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Volumn 10, Issue 2, 2004, Pages 119-126

Effect of polymorphisms on the replicative capacity of protease inhibitor-resistant HIV-1 variants under drug pressure

Author keywords

Fitness; HIV; Polymorphisms; Protease inhibitors; Resistance

Indexed keywords

AMINO ACID; GAG PROTEIN; INDINAVIR; PROTEIN P55; PROTEINASE; PROTEINASE INHIBITOR; SAQUINAVIR;

EID: 1342290276     PISSN: 1198743X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2004.00832.x     Document Type: Article
Times cited : (27)

References (35)
  • 1
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho DD, Neumann AD, Perelson AS et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995; 373: 123-126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1    Neumann, A.D.2    Perelson, A.S.3
  • 2
    • 0028811974 scopus 로고
    • Viral dynamics in human immunodeficiency virus type 1 infection
    • Wei X, Ghosh SK, Taylor ME et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373: 117-122.
    • (1995) Nature , vol.373 , pp. 117-122
    • Wei, X.1    Ghosh, S.K.2    Taylor, M.E.3
  • 3
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • Preston BD, Poiesz BJ, Loeb LA. Fidelity of HIV-1 reverse transcriptase. Science 1988; 242: 1168-1171.
    • (1988) Science , vol.242 , pp. 1168-1171
    • Preston, B.D.1    Poiesz, B.J.2    Loeb, L.A.3
  • 4
    • 0028988479 scopus 로고
    • Pol gene quasispecies of human immunodeficiency virus: Mutations associated with drug resistance in virus from patients undergoing no drug therapy
    • Najera I, Holguin A, Quiñones-Mateu ME et al. Pol gene quasispecies of human immunodeficiency virus: mutations associated with drug resistance in virus from patients undergoing no drug therapy. J Virol 1995; 69: 23-31.
    • (1995) J. Virol. , vol.69 , pp. 23-31
    • Najera, I.1    Holguin, A.2    Quiñones-Mateu, M.E.3
  • 5
    • 15844378825 scopus 로고    scopus 로고
    • Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays
    • Kozal MJ, Shah N, Shen N et al. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat Med 1996; 2: 753-759.
    • (1996) Nat. Med. , vol.2 , pp. 753-759
    • Kozal, M.J.1    Shah, N.2    Shen, N.3
  • 6
    • 0035887629 scopus 로고    scopus 로고
    • Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy
    • Perno CF, Cozzi-Lepri A, Balotta C et al. Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy. J Infect Dis 2001; 184: 983-991.
    • (2001) J. Infect. Dis. , vol.184 , pp. 983-991
    • Perno, C.F.1    Cozzi-Lepri, A.2    Balotta, C.3
  • 7
    • 9044230526 scopus 로고    scopus 로고
    • In vivo sequence diversity of the protease of human immunodeficiency virus type 1: Presence of protease inhibitor-resistant variants in untreated subjects
    • Lech WJ, Wang G, Li Yan YL et al. In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J Virol 1996; 70: 2038-2043.
    • (1996) J. Virol. , vol.70 , pp. 2038-2043
    • Lech, W.J.1    Wang, G.2    Li Yan, Y.L.3
  • 8
    • 0033820923 scopus 로고    scopus 로고
    • Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease-naive individuals worldwide
    • Pieniazek D, Rayfield M, Hu DJ et al. Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease-naive individuals worldwide. AIDS 2000; 14: 1489-1495.
    • (2000) AIDS , vol.14 , pp. 1489-1495
    • Pieniazek, D.1    Rayfield, M.2    Hu, D.J.3
  • 9
    • 0034952105 scopus 로고    scopus 로고
    • Resistance-associated mutations in the human immunodeficiency virus type 1 subtype C protease gene from treated and untreated patients in the United Kingdom
    • Cane PA, de Ruiter A, Rice P et al. Resistance-associated mutations in the human immunodeficiency virus type 1 subtype C protease gene from treated and untreated patients in the United Kingdom. J Clin Microbiol 2001; 39: 2652-2654.
    • (2001) J. Clin. Microbiol. , vol.39 , pp. 2652-2654
    • Cane, P.A.1    de Ruiter, A.2    Rice, P.3
  • 10
    • 0037165905 scopus 로고    scopus 로고
    • High prevalence of subtype G and spectrum of natural polymorphisms at the protease gene among HIV-infected immigrants attended in Madrid
    • Holguín A, Álvarez A, Soriano V. High prevalence of subtype G and spectrum of natural polymorphisms at the protease gene among HIV-infected immigrants attended in Madrid. AIDS 2002; 16: 1163-1170.
    • (2002) AIDS , vol.16 , pp. 1163-1170
    • Holguín, A.1    Álvarez, A.2    Soriano, V.3
  • 11
    • 0034460604 scopus 로고    scopus 로고
    • Genetic diversity of protease and reverse transcriptase sequences in non-B HIV type 1 strains: Evidence of many minor drug resistance mutations in treatment-naive patients
    • Vergne L, Peeters M, Mpoudi-Ngole E et al. Genetic diversity of protease and reverse transcriptase sequences in non-B HIV type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol 2000; 38: 3919-3925.
    • (2000) J. Clin. Microbiol. , vol.38 , pp. 3919-3925
    • Vergne, L.1    Peeters, M.2    Mpoudi-Ngole, E.3
  • 12
    • 0028854676 scopus 로고
    • Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz M, Mo H, Kempf DJ et al. Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J Virol 1995; 69: 701-706.
    • (1995) J. Virol. , vol.69 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3
  • 13
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado J, Savara AV, Sutton L, D'Aquila RT. Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J Virol 1999; 73: 3744-3752.
    • (1999) J. Virol. , vol.73 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.V.2    Sutton, L.3    D'Aquila, R.T.4
  • 14
    • 0031946007 scopus 로고    scopus 로고
    • Loss of viral fitness associated with multiple gag and gagpol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo
    • Zennou V, Mammano F, Paulous S, Mathez D, Clavel F. Loss of viral fitness associated with multiple gag and gagpol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo. J Virol 1998; 72: 3300-3306.
    • (1998) J. Virol. , vol.72 , pp. 3300-3306
    • Zennou, V.1    Mammano, F.2    Paulous, S.3    Mathez, D.4    Clavel, F.5
  • 15
    • 0029869305 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors
    • Rose RE, Gong YF, Greytok JA et al. Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proc Natl Acad Sci USA 1996; 93: 1648-1653.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1648-1653
    • Rose, R.E.1    Gong, Y.F.2    Greytok, J.A.3
  • 16
    • 0030065565 scopus 로고    scopus 로고
    • Resistance of human immunodeficiency virus type 1 to protease inhibitors: Selection of resistance mutations in the presence and absence of the drug
    • Borman AM, Paulous S, Clavel F. Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug. J Gen Virol 1996; 77: 419-426.
    • (1996) J. Gen. Virol. , vol.77 , pp. 419-426
    • Borman, A.M.1    Paulous, S.2    Clavel, F.3
  • 17
    • 0033863985 scopus 로고    scopus 로고
    • Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: Virus fitness in the absence and presence of drug
    • Mammano F, Trouplin V, Zennou V, Clavel F. Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and presence of drug. J Virol 2000; 74: 8524-8531.
    • (2000) J. Virol. , vol.74 , pp. 8524-8531
    • Mammano, F.1    Trouplin, V.2    Zennou, V.3    Clavel, F.4
  • 18
    • 0031742023 scopus 로고    scopus 로고
    • Dissecting the mode of action of various HIV-inhibitor classes in a stable cellular system
    • Klimkait T, Stauffer F, Lupo E, Sonderegger-Rubli C. Dissecting the mode of action of various HIV-inhibitor classes in a stable cellular system. Arch Virol 1998; 143: 2109-2131.
    • (1998) Arch. Virol. , vol.143 , pp. 2109-2131
    • Klimkait, T.1    Stauffer, F.2    Lupo, E.3    Sonderegger-Rubli, C.4
  • 19
    • 0028843163 scopus 로고
    • Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959
    • Jacobsen H, Yasargil K, Winslow DL et al. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959. Virology 1995; 206: 527-534.
    • (1995) Virology , vol.206 , pp. 527-534
    • Jacobsen, H.1    Yasargil, K.2    Winslow, D.L.3
  • 20
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra JH, Schleif WA, Blahy OM et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995; 374: 569-571.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 21
    • 0005241362 scopus 로고
    • Active human immunodeficiency virus protease is required for viral infectivity
    • Kohl NE, Emini EA, Schleif WA et al. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci USA 1988; 85: 4686-4690.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4686-4690
    • Kohl, N.E.1    Emini, E.A.2    Schleif, W.A.3
  • 22
    • 0030468331 scopus 로고    scopus 로고
    • Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex
    • Maschera B, Darby G, Palu G et al. Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex. J Biol Chem 1996; 271: 33231-33235.
    • (1996) J. Biol. Chem. , vol.271 , pp. 33231-33235
    • Maschera, B.1    Darby, G.2    Palu, G.3
  • 23
    • 0031015475 scopus 로고    scopus 로고
    • Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors
    • Croteau G, Doyon L, Thibeault D et al. Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J Virol 1997; 71: 1089-1096.
    • (1997) J. Virol. , vol.71 , pp. 1089-1096
    • Croteau, G.1    Doyon, L.2    Thibeault, D.3
  • 24
    • 0034946066 scopus 로고    scopus 로고
    • Durable HIV treatment benefit despite low-level viremia: Reassessing definitions of success or failure
    • Deeks SG. Durable HIV treatment benefit despite low-level viremia: reassessing definitions of success or failure. JAMA 2001; 286: 224-226.
    • (2001) JAMA , vol.286 , pp. 224-226
    • Deeks, S.G.1
  • 25
    • 0033009094 scopus 로고    scopus 로고
    • Impact of drug resistance mutations on virologic response to salvage therapy. Swiss HIV Cohort Study
    • Lorenzi P, Opravil M, Hirschel B et al. Impact of drug resistance mutations on virologic response to salvage therapy. Swiss HIV Cohort Study. AIDS 1999; 13: F17-F21.
    • (1999) AIDS , vol.13
    • Lorenzi, P.1    Opravil, M.2    Hirschel, B.3
  • 26
    • 0034071659 scopus 로고    scopus 로고
    • Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppression
    • Ruiz L, Martinez-Picado J, Romeu J et al. Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppression. AIDS 2000; 14: 397-403.
    • (2000) AIDS , vol.14 , pp. 397-403
    • Ruiz, L.1    Martinez-Picado, J.2    Romeu, J.3
  • 27
    • 0033762620 scopus 로고    scopus 로고
    • Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen
    • Izopet J, Massip P, Souyris C et al. Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen. AIDS 2000; 14: 2247-2255.
    • (2000) AIDS , vol.14 , pp. 2247-2255
    • Izopet, J.1    Massip, P.2    Souyris, C.3
  • 28
    • 0034523865 scopus 로고    scopus 로고
    • Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure
    • Miller V, Sabin C, Hertogs K et al. Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure. AIDS 2000; 14: 2857-2867.
    • (2000) AIDS , vol.14 , pp. 2857-2867
    • Miller, V.1    Sabin, C.2    Hertogs, K.3
  • 29
    • 0030938867 scopus 로고    scopus 로고
    • Escape mutants of HIV-1 proteinase: Enzymic efficiency and susceptibility to inhibition
    • Wilson SI, Phylip LH, Mills JS et al. Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition. Biochem Biophys Acta 1997; 1339: 113-125.
    • (1997) Biochem. Biophys. Acta , vol.1339 , pp. 113-125
    • Wilson, S.I.1    Phylip, L.H.2    Mills, J.S.3
  • 30
    • 0034734783 scopus 로고    scopus 로고
    • Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants
    • Martinez-Picado J, Savara AV, Shi L, Sutton L, D'Aquila RT. Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants. Virology 2000; 275: 318-322.
    • (2000) Virology , vol.275 , pp. 318-322
    • Martinez-Picado, J.1    Savara, A.V.2    Shi, L.3    Sutton, L.4    D'Aquila, R.T.5
  • 31
    • 0032804864 scopus 로고    scopus 로고
    • Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
    • Nijhuis M, Schuurman R, de Jong D et al. Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy. AIDS 1999; 13: 2349-2359.
    • (1999) AIDS , vol.13 , pp. 2349-2359
    • Nijhuis, M.1    Schuurman, R.2    de Jong, D.3
  • 32
    • 0029824426 scopus 로고    scopus 로고
    • In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: Mutations, kinetics, and frequencies
    • Jacobsen H, Hanggi M, Ott M et al. In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: mutations, kinetics, and frequencies. J Infect Dis 1996; 173: 1379-1387.
    • (1996) J. Infect. Dis. , vol.173 , pp. 1379-1387
    • Jacobsen, H.1    Hanggi, M.2    Ott, M.3
  • 33
    • 0031950370 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy
    • Eastman PS, Mittler J, Kelso R et al. Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy. J Virol 1998; 72: 5154-5164.
    • (1998) J. Virol. , vol.72 , pp. 5154-5164
    • Eastman, P.S.1    Mittler, J.2    Kelso, R.3
  • 34
    • 0031884993 scopus 로고    scopus 로고
    • In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection
    • Blaak H, Brouwer M, Ran LJ, Wolf F, Schuitemaker H. In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection. J Infect Dis 1998; 177: 600-610.
    • (1998) J. Infect. Dis. , vol.177 , pp. 600-610
    • Blaak, H.1    Brouwer, M.2    Ran, L.J.3    Wolf, F.4    Schuitemaker, H.5
  • 35
    • 0033803642 scopus 로고    scopus 로고
    • A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression
    • Quiñones-Mateu ME, Ball SC, Marozsan AJ et al. A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression. J Virol 2000; 74: 9222-9233.
    • (2000) J. Virol. , vol.74 , pp. 9222-9233
    • Quiñones-Mateu, M.E.1    Ball, S.C.2    Marozsan, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.