A. & Stammers, D.K. (1999). Closing in on HIV drug resistance. Nat. Struct. Biol. 6, 103-106.
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 103-106
-
-
Larder, B.A.1
Stammers, D.K.2
-
42
-
-
0024310253
-
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
-
42. Larder, B.A. & Kemp, S.D. (1989). Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 246, 1155-1158.
-
(1989)
Science
, vol.246
, pp. 1155-1158
-
-
Larder, B.A.1
Kemp, S.D.2
-
43
-
-
0026042638
-
Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture
-
43. Larder, B.A., Coates, K.E. & Kemp, S.D. (1991). Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture. J. Virol. 65, 5232-5236.
-
(1991)
J. Virol.
, vol.65
, pp. 5232-5236
-
-
Larder, B.A.1
Coates, K.E.2
Kemp, S.D.3
-
44
-
-
0027155374
-
The same mutation that encodes low-level human immunodeficiency virus type-1 resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2′,3′-dideoxy-3′-thiacytidine
-
44. Gao, Q., et al., & Wainberg, M.A. (1993). The same mutation that encodes low-level human immunodeficiency virus type-1 resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2′,3′-dideoxy-3′-thiacytidine. Antimicrob. Agents Chemother. 37, 1390-1392.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1390-1392
-
-
Gao, Q.1
Wainberg, M.A.2
-
45
-
-
0027285372
-
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
-
45. Tisdale, M., Kemp, S.D., Parry, N.R. & Larder, B.A. (1993). Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc. Natl Acad. Sci. USA 90, 5653-5656.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 5653-5656
-
-
Tisdale, M.1
Kemp, S.D.2
Parry, N.R.3
Larder, B.A.4
-
46
-
-
0030896362
-
Initial appearance of the 184lle variant of Lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase
-
46. Keulen, W., Back, N.K.T., Van Wijk, A., Boucher, C.A.B. & Berkhout, B. (1997). Initial appearance of the 184lle variant of Lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase. J. Virol. 71, 3346-3350.
-
(1997)
J. Virol.
, vol.71
, pp. 3346-3350
-
-
Keulen, W.1
Back, N.K.T.2
Van Wijk, A.3
Boucher, C.A.B.4
Berkhout, B.5
-
47
-
-
0009612377
-
Structures of Met184→lle and Met184→Val mutants of HIV-1 reverse transcriptase with and without bound nucleic acid reveal template-primer repositioning and steric hindrance mechanism for lamivudine resistance
-
47. Sarafianos, S.G., et al., & Arnold, E. (1998). Structures of Met184→lle and Met184→Val mutants of HIV-1 reverse transcriptase with and without bound nucleic acid reveal template-primer repositioning and steric hindrance mechanism for lamivudine resistance. Antiviral Therapy 3, Supplement 117-18.
-
(1998)
Antiviral Therapy
, vol.3
, Issue.SUPPL.
, pp. 117-118
-
-
Sarafianos, S.G.1
Arnold, E.2
-
48
-
-
0027409698
-
Characterization of human immunodeficiency virus resistant to oxathiolane-cytosine nucleosides
-
48. Schinazi, R.F., et al., & Mellors, J.W. (1993). Characterization of human immunodeficiency virus resistant to oxathiolane-cytosine nucleosides. Antimicrob. Agents Chemother. 37, 875-881.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 875-881
-
-
Schinazi, R.F.1
Mellors, J.W.2
-
49
-
-
0028230923
-
Anti-human immunodeficiency virus activities of the beta-⌊-enantiomer of 2′,3′-dideoxycytidine and its 5-fluoro derivative in vitro
-
49. Gosselin, G., et al., & Imbach, J.L. (1994). Anti-human immunodeficiency virus activities of the beta-⌊-enantiomer of 2′,3′-dideoxycytidine and its 5-fluoro derivative in vitro. Antimicrob. Agents Chemother. 38, 1292-1297.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1292-1297
-
-
Gosselin, G.1
Imbach, J.L.2
-
50
-
-
10244227943
-
An in vivo mutation from leucine to tryptophan at position 210 in HIV-1 reverse transcriptase contributes to high-level resistance to AZT
-
50. Hooker, D.J., et al., & Deacon, N.J. (1996). An in vivo mutation from leucine to tryptophan at position 210 in HIV-1 reverse transcriptase contributes to high-level resistance to AZT. J. Virol. 70, 8010-8018.
-
(1996)
J. Virol.
, vol.70
, pp. 8010-8018
-
-
Hooker, D.J.1
Deacon, N.J.2
-
51
-
-
0026755210
-
Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3′-azido-3′-deoxythymidine
-
51. Lacey, S.F., et al., & Larder, B.A. (1992). Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3′-azido-3′-deoxythymidine. J. Biol. Chem. 267, 15789-15794.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 15789-15794
-
-
Lacey, S.F.1
Larder, B.A.2
-
52
-
-
0009653840
-
AZT resistance suppressed by a mutation conferring HIV-1 resistance to non-nucleoside reverse transcriptase inhibitors
-
52. Larder, B.A. (1992). AZT resistance suppressed by a mutation conferring HIV-1 resistance to non-nucleoside reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 36, 1171-1174.
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 1171-1174
-
-
Larder, B.A.1
-
53
-
-
0029077992
-
Molecular mechanisms of antiviral resistance
-
53. Kimberlin, D.W., et al., & Whitley, R.J. (1995). Molecular mechanisms of antiviral resistance. Antiviral Res. 26, 369-401.
-
(1995)
Antiviral Res.
, vol.26
, pp. 369-401
-
-
Kimberlin, D.W.1
Whitley, R.J.2
-
54
-
-
0343811737
-
Single-Step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3TC
-
54. Krebs, R., Immendorfer, U., Thrall, S.H., Wohrl, B.M. & Goody, R.S. (1997). Single-Step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3TC. Biochemistry 36, 10292-10300.
-
(1997)
Biochemistry
, vol.36
, pp. 10292-10300
-
-
Krebs, R.1
Immendorfer, U.2
Thrall, S.H.3
Wohrl, B.M.4
Goody, R.S.5
-
55
-
-
0032506055
-
Phenotypic mechanism of HIV-1 resistance to AZT: Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase
-
55. Arion, D., Borkow, G., Gu, Z., M., W. & Parniak, M.A. (1998). Phenotypic mechanism of HIV-1 resistance to AZT: Increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry 37, 15908-15917.
-
(1998)
Biochemistry
, vol.37
, pp. 15908-15917
-
-
Arion, D.1
Borkow, G.2
Gu, Z.M.W.3
Parniak, M.A.4
-
56
-
-
0032486287
-
Enhanced binding of AZT-resistant HIV-1 RT to the AZT-5′-monophosphate-terminated primer
-
56. Canard, B., Sarfati, S.R. & Richardson, C.C. (1998). Enhanced binding of AZT-resistant HIV-1 RT to the AZT-5′-monophosphate-terminated primer. J. Biol. Chem. 273, 14596-14604.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14596-14604
-
-
Canard, B.1
Sarfati, S.R.2
Richardson, C.C.3
-
57
-
-
0032506228
-
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism
-
57. Meyer, P.R., Matsuura, S.E., So, A.G. & Scott, W.A. (1998). Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism. Proc. Natl Acad. Sci. USA 95, 13471-13476.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13471-13476
-
-
Meyer, P.R.1
Matsuura, S.E.2
So, A.G.3
Scott, W.A.4
-
58
-
-
0023657032
-
Kinetic mechanism of DNA polymerase I (Klenow)
-
58. Kuchta, R.D., Mizrahi, V., Benkovic, P.A., Johnson, K.A. & Benkovic, S.J. (1987). Kinetic mechanism of DNA polymerase I (Klenow). Biochemistry 26, 8410-8417.
-
(1987)
Biochemistry
, vol.26
, pp. 8410-8417
-
-
Kuchta, R.D.1
Mizrahi, V.2
Benkovic, P.A.3
Johnson, K.A.4
Benkovic, S.J.5
-
59
-
-
0023775755
-
Studies on the mechanism of human immunodeficiency virus reverse transcriptase: Steady-state kinetics, processivity and polynucleotide inhibition
-
59. Majumdar, C., Abbotts, J., Broder, S. & Wilson, S.H. (1988). Studies on the mechanism of human immunodeficiency virus reverse transcriptase: steady-state kinetics, processivity and polynucleotide inhibition. J. Biol. Chem. 263, 15657-15665.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 15657-15665
-
-
Majumdar, C.1
Abbotts, J.2
Broder, S.3
Wilson, S.H.4
-
60
-
-
0025799903
-
Kinetic mechanism of DNA polymerase I (Klenow fragment): Identification of a second conformational change
-
60. Dahlberg, M.E. & Benkovic, S.J. (1991). Kinetic mechanism of DNA polymerase I (Klenow fragment): identification of a second conformational change. Biochemistry 30, 4835-4843.
-
(1991)
Biochemistry
, vol.30
, pp. 4835-4843
-
-
Dahlberg, M.E.1
Benkovic, S.J.2
-
61
-
-
0027092323
-
Mechanism and fidelity of HIV reverse transcriptase
-
61. Kati, W.M., Johnson, K.A., Jerva, L.F. & Anderson, K.S. (1992). Mechanism and fidelity of HIV reverse transcriptase. J. Biol. Chem. 267, 25988-25997.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25988-25997
-
-
Kati, W.M.1
Johnson, K.A.2
Jerva, L.F.3
Anderson, K.S.4
-
62
-
-
0027414018
-
Human immunodeficiency virus reverse transcriptase
-
62. Reardon, J.E. (1993). Human immunodeficiency virus reverse transcriptase. J. Biol. Chem. 268, 8743-8751.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 8743-8751
-
-
Reardon, J.E.1
-
63
-
-
0027365750
-
Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase
-
63. Hsieh, J., Zinnen, S. & Modrich, P. (1993). Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. J. Biol. Chem. 268, 24607-24613.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 24607-24613
-
-
Hsieh, J.1
Zinnen, S.2
Modrich, P.3
-
64
-
-
0029150042
-
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
-
64. Rittinger, K., Divita, G. & Goody, R. (1995). Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. Proc. Natl Acad. Sci. USA 92, 8046-8049.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 8046-8049
-
-
Rittinger, K.1
Divita, G.2
Goody, R.3
-
65
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
65. Spence, R.A., Kati, W.M., Anderson, K.S. & Johnson, K.A. (1995). Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 267, 988-993.
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anderson, K.S.3
Johnson, K.A.4
-
66
-
-
0027220197
-
Conformational coupling in polymerase fidelity
-
66. Johnson, K.A. (1993). Conformational coupling in polymerase fidelity. Annu. Rev. Biochem. 62, 685-713.
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 685-713
-
-
Johnson, K.A.1
-
67
-
-
0030991442
-
Difluorotoluene, a nonpolar isostere of thymine, codes specifically and efficiently for adenine in DNA replication
-
67. Moran, S., Ren, X.F.R., Rumney, S.I. & Kool, E.T. (1997). Difluorotoluene, a nonpolar isostere of thymine, codes specifically and efficiently for adenine in DNA replication. J. Am. Chem. Soc. 119, 2056-2057
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 2056-2057
-
-
Moran, S.1
Ren, X.F.R.2
Rumney, S.I.3
Kool, E.T.4
-
68
-
-
0033552832
-
Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 are resistant to multiple nucleoside analogs
-
68. De Jong J.J., et al., & Jurriaans, S. (1999). Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 are resistant to multiple nucleoside analogs. AIDS 13, 75-80.
-
(1999)
AIDS
, vol.13
, pp. 75-80
-
-
De Jong, J.J.1
Jurriaans, S.2
|