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Volumn 73, Issue 5, 1999, Pages 3744-3752

Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1

Author keywords

[No Author keywords available]

Indexed keywords

NELFINAVIR; PROTEINASE INHIBITOR; SAQUINAVIR;

EID: 0032928065     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.5.3744-3752.1999     Document Type: Article
Times cited : (365)

References (62)
  • 1
    • 0022495870 scopus 로고
    • Production of acquired immunodeficiency syndrome-associated retrovirus in human and non-human cells transfected with an infectious molecular clone
    • Adachi, A., H. E. Gendelman, S. Koening, T. Folks, R. Willey, A. Rabson, and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and non-human cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
    • (1986) J. Virol. , vol.59 , pp. 284-291
    • Adachi, A.1    Gendelman, H.E.2    Koening, S.3    Folks, T.4    Willey, R.5    Rabson, A.6    Martin, M.A.7
  • 2
    • 0029757751 scopus 로고    scopus 로고
    • Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme
    • Back, N. K., M. Nijhuls, W. Keulen, C. A. Boucher, B. O. Oude Essink, A. B. van Kuilenburg, A. H. van Gennip, and B. Berkhout. 1996. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J. 15:4040-4049.
    • (1996) EMBO J. , vol.15 , pp. 4040-4049
    • Back, N.K.1    Nijhuls, M.2    Keulen, W.3    Boucher, C.A.4    Oude Essink, B.O.5    Van Kuilenburg, A.B.6    Van Gennip, A.H.7    Berkhout, B.8
  • 3
    • 0031884993 scopus 로고    scopus 로고
    • In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection
    • Blaak, H., M. Brouwer, L. J. Ran, F. Wolf, and H. Schuitemaker. 1998. In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection. J. Infect. Dis. 177:600-610.
    • (1998) J. Infect. Dis. , vol.177 , pp. 600-610
    • Blaak, H.1    Brouwer, M.2    Ran, L.J.3    Wolf, F.4    Schuitemaker, H.5
  • 4
    • 0030065565 scopus 로고    scopus 로고
    • Resistance of human immunodeficiency virus type 1 to protease inhibitors: Selection of resistance mutations in the presence and absence of the drug
    • Borman, A. M., S. Paulous, and F. Clavel. 1996. Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug. J. Gen. Virol. 77:419-426.
    • (1996) J. Gen. Virol. , vol.77 , pp. 419-426
    • Borman, A.M.1    Paulous, S.2    Clavel, F.3
  • 6
    • 0344814073 scopus 로고    scopus 로고
    • Viral load reduction after changing from nelfinavir-to indinavir-containing regimens and associated resistance mutations
    • abstract 12342
    • Brooks, J. T., M. V. Vliet, and P. E. Sax. 1998. Viral load reduction after changing from nelfinavir-to indinavir-containing regimens and associated resistance mutations, abstract 12342. In Abstracts of the 12th World AIDS Conference.
    • (1998) Abstracts of the 12th World AIDS Conference
    • Brooks, J.T.1    Vliet, M.V.2    Sax, P.E.3
  • 7
    • 0030004944 scopus 로고    scopus 로고
    • Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication
    • Caliendo, A. M., A. Savara, D. An, K. DeVore, J. C. Kaplan, and R. T. D'Aquila. 1996. Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication. J. Virol. 70:2146-2153.
    • (1996) J. Virol. , vol.70 , pp. 2146-2153
    • Caliendo, A.M.1    Savara, A.2    An, D.3    DeVore, K.4    Kaplan, J.C.5    D'Aquila, R.T.6
  • 9
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin, J. M. 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267:483-489.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 12
    • 0031015475 scopus 로고    scopus 로고
    • Impaired fitness of HIV-1 variants with high-level resistance to protease inhibitors
    • Croteau, G., L. Doyon, D. Thibeault, G. McKercher, L. Pilote, and D. Lamarre. 1997. Impaired fitness of HIV-1 variants with high-level resistance to protease inhibitors. J Virol. 71:1089-1096.
    • (1997) J Virol. , vol.71 , pp. 1089-1096
    • Croteau, G.1    Doyon, L.2    Thibeault, D.3    McKercher, G.4    Pilote, L.5    Lamarre, D.6
  • 13
    • 0028937012 scopus 로고
    • Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy
    • AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group
    • D'Aquila, R. T., V. A. Johnson, S. L. Welles, A. J. Japour, D. R. Kuritzkes, V. DeGruttola, P. S. Reichelderfer, R. W. Coombs, C. S. Crumpacker, J. O. Kahn, et al. 1995. Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group. Ann. Intern. Med. 122:401-408.
    • (1995) Ann. Intern. Med. , vol.122 , pp. 401-408
    • D'Aquila, R.T.1    Johnson, V.A.2    Welles, S.L.3    Japour, A.J.4    Kuritzkes, D.R.5    DeGruttola, V.6    Reichelderfer, P.S.7    Coombs, R.W.8    Crumpacker, C.S.9    Kahn, J.O.10
  • 16
    • 0031950370 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy
    • Eastman, P. S., J. Mittler, R. Kelso, C. Gee, E. Boyer, J. Kolberg, M. Urdea, J. M. Leonard, D. W. Norbeck, H. Mo, and M. Markowitz. 1998. Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy. J. Virol. 72:5154-5164.
    • (1998) J. Virol. , vol.72 , pp. 5154-5164
    • Eastman, P.S.1    Mittler, J.2    Kelso, R.3    Gee, C.4    Boyer, E.5    Kolberg, J.6    Urdea, M.7    Leonard, J.M.8    Norbeck, D.W.9    Mo, H.10    Markowitz, M.11
  • 18
    • 0005472257 scopus 로고    scopus 로고
    • Efficacy and durability of ritonavir/saquinavir as salvage therapy after failure of initial protease inhibitor regimen
    • abstr. 12330
    • Gallant, J. E., S. Barnett, C. Raines, and C. Hall. 1998. Efficacy and durability of ritonavir/saquinavir as salvage therapy after failure of initial protease inhibitor regimen, abstr. 12330. In Abstracts of the 12th World AIDS Conference.
    • (1998) Abstracts of the 12th World AIDS Conference
    • Gallant, J.E.1    Barnett, S.2    Raines, C.3    Hall, C.4
  • 19
    • 0003253191 scopus 로고    scopus 로고
    • Ritonavir/saquinavir (RTV/SQV) as salvage therapy after failure of initial protease inhibitor (Pl) regimen
    • J. E., C. Hall, S. Barnett, and C. Raines. 1998 abstr. 510
    • Gallant, J. E., C. Hall, S. Barnett, and C. Raines. 1998. J. E., C. Hall, S. Barnett, and C. Raines. 1998. Ritonavir/saquinavir (RTV/SQV) as salvage therapy after failure of initial protease inhibitor (Pl) regimen, abstr. 510. In Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections.
    • (1998) Abstracts of the 5th Conference on Retroviruses and Opportunistic Infections
    • Gallant, J.E.1    Hall, C.2    Barnett, S.3    Raines, C.4
  • 20
    • 0028195026 scopus 로고
    • Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes
    • Gibbs, J. S., D. A. Regier, and R. C. Desrosiers. 1994. Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res. Hum. Retroviruses 10:343-350.
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 343-350
    • Gibbs, J.S.1    Regier, D.A.2    Desrosiers, R.C.3
  • 21
    • 0030926277 scopus 로고    scopus 로고
    • Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 sub-populations differing at reverse transcriptase codons 41 and 215
    • Goudsmit, J., A. de Ronde, E. de Rooij, and R. de Boer. 1997. Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 sub-populations differing at reverse transcriptase codons 41 and 215. J. Virol. 71:4479-4484.
    • (1997) J. Virol. , vol.71 , pp. 4479-4484
    • Goudsmit, J.1    De Ronde, A.2    De Rooij, E.3    De Boer, R.4
  • 22
    • 0030011523 scopus 로고    scopus 로고
    • Human immunodeficiency virus fitness in vivo: Calculations based on a single zidovudine resistance mutation at codon 215 of reverse transcriptase
    • Goudsmit, J., A. de Ronde, D. D. Ho, and A. S. Perelson. 1996. Human immunodeficiency virus fitness in vivo: calculations based on a single zidovudine resistance mutation at codon 215 of reverse transcriptase. J. Virol. 70:5662-5664.
    • (1996) J. Virol. , vol.70 , pp. 5662-5664
    • Goudsmit, J.1    De Ronde, A.2    Ho, D.D.3    Perelson, A.S.4
  • 23
    • 0029151345 scopus 로고
    • Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
    • Gulnik, S. V., L. I. Suvorov, B. Liu, B. Yu, B. Anderson, H. Mitsuya, and J. W. Erickson. 1995. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry 34: 9282-9287.
    • (1995) Biochemistry , vol.34 , pp. 9282-9287
    • Gulnik, S.V.1    Suvorov, L.I.2    Liu, B.3    Yu, B.4    Anderson, B.5    Mitsuya, H.6    Erickson, J.W.7
  • 24
    • 0023926115 scopus 로고
    • Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2′,3′-dideoxyadenosine derivatives
    • Haertle, T., C. J. Carrera, D. B. Wasson, L. C. Sowers, D. D. Richman, and D. A. Carson. 1988. Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2′,3′-dideoxyadenosine derivatives. J. Biol. Chem. 263: 5870-5875.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5870-5875
    • Haertle, T.1    Carrera, C.J.2    Wasson, D.B.3    Sowers, L.C.4    Richman, D.D.5    Carson, D.A.6
  • 25
    • 0022404296 scopus 로고
    • Infection of HTLV-III/ LAV in HTLV-i-carrying cells MT-2 and MT-4 and application in a plaque assay
    • Harada, S., Y. Koyanagi, and N. Yamamoto. 1985. Infection of HTLV-III/ LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 229:563-566.
    • (1985) Science , vol.229 , pp. 563-566
    • Harada, S.1    Koyanagi, Y.2    Yamamoto, N.3
  • 26
    • 0031958266 scopus 로고    scopus 로고
    • Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro
    • Harrigan, P. R., S. Bloor, and B. A. Larder. 1998. Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro. J. Virol. 72:3773-3778.
    • (1998) J. Virol. , vol.72 , pp. 3773-3778
    • Harrigan, P.R.1    Bloor, S.2    Larder, B.A.3
  • 27
    • 0029843986 scopus 로고    scopus 로고
    • Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility
    • Harrigan, P. R., I. Kinghorn, S. Bloor, S. D. Kemp, I. Najera, A. Kohli, and B. A. Larder. 1996. Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility. J. Virol. 70:5930-5934.
    • (1996) J. Virol. , vol.70 , pp. 5930-5934
    • Harrigan, P.R.1    Kinghorn, I.2    Bloor, S.3    Kemp, S.D.4    Najera, I.5    Kohli, A.6    Larder, B.A.7
  • 30
    • 0027270541 scopus 로고
    • Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates
    • The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group
    • Japour, A. J., D. L. Mayers, V. A. Johnson, D. R. Kuritzkes, L. A. Beckett, J. M. Arduino, J. Lane, R. J. Black, P. S. Reichelderfer, R. T. D'Aquila, et al. 1993. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group. Antimicrob. Agents Chemother. 37:1095-1101.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1095-1101
    • Japour, A.J.1    Mayers, D.L.2    Johnson, V.A.3    Kuritzkes, D.R.4    Beckett, L.A.5    Arduino, J.M.6    Lane, J.7    Black, R.J.8    Reichelderfer, P.S.9    D'Aquila, R.T.10
  • 32
    • 0029028067 scopus 로고
    • Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
    • Larder, B. A., S. D. Kemp, and P. R. Harrigan. 1995. Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 269:696-699.
    • (1995) Science , vol.269 , pp. 696-699
    • Larder, B.A.1    Kemp, S.D.2    Harrigan, P.R.3
  • 33
    • 9044230526 scopus 로고    scopus 로고
    • In vivo sequence diversity of the protease of human immunodeficiency virus type 1: Presence of protease inhibitor-resistant variants in untreated subjects
    • Lech, W. J., G. Wang, Y. L. Yang, Y. Chee, K. Dorman, D. McCrae, L. C. Lazzeroni, J. W. Erickson, J. S. Sinsheimer, and A. H. Kaplan. 1996. In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J. Virol. 70:2038-2043.
    • (1996) J. Virol. , vol.70 , pp. 2038-2043
    • Lech, W.J.1    Wang, G.2    Yang, Y.L.3    Chee, Y.4    Dorman, K.5    McCrae, D.6    Lazzeroni, L.C.7    Erickson, J.W.8    Sinsheimer, J.S.9    Kaplan, A.H.10
  • 35
    • 0031948662 scopus 로고    scopus 로고
    • Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance
    • Maeda, Y., D. J. Venzon, and H. Mitsuya. 1998. Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. J. Infect. Dis. 177: 1207-1213.
    • (1998) J. Infect. Dis. , vol.177 , pp. 1207-1213
    • Maeda, Y.1    Venzon, D.J.2    Mitsuya, H.3
  • 36
    • 0028854676 scopus 로고
    • Selection and analysis of HIV-1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz, M., H. Mo, D. J. Kempf, D. W. Norbeck, T. N. Bhat, J. W. Erickson, and D. D. Ho. 1995. Selection and analysis of HIV-1 variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69:701-706.
    • (1995) J. Virol. , vol.69 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3    Norbeck, D.W.4    Bhat, T.N.5    Erickson, J.W.6    Ho, D.D.7
  • 38
    • 0030468331 scopus 로고    scopus 로고
    • Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex
    • Maschera, B., G. Darby, G. Palu, L. L. Wright, M. Tisdale, R. Myers, E. D. Blair, and E. S. Furfine. 1996. Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex. J. Biol. Chem. 271: 33231-33235.
    • (1996) J. Biol. Chem. , vol.271 , pp. 33231-33235
    • Maschera, B.1    Darby, G.2    Palu, G.3    Wright, L.L.4    Tisdale, M.5    Myers, R.6    Blair, E.D.7    Furfine, E.S.8
  • 39
    • 0029087303 scopus 로고
    • Analysis of resistance to HIV-1 protease inhibitors by using matched bacterial expression and proviral infection vectors
    • Maschera, B., E. Furfine, and E. D. Blair. 1995. Analysis of resistance to HIV-1 protease inhibitors by using matched bacterial expression and proviral infection vectors. J. Virol. 69:5431-5436.
    • (1995) J. Virol. , vol.69 , pp. 5431-5436
    • Maschera, B.1    Furfine, E.2    Blair, E.D.3
  • 51
  • 52
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson, A. S., A. U. Neumann, M. Markowitz, J. M. Leonard, and D. D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 53
    • 0026801914 scopus 로고
    • Uracil DNA glycosilase-mediated cloning of PCR-amplified DNA: Application to genomic and cDNA cloning
    • Rashtchian, A., D. M. Buchman, D. M. Schuster, and M. S. Beringer. 1992. Uracil DNA glycosilase-mediated cloning of PCR-amplified DNA: application to genomic and cDNA cloning. Anal. Biochem. 206:91-97.
    • (1992) Anal. Biochem. , vol.206 , pp. 91-97
    • Rashtchian, A.1    Buchman, D.M.2    Schuster, D.M.3    Beringer, M.S.4
  • 54
    • 85045496522 scopus 로고
    • A novel method for site-directed mutagenesis using PCR and uracil DNA glycosylase
    • Rashtchian, A., C. G. Thorton, and G. Heidecker. 1992. A novel method for site-directed mutagenesis using PCR and uracil DNA glycosylase. PCR Methods Appl. 2:124.
    • (1992) PCR Methods Appl. , vol.2 , pp. 124
    • Rashtchian, A.1    Thorton, C.G.2    Heidecker, G.3
  • 56
    • 0029731556 scopus 로고    scopus 로고
    • Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials
    • Schock, H. B., V. M. Garsky, and L. C. Kuo. 1996. Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. J. Biol. Chem. 271:31957-31963.
    • (1996) J. Biol. Chem. , vol.271 , pp. 31957-31963
    • Schock, H.B.1    Garsky, V.M.2    Kuo, L.C.3
  • 57
    • 0030768138 scopus 로고    scopus 로고
    • Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation
    • Sharma, P. L., and C. S. Crumpacker. 1997. Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation. J. Virol. 71:8846-8851.
    • (1997) J. Virol. , vol.71 , pp. 8846-8851
    • Sharma, P.L.1    Crumpacker, C.S.2
  • 59
    • 0031946007 scopus 로고    scopus 로고
    • Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo
    • Zennou, V., F. Mammano, S. Paulous, D. Mathez, and F. Clavel. 1998. Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo. J. Virol. 72:3300-3306.
    • (1998) J. Virol. , vol.72 , pp. 3300-3306
    • Zennou, V.1    Mammano, F.2    Paulous, S.3    Mathez, D.4    Clavel, F.5
  • 60
    • 0028031833 scopus 로고
    • Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase
    • Zhang, D., A. M. Caliendo, J. J. Eron, K. M. DeVore, J. C. Kaplan, M. S. Hirsch, and R. T. D'Aquila. 1994. Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 38:282-287.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 282-287
    • Zhang, D.1    Caliendo, A.M.2    Eron, J.J.3    DeVore, K.M.4    Kaplan, J.C.5    Hirsch, M.S.6    D'Aquila, R.T.7
  • 61
    • 0030769354 scopus 로고    scopus 로고
    • Drug resistance during indinavir therapy is caused by mutations in the protease gene and its gag substrate cleavage sites
    • Zhang, Y.-M., H. Imamichi, T. Imamichi, H. C. Lane, J. Falloon, M. B. Vasudevachari, and N. P. Salzman. 1997. Drug resistance during indinavir therapy is caused by mutations in the protease gene and its gag substrate cleavage sites. J. Virol. 71:6662-6670.
    • (1997) J. Virol. , vol.71 , pp. 6662-6670
    • Zhang, Y.-M.1    Imamichi, H.2    Imamichi, T.3    Lane, H.C.4    Falloon, J.5    Vasudevachari, M.B.6    Salzman, N.P.7
  • 62
    • 0003247871 scopus 로고    scopus 로고
    • Predictors of antiviral response to saquinavir/ritonavir therapy in a clinical cohort who failed prior protease inhibitors: A comparison of clinical characteristics, antiretroviral drug history and HIV genotype
    • abstr. 54
    • Zolopa, A. R., R. W. Shafer, A. Warford, J. G. Montoya, D. Katzenstein, and T. C. Merigan. 1998. Predictors of antiviral response to saquinavir/ritonavir therapy in a clinical cohort who failed prior protease inhibitors: a comparison of clinical characteristics, antiretroviral drug history and HIV genotype, abstr. 54. In Abstracts of the 2nd International Workshop on Drug Resistance and Treatment Strategies.
    • (1998) Abstracts of the 2nd International Workshop on Drug Resistance and Treatment Strategies
    • Zolopa, A.R.1    Shafer, R.W.2    Warford, A.3    Montoya, J.G.4    Katzenstein, D.5    Merigan, T.C.6


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