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Volumn 48, Issue 5-6, 2011, Pages 250-268

Genetic predisposition to respiratory infection and sepsis

Author keywords

epigenetics; genome wide association study; pneumonia; Polymorphism; post immune suppression; sepsis

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; CD14 ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE BINDING PROTEIN; LYMPHOTOXIN; MACROPHAGE MIGRATION INHIBITION FACTOR; MANNOSE BINDING LECTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 84055182880     PISSN: 10408363     EISSN: 1549781X     Source Type: Journal    
DOI: 10.3109/10408363.2011.641517     Document Type: Review
Times cited : (30)

References (220)
  • 3
    • 1842610168 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor 1 (PAI-1): In vitro activities and clinical relevance
    • DOI 10.1111/j.1365-2141.2004.04844.x
    • Horrevoets A. Plasminogen activator inhibitor 1 (PAI-1)-in vitro activities and clinical relevance. Br J Haematol 2004;125:12-23. (Pubitemid 38453272)
    • (2004) British Journal of Haematology , vol.125 , Issue.1 , pp. 12-23
    • Horrevoets, A.J.G.1
  • 5
    • 76749135794 scopus 로고    scopus 로고
    • Association of mannose-binding lectin-2 genotype and serum levels with prognosis of sepsis
    • Huh J, Song K, Yum J, Hong S, Lim C, Koh Y. Association of mannose-binding lectin-2 genotype and serum levels with prognosis of sepsis. Crit Care 2009;13:R176.
    • (2009) Crit Care , vol.13
    • Huh, J.1    Song, K.2    Yum, J.3    Hong, S.4    Lim, C.5    Koh, Y.6
  • 6
    • 48749126099 scopus 로고    scopus 로고
    • Low serum mannosebinding lectin level increases the risk of death due to pneumococcal infection
    • Eisen DP, Dean MM, Boermeester MA. Low serum mannosebinding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis 2008;47:510-516.
    • (2008) Clin Infect Dis , vol.47 , pp. 510-516
    • Eisen, D.P.1    Dean, M.M.2    Boermeester, M.A.3
  • 7
    • 33644772194 scopus 로고    scopus 로고
    • Mannose-binding lectin and its genetic variants
    • DOI 10.1038/sj.gene.6364283, PII 6364283
    • Garred P, Larsen F, Seyfarth J, Fujita R, Maden H. Mannosebinding lectin and its genetic variants. Genes Immunol 2006;7: 85-94. (Pubitemid 43336050)
    • (2006) Genes and Immunity , vol.7 , Issue.2 , pp. 85-94
    • Garred, P.1    Larsen, F.2    Seyfarth, J.3    Fujita, R.4    Madsen, H.O.5
  • 8
    • 0036456891 scopus 로고    scopus 로고
    • Analysis of the relationship between mannose-binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population
    • DOI 10.1046/j.1365-3083.2002.01167.x
    • Minchinton RM, Dean MM, Clark TR, Heatley S, Mullighan CG. Analysis of the relationship between mannose-binding lectin (MBL) genotype, MBL levels and function in an Australian blood donor population. Scand J Immunol 2002;56:630-641. (Pubitemid 35454347)
    • (2002) Scandinavian Journal of Immunology , vol.56 , Issue.6 , pp. 630-641
    • Minchinton, R.M.1    Dean, M.M.2    Clark, T.R.3    Heatley, S.4    Mullighan, C.G.5
  • 9
    • 0029045792 scopus 로고
    • Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein
    • Madsen HO, Garred P, Thiel S, Kurtzhals JA, Lamm LU, Ryder LP, Svejgaard A. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol 1995;155:3013-3020.
    • (1995) J Immunol , vol.155 , pp. 3013-3020
    • Madsen, H.O.1    Garred, P.2    Thiel, S.3    Kurtzhals, J.A.4    Lamm, L.U.5    Ryder, L.P.6    Svejgaard, A.7
  • 13
    • 0242551989 scopus 로고    scopus 로고
    • Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome
    • DOI 10.1086/379044
    • Garred P, J. StrÃ̧m J, Quist L, Taaning E, Madsen HO. Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis 2003;18:1394-1403. (Pubitemid 37433712)
    • (2003) Journal of Infectious Diseases , vol.188 , Issue.9 , pp. 1394-1403
    • Garred, P.1    Strom, J.J.2    Quist, L.3    Taaning, E.4    Madsen, H.O.5
  • 15
    • 14944375926 scopus 로고    scopus 로고
    • Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    • DOI 10.1097/01.CCM.0000156242.44356.C5
    • Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005;33:638-644 (Pubitemid 40365568)
    • (2005) Critical Care Medicine , vol.33 , Issue.3 , pp. 638-644
    • Sutherland, A.M.1    Walley, K.R.2    Russell, J.A.3
  • 16
    • 0242551989 scopus 로고    scopus 로고
    • Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome
    • DOI 10.1086/379044
    • Garred P, Strom JJ, Quist L. Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis 2003;188:1394-1403 (Pubitemid 37433712)
    • (2003) Journal of Infectious Diseases , vol.188 , Issue.9 , pp. 1394-1403
    • Garred, P.1    Strom, J.J.2    Quist, L.3    Taaning, E.4    Madsen, H.O.5
  • 20
    • 0037094086 scopus 로고    scopus 로고
    • Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients
    • DOI 10.1086/340216
    • Kronborg G, Weis N, Madsen HO, Pedersen SS, Wejse C, Nielsen H, SkinhÃ̧j P, Garred P. Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J Infect Dis 2002;185:1517-1520. (Pubitemid 34507977)
    • (2002) Journal of Infectious Diseases , vol.185 , Issue.10 , pp. 1517-1520
    • Kronborg, G.1    Weis, N.2    Madsen, H.O.3    Pedersen, S.S.4    Wejse, C.5    Nielsen, H.6    Skinhoj, P.7    Garred, P.8
  • 22
    • 0037068967 scopus 로고    scopus 로고
    • Mannose-binding lectin genotype as a risk factor for invasive pneumococcal infection [5]
    • Kronborg G, Garred P. Mannose-binding lectin genotype as a risk factor for invasive pneumococcal infection. Lancet 2002;360:1176. (Pubitemid 35246501)
    • (2002) Lancet , vol.360 , Issue.9340 , pp. 1176
    • Kronborg, G.1    Garred, P.2
  • 23
    • 33746969870 scopus 로고    scopus 로고
    • Mannose-binding lectin genotype and invasive pneumococcal infection
    • DOI 10.1016/j.humimm.2006.04.014, PII S0198885906001303
    • Moens L, Van Hoeyveld E, Peetermans W, De Boeck C, Verhaegen J, Bossuyt X. Mannose-binding lectin genotype and invasive pneumococcal infection. Hum Immunol 2006;67:605-611. (Pubitemid 44205326)
    • (2006) Human Immunology , vol.67 , Issue.8 , pp. 605-611
    • Moens, L.1    Van Hoeyveld, E.2    Peetermans, W.E.3    De Boeck, C.4    Verhaegen, J.5    Bossuyt, X.6
  • 26
    • 0036580648 scopus 로고    scopus 로고
    • Effects of cigarette smoke on the immune system
    • Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol 2002;2:372-377. (Pubitemid 37328760)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.5 , pp. 372-377
    • Sopori, M.1
  • 27
    • 0033978938 scopus 로고    scopus 로고
    • Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition
    • DOI 10.1128/IAI.68.2.688-693.2000
    • Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 2000;68:688-693. (Pubitemid 30056524)
    • (2000) Infection and Immunity , vol.68 , Issue.2 , pp. 688-693
    • Neth, O.1    Jack, D.L.2    Dodds, A.W.3    Holzel, H.4    Klein, N.J.5    Turner, M.W.6
  • 29
    • 0037448061 scopus 로고    scopus 로고
    • Differential microorganism-induced mannose-binding lectin activation
    • DOI 10.1016/S0928-8244(03)00032-4
    • Kuipers S, Aerts PC, van Dijk H. Differential microorganisminduced mannose-binding lectin activation. FEMS Immunol Med Microbiol 2003;36:33-39. (Pubitemid 36515081)
    • (2003) FEMS Immunology and Medical Microbiology , vol.36 , Issue.1-2 , pp. 33-39
    • Kuipers, S.1    Aerts, P.C.2    Van Dijk, H.3
  • 33
    • 12844264792 scopus 로고    scopus 로고
    • Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules Mannan-binding lectin, L-ficolin, and H-ficolin
    • DOI 10.1128/IAI.73.2.1052-1060.2005
    • Krarup A, Sorensen UBS, Matsushita M, Jensenius JC, Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-Ficolin, and H-Ficolin. Infect Immun 2005;73:1052-1060. (Pubitemid 40165766)
    • (2005) Infection and Immunity , vol.73 , Issue.2 , pp. 1052-1060
    • Krarup, A.1    Sorensen, U.B.S.2    Matsushita, M.3    Jensenius, J.C.4    Thiel, S.5
  • 35
    • 1642495736 scopus 로고    scopus 로고
    • L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement
    • Lynch NJ, Roscher S, Hartung T, Morath S, Matsushita M, Maennel DN, Kuraya M, Fujita T, Schwaeble WJ. L-Ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement. J Immunol 2004;172:1198-1202 (Pubitemid 38113782)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 1198-1202
    • Lynch, N.J.1    Roscher, S.2    Hartung, T.3    Morath, S.4    Matsushita, M.5    Maennel, D.N.6    Kuraya, M.7    Fujita, T.8    Schwaeble, W.J.9
  • 38
    • 77953390725 scopus 로고    scopus 로고
    • Mannose-binding lectin deficiency and respiratory tract infection
    • Eisen DP. Mannose-binding lectin deficiency and respiratory tract infection. J Innate Immun 2010;2:114-122.
    • (2010) J Innate Immun , vol.2 , pp. 114-122
    • Eisen, D.P.1
  • 39
    • 34250213685 scopus 로고    scopus 로고
    • Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease
    • DOI 10.1111/j.1365-2249.2007.03390.x
    • Eisen DP, Stubbs J, Spilsbury D, Carnie J, Leydon J, Howden BP. Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease. Clin Exp Immunol 2007;149:97-102. (Pubitemid 46897100)
    • (2007) Clinical and Experimental Immunology , vol.149 , Issue.1 , pp. 97-102
    • Eisen, D.P.1    Stubbs, J.2    Spilsbury, D.3    Carnie, J.4    Leydon, J.5    Howden, B.P.6
  • 40
    • 77956530119 scopus 로고    scopus 로고
    • Mannose-binding lectin and susceptibility to tuberculosis: A meta-analysis
    • Denholm JT, McBryde ES, Eisen DP. Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin Exp Immunol 2010;162:84-90.
    • (2010) Clin Exp Immunol , vol.162 , pp. 84-90
    • Denholm, J.T.1    McBryde, E.S.2    Eisen, D.P.3
  • 42
    • 25844469142 scopus 로고    scopus 로고
    • Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
    • DOI 10.1086/491479
    • Zhang H, Zhou G, Zhi L, Yang H, Zhai Y, Dong X, Zhang X, Gao X, Zhu Y, He F. Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome Coronavirus infection. J Infect Dis 2005;192:1355-1361. (Pubitemid 41401148)
    • (2005) Journal of Infectious Diseases , vol.192 , Issue.8 , pp. 1355-1361
    • Zhang, H.1    Zhou, G.2    Zhi, L.3    Yang, H.4    Zhai, Y.5    Dong, X.6    Zhang, X.7    Gao, X.8    Zhu, Y.9    He, F.10
  • 43
    • 0027296942 scopus 로고
    • Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster
    • DOI 10.1006/geno.1993.1324
    • Kolble K, Lu J, Mole S, Kaluz S, Reid K. Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster. Genomics 1993;17:294-298. (Pubitemid 23231282)
    • (1993) Genomics , vol.17 , Issue.2 , pp. 294-298
    • Kolble, K.1    Lu, J.2    Mole, S.E.3    Kaluz, S.4    Reid, K.B.M.5
  • 45
    • 2442508997 scopus 로고    scopus 로고
    • Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia
    • DOI 10.1097/01.CCM.0000124872.55243.5A
    • Quasney MW, Waterer GW, Dahmer MK, Kron GK, Zhang Q, Kessler LA, Wunderink RG. Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia. Crit Care Med 2004;32:1115-1119. (Pubitemid 38620977)
    • (2004) Critical Care Medicine , vol.32 , Issue.5 , pp. 1115-1119
    • Quasney, M.W.1    Waterer, G.W.2    Dahmer, M.K.3    Kron, G.K.4    Zhang, Q.5    Kessler, L.A.6    Wunderink, R.G.7
  • 46
    • 0043069635 scopus 로고    scopus 로고
    • Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): Structure, function and regulation in host defence against Gram-negative bacteria
    • DOI 10.1042/BST0310785
    • Weiss J. Bacteriricidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against gram negative bacteria. Biochem Soc Trans 2003;31:785-790. (Pubitemid 36981128)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.4 , pp. 785-790
    • Weiss, J.1
  • 48
    • 0035103891 scopus 로고    scopus 로고
    • Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: Gender-specific genetic predisposition to sepsis
    • Hubacek JA, Stuber F, Frohlich D, Book M, Wetegrove S, Ritter M, Rothe G, Schmitz G. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: Gender-specific genetic predisposition to sepsis. Crit Care Med 2001;29:557-561. (Pubitemid 32225297)
    • (2001) Critical Care Medicine , vol.29 , Issue.3 , pp. 557-561
    • Hubacek, J.A.1    Stuber, F.2    Frohlich, D.3    Book, M.4    Wetegrove, S.5    Ritter, M.6    Rothe, G.7    Schmitz, G.8
  • 49
    • 0344348974 scopus 로고    scopus 로고
    • Molecules in focus: CD14
    • Schutt C. Molecules in focus: CD14. Int J Biochem Cell Biol 1999;31:545-549.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 545-549
    • Schutt, C.1
  • 50
    • 29144458862 scopus 로고    scopus 로고
    • Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells
    • DOI 10.1111/j.1440-1711.2005.01370.x
    • Jersmann H. Time to abandon dogma: CD14 is expressed by nonmyeloid lineage cells. Immunol Cell Biol 2005;83:462-467. (Pubitemid 41805746)
    • (2005) Immunology and Cell Biology , vol.83 , Issue.5 , pp. 462-467
    • Jersmann, H.P.1
  • 51
    • 0023835464 scopus 로고
    • The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors
    • Goyert S, Ferrero E, Rettig W, Yenamandra A, Obata F, Le Beau M. The CD14 monocyte differentiation antigen maps to regin encoding growth factors and receptors. Science 1988;239:497-500. (Pubitemid 18084313)
    • (1988) Science , vol.239 , Issue.4839 , pp. 497-500
    • Goyert, S.M.1    Ferrero, E.2    Rettig, W.J.3    Yenamandra, A.K.4    Obata, F.5    Le Beau, M.M.6
  • 53
    • 33646813341 scopus 로고    scopus 로고
    • TLR2, TLR4, CD14, CD11B, and CD11C expression on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock
    • Brunialti M, Martins P, Carvalho H, Machado F, Barbosa L, Salomao R. TLR2, TLR4, CD14, CD11B, and CD11C expression on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock 2006;25:351-357.
    • (2006) Shock , vol.25 , pp. 351-357
    • Brunialti, M.1    Martins, P.2    Carvalho, H.3    MacHado, F.4    Barbosa, L.5    Salomao, R.6
  • 55
    • 0034984718 scopus 로고    scopus 로고
    • Early elevation of soluble CD14 may help identify trauma patients at high risk for infection
    • Carrillo E, Gordon L, Goode E, Davis E, Polk H. Early elevation of soluble CD14 may help identify trauma patients at high risk for infection. J Trauma 2001;50:810-815.
    • (2001) J Trauma , vol.50 , pp. 810-815
    • Carrillo, E.1    Gordon, L.2    Goode, E.3    Davis, E.4    Polk, H.5
  • 56
    • 0035959590 scopus 로고    scopus 로고
    • Parameters influencing membrane CD14 expression and soluble CD14 levels in sepsis
    • Gluck T, Silver J, Epstein M, Cao P, Farber B, Goyert S. Parameters influencing membrane CD14 expression and soluble CD14 levels in sepsis. Eur J Med Res 2001;6:351-358.
    • (2001) Eur J Med Res , vol.6 , pp. 351-358
    • Gluck, T.1    Silver, J.2    Epstein, M.3    Cao, P.4    Farber, B.5    Goyert, S.6
  • 57
    • 0031888096 scopus 로고    scopus 로고
    • Endotoxin binding and elimination by monocytes: Secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria
    • Hiki N, Berger D, Prigl C, Boelke E, Wiedeck H, Seidelmann M, Staib L, Kaminishi M, Ooohara T, Beger H. Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an indubicle mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria. Infect Immun 1998;66:1135-1141. (Pubitemid 28101157)
    • (1998) Infection and Immunity , vol.66 , Issue.3 , pp. 1135-1141
    • Hiki, N.1    Berger, D.2    Prigl, C.3    Boelke, E.4    Wiedeck, H.5    Seidelmann, M.6    Staib, L.7    Kaminishi, M.8    Oohara, T.9    Beger, H.G.10
  • 58
    • 0028901991 scopus 로고
    • Increased circulating soluble Cd14 is associated with high mortality in Gram-negative septic shock
    • Landmann R, Zimmerli W, Sansano S, Link S, Hahn A, Glauser MP, Calandra T. Increased circulating soluble Cd14 is associated with high mortality in Gram-negative septic shock. J Infect Dis 1995;171:639-644.
    • (1995) J Infect Dis , vol.171 , pp. 639-644
    • Landmann, R.1    Zimmerli, W.2    Sansano, S.3    Link, S.4    Hahn, A.5    Glauser, M.P.6    Calandra, T.7
  • 59
    • 0028937425 scopus 로고
    • Downregulation of proinflammatory cytokine release in whole blood from septic patients
    • Ertel W, Kremer J, Steckholzer U, Jarrar D, Trentz O, Schildberg F. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995;85:1341-1347.
    • (1995) Blood , vol.85 , pp. 1341-1347
    • Ertel, W.1    Kremer, J.2    Steckholzer, U.3    Jarrar, D.4    Trentz, O.5    Schildberg, F.6
  • 60
    • 2942638466 scopus 로고    scopus 로고
    • Modulation of the lipopolysaccharide receptor complex (CD14, TLR4, MD-2) and toll-like receptor 2 in systemic inflammatory response syndromepositive patients with and without infection:relationship to tolerance
    • Calvano J, Agnese D, Um J, Goshima M, Singhal R, Coyle S, Reddell M, Kumar A, Calvano S, Lowry S. Modulation of the lipopolysaccharide receptor complex (CD14, TLR4, MD-2) and toll-like receptor 2 in systemic inflammatory response syndromepositive patients with and without infection:relationship to tolerance. Shock 2003;20:415-419.
    • (2003) Shock , vol.20 , pp. 415-419
    • Calvano, J.1    Agnese, D.2    Um, J.3    Goshima, M.4    Singhal, R.5    Coyle, S.6    Reddell, M.7    Kumar, A.8    Calvano, S.9    Lowry, S.10
  • 63
    • 0036255629 scopus 로고    scopus 로고
    • Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate
    • Gibot S, Cariou A, Drouet L, Rossignol M, Ripoll L. Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality. Crit Care Med 2002;30:969-973. (Pubitemid 34508015)
    • (2002) Critical Care Medicine , vol.30 , Issue.5 , pp. 969-973
    • Gibot, S.1    Cariou, A.2    Drouet, L.3    Rossignol, M.4    Ripoll, L.5
  • 64
    • 0141455861 scopus 로고    scopus 로고
    • Polymorphisms in lymphotoxin alpha and CD14 genes influence TNFα production induced by Gram-positive and Gram-negative bacteria
    • DOI 10.1038/sj.gene.6363963
    • Temple SEL, Cheong KY, Almeida C-AM, Price P, Waterer GW. Polymorphisms in lymphotoxin alpha and CD14 genes influence TNFalpha production induced by Gram-positive and Gramnegative bacteria. Genes Immunol 2003;4:283-288. (Pubitemid 39562128)
    • (2003) Genes and Immunity , vol.4 , Issue.4 , pp. 283-288
    • Temple, S.E.L.1    Cheong, K.Y.2    Almeida, C.M.3    Price, P.4    Waterer, G.W.5
  • 66
    • 0033614734 scopus 로고    scopus 로고
    • C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction
    • Hubacek J, Pit'ha J, Skodova Z, Stanek V, Poledne R, Schmitz G. C(-260) a T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 1999;99:3218-3220. (Pubitemid 29293428)
    • (1999) Circulation , vol.99 , Issue.25 , pp. 3218-3220
    • Hubacek, J.A.1    Pit'ha, J.2    Skodova, Z.3    Stanek, V.4    Poledne, R.5
  • 68
    • 0037014564 scopus 로고    scopus 로고
    • CD14 C(-260)→T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
    • DOI 10.1016/S0735-1097(02)01937-X, PII S073510970201937X
    • Koenig W, Khuseyinova N, Hoffmann M, Marz W, Frohlich M, Hoffmeister A, Bremner H, Rothenbacher D. CD14C(-260) aT polymorphism plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stale coronoary artery disease. J Am Coll Cardiol 2002;40:34-42. (Pubitemid 34701374)
    • (2002) Journal of the American College of Cardiology , vol.40 , Issue.1 , pp. 34-42
    • Koenig, W.1    Khuseyinova, N.2    Hoffmann, M.M.3    Marz, W.4    Frohlich, M.5    Hoffmeister, A.6    Brenner, H.7    Rothenbacher, D.8
  • 69
    • 34547700084 scopus 로고    scopus 로고
    • Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture
    • DOI 10.1097/SHK.0b013e3180341d35, PII 0002438220070800000004
    • Lin J, Yao YM, Yu Y, Chai JK, Huang ZH, Dong N, Sheng ZY. Effects of Cd14-159 C/T polymorphism on Cd14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture. Shock 2007;28:148-153. (Pubitemid 47220824)
    • (2007) Shock , vol.28 , Issue.2 , pp. 148-153
    • Lin, J.1    Yao, Y.-M.2    Yu, Y.3    Chai, J.-K.4    Huang, Z.-H.5    Dong, N.6    Sheng, Z.-Y.7
  • 70
    • 7444263437 scopus 로고    scopus 로고
    • Association between a genomic polymorphism within the CD14 locus and severe sepsis susceptibility as well as prognosis in patients after extensive burns
    • Lin J, Yao Y, Huang ZH, Hou X, Zhu J, Chai J. Association between a genomic polymorphism within the CD14 locus and severe sepsis susceptibility as well as prognosis in patients after extensive burns. Zhong Bing Ji Jiu Yi Xue 2004;16:271-273.
    • (2004) Zhong Bing Ji Jiu Yi Xue , vol.16 , pp. 271-273
    • Lin, J.1    Yao, Y.2    Zh, H.3    Hou, X.4    Zhu, J.5    Chai, J.6
  • 71
    • 33847019483 scopus 로고    scopus 로고
    • CD14-159 C allele is associated with increased riks of mortality after burn injury
    • Barber R, Aragaki C, Chang L, Purdue G, Hunt J, Arnoldo B, Horton J. CD14-159 C allele is associated with increased riks of mortality after burn injury. Shock 2007;27:232-237.
    • (2007) Shock , vol.27 , pp. 232-237
    • Barber, R.1    Aragaki, C.2    Chang, L.3    Purdue, G.4    Hunt, J.5    Arnoldo, B.6    Horton, J.7
  • 73
    • 0037111078 scopus 로고    scopus 로고
    • Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
    • DOI 10.1086/344893
    • Agnese D, Calvano J, Hahm S, Coyle S, Corbett S, Calvano S, Lowry S. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated wtih an increased risk of gramnegative infections. J Infect Dis 2002;186:1522-1525. (Pubitemid 35286126)
    • (2002) Journal of Infectious Diseases , vol.186 , Issue.10 , pp. 1522-1525
    • Agnese, D.M.1    Calvano, J.E.2    Hahm, S.J.3    Coyle, S.M.4    Corbett, S.A.5    Calvano, S.E.6    Lowry, S.F.7
  • 75
    • 0346047286 scopus 로고    scopus 로고
    • The common functional C(-159)T polymorphism within promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality
    • Hubacek J, Stuber F, Frohlich D, Book M, Wetegrove S, Rothe G, Schmitz G. The common functional C(-159)T polymorphism within promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality. Genes Immunol 2000;1:405-407.
    • (2000) Genes Immunol , vol.1 , pp. 405-407
    • Hubacek, J.1    Stuber, F.2    Frohlich, D.3    Book, M.4    Wetegrove, S.5    Rothe, G.6    Schmitz, G.7
  • 78
    • 0036134963 scopus 로고    scopus 로고
    • Toll-like receptors: How they work and what they do
    • DOI 10.1097/00062752-200201000-00002
    • Beutler B. Toll-like receptors: how they work and what they do. Curr Opin Hematol 2002;9:2-10. (Pubitemid 34025305)
    • (2002) Current Opinion in Hematology , vol.9 , Issue.1 , pp. 2-10
    • Beutler, B.1
  • 80
    • 0037071251 scopus 로고    scopus 로고
    • Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    • Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with Gram-negative septic shock. Arch Intern Med 2002;162:1028-1032. (Pubitemid 34492532)
    • (2002) Archives of Internal Medicine , vol.162 , Issue.9 , pp. 1028-1032
    • Lorenz, E.1    Mira, J.P.2    Frees, K.L.3    Schwartz, D.A.4
  • 83
    • 84855565743 scopus 로고    scopus 로고
    • accessed 15 Jan 2011
    • www.hapmap.org: accessed 15 Jan 2011.
  • 84
    • 0033794461 scopus 로고    scopus 로고
    • A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection
    • Lorenz E, Mira J, Cornish K, Arbour N, Schwartz D. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000;68:6398-6401.
    • (2000) Infect Immun , vol.68 , pp. 6398-6401
    • Lorenz, E.1    Mira, J.2    Cornish, K.3    Arbour, N.4    Schwartz, D.5
  • 90
    • 41149120598 scopus 로고    scopus 로고
    • Clinical relevance of TLR2, TLR4, CD14 and FcγRIIA gene polymorphisms in Streptococcus pneumoniae infection
    • DOI 10.1038/sj.icb.7100155, PII 7100155
    • Yuan FF, Marks K, Wong M, Watson S, de Leon E, McIntyre PB, Sullivan JS. Clinical relevance of TLR2, TLR4, CD14 and Fcgamma RIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol 2008;86:268-270. (Pubitemid 351430807)
    • (2008) Immunology and Cell Biology , vol.86 , Issue.3 , pp. 268-270
    • Yuan, F.F.1    Marks, K.2    Wong, M.3    Watson, S.4    De Leon, E.5    McIntyre, P.B.6    Sullivan, J.S.7
  • 91
    • 78650790250 scopus 로고    scopus 로고
    • Identification of haplotype Tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma
    • Chen K, Gu W, Zeng L, Jiang D, Zhang L, Zhou J, Du D, Hu P, Liu Q, Huang S et al. Identification of haplotype Tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma. Shock 2011;35:35-41.
    • (2011) Shock , vol.35 , pp. 35-41
    • Chen, K.1    Gu, W.2    Zeng, L.3    Jiang, D.4    Zhang, L.5    Zhou, J.6    Du, D.7    Hu, P.8    Liu, Q.9    Huang, S.10
  • 93
    • 0026492077 scopus 로고
    • On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2
    • Parren PW, Warmerdam PA, Boeije LC, Arts J, Westerdaal NA, Vlug A, Capel PJ, Aarden LA, van de Winkel JG. On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2. J Clin Invest 1992;90: 1537-1546.
    • (1992) J Clin Invest , vol.90 , pp. 1537-1546
    • Parren, P.W.1    Warmerdam, P.A.2    Boeije, L.C.3    Arts, J.4    Westerdaal, N.A.5    Vlug, A.6    Capel, P.J.7    Aarden, L.A.8    Van De Winkel, J.G.9
  • 94
    • 0030609855 scopus 로고    scopus 로고
    • FcγRIIA polymorphism as a risk factor for invasive pneumococcal infections in systemic lupus erythematosus
    • DOI 10.1002/art.1780400626
    • Yee A, Ng S, Sober R, Salmon J. Fcgamma RIIA polymorphism as a risk factor for invasive pneumococcal infections in systemic lupus erythematosus. Arthritis Rheum 1997;40:1180-1182. (Pubitemid 27242309)
    • (1997) Arthritis and Rheumatism , vol.40 , Issue.6 , pp. 1180-1182
    • Yee, A.M.F.1    Ng, S.C.2    Sobel, R.E.3    Salmon, J.E.4
  • 95
    • 32444439967 scopus 로고    scopus 로고
    • FcγRIIA polymorphism as a risk factor for invasive Streptococcus pneumoniae
    • DOI 10.1016/j.cair.2005.11.001, PII S1529104905000735
    • Yuan F, Sullivan J. Fcgamma RIIA polymorphism as risk factor for invasive Streptococcus pneumoniae. Clin Appl Immunol Rev 2005;5:397-403. (Pubitemid 43224937)
    • (2005) Clinical and Applied Immunology Reviews , vol.5 , Issue.6 , pp. 397-403
    • Yuan, F.F.1    Sullivan, J.S.2
  • 105
    • 70350536773 scopus 로고    scopus 로고
    • Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF?238A polymorphism
    • Pappachan J, Coulson T, Child N, Markham D, Nour S, Pulletz M, Rose-Zerilli M, de Courcey-Golder K, Barton S, Yang I et al. Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF?238A polymorphism. Immunogenetics 2009;61:657-662.
    • (2009) Immunogenetics , vol.61 , pp. 657-662
    • Pappachan, J.1    Coulson, T.2    Child, N.3    Markham, D.4    Nour, S.5    Pulletz, M.6    Rose-Zerilli, M.7    De Courcey-Golder, K.8    Barton, S.9    Yang, I.10
  • 106
    • 0037644804 scopus 로고    scopus 로고
    • Biological functions of tumor necrosis factor cytokines and their receptors
    • DOI 10.1016/S1359-6101(03)00022-4
    • Pfeffer K. Biological functions of tumour necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev 2003;14:185-191. (Pubitemid 36693140)
    • (2003) Cytokine and Growth Factor Reviews , vol.14 , Issue.3-4 , pp. 185-191
    • Pfeffer, K.1
  • 108
    • 4644336088 scopus 로고    scopus 로고
    • The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B
    • DOI 10.1007/s00134-004-2359-5
    • Temple SEL, Cheong KY, Ardlie KG, Sayer D, Waterer GW. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. Intensive Care Med 2004;30:1761-1767. (Pubitemid 39297180)
    • (2004) Intensive Care Medicine , vol.30 , Issue.9 , pp. 1761-1767
    • Temple, S.E.L.1    Cheong, K.Y.2    Ardlie, K.G.3    Sayer, D.4    Waterer, G.W.5
  • 109
    • 0037568026 scopus 로고    scopus 로고
    • Heat shock protein 70-2 + 1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia
    • DOI 10.1097/01.CCM.0000063088.86079.03
    • Waterer GW, ElBahlawan L, Quasney MW, Zhang Q, Kessler LA, Wunderink RG. Heat shock protein 70-2 + 1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Crit Care Med 2003;31:1367-1372 (Pubitemid 36583845)
    • (2003) Critical Care Medicine , vol.31 , Issue.5 , pp. 1367-1372
    • Waterer, G.W.1    ElBahlawan, L.2    Quasney, M.W.3    Zhang, Q.4    Kessler, L.A.5    Wunderink, R.G.6
  • 110
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic- onset juvenile chronic arthritis
    • Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin J, Humphries S, Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369-1376. (Pubitemid 28467565)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.7 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffey, R.3    Mohamed-Ali, V.4    Yudkin, J.S.5    Humphries, S.6    Woo, P.7
  • 111
    • 0041414587 scopus 로고    scopus 로고
    • The-174G/C interluekin-6 polymorphism influences postoperative interleukin-6 levels and postoperative arterial fibrillation Is atrial fibrillation an inflammatory complication?
    • Gaudino M, Andreotti F, Zamparelli R, Di Castelnuovo A, Nasso G, Burzotta F, Lacoviello L, Donati MB, Schiavello R, Maseri A et al. The-174G/C interluekin-6 polymorphism influences postoperative interleukin-6 levels and postoperative arterial fibrillation. Is atrial fibrillation an inflammatory complication? Circulation 2003;108:195-199.
    • (2003) Circulation , vol.108 , pp. 195-199
    • Gaudino, M.1    Andreotti, F.2    Zamparelli, R.3    Di Castelnuovo, A.4    Nasso, G.5    Burzotta, F.6    Lacoviello, L.7    Donati, M.B.8    Schiavello, R.9    Maseri, A.10
  • 116
    • 11844292713 scopus 로고    scopus 로고
    • The association of interleukin 6 haplotype clades with mortality in critically ill adults
    • DOI 10.1001/archinte.165.1.75
    • Sutherland AM, Walley KR, Monacha S, Russell JA. The association of interluekin 6 haplotype clades with mortality in critically ill patients. Arch Intern Med 2005;165: 75-82. (Pubitemid 40096085)
    • (2005) Archives of Internal Medicine , vol.165 , Issue.1 , pp. 75-82
    • Sutherland, A.M.1    Walley, K.R.2    Manocha, S.3    Russell, J.A.4
  • 117
    • 45949100694 scopus 로고    scopus 로고
    • IL6 gene-wide haplotype is associated with susceptibility to acute lung injury
    • DOI 10.1016/j.trsl.2008.05.006, PII S1931524408001503
    • Flores C, Ma S, Marresso K, Wade M, Villar J, Garcia J. IL6 genome-wide haplotype is associated with susceptibility to acute lung injury. Transl Res 2008;152:11-17. (Pubitemid 351890454)
    • (2008) Translational Research , vol.152 , Issue.1 , pp. 11-17
    • Flores, C.1    Ma, S.-F.2    Maresso, K.3    Wade, M.S.4    Villar, J.5    Garcia, J.G.N.6
  • 118
    • 39749133713 scopus 로고    scopus 로고
    • Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patients
    • Sainz J, Perez E, Gomex-Lopera S, Lopez-Fernandez E, Moratalla L, Oyonarte S, Jurado M. Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patients. Cytokine 2008;41:268-278.
    • (2008) Cytokine , vol.41 , pp. 268-278
    • Sainz, J.1    Perez, E.2    Gomex-Lopera, S.3    Lopez-Fernandez, E.4    Moratalla, L.5    Oyonarte, S.6    Jurado, M.7
  • 119
    • 0036162165 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor
    • Baugh JA, Bucala R. Macrophage migration inhibitory factor. Crit Care Med 2002;30:S27-S35. (Pubitemid 34131159)
    • (2002) Critical Care Medicine , vol.30 , Issue.1 SUPPL. B
    • Baugh, J.A.1    Bucala, R.2
  • 123
    • 0034966944 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness
    • DOI 10.1210/jc.86.6.2811
    • Beishuizen A, Thijs L, Haanen C, Vermes I. Macrophage migration inhibitory factor and hypothalamo-pituitaryadrenal function during critical illness. J Clin Endocrinol Metab 2001;86:2811-2816. (Pubitemid 32545744)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.6 , pp. 2811-2816
    • Beishuizen, A.1    Thijs, L.G.2    Haanen, C.3    Vermes, I.4
  • 124
    • 8344274437 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis
    • DOI 10.1097/01.shk.0000140305.01641.c8
    • Bozza F, Gomes R, Japiassu A, Soares M, Castro-Faria-Neto H, Bozza M. Macrophage migration inhibitory factor levels correlated with fatal outcome in sepsis. Shock 2004;22: 309-313. (Pubitemid 39480698)
    • (2004) Shock , vol.22 , Issue.4 , pp. 309-313
    • Bozza, F.A.1    Gomes, R.N.2    Japiassu, A.M.3    Soares, M.4    Castro-Faria-Neto, H.C.5    Bozza, P.T.6    Bozza, M.T.7
  • 127
    • 25444507679 scopus 로고    scopus 로고
    • Improved resistance to bacterial superinfection in mice by treatment with macrophage migration inhibitory factor
    • DOI 10.1128/IAI.73.10.6488-6492.2005
    • Pollak N, Sterns T, Echtenacher B, Mannel D. Improved resistance to bacterial superinfection in mice by treatment with macrophage migration inhibitory factor. Infect Immun 2005;73:6488-6492. (Pubitemid 41368811)
    • (2005) Infection and Immunity , vol.73 , Issue.10 , pp. 6488-6492
    • Pollak, N.1    Sterns, T.2    Echtenacher, B.3    Mannel, D.N.4
  • 128
    • 0036561069 scopus 로고    scopus 로고
    • A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis
    • DOI 10.1038/sj.gene.6363867
    • Baugh JA, Chitnis S, Donnelly S, Monteiro J, Lin X, Plant B, Wolfe F, Gregersen P, Bucala R. A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun 2002;3:170-176. (Pubitemid 38961128)
    • (2002) Genes and Immunity , vol.3 , Issue.3 , pp. 170-176
    • Baugh, J.A.1    Chitnis, S.2    Donnelly, S.C.3    Monteiro, J.4    Lin, X.5    Plant, B.J.6    Wolfe, F.7    Gregersen, P.K.8    Bucala, R.9
  • 129
    • 0034742201 scopus 로고    scopus 로고
    • A novel 5′-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    • DOI 10.1002/1529-0131(200 108)44:8<1782::A ID-ART314>3.0.CO;2-#
    • Donn R, Shelley E, Ollier W, Thomson W. A novel 5′-flanking region polymrophism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. Arthris Rheum 2001;44:1782-1785. (Pubitemid 32758224)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.8 , pp. 1782-1785
    • Donn, R.P.1    Shelley, E.2    Ollier, W.E.R.3    Thomson, W.4
  • 130
    • 68849109968 scopus 로고    scopus 로고
    • The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia
    • Yende S, Angus D, Kong L, Kellum J, Weissfeld L, Ferrell R, Finegold D, Carter M, Leng L, Peng Z et al. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. FASEB J 2009;23:2403-2411.
    • (2009) FASEB J , vol.23 , pp. 2403-2411
    • Yende, S.1    Angus, D.2    Kong, L.3    Kellum, J.4    Weissfeld, L.5    Ferrell, R.6    Finegold, D.7    Carter, M.8    Leng, L.9    Peng, Z.10
  • 132
    • 84055218634 scopus 로고    scopus 로고
    • Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients
    • Surbatovic M, Grujic K, Cikota B, Jevtic M, Filipovic N, Romic P, Strelic N, Magic Z. Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients. J Crit Care 2010;25:542.e1-8.
    • (2010) J Crit Care , vol.25
    • Surbatovic, M.1    Grujic, K.2    Cikota, B.3    Jevtic, M.4    Filipovic, N.5    Romic, P.6    Strelic, N.7    Magic, Z.8
  • 133
    • 32844458670 scopus 로고    scopus 로고
    • Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility
    • DOI 10.1007/s00134-005-0022-4
    • Stanilova S, Miteva L, Karakolev Z, Stefanov C. Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility. Intensive Care Med 2006;32:260-266. (Pubitemid 43251147)
    • (2006) Intensive Care Medicine , vol.32 , Issue.2 , pp. 260-266
    • Stanilova, S.A.1    Miteva, L.D.2    Karakolev, Z.T.3    Stefanov, C.S.4
  • 134
    • 0037312723 scopus 로고    scopus 로고
    • Association of IL-10 polymorphism with severity of illness in community acquired pneumonia
    • DOI 10.1136/thorax.58.2.154
    • Gallagher PM, Lowe G, Fitzgerald T, Bella A, Greene CM, McElvaney NG, O'Neill SJ. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 2003;58:154-156. (Pubitemid 36183005)
    • (2003) Thorax , vol.58 , Issue.2 , pp. 154-156
    • Gallagher, P.M.1    Lowe, G.2    Fitzgerald, T.3    Bella, A.4    Greene, C.M.5    McElvaney, N.G.6    O'Neill, S.J.7
  • 137
    • 0347003618 scopus 로고    scopus 로고
    • Alleles carried at positions -819 and -592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae
    • DOI 10.1007/s00251-003-0621-6
    • Temple SEL, Lim E, Cheong KY, Almeida C-AM, Price P, Ardlie KG, Waterer GW. Alleles carried at positions-819 and-592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae. Immunogenetics 2003;55:629-632. (Pubitemid 38085116)
    • (2003) Immunogenetics , vol.55 , Issue.9 , pp. 629-632
    • Temple, S.E.L.1    Lim, E.2    Cheong, K.Y.3    Almeida, C.-A.M.4    Price, P.5    Ardlie, K.G.6    Waterer, G.W.7
  • 138
    • 24944436195 scopus 로고    scopus 로고
    • Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis
    • DOI 10.1378/chest.128.3.1690
    • Wattanathum A, Manocha S, Groshaus H, Russell JA, Walley KR. Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis. Chest 2005;128:1690-1698. (Pubitemid 41324465)
    • (2005) Chest , vol.128 , Issue.3 , pp. 1690-1698
    • Wattanathum, A.1    Manocha, S.2    Groshaus, H.3    Russell, J.A.4    Walley, K.R.5
  • 141
    • 27744559524 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 gene polymorphism and sepsis
    • DOI 10.1086/431996
    • Hermans P, Hazelzet J. Plasminogen activator inhibitor type 1 gene polymorphism and sepsis. Clin Infect Dis 2005;41:S453-458. (Pubitemid 41598305)
    • (2005) Clinical Infectious Diseases , vol.41 , Issue.SUPPL. 7
    • Hermans, P.W.M.1    Hazelzet, J.A.2
  • 144
    • 0345860914 scopus 로고    scopus 로고
    • Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children
    • DOI 10.1097/01.CCM.0000100122.57249.5D
    • Haralambous E, Hibberd M, Hermans P, Ninis N, Nadel S, Levin M. Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit Care Med 2003;31:2788-2793. (Pubitemid 38010636)
    • (2003) Critical Care Medicine , vol.31 , Issue.12 , pp. 2788-2793
    • Haralambous, E.1    Hibberd, M.L.2    Hermans, P.W.M.3    Ninis, N.4    Nadel, S.5    Levin, M.6
  • 145
    • 0035820317 scopus 로고    scopus 로고
    • Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients
    • DOI 10.1016/S0140-6736(00)04311-7
    • Menges T, Hermans P, Little S, Langefeld T, Boning O, Engel J, Sluijter M, de Groot R, Hempelmann G. Plasminogen-activatorinhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients. Lancet 2001;357:1096-1097. (Pubitemid 32322544)
    • (2001) Lancet , vol.357 , Issue.9262 , pp. 1096-1097
    • Menges, T.1    Hermans, P.W.M.2    Little, S.G.3    Langefeld, T.4    Boning, O.5    Engel, J.6    Sluijter, M.7    De Groot, R.8    Hempelmann, G.9
  • 146
    • 0033554267 scopus 로고    scopus 로고
    • Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock
    • DOI 10.1016/S0140-6736(98)09376-3
    • Westendorp R, Hottenga J, Slagboom P. Variation in plasminogenactivator- inhibitor-1 gene and risk of meningococcal septic shock. Lancet 1999;354:561-563. (Pubitemid 29381371)
    • (1999) Lancet , vol.354 , Issue.9178 , pp. 561-563
    • Westendorp, R.G.J.1    Hottenga, J.-J.2    Slagboom, P.E.3
  • 147
    • 65549105461 scopus 로고    scopus 로고
    • 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia
    • Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology 2009;110:1086-1091.
    • (2009) Anesthesiology , vol.110 , pp. 1086-1091
    • Sapru, A.1    Hansen, H.2    Ajayi, T.3    Brown, R.4    Garcia, O.5    Zhuo, H.6    Wiemels, J.7    Matthay, M.A.8    Wiener-Kronish, J.9
  • 148
    • 77951586510 scopus 로고    scopus 로고
    • 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: Prospective, observational, genetic study
    • Madach K, Aladzsity I, Szilagyi A, Fust G, Gal J, Penzes I, Prohaszka Z. 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. Crit Care Med 2010;14:R79-87.
    • (2010) Crit Care Med , vol.14
    • Madach, K.1    Aladzsity, I.2    Szilagyi, A.3    Fust, G.4    Gal, J.5    Penzes, I.6    Prohaszka, Z.7
  • 149
    • 0033554250 scopus 로고    scopus 로고
    • 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease
    • DOI 10.1016/S0140-6736(99)02220-5
    • Hermans P, Hibberd M, Booy R, Daramola O, Hazelzet J, De Groot R, Levin M. 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococal disease. Meningococcal Research Group. Lancet 1999;354:556-560. (Pubitemid 29381370)
    • (1999) Lancet , vol.354 , Issue.9178 , pp. 556-560
    • Hermans, P.W.M.1    Hibberd, M.L.2    Booy, R.3    Daramola, O.4    Hazelzet, J.A.5    De Groot, R.6    Levin, M.7
  • 151
    • 2942703851 scopus 로고    scopus 로고
    • Effect of factor v Leiden polymorphisms in severe sepsis adn on treatment with recombinant human activated protein C
    • Yan S, Nelson D. Effect of factor V Leiden polymorphisms in severe sepsis adn on treatment with recombinant human activated protein C. Crit Care Med 2004;5:S239-246.
    • (2004) Crit Care Med , vol.5
    • Yan, S.1    Nelson, D.2
  • 152
    • 0028968010 scopus 로고
    • Genotypic variation in promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk
    • Spek C, Koster T, Rosendaal F, Bertina R, Reitsma P. Genotypic variation in promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk. Arterioscler Thromb Vasc Biol 1995;15:214-218.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 214-218
    • Spek, C.1    Koster, T.2    Rosendaal, F.3    Bertina, R.4    Reitsma, P.5
  • 153
    • 33845954994 scopus 로고    scopus 로고
    • Protein C - 1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis
    • DOI 10.1097/01.CCM.0000249823.44726.4E, PII 0000324620070100000003
    • Walley KR, Russell J. Protein C-1641AA is associatd with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med 2007;35:12-17. (Pubitemid 46035671)
    • (2007) Critical Care Medicine , vol.35 , Issue.1 , pp. 12-17
    • Walley, K.R.1    Russell, J.A.2
  • 154
    • 0037393046 scopus 로고    scopus 로고
    • Genetics of coagulation factors in acute lung injury
    • Russell J. Genetics of coaguation factors in acute lung injury. Crit Care Med 2003;31:S243-247. (Pubitemid 36458174)
    • (2003) Critical Care Medicine , vol.31 , Issue.4 SUPPL.
    • Russell, J.A.1
  • 155
    • 41149088131 scopus 로고    scopus 로고
    • Protein C-1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population
    • Chen Q, Wu S, Wang H, Lv C, Cheng B, Xie G, Fang X. Protein C-1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population. Hum Genet 2008;123:281-287.
    • (2008) Hum Genet , vol.123 , pp. 281-287
    • Chen, Q.1    Wu, S.2    Wang, H.3    Lv, C.4    Cheng, B.5    Xie, G.6    Fang, X.7
  • 156
    • 45049085042 scopus 로고    scopus 로고
    • Protein C rs2069912 C allele is associated with increased mortality from sepsis in North Americans of East Asian ancestry
    • Russell J, Wellman H, Walley KR. Protein C rs2069912 C allele is associated with increased mortality from sepsis in North Americans of East Asian ancestry. Hum Genet 2008;123:661-663.
    • (2008) Hum Genet , vol.123 , pp. 661-663
    • Russell, J.1    Wellman, H.2    Walley, K.R.3
  • 158
    • 74049136812 scopus 로고    scopus 로고
    • Association between lymphotoxin-[alpha] (tumor necrosis factor-[beta]) intron polymorphism and predisposition to severe sepsis is modified by gender and age
    • Watanabe E, Buchman T, Hirasawa H, Zehnbauer B. Association between lymphotoxin-[alpha] (tumor necrosis factor-[beta]) intron polymorphism and predisposition to severe sepsis is modified by gender and age. Crit Care Med 2010;38:181-193.
    • (2010) Crit Care Med , vol.38 , pp. 181-193
    • Watanabe, E.1    Buchman, T.2    Hirasawa, H.3    Zehnbauer, B.4
  • 159
    • 35448984009 scopus 로고    scopus 로고
    • Common TNFalpha, IL1beta PAI-1 uPA CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis
    • Jessen K, Lindboe S, Petersen A, Eugen-Olsen J, Benfield T. Common TNFalpha, IL1beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis 2007;7:108.
    • (2007) BMC Infect Dis , vol.7 , pp. 108
    • Jessen, K.1    Lindboe, S.2    Petersen, A.3    Eugen-Olsen, J.4    Benfield, T.5
  • 160
    • 84855565741 scopus 로고    scopus 로고
    • Accessed February 15 2011
    • http://wtccc.org.uk. Accessed February 15 2011.
  • 162
    • 84855536333 scopus 로고    scopus 로고
    • Accessed 1 March 2011
    • http://www.nihroadmap.nih.gov/GTEx/index.asp. Accessed 1 March 2011.
  • 163
    • 78650624395 scopus 로고    scopus 로고
    • Genome-wide transcription profiling of human sepsis: A systematic review
    • Tang B, Huang S, McLean A. Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care 2010;14:R237.
    • (2010) Crit Care , vol.14
    • Tang, B.1    Huang, S.2    McLean, A.3
  • 164
    • 0029115513 scopus 로고
    • Long term survival and function after suspected gram-negative sepsis
    • Perl T, Dvolak L, Hwang T, Wenzel R. Long term survival and function after suspected gram-negative sepsis. JAMA 1995;274:338-345.
    • (1995) JAMA , vol.274 , pp. 338-345
    • Perl, T.1    Dvolak, L.2    Hwang, T.3    Wenzel, R.4
  • 165
    • 0031003777 scopus 로고    scopus 로고
    • Magnitude and duration of the effect of sepsis on survival Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group
    • Quartin A, Schein R, Kett D, Peduzzi P. Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 1997;277:1058-1063.
    • (1997) JAMA , vol.277 , pp. 1058-1063
    • Quartin, A.1    Schein, R.2    Kett, D.3    Peduzzi, P.4
  • 167
    • 18244376372 scopus 로고    scopus 로고
    • Reversal of long-term sepsis-induced immunosuppression by dendritic cells
    • DOI 10.1182/blood-2004-08-3251
    • Benjamin C, Lunky S, Lukacs N, Hogaboam C, Kunkel S. Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood 2005;105:3588-3595. (Pubitemid 40628205)
    • (2005) Blood , vol.105 , Issue.9 , pp. 3588-3595
    • Benjamim, C.F.1    Lundy, S.K.2    Lukacs, N.W.3    Hogaboam, C.M.4    Kunkel, S.L.5
  • 171
    • 21244481640 scopus 로고    scopus 로고
    • Endotoxin tolerance disrupts chromatin remodeling and NF-κB transactivation at the IL-1β promoter
    • Chan C, Li L, McCall C, Yoza B. Endotoxin tolerance disrupts chromatin remodelling and NFkappaB transactivation at the IL-1beta promoter. J Immunol 2005;175:461-468. (Pubitemid 40884350)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 461-468
    • Chan, C.1    Li, L.2    McCall, C.E.3    Yoza, B.K.4
  • 172
    • 63049092806 scopus 로고    scopus 로고
    • Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance
    • El Gazzar M, Yoza B, Chen X, Garcia B, Young N, McCall C. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol 2009;29:1959-1971.
    • (2009) Mol Cell Biol , vol.29 , pp. 1959-1971
    • El Gazzar, M.1    Yoza, B.2    Chen, X.3    Garcia, B.4    Young, N.5    McCall, C.6
  • 173
    • 79952378225 scopus 로고    scopus 로고
    • Epigenetic regulation of immune cell functions during post-septic immunosuppression
    • Carson W, Cavassani K, Dou Y, Kunkel S. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011;6:273-283.
    • (2011) Epigenetics , vol.6 , pp. 273-283
    • Carson, W.1    Cavassani, K.2    Dou, Y.3    Kunkel, S.4
  • 174
    • 33846876336 scopus 로고    scopus 로고
    • Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
    • DOI 10.1182/blood-2006-04-019711
    • Brogdon JL, Xu Y, Szabo SJ, An S, Buxton F, Cohen D, Huang Q. Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood 2007;109:1123-1130. (Pubitemid 46220659)
    • (2007) Blood , vol.109 , Issue.3 , pp. 1123-1130
    • Brogdon, J.L.1    Xu, Y.2    Szabo, S.J.3    An, S.4    Buxton, F.5    Cohen, D.6    Huang, Q.7
  • 175
    • 9644312767 scopus 로고    scopus 로고
    • Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice
    • DOI 10.1097/01.shk.0000131194.80038.3f
    • Ding Y, Chung C, Newton S, Chen Y, Carlton S, Albina J, Ayala A. Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice. Shock 2004;22:137-144. (Pubitemid 40228191)
    • (2004) Shock , vol.22 , Issue.2 , pp. 137-144
    • Ding, Y.1    Chung, C.-S.2    Newton, S.3    Chen, Y.4    Carlton, S.5    Albina, J.E.6    Ayala, A.7
  • 177
    • 33646087221 scopus 로고    scopus 로고
    • Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response
    • DOI 10.1189/jlb.0705413
    • Flohe S, Agrawal H, Schmitz D, Gertz M, Flohe S, Schade F. Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J Leukoc Biol 2006;79:473-481. (Pubitemid 44831224)
    • (2006) Journal of Leukocyte Biology , vol.79 , Issue.3 , pp. 473-481
    • Flohe, S.B.1    Agrawal, H.2    Schmitz, D.3    Gertz, M.4    Flohe, S.5    Schade, F.U.6
  • 178
    • 0031110570 scopus 로고    scopus 로고
    • Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and GUT by an endotoxin and TNF- independent pathway
    • Hiramatsu M, Hotchkiss R, Karl I, Buchman TG. Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 1997;7:247-253. (Pubitemid 127654275)
    • (1997) Shock , vol.7 , Issue.4 , pp. 247-253
    • Hiramatsu, M.1    Hotchkiss, R.S.2    Karl, I.E.3    Buchman, T.G.4
  • 179
    • 33750288937 scopus 로고    scopus 로고
    • Apoptosis and caspases regulate death and inflammation in sepsis
    • DOI 10.1038/nri1943, PII NRI1943
    • Hotchkiss R, Nicholson D. Apoptosis and caspases regulated death and inflammation in sepsis. Nat Rev Immunol 2006;6:813-822. (Pubitemid 44631650)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.11 , pp. 813-822
    • Hotchkiss, R.S.1    Nicholson, D.W.2
  • 180
    • 0030739250 scopus 로고    scopus 로고
    • Apoptosis in lymphoid and parenchymal cells during sepsis: Findings in normal and T- and B-celldeficient mice
    • DOI 10.1097/00003246-199708000-00015
    • Hotchkiss R, Swanson P, Cobb J, Jacobson A, Buchman TG, Karl I. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T-and B-cell-deficient mice. Crit Care Med 1997;25:1298-1307. (Pubitemid 27347292)
    • (1997) Critical Care Medicine , vol.25 , Issue.8 , pp. 1298-1307
    • Hotchkiss, R.S.1    Swanson, P.E.2    Cobb, J.P.3    Jacobson, A.4    Buchman, T.G.5    Karl, I.E.6
  • 182
    • 41349119386 scopus 로고    scopus 로고
    • Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response
    • DOI 10.1182/blood-2007-08-106443
    • Wen H, Dou Y, Hogaboam C, Kunkel S. Epigenetic regulation of dendritic derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood 2008;111:1797-1804. (Pubitemid 351451484)
    • (2008) Blood , vol.111 , Issue.4 , pp. 1797-1804
    • Wen, H.1    Dou, Y.2    Hogaboam, C.M.3    Kunkel, S.L.4
  • 183
    • 43349088279 scopus 로고    scopus 로고
    • Dendritic cells at the interface of innate and acquired immunity: The role for epigenetic changes
    • DOI 10.1189/jlb.0607357
    • Wen H, Schaller MA, Dou Y, Hogaboam CM, Kunkel SL. Dendritic cells at the interface of innate and acquired immunity: the role for epigenetic changes. J Leuko Biol 2008;83:439-446. (Pubitemid 351966848)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.3 , pp. 439-446
    • Wen, H.1    Schaller, M.A.2    Dou, Y.3    Hogaboam, C.M.4    Kunkel, S.L.5
  • 184
    • 0029166176 scopus 로고
    • Polymicrobial sepsis folllowing trauma inhibits interleukin-10 secretion and lymphocyte proliferation
    • Napolitano L, Campbell C. Polymicrobial sepsis folllowing trauma inhibits interleukin-10 secretion and lymphocyte proliferation. J Trauma 1995;39:104-110.
    • (1995) J Trauma , vol.39 , pp. 104-110
    • Napolitano, L.1    Campbell, C.2
  • 187
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman RC, Farh KK-H, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009;19:92-105.
    • (2009) Genome Res , vol.19 , pp. 92-105
    • Friedman, R.C.1    Kk-H, F.2    Burge, C.B.3    Bartel, D.P.4
  • 190
    • 77954225513 scopus 로고    scopus 로고
    • MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance
    • El Mazzar M, McCall C. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem 2010;285:20940-20951.
    • (2010) J Biol Chem , vol.285 , pp. 20940-20951
    • El Mazzar, M.1    McCall, C.2
  • 193
    • 33846487358 scopus 로고    scopus 로고
    • Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease
    • DOI 10.1016/j.micinf.2006.10.002, PII S1286457906003558
    • Moens L, Verhaegen J, Pierik M, Vermeire S, De Boeck K, Peetermans WE, Bossuyt X. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease. Microbes Infect 2007;9:15-20. (Pubitemid 46151757)
    • (2007) Microbes and Infection , vol.9 , Issue.1 , pp. 15-20
    • Moens, L.1    Verhaegen, J.2    Pierik, M.3    Vermeire, S.4    De Boeck, K.5    Peetermans, W.E.6    Bossuyt, X.7
  • 197
    • 34347334610 scopus 로고    scopus 로고
    • Genetic polymorphisms and the risk of infection following esophagectomy. Positive association with TNF-α gene -308 genotype
    • DOI 10.1097/01.sla.0000259389.09161.49, PII 0000065820070700000019
    • Azim K, McManus R, Brophy K, Ryan A, Kellleher D, Reynolds J. Genetic polymorphisms and the risk of infection followign esophagectomy positive assocation with TNF alpha gene-308 genotype. Ann Surg 2007;246:122-128. (Pubitemid 47012216)
    • (2007) Annals of Surgery , vol.246 , Issue.1 , pp. 122-128
    • Azim, K.1    McManus, R.2    Brophy, K.3    Ryan, A.4    Kelleher, D.5    Reynolds, J.V.6
  • 198
    • 0042921428 scopus 로고    scopus 로고
    • Influence of the TNF-α and TNF-β polymorphisms upon infectious risk and outcome in surgical intensive care patients
    • Calvano J, Um J, Agnese D, Hahm S, Kumar A, Coyle S, Calvano S, Lowry S. Influence of the TNFalpha and TNFbeta polymorphisms upon infectious risk and outcome in surgical intensive care patients. Surg Infect (Larchmt) 2003;4:163-169. (Pubitemid 37038782)
    • (2003) Surgical Infections , vol.4 , Issue.2 , pp. 163-169
    • Calvano, J.E.1    Um, J.Y.2    Agnese, D.M.3    Hahm, S.J.4    Kumar, A.5    Coyle, S.M.6    Calvano, S.E.7    Lowry, S.F.8
  • 199
    • 2442544293 scopus 로고    scopus 로고
    • Tumor Necrosis Factor α - 308 Polymorphism Associated with Increased Sepsis Mortality in Ventilated Very Low Birth Weight Infants
    • DOI 10.1097/01.inf.0000122607.73324.20
    • Hedberg CL, Adcock K, Martin J, Loggin J, Kruger TE, Baier RJ. Tumor necrosis factor alpha-308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants. Pediatr Infect Dis J 2004;25:424-428. (Pubitemid 38621481)
    • (2004) Pediatric Infectious Disease Journal , vol.23 , Issue.5 , pp. 424-428
    • Hedberg, C.L.1    Adcock, K.2    Martin, J.3    Loggins, J.4    Kruger, T.E.5    Baier, R.J.6
  • 202
    • 0032745383 scopus 로고    scopus 로고
    • Polymorphism in the promoter region of tumor necrosis factor-alpha gene is associated with severe melioidosis
    • DOI 10.1016/S0198-8859(99)00073-7, PII S0198885999000737
    • Nuntayamuwat S, Dharakul T, Chaowagul W, Songsivilai S. Polymorphism in the promoter region of tumor necrosis factor alpha gene is associated with severe meliodosis. Hum Immunol 1999;60:979-983. (Pubitemid 29518123)
    • (1999) Human Immunology , vol.60 , Issue.10 , pp. 979-983
    • Nuntayanuwat, S.1    Dharakul, T.2    Chaowagul, W.3    Songsivilai, S.4
  • 203
    • 0036097720 scopus 로고    scopus 로고
    • The G→A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-α promoter increases the risk for severe sepsis after trauma
    • O'Keefe G, Hybki D, Munford R. The G < A single nucleotide polymorphism at the-108 position in the tumor necrosis factoralpha promoter increases the risk for severe sepsis after trauma. J Trauma 2002;52:817-825. (Pubitemid 34534455)
    • (2002) Journal of Trauma - Injury, Infection and Critical Care , vol.52 , Issue.5 , pp. 817-825
    • O'Keefe, G.E.1    Hybki, D.L.2    Munford, R.S.3
  • 204
    • 0029922017 scopus 로고    scopus 로고
    • A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-α concentrations and outcome of patients with severe sepsis
    • DOI 10.1097/00003246-199603000-00004
    • Stuber F, Petersen M, Bokelmann F, Schade U. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor alpha concentrations an outcome of patients with sepsis. Crit Care Med 1996;24:381-384. (Pubitemid 26097828)
    • (1996) Critical Care Medicine , vol.24 , Issue.3 , pp. 381-384
    • Stuber, F.1    Petersen, M.2    Bokelmann, F.3    Schade, U.4
  • 206
    • 0012382804 scopus 로고    scopus 로고
    • Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis
    • DOI 10.1097/00003246-199907000-00024
    • Fang XM, Schroder S, Hoeft A, Stuber F. Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med 1999;27:1330-1334. (Pubitemid 29379372)
    • (1999) Critical Care Medicine , vol.27 , Issue.7 , pp. 1330-1334
    • Fang, X.M.1    Schroder, S.2    Hoeft, A.3    Stuber, F.4
  • 207
    • 0036250135 scopus 로고    scopus 로고
    • Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients
    • Ma P, Chen D, Pan J, Du B. Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients. Crit Care Med 2002;30:1046-1050. (Pubitemid 34508027)
    • (2002) Critical Care Medicine , vol.30 , Issue.5 , pp. 1046-1050
    • Ma, P.1    Chen, D.2    Pan, J.3    Du, B.4
  • 209
    • 33746571068 scopus 로고    scopus 로고
    • IL10 IL6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight children
    • Baier R, Loggins J, Yanamandra K. IL10, IL6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight children. BMC Med 2006;12:10-12.
    • (2006) BMC Med , vol.12 , pp. 10-12
    • Baier, R.1    Loggins, J.2    Yanamandra, K.3
  • 210
    • 0041827043 scopus 로고    scopus 로고
    • IL-18 promoter polymorphisms correlate with the development of post-injury sepsis
    • DOI 10.1067/msy.2003.248
    • Stassen N, Breit C, Norfleet L, Polk HJ. IL18 promoter polymorphisms correlated with the development of post-injury sepsis. Surgery 2003;134:351-356. (Pubitemid 37070360)
    • (2003) Surgery , vol.134 , Issue.2 , pp. 351-356
    • Stassen, N.A.1    Breit, C.M.2    Norfleet, L.A.3    Polk Jr., H.C.4
  • 211
    • 0036675051 scopus 로고    scopus 로고
    • Interferon-γ gene polymorphisms and the development of sepsis in patients with trauma
    • DOI 10.1067/msy.2002.127167
    • Stassen N, Leslie-Norfleet L, Robertson A, Eichenberger M, Polk HJ. Interferon gamma gene polymorphisms and the development of sepsis in patients with trauma. Surgery 2002; 132:289-292. (Pubitemid 35024775)
    • (2002) Surgery , vol.132 , Issue.2 , pp. 289-292
    • Stassen, N.A.1    Leslie-Norfleet, L.A.2    Robertson, A.M.3    Eichenberger, M.R.4    Polk Jr., H.C.5
  • 213
    • 0037312723 scopus 로고    scopus 로고
    • Association of IL-10 polymorphism with severity of illness in community acquired pneumonia
    • DOI 10.1136/thorax.58.2.154
    • Gallagher PM, Lowe G, Fitzgerald T, Bella A, Greene CM, McElvaney NG, O'Neill SJ. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 2003;58:154-156. (Pubitemid 36183005)
    • (2003) Thorax , vol.58 , Issue.2 , pp. 154-156
    • Gallagher, P.M.1    Lowe, G.2    Fitzgerald, T.3    Bella, A.4    Greene, C.M.5    McElvaney, N.G.6    O'Neill, S.J.7
  • 215
    • 0346896374 scopus 로고    scopus 로고
    • IL-10 polymorphism is associated with increased incidence of severe sepsis
    • Shu Q, Fang X, Chen Q, Stuber F. IL10 polymorphism is associated with increased incidence of severe sepsis. Chin Med J (Engl) 2003;116:1756-1759. (Pubitemid 38008256)
    • (2003) Chinese Medical Journal , vol.116 , Issue.11 , pp. 1756-1759
    • Shu, Q.1    Fang, X.2    Chen, Q.3    Stuber, F.4
  • 217
    • 27944465278 scopus 로고    scopus 로고
    • For the Perioperative Genetics,and Safety Outcomes Study (PEGASUS) Investigative Team. APOE polymorphism is associated with risk of severe sepsis in surgical patients
    • Moretti EW, Morris RW, Podgoreanu M, Schwinn DA, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT, for the Perioperative Genetics,and Safety Outcomes Study (PEGASUS) Investigative Team. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit Care Med 2005;33:2521-2526
    • (2005) Crit Care Med , vol.33 , pp. 2521-2526
    • Moretti, E.W.1    Morris, R.W.2    Podgoreanu, M.3    Schwinn, D.A.4    Newman, M.F.5    Bennett, E.6    Moulin, V.G.7    Mba, U.U.8    Laskowitz, D.T.9
  • 218
    • 60849088006 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection
    • Bunder-Wiersman H, Koopmans R, Kuipers T, Knoester H, Bos A. Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection. Pediatr Crit Care Med 2008;9:517-523.
    • (2008) Pediatr Crit Care Med , vol.9 , pp. 517-523
    • Bunder-Wiersman, H.1    Koopmans, R.2    Kuipers, T.3    Knoester, H.4    Bos, A.5


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